The DOI matches its Crossref record; 174 of the 176 references it cites were found in a registry or an index.
Surface-Modified Nanocarriers for Nose-To-Brain Delivery: From Bioadhesion to Targeting
Open accessPreprint — published as 10.3390/pharmaceutics10010034 · Paper page
Abstract
In the field of nasal delivery, one of the most fascinating applications is the delivery of drugs directly to the central nervous system bypassing the blood brain barrier. This approach would provide a series of benefits, such as dose lowering and direct targeting of potent drugs, ultimately reducing their systemic side effects. Recently, clinical trials have explored the nasal administration of insulin for the treatment of Alzheimer’s disease, with promising results. The use of nanomedicines could provide further options for making nose-to-brain delivery reality. In particular, apart from the selection of devices able to deposit the formulation in the upper part of the nose, surface modification of these nanomedicines appears the key strategy to optimize the delivery of drugs from the nasal cavity to the brain. In this review, nanomedicines delivery approaches based on surface electrostatic charges, mucoadhesive polymers, as well as chemical moieties targeting nasal epithelium, will be discussed and critically evaluated for nose-to-brain delivery.
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“According to the present literature, different kinds of nanocarriers are used to prepare nasal formulations able to target the brain, constituted by polymer-based and lipid-based nanoparticles [21,22,23].”
From Nanoemulsions for “Nose-to-Brain” Drug Delivery (2019) · cites this paper as [22]
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1 retracted
Ahmad, N., Ahmad, I., Umar, S., Iqbal, Z., Samim, M., & Ahmad, F. J. (2014) · Drug Delivery · doi:10.3109/10717544.2014.941076 · Cited by 70
RetractedMucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues
Lai, S. K., Wang, Y.-Y., & Hanes, J. S. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.11.002 · Cited by 1,863
Cone, R. A. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.09.008 · Cited by 1,459
Intranasal delivery to the central nervous system: Mechanisms and experimental considerations
Dhuria, S. V., Hanson, L. R., & Frey, W. H. (2010) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21924 · Cited by 1,239
Nasal drug delivery—possibilities, problems and solutions
Illum, L. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00363-2 · Cited by 1,139
Modern methods for delivery of drugs across the blood–brain barrier
Chen, Y., & Liu, L. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.11.010 · Cited by 1,036
Thorne, R. G., Pronk, G. J., Padmanabhan, V., & Frey, W. H. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.05.029 · Cited by 958
Transport of drugs from the nasal cavity to the central nervous system
Illum, L. (2000) · European Journal of Pharmaceutical Sciences · doi:10.1016/s0928-0987(00)00087-7 · Cited by 907
Intranasal insulin improves cognition and modulates β-amyloid in early AD
Reger, M. A., Watson, G. S., Green, P. S., Wilkinson, C. W., Baker, L. D., Cholerton, B., Fishel, M. A., Plymate, S. R., Breitner, J. C. S., DeGroodt, W., et al. (2008) · Neurology · doi:10.1212/01.wnl.0000265401.62434.36 · Cited by 830
Approaches to transport therapeutic drugs across the blood–brain barrier to treat brain diseases
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Items 301–305 of 305
Mittal, V., & Yadav, K. S. (2026) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2026.146511
Nose-to-Brain Delivery of Biologicals
Torres, J., Correia, A. C., & Silva, A. C. (2025) · Springer handbooks · doi:10.1007/978-3-032-01636-2_8
Human serum albumin–based nanocarriers for drug delivery
Nematollahzadeh, A., & Ahadi-Jomairan, N. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-33639-3.00022-2
Singh, A., Bhukta, S., Mishra, D., Palei, N. N., Verma, A., & Mohapatra, L. (2026) · AAPS PharmSciTech · doi:10.1208/s12249-026-03563-8
Li, L., Wu, M., & Li, L. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1950362
Metadata
- Authors
- Sonvico, F., Clementino, A. R., Buttini, F., Colombo, G., Pescina, S., Stanisçuaski Guterres, S., Raffin Pohlmann, A., & Nicoli, S.
- Affiliations
- University of Parma (IT)
- University of Ferrara (IT)
- Corresponding author
- Sonvico, Fabio
- ORCID
- Venue
- Pharmaceutics
- Publisher
- MDPI AG
- Published
- 2018-02-09
- Volume
- 10
- Issue
- 1
- Pages
- 34-34
- ISSN
- 1999-4923 (ISSN-L)
- PMC
- PMC5874847
- OpenAlex
- W2786145144
- Cited by
- 306
- References
- 176
- Citations by year
- 2026: 16 · 2025: 36 · 2024: 35 · 2023: 35 · 2022: 49 · 2021: 54 · 2020: 45 · 2019: 24 · 2018: 11
- FWCI
- 2.93
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Pharmaceutics (publishedVersion, cc-by)
- Preprints.org (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion, cc-by)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (401196/2014-3, PVE 401196/2014-3)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
- Keywords
- nose-to-brain delivery, intranasal drug delivery, nanocarriers, surface modification, blood-brain barrier bypass, mucoadhesion, mucoadhesive polymers, static electricity, insulin, Alzheimer's disease, brain drug delivery, particle engineering
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