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PreprintCited by 306Advanced Drug Delivery SystemsNanoparticle-Based Drug DeliveryInhalation and Respiratory Drug Delivery

The DOI matches its Crossref record; 174 of the 176 references it cites were found in a registry or an index.

Surface-Modified Nanocarriers for Nose-To-Brain Delivery: From Bioadhesion to Targeting

Open access
Sonvico, Fabio, Clementino, Adryana Rocha, Buttini, Francesca, Colombo, Gaia, Pescina, Silvia, Stanisçuaski Guterres, Silvia, Raffin Pohlmann, Adriana, Nicoli, Sara·2018·Pharmaceutics
DOI 10.20944/preprints201802.0077.v1PMC PMC5874847

Preprint — published as 10.3390/pharmaceutics10010034 · Paper page

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Abstract

In the field of nasal delivery, one of the most fascinating applications is the delivery of drugs directly to the central nervous system bypassing the blood brain barrier. This approach would provide a series of benefits, such as dose lowering and direct targeting of potent drugs, ultimately reducing their systemic side effects. Recently, clinical trials have explored the nasal administration of insulin for the treatment of Alzheimer’s disease, with promising results. The use of nanomedicines could provide further options for making nose-to-brain delivery reality. In particular, apart from the selection of devices able to deposit the formulation in the upper part of the nose, surface modification of these nanomedicines appears the key strategy to optimize the delivery of drugs from the nasal cavity to the brain. In this review, nanomedicines delivery approaches based on surface electrostatic charges, mucoadhesive polymers, as well as chemical moieties targeting nasal epithelium, will be discussed and critically evaluated for nose-to-brain delivery.

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Crossref · 10.20944/preprints201802.0077.v1

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Figures

Figure 1 (a) Nasal innervation; (b) Nose-to-brain (N2B) pathways of drug delivery (modified from [15,16] with permission).
Figure 1 (a) Nasal innervation; (b) Nose-to-brain (N2B) pathways of drug delivery (modified from [15,16] with permission).CC BY · PubMed Central
Figure 2 Dynamics of Alexa-dextran in brain tissue following nasal administration of hydrophobic (STR–CH2R4H2C) and hydrophilic (MPEG–PCL–CH2R4H2C) surface nanocarriers in: (a) whole brain and (b) 2 mm-sliced brain sections (reprinted with permission from [76]).
Figure 2 Dynamics of Alexa-dextran in brain tissue following nasal administration of hydrophobic (STR–CH2R4H2C) and hydrophilic (MPEG–PCL–CH2R4H2C) surface nanocarriers in: (a) whole brain and (b) 2 mm-sliced brain sections (reprinted with permission from [76]).CC BY · PubMed Central
Figure 3 Surface chemistry of nanoparticles having an influence on mucoadhesion (modified with permission from [84]).
Figure 3 Surface chemistry of nanoparticles having an influence on mucoadhesion (modified with permission from [84]).CC BY · PubMed Central
Figure 4 Fraction of total radioactivity recovered per organ 90 min after nasal administration to rats of (a) 99mTc-labelled simvastatin-loaded nanoparticles; (b) 99mTc-labelled simvastatin suspension [113].
Figure 4 Fraction of total radioactivity recovered per organ 90 min after nasal administration to rats of (a) 99mTc-labelled simvastatin-loaded nanoparticles; (b) 99mTc-labelled simvastatin suspension [113].CC BY · PubMed Central
Figure 5 Major mechanisms hindering particles from diffusing through mucus: (a) Size filtering, by which only particles smaller than the mesh pores of the mucin fiber network can cross, whereas larger objects are blocked; (b) Interaction filtering, when particles behavior is different according to their surface properties: orange particles interacting strongly with the components of the mucus gel are trapped, whereas green particles showing weak interactions are allowed to go across (reproduced with permission from [121]).
Figure 5 Major mechanisms hindering particles from diffusing through mucus: (a) Size filtering, by which only particles smaller than the mesh pores of the mucin fiber network can cross, whereas larger objects are blocked; (b) Interaction filtering, when particles behavior is different according to their surface properties: orange particles interacting strongly with the components of the mucus gel are trapped, whereas green particles showing weak interactions are allowed to go across (reproduced with permission from [121]).CC BY · PubMed Central
Figure 6 Distribution of wheat germ agglutinin (WGA)-conjugated quantum dots-loaded nanoparticles in various organs, 3 h after intranasal administration: (a) optical image (b) quantification of luminescence signals (adapted with permission from [153]. Copyright 2008 American Chemical Society).
Figure 6 Distribution of wheat germ agglutinin (WGA)-conjugated quantum dots-loaded nanoparticles in various organs, 3 h after intranasal administration: (a) optical image (b) quantification of luminescence signals (adapted with permission from [153]. Copyright 2008 American Chemical Society).CC BY · PubMed Central

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Metadata

Authors
Sonvico, F., Clementino, A. R., Buttini, F., Colombo, G., Pescina, S., Stanisçuaski Guterres, S., Raffin Pohlmann, A., & Nicoli, S.
Affiliations
  • University of Parma (IT)
  • University of Ferrara (IT)
Corresponding author
Sonvico, Fabio
ORCID
Venue
Pharmaceutics
Publisher
MDPI AG
Published
2018-02-09
Volume
10
Issue
1
Pages
34-34
ISSN
1999-4923 (ISSN-L)
DOI
10.20944/preprints201802.0077.v1
PMC
PMC5874847
OpenAlex
W2786145144
Cited by
306
References
176
Citations by year
2026: 16 · 2025: 36 · 2024: 35 · 2023: 35 · 2022: 49 · 2021: 54 · 2020: 45 · 2019: 24 · 2018: 11
FWCI
2.93
Type
journal article
Language
en
Open access
Licence
Locations
  • Pharmaceutics (publishedVersion, cc-by)
  • Preprints.org (acceptedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion, cc-by)
Funders
Conselho Nacional de Desenvolvimento Científico e Tecnológico (401196/2014-3, PVE 401196/2014-3)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
Keywords
nose-to-brain delivery, intranasal drug delivery, nanocarriers, surface modification, blood-brain barrier bypass, mucoadhesion, mucoadhesive polymers, static electricity, insulin, Alzheimer's disease, brain drug delivery, particle engineering

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