CoChat
Sign Up
Cited by 49Celiac Disease Research and ManagementWheat and Barley Genetics and PathologyEosinophilic Esophagitis

Turner syndrome and celiac disease: a case-control study

Mårild, Karl, Størdal, Ketil, Hagman, Anna, Ludvigsson, Jonas F.·2016·PEDIATRICS
DOI 10.1542/peds.2015-2232
Open this paper in CoChat — free account

Abstract

OBJECTIVE: Turner syndrome (TS) is the most common sex chromosome abnormality in females. Previous research has indicated a high prevalence of celiac disease (CD) in TS, but data have mostly been limited to case series at tertiary centers. We aimed to examine the risk for CD in individuals with TS compared with the general population. METHODS: This Swedish nationwide case-control study included individuals with CD and controls born in 1973-2006. The study consisted of 2 groups: (1) 7548 females with biopsy-verified CD (villous atrophy; Marsh stage 3) diagnosed until January 2008 according to histopathology report data from all 28 Swedish pathology departments and (2) 34 492 population-based controls matched by gender, age, calendar year of birth, and county of residence. TS, diagnosed by the end of 2009, was identified using prospectively recorded data from 3 nationwide health registries. Odds ratios (ORs) for CD were calculated using conditional logistic regression. RESULTS: Of the 7548 females with CD, 20 had a diagnosis of TS (0.26%) compared with 21 of 34 492 controls (0.06%), corresponding to an OR of 3.29 (95% confidence interval [CI] 1.94-5.56) for CD in individuals with TS. The risk of CD in females with TS ranged from twofold (OR 2.16; 95% CI 0.91-5.11) in the first 5 years of life to a more than fivefold increase in females aged >10 years at CD diagnosis (OR 5.50; 95% CI 1.53-19.78). The association between TS and CD was largely unaffected by concurrent type 1 diabetes. CONCLUSIONS: Females with TS are more likely to develop CD. This study supports active case-finding for CD in TS.

Integrity signals

Registry

Crossref · 10.1542/peds.2015-2232

Cites

46 of 46 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The prevalence of coeliac disease increases with age and is highest in 45,X, 45,X/iso q or ring chromosome karyotypes where up to 7.5% have positive coeliac antibodies.

    “The prevalence of coeliac disease increases with age725,726 and is highest in 45,X, 45,X/iso q or ring chromosome karyotypes where up to 7.5% have positive coeliac antibodies.26,630”

    From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [725]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Mårild, K., Størdal, K., Hagman, A., & Ludvigsson, J. F.
Affiliations
  • Norwegian Institute of Public Health (NO)
  • Norra Älvsborgs Länssjukhus (SE)
  • Karolinska Institutet (SE)
ORCID
Venue
PEDIATRICS
Publisher
American Academy of Pediatrics (AAP)
Published
2016-02-01
Volume
137
Issue
2
Pages
e20152232-e20152232
ISSN
  • 0031-4005 (ISSN-L)
  • 1098-4275
DOI
10.1542/peds.2015-2232
OpenAlex
W2389274355
Cited by
49
References
45
Citations by year
2025: 5 · 2024: 5 · 2023: 3 · 2022: 6 · 2021: 7 · 2020: 8 · 2019: 8 · 2018: 1 · 2017: 5
FWCI
5.09
Type
journal article
Language
en
Open access
closed
Locations
  • PEDIATRICS (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Wheat and Barley Genetics and Pathology
  • Health Sciences › Medicine › Surgery › Eosinophilic Esophagitis
Keywords
Turner syndrome, celiac disease, sex chromosome abnormalities, villous atrophy, type 1 diabetes, autoimmune disease susceptibility, case finding
MeSH terms
Adolescent, Celiac Disease, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Registries, Risk Factors, Sweden, Turner Syndrome, Logistic Models, Odds Ratio, Case-Control Studies

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review