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Cited by 141Skin Protection and Agingmelanin and skin pigmentationAntioxidant Activity and Oxidative Stress

The Protective Role of Astaxanthin for UV-Induced Skin Deterioration in Healthy People—A Randomized, Double-Blind, Placebo-Controlled Trial

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Ito, Naoki, Seki, Shinobu, Ueda, Fumitaka·2018·Nutrients
DOI 10.3390/nu10070817PMC PMC6073124
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Abstract

Skin is a major safeguard tissue in humans. Because biological barrier function is deteriorated by several kinds of stresses including exposure to ultra-violet (UV) rays, the protection and treatment of skin conditions by dietary supplements are important. We therefore evaluated the effects of dietary supplementation with an algal food-derived antioxidant, astaxanthin, on UV-induced skin deterioration. Twenty-three healthy Japanese participants were recruited to a 10-week double-blind placebo-controlled study. They were assigned to the astaxanthin group supplemented with a capsule containing 4 mg of astaxanthin or the placebo group. To assess the protective role of astaxanthin for UV-induced skin deterioration, we determined the minimal erythema dose (MED) and analyzed UV-induced changes of moisture and transepidermal water loss (TEWL) at baseline and after 9 weeks of supplementation. Subjective skin conditions were assessed by the visual analog scale. The astaxanthin group showed increased MED compared with placebo. In addition, the astaxanthin group had a reduced loss of skin moisture in the irradiated area compared with placebo. Subjective skin conditions for “improvement of rough skin” and “texture” in non-irradiated areas were significantly improved by astaxanthin. Astaxanthin seems protective against UV-induced skin deterioration and helps maintain healthy skin in healthy people.

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  • In a 10-week double-blind placebo-controlled study, participants supplemented with astaxanthin had reduced loss of back skin moisture and significantly improved back skin texture compared with placebo.

    “In a 10-week, double-blind, placebo-controlled study, there was reduced loss of back skin moisture and the back skin texture was significantly improved in participants who were supplemented with astaxanthin, compared with a placebo group [97,98].”

    From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [97]

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Authors
Ito, N., Seki, S., & Ueda, F.
Affiliations
Fujifilm (Japan) (JP)
Corresponding author
Ito, Naoki
ORCID
Ito, Naoki
Venue
Nutrients
Publisher
MDPI AG
Published
2018-06-25
Volume
10
Issue
7
Pages
817
ISSN
2072-6643 (ISSN-L)
DOI
10.3390/nu10070817
PMC
PMC6073124
OpenAlex
W2809446677
Cited by
141
References
34
Citations by year
2026: 17 · 2025: 21 · 2024: 19 · 2023: 21 · 2022: 19 · 2021: 26 · 2020: 10 · 2019: 6 · 2018: 2
FWCI
11.90
Type
journal article
Language
en
Open access
Licence
Locations
  • Nutrients (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Fujifilm Corporation
Topics
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords
astaxanthin, ultraviolet radiation, UV-induced skin damage, dietary supplementation, antioxidants, minimal erythema dose, transepidermal water loss, skin hydration, skin texture, skin roughness, healthy adults
MeSH terms
Administration, Oral, Adult, Antioxidants, Capsules, Double-Blind Method, Erythema, Female, Humans, Japan, Male, Middle Aged, Skin, Sunburn, Sunscreening Agents, Time Factors, Ultraviolet Rays, Water Loss, Insensible, Skin Aging, Dietary Supplements, Xanthophylls, Healthy Volunteers

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