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Surface-Modified Nanocarriers for Nose-To-Brain Delivery: From Bioadhesion to Targeting
Open accessPreprint — published as 10.3390/pharmaceutics10010034 · Paper page
Abstract
In the field of nasal delivery, one of the most fascinating applications is the delivery of drugs directly to the central nervous system bypassing the blood brain barrier. This approach would provide a series of benefits, such as dose lowering and direct targeting of potent drugs, ultimately reducing their systemic side effects. Recently, clinical trials have explored the nasal administration of insulin for the treatment of Alzheimer’s disease, with promising results. The use of nanomedicines could provide further options for making nose-to-brain delivery reality. In particular, apart from the selection of devices able to deposit the formulation in the upper part of the nose, surface modification of these nanomedicines appears the key strategy to optimize the delivery of drugs from the nasal cavity to the brain. In this review, nanomedicines delivery approaches based on surface electrostatic charges, mucoadhesive polymers, as well as chemical moieties targeting nasal epithelium, will be discussed and critically evaluated for nose-to-brain delivery.
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“According to the present literature, different kinds of nanocarriers are used to prepare nasal formulations able to target the brain, constituted by polymer-based and lipid-based nanoparticles [21,22,23].”
From Nanoemulsions for “Nose-to-Brain” Drug Delivery (2019) · cites this paper as [22]
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Self-citationFormulation strategies for nose-to-brain delivery of therapeutic molecules
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Metadata
- Authors
- Sonvico, F., Clementino, A. R., Buttini, F., Colombo, G., Pescina, S., Stanisçuaski Guterres, S., Raffin Pohlmann, A., & Nicoli, S.
- Affiliations
- University of Parma (IT)
- University of Ferrara (IT)
- Corresponding author
- Sonvico, Fabio
- ORCID
- Venue
- Pharmaceutics
- Publisher
- MDPI AG
- Published
- 2018-02-09
- Volume
- 10
- Issue
- 1
- Pages
- 34-34
- ISSN
- 1999-4923 (ISSN-L)
- PMC
- PMC5874847
- OpenAlex
- W2786145144
- Cited by
- 306
- References
- 176
- Citations by year
- 2026: 16 · 2025: 36 · 2024: 35 · 2023: 35 · 2022: 49 · 2021: 54 · 2020: 45 · 2019: 24 · 2018: 11
- FWCI
- 2.93
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Pharmaceutics (publishedVersion, cc-by)
- Preprints.org (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion, cc-by)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (401196/2014-3, PVE 401196/2014-3)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
- Keywords
- nose-to-brain delivery, intranasal drug delivery, nanocarriers, surface modification, blood-brain barrier bypass, mucoadhesion, mucoadhesive polymers, static electricity, insulin, Alzheimer's disease, brain drug delivery, particle engineering
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