Selenium Preserves Keratinocyte Stemness and Delays Senescence by Maintaining Epidermal Adhesion
Open accessAbstract
Skin is constantly exposed to environmental factors such as pollutants, chemicals and ultra violet radiation (UV), which can induce premature skin aging and increase the risk of skin cancer. One strategy to reduce the effect of oxidative stress produced by environmental exposure is the application of antioxidant molecules. Among the endogenous antioxidants, selenoproteins play a key role in antioxidant defense and in maintaining a reduced cellular environment. Selenium, essential for the activity of selenoproteins, is a trace element that is not synthesized by organisms and must be supplied by diet or supplementation. The aim of this study is to evaluate the effect of Selenium supplementation on skin aging, especially on keratinocytes, the main cells of the epidermis. Our results demonstrate for the first time to our knowledge, the major role of Selenium on the replicative life span of keratinocytes and on aging skin. Selenium protects keratinocyte stem cells (KSCs) against senescence via preservation of their stemness phenotype through adhesion to the basement membrane. Additionally, Selenium supplementation maintains the homeostasis of skin during chronological aging in our senescent skin equivalent model. Controlled supplementation with Selenium could be a new strategy to protect skin against aging.
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The structural and functional roles of zinc, selenium, magnesium, copper, and manganese are crucial for antioxidant defence.
“Concerning the latter, the structural and functional roles of a few minerals such as zinc (Zn), selenium (Se), magnesium (Mg) copper (Cu) and manganese (Mn) is crucial (Table 5) [409,410,411,412,413,414,415,416,417,418,419,420].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [413]
In vitro, selenium supplementation reduces ROS levels, DNA damage, telomere shortening, and senescence biomarkers in bone marrow stromal cells, cultured human fibroblasts, and keratinocytes.
“For instance, in bone marrow stromal cells [443], cultured human fibroblasts [412], and keratinocytes [413], Se supplementation reduces ROS levels, DNA damage, telomere shortening and senescence biomarkers.”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [413]
Selenium delays skin ageing by protecting keratinocyte stem cells.
“This was confirmed in a study by Jobeili et al., which showed that selenium delays skin ageing by protecting keratinocyte stem cells [91].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [91]
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- [12]Rafferty TS McKenzie RC Hunter JA Howie AF Arthur JR Nicol F Beckett GJ Differential expression of selenoproteins by human skin cells and protection by selenium from UVB-radiation-induced cell death Biochem J 1998 332 231 36 https://doi.org/10.1042/bj3320231 9576872 PMC1219472 · DOI
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Bioactive Compounds for Skin Health: A Review
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“, which showed that selenium delays skin ageing by protecting keratinocyte stem cells [91].”
BackgroundSelenium, aging and aging-related diseases
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Self-citation
- Authors
- Jobeili, L., Rousselle, P., Béal, D., Blouin, E., Roussel, A.-M., Damour, O., & Rachidi, W.
- Affiliations
- Lyon 1 Université (FR)
- Grenoble Alpes University, Grenoble, France
- LABCATAL (France) (FR)
- Université Grenoble Alpes (FR)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Venue
- Aging
- Publisher
- Impact Journals, LLC
- Published
- 2017-11-25
- Volume
- 9
- Issue
- 11
- Pages
- 2302-2315
- ISSN
- 1945-4589 (ISSN-L)
- PMC
- PMC5723688
- OpenAlex
- W2770049680
- Cited by
- 44
- References
- 47
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 8 · 2021: 7 · 2020: 3 · 2019: 7 · 2018: 6
- FWCI
- 3.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by
- Locations
- Aging (publishedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- HAL (submittedVersion, cc-by)
- Funders
- Agence Nationale de la Recherche (ANR-13-RPIB-0003)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Keywords
- selenium supplementation, epidermal stem cells, cellular senescence, skin aging, epidermal adhesion, basement membrane, selenoproteins, antioxidant defense, oxidative stress, skin equivalent model, chronological aging
- MeSH terms
- Antioxidants, Basement Membrane, Cell Adhesion, Cell Differentiation, Cell Survival, Cells, Cultured, Dose-Response Relationship, Drug, Epidermis, Humans, Phenotype, Stem Cells, Time Factors, Skin Aging, Keratinocytes, Cellular Senescence, Sodium Selenite, Cell Proliferation
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