Cosmetic benefits of astaxanthin on humans subjects.
Open accessAbstract
Two human clinical studies were performed. One was an open-label non-controlled study involving 30 healthy female subjects for 8 weeks. Significant improvements were observed by combining 6 mg per day oral supplementation and 2 ml (78.9 μM solution) per day topical application of astaxanthin. Astaxanthin derived from the microalgae, Haematococcus pluvialis showed improvements in skin wrinkle (crow's feet at week-8), age spot size (cheek at week-8), elasticity (crow's feet at week-8), skin texture (cheek at week-4), moisture content of corneocyte layer (cheek in 10 dry skin subjects at week-8) and corneocyte condition (cheek at week-8). It may suggest that astaxanthin derived from H. pluvialis can improve skin condition in all layers such as corneocyte layer, epidermis, basal layer and dermis by combining oral supplementation and topical treatment. Another was a randomized double-blind placebo controlled study involving 36 healthy male subjects for 6 weeks. Crow's feet wrinkle and elasticity; and transepidermal water loss (TEWL) were improved after 6 mg of astaxanthin (the same as former study) daily supplementation. Moisture content and sebum oil level at the cheek zone showed strong tendencies for improvement. These results suggest that astaxanthin derived from Haematococcus pluvialis may improve the skin condition in not only in women but also in men.
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Carotenoids stimulate fibroblasts to produce collagen and elastin.
“Carotenoids prevent ageing, stimulate fibroblasts to produce collagen and elastin, inhibit the activity of MMPs, and exhibit anti-inflammatory and UV-filtering effects [222,226,231].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [231]
Carotenoids exhibit UV-filtering effects.
“Carotenoids prevent ageing, stimulate fibroblasts to produce collagen and elastin, inhibit the activity of MMPs, and exhibit anti-inflammatory and UV-filtering effects [222,226,231].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [231]
Carotenoids improve the elasticity of skin.
“They have been shown to improve the elasticity, hydration and texture of skin; reduce TEWL; lighten the skin; reduce discoloration; and delay the signs of photoaging [222,231,232,233].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [231]
Carotenoids inhibit the activity of MMPs.
“Carotenoids prevent ageing, stimulate fibroblasts to produce collagen and elastin, inhibit the activity of MMPs, and exhibit anti-inflammatory and UV-filtering effects [222,226,231].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [231]
Carotenoids exhibit anti-inflammatory effects.
“Carotenoids prevent ageing, stimulate fibroblasts to produce collagen and elastin, inhibit the activity of MMPs, and exhibit anti-inflammatory and UV-filtering effects [222,226,231].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [231]
Carotenoids prevent ageing.
“Carotenoids prevent ageing, stimulate fibroblasts to produce collagen and elastin, inhibit the activity of MMPs, and exhibit anti-inflammatory and UV-filtering effects [222,226,231].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [231]
Carotenoids lighten the skin.
“They have been shown to improve the elasticity, hydration and texture of skin; reduce TEWL; lighten the skin; reduce discoloration; and delay the signs of photoaging [222,231,232,233].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [231]
Carotenoids reduce discoloration.
“They have been shown to improve the elasticity, hydration and texture of skin; reduce TEWL; lighten the skin; reduce discoloration; and delay the signs of photoaging [222,231,232,233].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [231]
Carotenoids reduce TEWL.
“They have been shown to improve the elasticity, hydration and texture of skin; reduce TEWL; lighten the skin; reduce discoloration; and delay the signs of photoaging [222,231,232,233].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [231]
Carotenoids improve the hydration of skin.
“They have been shown to improve the elasticity, hydration and texture of skin; reduce TEWL; lighten the skin; reduce discoloration; and delay the signs of photoaging [222,231,232,233].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [231]
Carotenoids improve the texture of skin.
“They have been shown to improve the elasticity, hydration and texture of skin; reduce TEWL; lighten the skin; reduce discoloration; and delay the signs of photoaging [222,231,232,233].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [231]
Carotenoids delay the signs of photoaging.
“They have been shown to improve the elasticity, hydration and texture of skin; reduce TEWL; lighten the skin; reduce discoloration; and delay the signs of photoaging [222,231,232,233].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [231]
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- Authors
- Tominaga, K., Hongo, N., Karato, M., & Yamashita, E.
- Affiliations
- Fuji Chemical Industries (Japan) (JP)
- Venue
- Acta Biochimica Polonica
- Publisher
- Frontiers Media SA
- Published
- 2012-03-17
- Volume
- 59
- Issue
- 1
- Pages
- 43-7
- ISSN
- 0001-527X (ISSN-L)
- 1734-154X
- OpenAlex
- W2020170263
- Cited by
- 248
- References
- 7
- Citations by year
- 2026: 19 · 2025: 20 · 2024: 12 · 2023: 28 · 2022: 25 · 2021: 40 · 2020: 21 · 2019: 17 · 2018: 24 · 2017: 11 · 2016: 5 · 2015: 12 · 2014: 9 · 2013: 4 · 2012: 1
- FWCI
- 10.41
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-sa
- Locations
- Acta Biochimica Polonica (publishedVersion, cc-by-sa)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- astaxanthin, Haematococcus pluvialis, skin aging, crow's feet, skin elasticity, liver spots, skin texture, transepidermal water loss, sebum, oral supplementation, topical application, carotenoids
- MeSH terms
- Adult, Cosmetics, Double-Blind Method, Female, Humans, Male, Middle Aged, Skin, Skin Aging, Treatment Outcome, Xanthophylls, Young Adult
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