The National Children's Study: A 21-Year Prospective Study of 100 000 American Children
Abstract
Prospective, multiyear epidemiologic studies have proven to be highly effective in discovering preventable risk factors for chronic disease. Investigations such as the Framingham Heart Study have produced blueprints for disease prevention and saved millions of lives and billions of dollars. To discover preventable environmental risk factors for disease in children, the US Congress directed the National Institute of Child Health and Human Development, through the Children's Health Act of 2000, to conduct the National Children's Study. The National Children's Study is hypothesis-driven and will seek information on environmental risks and individual susceptibility factors for asthma, birth defects, dyslexia, attention-deficit/hyperactivity disorder, autism, schizophrenia, and obesity, as well as for adverse birth outcomes. It will be conducted in a nationally representative, prospective cohort of 100000 US-born children. Children will be followed from conception to 21 years of age. Environmental exposures (chemical, physical, biological, and psychosocial) will be assessed repeatedly during pregnancy and throughout childhood in children's homes, schools, and communities. Chemical assays will be performed by the Centers for Disease Control and Prevention, and banks of biological and environmental samples will be established for future analyses. Genetic material will be collected on each mother and child and banked to permit study of gene-environment interactions. Recruitment is scheduled to begin in 2007 at 7 Vanguard Sites and will extend to 105 sites across the United States. The National Children's Study will generate multiple satellite studies that explore methodologic issues, etiologic questions, and potential interventions. It will provide training for the next generation of researchers and practitioners in environmental pediatrics and will link to planned and ongoing prospective birth cohort studies in other nations. Data from the National Children's Study will guide development of a comprehensive blueprint for disease prevention in children.
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Two large-scale prospective epidemiological studies aiming at exploring environmental factors and GxE interaction were recently launched.
“Two large-scale prospective epidemiological studies aiming at exploring environmental factors and GxE interaction were recently launched.”
From Autism risk factors: genes, environment, and gene-environment interactions (2012) · cites this paper as [109]
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Autism risk factors: genes, environment, and gene-environment interactions
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The Contribution of Maternal Stress to Preterm Birth: Issues and Considerations
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Self-citationWhat causes autism? Exploring the environmental contribution
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Self-citationMaternal environment and the transgenerational cycle of obesity and diabetes.
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Autism Spectrum Disorders in the Stockholm Youth Cohort: Design, Prevalence and Validity
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Association of tobacco and lead exposures with attention-deficit/hyperactivity disorder
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Keil, A. P., Daniels, J. L., & Hertz-Picciotto, I. (2014) · Environmental Health · doi:10.1186/1476-069x-13-3 · Cited by 142 · see citing works
- Authors
- Landrigan, P. J., Trasande, L., Thorpe, L. E., Gwynn, C., Lioy, P. J., D'Alton, M. E., Lipkind, H. S., Swanson, J., Wadhwa, P. D., Clark, E. B., Rauh, V. A., Perera, F. P., & Susser, E.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- New York City Department of Health and Mental Hygiene (US)
- University of Medicine and Dentistry of New Jersey (US)
- Division of Maternal Fetal Medicine, Columbia University Medical Center, New York, New York
- Columbia University Irving Medical Center (US)
- Departments of Pediatrics
- University of California, Irvine (US)
- University of Utah (US)
- Heilbrunn Department of Population and Family Health
- Environmental Health Sciences
- Epidemiology, Mailman School of Public Health, New York, New York
- ORCID
- Venue
- Pediatrics
- Publisher
- American Academy of Pediatrics (AAP)
- Published
- 2006-11-01
- Volume
- 118
- Issue
- 5
- Pages
- 2173-2186
- ISSN
- 0031-4005 (ISSN-L)
- 1098-4275
- OpenAlex
- W2081538746
- Cited by
- 170
- References
- 138
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 6 · 2021: 5 · 2020: 6 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 7 · 2014: 10 · 2013: 7 · 2012: 22
- FWCI
- 10.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- PEDIATRICS (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (N01HD53411)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Human Health and Disease
- Health Sciences › Health Professions › General Health Professions › Child and Adolescent Health
- Keywords
- National Children's Study, environmental risk factors, gene-environment interaction, environmental exposure, asthma, congenital malformations, dyslexia, attention deficit hyperactivity disorder, autism spectrum disorder, schizophrenia, childhood obesity, adverse birth outcomes
- MeSH terms
- Child, Child Welfare, Humans, Pediatrics, Preventive Health Services, Prospective Studies, Time Factors, United States
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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