Clinical correlates of sex steroids and gonadotropins in men over the late adulthood: the Framingham Heart Study
Open accessAbstract
Low serum concentrations of sex steroids and gonadotropins in men have been associated with increased cardiometabolic risk and mortality, but the clinical correlates of these hormones in men over late adulthood are less clearly understood. We analysed up to five serial measurements of total testosterone (TT), dehydroepiandrosterone sulphate (DHEAS), follicle stimulating hormone (FSH), luteinizing hormone (LH) and total estradiol (EST) in older men in the original cohort of the Framingham Heart Study to determine the short- (2-years; 1,165 person-observations in 528 individuals) and long-term (up to 10-years follow-up; 2520 person-observations in 835 individuals with mean baseline age: 71.2 years) clinical correlates of these sex steroids and gonadotropins using multilevel modelling and Generalized Estimating Equations. Age, body mass index and pre-existing type 2 diabetes were inversely related to long-term TT concentrations, whereas higher systolic blood pressure showed a positive association. Furthermore, age and pre-existing cardiovascular disease (CVD) were inversely associated and HDL cholesterol concentrations positively associated with long-term DHEAS concentrations respectively. Analyses of short-term changes revealed age was inversely related to DHEAS, but positively related to FSH and LH concentrations. Our community-based study identified modifiable correlates of decreasing TT and DHEAS concentrations in elderly men, suggesting that maintenance of a low CVD risk factor burden may mitigate the age-related decline of these hormones over the late adulthood.
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In large prospective observational studies, weight gain and development of comorbidities were consistently associated with an acceleration of the age-related decline in testosterone levels.
“In large prospective observational studies, weight gain and development of comorbidities were consistently associated with an acceleration of the age-related decline in testosterone levels (17, 18).”
From A Perspective on Middle-Aged and Older Men With Functional Hypogonadism: Focus on Holistic Management (2017) · cites this paper as [18]
In the Framingham Heart Study, a high cardiovascular disease risk factor burden markedly increased the age-related testosterone decline.
“In the Framingham Heart Study, a high cardiovascular disease risk factor burden markedly increased the age-related testosterone decline (18).”
From A Perspective on Middle-Aged and Older Men With Functional Hypogonadism: Focus on Holistic Management (2017) · cites this paper as [18]
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- Schipf S Haring R Friedrich N Nauck MA Lau K Alte D Stang A Volzke H Wallaschofski H 2010 Low Total Testosterone is Associated with Increased Risk of Incident Type 2 Diabetes Mellitus in Men: Results from the Study of Health in Pomerania (SHIP) Aging Male 21039324
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Grossmann, M., & Matsumoto, A. M. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-3580 · Cited by 246 · see citing works
Longitudinal changes in testosterone over five years in community-dwelling men
Shi, Z., Araujo, A. B., Martin, S., O'Loughlin, P., & Wittert, G. A. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-3842 · Cited by 165 · see citing works
- Authors
- Haring, R., Xanthakis, V., Coviello, A., Sullivan, L., Bhasin, S., Wallaschofski, H., Murabito, J. M., & Vasan, R. S.
- Affiliations
- Universitätsmedizin Greifswald (DE)
- General Department of Preventive Medicine (VN)
- Boston University (US)
- Corresponding author
- Haring, R.
- Vasan, R. S.
- Venue
- International Journal of Andrology
- Publisher
- Wiley
- Published
- 2012-05-29
- Volume
- 35
- Issue
- 6
- Pages
- 775-782
- ISSN
- 0105-6263 (ISSN-L)
- 1365-2605
- PMC
- PMC3434249
- OpenAlex
- W2099456194
- Cited by
- 22
- References
- 50
- Citations by year
- 2026: 1 · 2022: 1 · 2021: 1 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 5 · 2014: 4 · 2013: 4
- FWCI
- 3.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- International Journal of Andrology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (n01hc25195-41-0-1)
- National Heart, Lung, and Blood Institute (N01‐HC25195, N01-HC-025195)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK092938)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Keywords
- sex steroids, gonadotropins, old age, older men, total testosterone, dehydroepiandrosterone sulfate, follicle-stimulating hormone, luteinizing hormone, estradiol, cardiovascular disease, cardiometabolic risk, HDL cholesterol, systolic blood pressure, type 2 diabetes, Framingham Heart Study
- MeSH terms
- Aged, Cardiovascular Diseases, Gonadotropins, Humans, Longitudinal Studies, Male, Massachusetts, Middle Aged, Gonadal Steroid Hormones
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