PreprintCited by 306Advanced Drug Delivery SystemsNanoparticle-Based Drug DeliveryInhalation and Respiratory Drug Delivery

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Surface-Modified Nanocarriers for Nose-To-Brain Delivery: From Bioadhesion to Targeting

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Sonvico, Fabio, Clementino, Adryana Rocha, Buttini, Francesca, Colombo, Gaia, Pescina, Silvia, Stanisçuaski Guterres, Silvia, Raffin Pohlmann, Adriana, Nicoli, Sara·2018·Pharmaceutics

DOI 10.20944/preprints201802.0077.v1PMC PMC5874847

Preprint — published as 10.3390/pharmaceutics10010034 · Paper page

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Abstract

In the field of nasal delivery, one of the most fascinating applications is the delivery of drugs directly to the central nervous system bypassing the blood brain barrier. This approach would provide a series of benefits, such as dose lowering and direct targeting of potent drugs, ultimately reducing their systemic side effects. Recently, clinical trials have explored the nasal administration of insulin for the treatment of Alzheimer’s disease, with promising results. The use of nanomedicines could provide further options for making nose-to-brain delivery reality. In particular, apart from the selection of devices able to deposit the formulation in the upper part of the nose, surface modification of these nanomedicines appears the key strategy to optimize the delivery of drugs from the nasal cavity to the brain. In this review, nanomedicines delivery approaches based on surface electrostatic charges, mucoadhesive polymers, as well as chemical moieties targeting nasal epithelium, will be discussed and critically evaluated for nose-to-brain delivery.

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RETRACTED ARTICLE: PNIPAM nanoparticles for targeted and enhanced nose-to-brain delivery of curcuminoids: UPLC/ESI-Q-ToF-MS/MS-based pharmacokinetics and pharmacodynamic evaluation in cerebral ischemia model
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Authors: Sonvico, F., Clementino, A. R., Buttini, F., Colombo, G., Pescina, S., Stanisçuaski Guterres, S., Raffin Pohlmann, A., & Nicoli, S.
Affiliations: University of Parma (IT)
University of Ferrara (IT)
Corresponding author: Sonvico, Fabio
ORCID: Sonvico, Fabio
Clementino, Adryana Rocha
Buttini, Francesca
Colombo, Gaia
Pescina, Silvia
Raffin Pohlmann, Adriana
Nicoli, Sara
Venue: Pharmaceutics
Publisher: MDPI AG
Published: 2018-02-09
Volume: 10
Issue: 1
Pages: 34-34
ISSN: 1999-4923 (ISSN-L)
DOI: 10.20944/preprints201802.0077.v1
PMC: PMC5874847
OpenAlex: W2786145144
Cited by: 306
References: 176
Citations by year: 2026: 16 · 2025: 36 · 2024: 35 · 2023: 35 · 2022: 49 · 2021: 54 · 2020: 45 · 2019: 24 · 2018: 11
FWCI: 2.93
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (unspecified)
Locations: Pharmaceutics (publishedVersion, cc-by)
Preprints.org (acceptedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion, cc-by)
Funders: Conselho Nacional de Desenvolvimento Científico e Tecnológico (401196/2014-3, PVE 401196/2014-3)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
Keywords: nose-to-brain delivery, intranasal drug delivery, nanocarriers, surface modification, blood-brain barrier bypass, mucoadhesion, mucoadhesive polymers, static electricity, insulin, Alzheimer's disease, brain drug delivery, particle engineering

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Surface-Modified Nanocarriers for Nose-To-Brain Delivery: From Bioadhesion to Targeting

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