Cited by 57Skin Protection and AgingAntioxidant Activity and Oxidative StressPhytochemicals and Antioxidant Activities

Effects of astaxanthin supplementation on skin health: A systematic review of clinical studies

Ng, Qin Xiang, De Deyn, Michelle Lee Zhi Qing, Loke, Wayren, Foo, Nadine Xinhui, Chan, Hwei Wuen, Yeo, Wee Song·2021·Journal of Dietary Supplements

Abstract

. There is growing commercial interest in the application of astaxanthin in nutraceuticals and cosmeceuticals, due to its purported photoprotective, DNA repair, antioxidant, and anti-inflammatory benefits. This systematic review therefore aimed to summarize current clinical evidence on the effects of astaxanthin supplementation on skin health. Using the following combinations of broad Major Exploded Subject Headings (MesH) terms or text words [astaxanthin OR AST OR ASX OR carotenoid OR xanthophyll] AND [skin OR derm*], a comprehensive search of PubMed, EMBASE, Medline, Clinicaltrials.gov, and Google Scholar databases found a total of eleven clinical studies. There were six randomized, placebo-controlled, double-blind trials, while the rest were prospective, open-label studies. In many of the randomized, controlled trials reviewed, AST supplementation improved skin texture, appearance (wrinkles), and moisture content at the end of the study period. AST also appeared to protect against UV-induced skin damage. No serious adverse events were reported in any of the studies. However, most available studies had a relatively small sample size and were conducted on healthy Japanese females. Many of the studies were also funded by commercial entities, with potential conflicts of interests. This was difficult to account for in our analyses. Overall, there is some clinical data to support the benefits of astaxanthin supplementation (in the range of 3 to 6 mg/d) on skin health, especially for photoaged skin.

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Registry

Crossref · 10.1080/19390211.2020.1739187

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  • In a 10-week double-blind placebo-controlled study, participants supplemented with astaxanthin had reduced loss of back skin moisture and significantly improved back skin texture compared with placebo.

    “In a 10-week, double-blind, placebo-controlled study, there was reduced loss of back skin moisture and the back skin texture was significantly improved in participants who were supplemented with astaxanthin, compared with a placebo group [97,98].”

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Authors
Ng, Q. X., De Deyn, M. L. Z. Q., Loke, W., Foo, N. X., Chan, H. W., & Yeo, W. S.
Affiliations
  • University of Essex (GB)
  • Department of Medicine, James Cook University Hospital, Middlesbrough, United Kingdom
  • MOH Holdings (SG)
  • National University of Singapore (SG)
Corresponding author
Ng, Qin Xiang
Venue
Journal of Dietary Supplements
Published
2020-03-23
Volume
18
Issue
2
Pages
169-182
ISSN
  • 1939-0211 (ISSN-L)
  • 1939-022X
OpenAlex
W3012942386
Cited by
57
References
35
Citations by year
2026: 8 · 2025: 7 · 2024: 10 · 2023: 7 · 2022: 5 · 2021: 15 · 2020: 5
FWCI
1.34
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Dietary Supplements (publishedVersion)
  • PubMed (publishedVersion)
  • National University of Singapore (submittedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords
astaxanthin, skin health, photoprotection, photoaging, UV-induced skin damage, skin texture, wrinkles, skin hydration, antioxidants, anti-inflammatory agents, carotenoids, nutraceuticals, cosmeceuticals, dietary supplementation
MeSH terms
Female, Humans, Prospective Studies, Skin, Randomized Controlled Trials as Topic, Dietary Supplements, Xanthophylls

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