Sustained antinociceptive effect of cannabinoid receptor agonist WIN 55,212-2 over time in rat model of neuropathic spinal cord injury pain
Open accessAbstract
A significant complaint associated with spinal cord injury (SCI) is chronic pain, which includes symptoms such as cutaneous hypersensitivity and spontaneous unevoked pain and is difficult to treat with currently available drugs. One complication with current analgesics is tolerance, a decrease in efficacy with repeated treatment over time. One promising class of pharmacological treatment is cannabinoid (CB) receptor agonists. The current study assessed the efficacy of the CB receptor agonist WIN 55,212-2 (WIN) in a rat model of neuropathic SCI pain. Brief spinal compression leads to significant hindpaw hypersensitivity to tactile stimulation. WIN dose-dependently increased withdrawal thresholds and continued to demonstrate efficacy over a twice-daily 7-day treatment regimen. By contrast, the efficacy of morphine in SCI rats decreased over the same treatment period. Similarly, the antinociceptive efficacy of WIN to acute noxious heat in uninjured rats diminished over time. These data suggest that the sustained efficacy of a CB receptor agonist for pain could depend on the pain state. Such agonists may hold promise for long-term use in alleviating chronic SCI pain.
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Chronic WIN55,212-2 reduced mechanical allodynia in the spinal cord injury model with no decrease in effectiveness over time, unlike morphine.
“Unlike morphine, chronic administration of WIN55,212-2 reduced mechanical allodynia in the SCI model with no decrease in effectiveness over time.104”
From Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside (2009) · cites this paper as [104]
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Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside
Rahn, E. J., & Hohmann, A. G. (2009) · Neurotherapeutics · doi:10.1016/j.nurt.2009.08.002 · Cited by 305 · see citing works
- Authors
- Hama
- Venue
- The Journal of Rehabilitation Research and Development
- Published
- 2009
- Volume
- 46
- Issue
- 1
- Pages
- 135
- ISSN
- 0742-3241 (ISSN-L)
- 0748-7711
- PMC
- PMC2743245
- OpenAlex
- W2158497203
- Cited by
- 32
- References
- 52
- Citations by year
- 2025: 1 · 2023: 3 · 2021: 5 · 2020: 4 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 3
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Rehabilitation Research and Development (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R21NS061172, NS61172)
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Pathology and Forensic Medicine › Spinal Cord Injury Research
- Keywords
- spinal cord injury, neuropathic pain, chronic pain, WIN 55,212-2, cannabinoid receptor agonists, analgesic tolerance, morphine, tactile hypersensitivity, antinociception, withdrawal threshold
- MeSH terms
- Analgesics, Opioid, Animals, Cannabinoids, Dose-Response Relationship, Drug, Hot Temperature, Male, Morphine, Morpholines, Naphthalenes, Neuralgia, Pain Measurement, Spinal Cord Injuries, Rats, Sprague-Dawley, Pain Threshold, Benzoxazines, Rats, Cannabinoid Receptor Agonists
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