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Cited by 300

The DOI matches its Crossref record; 159 of the 159 references it cites were found in a registry or an index.

Metabolism, toxicity and anticancer activities of arsenic compounds

Open access
Khairul, Islam, Wang, Qian Qian, Jiang, Yu Han, Wang, Chao, Naranmandura, Hua·2017·Oncotarget
DOI 10.18632/oncotarget.14733
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Abstract

// Islam Khairul 1 , Qian Qian Wang 1,2 , Yu Han Jiang 1,3 , Chao Wang 1 and Hua Naranmandura 1,2,3 1 Department of Toxicology, School of Medicine and Public Health, Zhejiang University, Hangzhou, China 2 College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China 3 Ocean College, Zhejiang University, Hangzhou, China Correspondence to: Hua Naranmandura, email: // Keywords : arsenite, acute promyelocytic leukemia Received : November 23, 2016 Accepted : January 11, 2017 Published : January 18, 2017 Abstract A variety of studies indicated that inorganic arsenic and its methylated metabolites have paradoxical effects, namely, carcinogenic and anticancer effects. Epidemiological studies have shown that long term exposure to arsenic can increase the risk of cancers of lung, skin or bladder in man, which is probably associated with the arsenic metabolism. In fact, the enzymatic conversion of inorganic arsenic by Arsenic (+3 oxidation state) methyltransferase (AS3MT) to mono- and dimethylated arsenic species has long been considered as a major route for detoxification. However, several studies have also indicated that biomethylation of inorganic arsenic, particularly the production of trivalent methylated metabolites, is a process that activates arsenic as a toxin and a carcinogen. On the other hand, arsenic trioxide (As 2 O 3 ) has recently been recognized as one of the most effective drugs for the treatment of APL. However, elaboration of the cytotoxic mechanisms of arsenic and its methylated metabolites in eradicating cancer is sorely lacking. To provide a deeper understanding of the toxicity and carcinogenicity along with them use of arsenic in chemotherapy, caution is required considering the poor understanding of its various mechanisms of exerting toxicity. Thereby, in this review, we have focused on arsenic metabolic pathway, the roles of the methylated arsenic metabolites in toxicity and in the therapeutic efficacy for the treatments of solid tumors, APL and/or non-APL malignancies.

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Metadata

Authors
Khairul, I., Wang, Q. Q., Jiang, Y. H., Wang, C., & Naranmandura, H.
Venue
Oncotarget
Publisher
Impact Journals, LLC
Published
2017-01-18
Volume
8
Issue
14
Pages
23905-23926
ISSN
1949-2553 (ISSN-L)
DOI
10.18632/oncotarget.14733
OpenAlex
W2573398098
Cited by
300
References
159
FWCI
15.11
Type
journal article
Language
en
Open access
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