Surface-Modified Nanocarriers for Nose-To-Brain Delivery: From Bioadhesion to Targeting

Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues

Lai, S. K., Wang, Y.-Y., & Hanes, J. S. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.11.002 · Cited by 1,827 · see citing works

Barrier properties of mucus

Cone, R. A. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.09.008 · Cited by 1,459 · see citing works

Intranasal delivery to the central nervous system: Mechanisms and experimental considerations

Dhuria, S. V., Hanson, L. R., & Frey, W. H. (2010) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21924 · Cited by 1,239 · see citing works

Nasal drug delivery—possibilities, problems and solutions

Illum, L. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00363-2 · Cited by 1,107 · see citing works

Modern methods for delivery of drugs across the blood–brain barrier

Chen, Y., & Liu, L. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.11.010 · Cited by 1,005 · see citing works

Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration

Thorne, R. G., Pronk, G. J., Padmanabhan, V., & Frey, W. H. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.05.029 · Cited by 958 · see citing works

Transport of drugs from the nasal cavity to the central nervous system

Illum, L. (2000) · European Journal of Pharmaceutical Sciences · doi:10.1016/s0928-0987(00)00087-7 · Cited by 907 · see citing works

Intranasal insulin improves cognition and modulates β-amyloid in early AD

Reger, M. A., Watson, G. S., Green, P. S., Wilkinson, C. W., Baker, L. D., Cholerton, B., Fishel, M. A., Plymate, S. R., Breitner, J. C. S., DeGroodt, W., et al. (2008) · Neurology · doi:10.1212/01.wnl.0000265401.62434.36 · Cited by 830 · see citing works

Approaches to transport therapeutic drugs across the blood–brain barrier to treat brain diseases

Gabathuler, R. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.07.028 · Cited by 804 · see citing works

Nanoparticles for direct nose-to-brain delivery of drugs

Mistry, A., Stolnik, S., & Illum, L. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.06.019 · Cited by 734 · see citing works

Intranasal Drug Delivery: How, Why and What For?

Pires, A., Fortuna, A., Alves, G., & Falcão, A. (2009) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.18433/j3nc79 · Cited by 641 · see citing works

Addressing the PEG Mucoadhesivity Paradox to Engineer Nanoparticles that “Slip” through the Human Mucus Barrier

Wang, Y., Lai, S. K., Suk, J. S., Pace, A., Cone, R. A., & Hanes, J. S. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200803526 · Cited by 597 · see citing works

Impact of Surface Polyethylene Glycol (PEG) Density on Biodegradable Nanoparticle Transport in Mucus <i>ex Vivo</i> and Distribution <i>in Vivo</i>

Xu, Q., Ensign, L. M., Boylan, N. J., Schön, A., Gong, X., Yang, J.-C., Lamb, N. W., Cai, S., Yu, T., Freire, E., et al. (2015) · ACS Nano · doi:10.1021/acsnano.5b03876 · Cited by 568 · see citing works

Nasal drug delivery devices: characteristics and performance in a clinical perspective—a review

Djupesland, P. G. (2013) · Drug Delivery and Translational Research · doi:10.1007/s13346-012-0108-9 · Cited by 563 · see citing works

Recent advances in the use of cell-penetrating peptides for medical and biological applications☆

Fonseca, S. B., Pereira, M. P., & Kelley, S. O. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.06.001 · Cited by 553 · see citing works

Nasal mucoadhesive drug delivery: Background, applications, trends and future perspectives

Ugwoke, M. I., Agu, R. U., Verbeke, N., & Kinget, R. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2005.07.009 · Cited by 543 · see citing works

The applications of Vitamin E TPGS in drug delivery

Guo, Y., Luo, J., Tan, S., Otieno, B. O., & Zhang, Z. (2013) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2013.02.006 · Cited by 523 · see citing works

Polysaccharide-decorated nanoparticles

Lemarchand, C., Gref, R., & Couvreur, P. (2004) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2004.02.016 · Cited by 500 · see citing works

Mucoadhesive polymers in the design of nano-drug delivery systems for administration by non-parenteral routes: A review

Sosnik, A., das Neves, J., & Sarmento, B. F. C. C. (2014) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2014.07.010 · Cited by 489 · see citing works

Nanotechnological advances for the delivery of cns therapeutics.

Wong, H. L., Wu, X. Y., & Bendayan, R. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.10.007 · Cited by 488 · see citing works

Direct nose to brain drug delivery <i>via</i> integrated nerve pathways bypassing the blood–brain barrier: an excellent platform for brain targeting

Pardeshi, C. V., & Belgamwar, V. S. (2013) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2013.790887 · Cited by 482 · cited 1× · see citing works

Nasal mucociliary clearance as a factor in nasal drug delivery

Marttin, E., Schipper, N. G. M., Verhoef, J. C., & Merkus, F. W. H. M. (1998) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(97)00059-8 · Cited by 469 · cited 1× · see citing works

Nanoparticle diffusion in respiratory mucus from humans without lung disease

Schuster, B. S., Suk, J. S., Woodworth, G. F., & Hanes, J. S. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.01.064 · Cited by 468 · see citing works

Chitosan in nasal delivery systems for therapeutic drugs

Casettari, L., & Illum, L. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.05.003 · Cited by 448 · see citing works

Is nose-to-brain transport of drugs in man a reality?

Illum, L. (2004) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357022539 · Cited by 439 · see citing works

Intranasal nanoemulsion based brain targeting drug delivery system of risperidone

Kumar, M., Misra, A., Babbar, A. K., Mishra, A. K., Mishra, P., & Pathak, K. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2008.03.029 · Cited by 435 · see citing works

Permeability issues in nasal drug delivery

Arora, P., Sharma, S., & Garg, S. (2002) · Drug Discovery Today · doi:10.1016/s1359-6446(02)02452-2 · Cited by 426 · see citing works

Strategy for effective brain drug delivery

Alam, M. I., Beg, S., Samad, A., Baboota, S., Kohli, K., Ali, J., Ahuja, A., & Akbar, M. (2010) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2010.05.003 · Cited by 415 · see citing works

Lectin-mediated drug targeting: history and applications

Bies, C., Lehr, C., & Woodley, J. F. (2003) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2003.10.030 · Cited by 414 · see citing works

Biological hydrogels as selective diffusion barriers

Lieleg, O., & Ribbeck, K. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.06.002 · Cited by 387 · cited 2× · see citing works

Potential use of tight junction modulators to reversibly open membranous barriers and improve drug delivery

Deli, M. A. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2008.09.016 · Cited by 385 · see citing works

Lactoferrin

Suzuki, Y. A., López, V., & Lönnerdal, B. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5371-1 · Cited by 384 · see citing works

Development and evaluation of rivastigmine loaded chitosan nanoparticles for brain targeting

Fazil, M., Md, S., Haque, S., Kumar, M., Baboota, S., Sahni, J. K., & Ali, J. (2012) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2012.04.013 · Cited by 379 · see citing works

Comparative Uptake Studies of Bioadhesive and Non-Bioadhesive Nanoparticles in Human Intestinal Cell Lines and Rats: The Effect of Mucus on Particle Adsorption and Transport

Behrens, I., Pena, A. I. V., Alonso, M. J., & Kissel, T. (2002) · Pharmaceutical Research · doi:10.1023/a:1019854327540 · Cited by 372 · see citing works

Quantitative analysis of the olfactory pathway for drug delivery to the brain

Thorne, R. G., Emory, C. R., Ala, T. A., & Frey, W. H. (1995) · Brain Research · doi:10.1016/0006-8993(95)00637-6 · Cited by 352 · see citing works

Quantitative analysis of drug delivery to the brain via nasal route

Kozlovskaya, L., Abou-Kaoud, M., & Stepensky, D. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.06.053 · Cited by 345 · see citing works

Stealth Properties to Improve Therapeutic Efficacy of Drug Nanocarriers

Salmaso, S., & Caliceti, P. (2013) · Journal of Drug Delivery · doi:10.1155/2013/374252 · Cited by 340 · see citing works

Effects of Regular and Long-Acting Insulin on Cognition and Alzheimer’s Disease Biomarkers: A Pilot Clinical Trial

Craft, S., Claxton, A., Baker, L. D., Hanson, A. J., Cholerton, B., Trittschuh, E. H., Dahl, D., Caulder, E., Neth, B., Montine, T. J., et al. (2017) · Journal of Alzheimer’s Disease · doi:10.3233/jad-161256 · Cited by 335 · see citing works

Nanotechnology-based drug delivery systems for the treatment of Alzheimer’s disease

Fonseca‐Santos, B., Chorilli, M., & Gremião, M. P. D. (2015) · International Journal of Nanomedicine · doi:10.2147/ijn.s87148 · Cited by 313 · see citing works

Intranasal Treatment of Central Nervous System Dysfunction in Humans

Chapman, C. D., Frey, W. H., Craft, S., Danielyan, L., Hallschmid, M., Schiöth, H. B., & Benedict, C. (2013) · Pharmaceutical Research · doi:10.1007/s11095-012-0915-1 · Cited by 310 · see citing works

Bromocriptine loaded chitosan nanoparticles intended for direct nose to brain delivery: Pharmacodynamic, Pharmacokinetic and Scintigraphy study in mice model

Md, S., Khan, R. A., Mustafa, G., Chuttani, K., Baboota, S., Sahni, J. K., & Ali, J. (2012) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2012.12.007 · Cited by 307 · see citing works

Lectin-conjugated PEG–PLA nanoparticles: Preparation and brain delivery after intranasal administration

Gao, X., Tao, W., Lü, W., Zhang, Q., Zhang, Y., Jiang, X., & Fu, S. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.01.038 · Cited by 295 · see citing works

Davunetide in patients with progressive supranuclear palsy: a randomised, double-blind, placebo-controlled phase 2/3 trial

Boxer, A. L., Lang, A. E., Grossman, M., Knopman, D. S., Miller, B. L., Schneider, L. S., Doody, R. S., Lees, A., Golbe, L. I., Williams, D. R., et al. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70088-2 · Cited by 294 · see citing works

Neurological impacts from inhalation of pollutants and the nose–brain connection

Lucchini, R. G., Dorman, D. C., Elder, A., & Veronesi, B. (2012) · NeuroToxicology · doi:10.1016/j.neuro.2011.12.001 · Cited by 283 · see citing works

Mucus as a barrier to lipophilic drugs

Sigurðsson, H. H., Kirch, J., & Lehr, C. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.05.040 · Cited by 280 · see citing works

Nanosystem drug targeting: Facing up to complex realities

Ruenraroengsak, P., Cook, J. M., & Florence, A. T. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.10.032 · Cited by 265 · see citing works

Tight junction modulation by chitosan nanoparticles: Comparison with chitosan solution

Vllasaliu, D., Exposito-Harris, R., Heras, Á., Casettari, L., Garnett, M. C., Illum, L., & Stolnik, S. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.08.020 · Cited by 253 · see citing works

Transport of PLA-PEG particles across the nasal mucosa: effect of particle size and PEG coating density

Vila, A., Gill, H., McCallion, O. N. M., & Alonso, M. J. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.04.026 · Cited by 249 · see citing works

Delivery of siRNA to the brain using a combination of nose-to-brain delivery and cell-penetrating peptide-modified nano-micelles

Kanazawa, T., Akiyama, F., Kakizaki, S., Takashima, Y., & Seta, Y. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.08.036 · Cited by 242 · see citing works

Odorranalectin-conjugated nanoparticles: Preparation, brain delivery and pharmacodynamic study on Parkinson's disease following intranasal administration

Wen, Z., Yan, Z., Hu, K., Pang, Z., Cheng, X., Guo, L., Zhang, Q., Jiang, X., Fang, L., & Lai, R. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.02.022 · Cited by 241 · see citing works

Nose-to-brain delivery of BACE1 siRNA loaded in solid lipid nanoparticles for Alzheimer’s therapy

Rassu, G., Soddu, E., Posadino, A. M., Pintus, G., Sarmento, B., Giunchedi, P., & Gavini, E. (2017) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2017.01.031 · Cited by 239 · see citing works

Nanosystems in nose-to-brain drug delivery: A review of non-clinical brain targeting studies

Pires, P. C., & Santos, A. O. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.11.047 · Cited by 228 · see citing works

Development and evaluation of thymoquinone-encapsulated chitosan nanoparticles for nose-to-brain targeting: a pharmacoscintigraphic study

Alam, S., Mustafa, G., Khan, Z. I., Islam, F., Bhatnagar, A., Ahmad, F. J., & Kumar (2012) · International Journal of Nanomedicine · doi:10.2147/ijn.s35329 · Cited by 219 · see citing works

Lactoferrin-modified PEG-co-PCL nanoparticles for enhanced brain delivery of NAP peptide following intranasal administration

Liu, Z., Jiang, M., Kang, T., Miao, D., Gu, G., Song, Q., Yao, L., Hu, Q., Tu, Y., Pang, Z., et al. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.02.003 · Cited by 217 · see citing works

Nanoemulsion-based intranasal drug delivery system of saquinavir mesylate for brain targeting

Mahajan, H. S., Mahajan, M. S., Nerkar, P. P., & Agrawal, A. (2014) · Drug Delivery · doi:10.3109/10717544.2013.838014 · Cited by 212 · see citing works

Nose to brain transport pathways an overview: potential of nanostructured lipid carriers in nose to brain targeting

Selvaraj, K., Kuppusamy, G., & Karri, V. V. S. R. (2017) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2017.1420073 · Cited by 211 · see citing works

Brain delivery of vasoactive intestinal peptide enhanced with the nanoparticles conjugated with wheat germ agglutinin following intranasal administration

Gao, X., Wu, B., Zhang, Q., Chen, J., Zhu, J., Zhang, W., Rong, Z., Chen, H., & Jiang, X. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.05.026 · Cited by 207 · see citing works

Pramipexole dihydrochloride loaded chitosan nanoparticles for nose to brain delivery: Development, characterization and in vivo anti-Parkinson activity

Raj, R., Wairkar, S., Sridhar, V., & Gaud, R. S. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.12.056 · Cited by 205 · see citing works

Intranasal delivery of rotigotine to the brain with lactoferrin-modified PEG-PLGA nanoparticles for Parkinson’s disease treatment

Bi, C., Wang, A., Chu, Y., Liu, S., Mu, H., Liu, W., Wu, Z., Sun, K., & Li, Y. (2016) · International Journal of Nanomedicine · doi:10.2147/ijn.s120939 · Cited by 203 · see citing works

Evidence of nose-to-brain delivery of nanoemulsions: Cargoes but not vehicles

Ahmad, E., Feng, Y., Qi, J., Fan, W., Ma, Y., He, H., Xia, F., Dong, X., Zhao, W., Lu, Y., et al. (2017) · Nanoscale · doi:10.1039/c6nr07581a · Cited by 194 · see citing works

Optical tweezers reveal relationship between microstructure and nanoparticle penetration of pulmonary mucus

Kirch, J., Schneider, A., Abou, B., Hopf, A., Schaefer, U. F., Schneider, M., Schall, C., Wagner, C., & Lehr, C. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1214066109 · Cited by 190 · see citing works

Risks from accidental exposures to engineered nanoparticles and neurological health effects: A critical review

Simkó, M., & Mattsson, M. (2010) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-7-42 · Cited by 184 · see citing works

Helping oxytocin deliver: considerations in the development of oxytocin-based therapeutics for brain disorders

MacDonald, K., & Feifel, D. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00035 · Cited by 181 · see citing works

Endocytic and exocytic pathways of the neuronal secretory process and trans synaptic transfer of wheat germ agglutinin‐horseradish peroxidase in vivo

Broadwell, R. D., & Balin, B. J. (1985) · The Journal of Comparative Neurology · doi:10.1002/cne.902420410 · Cited by 180 · see citing works

Filamentous phage as vector-mediated antibody delivery to the brain

Frenkel, D., & Solomon, B. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.072027199 · Cited by 178 · see citing works

Nose-to-Brain Delivery: Investigation of the Transport of Nanoparticles with Different Surface Characteristics and Sizes in Excised Porcine Olfactory Epithelium

Mistry, A., Stolnik, S., & Illum, L. (2015) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5b00088 · Cited by 178 · see citing works

Nose-to-brain peptide delivery – The potential of nanotechnology

Samaridou, E., & Alonso, M. J. (2017) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2017.11.001 · Cited by 178 · see citing works

Systematic Approach for the Formulation and Optimization of Solid Lipid Nanoparticles of Efavirenz by High Pressure Homogenization Using Design of Experiments for Brain Targeting and Enhanced Bioavailability

Gupta, S. K., Kesarla, R., Chotai, N., Misra, A. R., & Omri, A. (2017) · BioMed Research International · doi:10.1155/2017/5984014 · Cited by 172 · see citing works

Cell-Penetrating Peptide-Modified Block Copolymer Micelles Promote Direct Brain Delivery via Intranasal Administration

Kanazawa, T., Taki, H., Tanaka, K., Takashima, Y., & Okada, H. (2011) · Pharmaceutical Research · doi:10.1007/s11095-011-0440-7 · Cited by 166 · see citing works

Neurotoxicity of nanoscale materials

Karmakar, A., Zhang, Q., & Zhang, Y. (2014) · Journal of Food and Drug Analysis · doi:10.1016/j.jfda.2014.01.012 · Cited by 164 · see citing works

A study of rivastigmine liposomes for delivery into the brain through intranasal route

Arumugam, K., Subramanian, G., Mallayasamy, S., Averineni, R. K., Reddy, M. S., & Udupa, N. (2008) · Acta Pharmaceutica · doi:10.2478/v10007-008-0014-3 · Cited by 162 · see citing works

Development, characterization and nasal delivery of rosmarinic acid-loaded solid lipid nanoparticles for the effective management of Huntington’s disease

Bhatt, R., Singh, D., Prakash, A. K., & Mishra, N. (2014) · Drug Delivery · doi:10.3109/10717544.2014.880860 · Cited by 160 · see citing works

Fabrication of an ionic-sensitive in situ gel loaded with resveratrol nanosuspensions intended for direct nose-to-brain delivery

Hao, J., Zhao, J., Zhang, S., Tong, T., Zhuang, Q., Jin, K., Chen, W., & Tang, H. (2016) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2016.08.011 · Cited by 160 · see citing works

Venlafaxine loaded chitosan NPs for brain targeting: Pharmacokinetic and pharmacodynamic evaluation

Haque, S., Md, S., Fazil, M., Kumar, M., Sahni, J. K., Ali, J., & Baboota, S. (2012) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2012.02.051 · Cited by 158 · see citing works

Formulations for Intranasal Delivery of Pharmacological Agents to Combat Brain Disease: A New Opportunity to Tackle GBM?

Woensel, M. V., Wauthoz, N., Rosière, R., Amighi, K., Mathieu, V., Lefranc, F., Gool, S. V., & Vleeschouwer, S. D. (2013) · Cancers · doi:10.3390/cancers5031020 · Cited by 158 · see citing works

Low molecular weight protamine-functionalized nanoparticles for drug delivery to the brain after intranasal administration

Xia, H., Gao, X., Gu, G., Liu, Z., Zeng, N., Hu, Q., Song, Q., Yao, L., Pang, Z., Jiang, X., et al. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.09.004 · Cited by 152 · see citing works

Drug carrier nanoparticles that penetrate human chronic rhinosinusitis mucus

Lai, S. K., Suk, J. S., Pace, A., Wang, Y.-Y., Yang, M., Mert, O., Chen, J., Kim, J., & Hanes, J. S. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.05.008 · Cited by 146 · see citing works

NAP: Research and Development of a Peptide Derived from Activity-Dependent Neuroprotective Protein (ADNP)

Gozes, I., Morimoto, B. H., Tiong, J., Fox, A. W., Sutherland, K., Dangoor, D., Holser-Cochav, M., Vered, K., Newton, P. E., Aisen, P. S. S., et al. (2006) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2005.tb00053.x · Cited by 144 · see citing works

Effect of surface charge on the brain delivery of nanostructured lipid carriers in situ gels via the nasal route

Gabal, Y. M., Kamel, A. O., Sammour, O. A., & Elshafeey, A. H. (2014) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2014.07.025 · Cited by 144 · see citing works

Brain Targeting of Temozolomide via the Intranasal Route Using Lipid-Based Nanoparticles: Brain Pharmacokinetic and Scintigraphic Analyses

Khan, A. S., Imam, S. S., Aqil, M., Ahad, A., Sultana, Y., Ali, A., & Khan, K. M. (2016) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.6b00586 · Cited by 144 · see citing works

Albumin nanoparticles carrying cyclodextrins for nasal delivery of the anti-Alzheimer drug tacrine

Luppi, B., Bigucci, F., Corace, G., Delucca, A., Cerchiara, T., Sorrenti, M., Catenacci, L., Pietra, A. M. D., & Zecchi, V. (2011) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2011.10.002 · Cited by 143 · see citing works

Brain targeting of olanzapine via intranasal delivery of core–shell difunctional block copolymer mixed nanomicellar carriers: In vitro characterization, ex vivo estimation of nasal toxicity and in vivo biodistribution studies

Abdelbary, G. A., & Tadros, M. I. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.04.084 · Cited by 138 · see citing works

Intranasal brain-targeted clonazepam polymeric micelles for immediate control of status epilepticus: in vitro optimization, ex vivo determination of cytotoxicity, in vivo biodistribution and pharmacodynamics studies

Nour, S. A. E.-K., Abdelmalak, N. S., Naguib, M. J., Rashed, H. M., & Ibrahim, A. B. (2016) · Drug Delivery · doi:10.1080/10717544.2016.1223216 · Cited by 138 · see citing works

Intranasal agomelatine solid lipid nanoparticles to enhance brain delivery: formulation, optimization and in vivo pharmacokinetics

Fatouh, A. M., Elshafeey, A. H., & Abdelbary, A. (2017) · Drug Design Development and Therapy · doi:10.2147/dddt.s102500 · Cited by 138 · see citing works

Optimization of nanostructured lipid carriers of lamotrigine for brain delivery:in vitrocharacterization andin vivoefficacy in epilepsy

Alam, T., Pandit, J., Vohora, D., Aqil, M., Ali, A., & Sultana, Y. (2014) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2014.945416 · Cited by 132 · see citing works

Effect of physicochemical properties on intranasal nanoparticle transit into murine olfactory epithelium

Mistry, A., Glud, S. Z., Kjems, J., Randel, J., Howard, K. A., Stolnik, S., & Illum, L. (2009) · Journal of drug targeting · doi:10.1080/10611860903055470 · Cited by 131 · see citing works

Design, characterization, and evaluation of intranasal delivery of ropinirole-loaded mucoadhesive nanoparticles for brain targeting

Jafarieh, O., Md, S., Ali, M., Baboota, S., Sahni, J. K., Kumar, B., Bhatnagar, A., & Ali, J. (2014) · Drug Development and Industrial Pharmacy · doi:10.3109/03639045.2014.991400 · Cited by 131 · see citing works

Trans-nasal zolmitriptan novasomes: in-vitro preparation, optimization and in-vivo evaluation of brain targeting efficiency

Abd-Elal, R. M. A., Shamma, R. N., Rashed, H. M., & Bendas, E. R. (2016) · Drug Delivery · doi:10.1080/10717544.2016.1183721 · Cited by 131 · see citing works

Nose-To-Brain Delivery of PLGA-Diazepam Nanoparticles

Sharma, D., Sharma, R. K., Sharma, N., Gabrani, R., Sharma, S. K., Ali, J., & Dang, S. (2015) · AAPS PharmSciTech · doi:10.1208/s12249-015-0294-0 · Cited by 127 · see citing works

An update on the role of nanovehicles in nose-to-brain drug delivery

Feng, Y., He, H., Li, F., Lü, Y., Qi, J., & Wu, W. (2018) · Drug Discovery Today · doi:10.1016/j.drudis.2018.01.005 · Cited by 127 · see citing works

Nanoparticle penetration of human cervicovaginal mucus: The effect of polyvinyl alcohol

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Scalable method to produce biodegradable nanoparticles that rapidly penetrate human mucus

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Receptor-based Targeting of Therapeutics

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Intranasal therapeutic strategies for management of Alzheimer’s disease

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Nose-to-Brain Transport Pathways of Wheat Germ Agglutinin Conjugated PEG-PLA Nanoparticles

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Brain distribution of ribavirin after intranasal administration

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Attenuation of Kindled Seizures by Intranasal Delivery of Neuropeptide-Loaded Nanoparticles

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Nanoneurotherapeutics approach intended for direct nose to brain delivery

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Increased brain radioactivity by intranasal 32P-labeled siRNA dendriplexes within in situ-forming mucoadhesive gels

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Intranasal Delivery of Camptothecin-Loaded Tat-Modified Nanomicells for Treatment of Intracranial Brain Tumors

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Carbamazepine Mucoadhesive Nanoemulgel (MNEG)asbrain targeting delivery system via the olfactory mucosa

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SLN approach for nose-to-brain delivery of alprazolam

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Nose-to-Brain Delivery: Evaluation of Polymeric Nanoparticles on Olfactory Ensheathing Cells Uptake

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Pharmacological evaluation of nasal delivery of selegiline hydrochloride-loaded thiolated chitosan nanoparticles for the treatment of depression

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Nasal-to-CNS Drug Delivery: Where are We Now and Where are We heading? an Industrial Perspective

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A potential non-invasive glioblastoma treatment: Nose-to-brain delivery of farnesylthiosalicylic acid incorporated hybrid nanoparticles

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Evaluation of brain-targeting for the nasal delivery of estradiol by the microdialysis method

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Self-Assembled, Chitosan Grafted PLGA Nanoparticles for Intranasal Delivery: Design, Development andEx VivoCharacterization

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Biovector™ Nanoparticles Improve Antinociceptive Efficacy of Nasal Morphine

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Improved Transnasal Transport and Brain Uptake of Tizanidine HCl-Loaded Thiolated Chitosan Nanoparticles for Alleviation of Pain

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In vitro and in vivo characterization of meloxicam nanoparticles designed for nasal administration

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Development of coated liposomes loaded with ghrelin for nose-to-brain delivery for the treatment of cachexia

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Thermosensitive PLA based nanodispersion for targeting brain tumor via intranasal route

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Formulation and Evaluation of Novel Micellar Nanocarrier for Nasal Delivery of Sumatriptan

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Intranasal gene delivery for treating Parkinson’s disease: overcoming the blood–brain barrier

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Effects of PAMAM dendrimers in the mouse brain after a single intranasal instillation

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Quantitative analysis of the brain-targeted delivery of drugs and model compounds using nano-delivery systems

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Intranasal delivery of tapentadol hydrochloride–loaded chitosan nanoparticles: formulation, characterisation and itsin vivoevaluation

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Expanding the Therapeutic Potential of Statins by Means of Nanotechnology Enabled Drug Delivery Systems

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Intranasal delivery of α-asarone to the brain with lactoferrin-modified mPEG-PLA nanoparticles prepared by premix membrane emulsification

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Nasal administration of drugs as a new non-invasive strategy for efficient treatment of multiple sclerosis

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Intranasal delivery of cyclobenzaprine hydrochloride-loaded thiolated chitosan nanoparticles for pain relief

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Intranasal delivery of N-terminal modified leptin-pluronic conjugate for treatment of obesity

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A systematic review of inhaled intranasal therapy for central nervous system neoplasms: an emerging therapeutic option

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Pharmacodynamic and pharmacokinetic investigation of cyclodextrin-mediated asenapine maleate in situ nasal gel for improved bioavailability

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A novel intranasal breath-powered delivery system for sumatriptan: a review of technology and clinical application of the investigational product AVP-825 in the treatment of migraine

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Aerosol-Stable Peptide-Coated Liposome Nanoparticles: A Proof-of-Concept Study with Opioid Fentanyl in Enhancing Analgesic Effects and Reducing Plasma Drug Exposure

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Nose to Brain Delivery of Midazolam Loaded PLGA Nanoparticles: In Vitro and In Vivo Investigations

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Nose to Brain Delivery: New Trends in Amphiphile-Based “Soft” Nanocarriers

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Nose-to-brain delivery of TS-002, prostaglandin D2 analogue

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Transferrin receptor antibody-modified α-cobrotoxin-loaded nanoparticles enable drug delivery across the blood–brain barrier by intranasal administration

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Drug Delivery to the brain: How Can Nanoencapsulated Statins Be Used in the Clinic?

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Evaluation of intranasal delivery route of drug administration for brain targeting

Erdő, F., Bors, L. A., Farkas, D., Bajza, Á., & Gizurarson, S. S. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.10.009 · Cited by 756 · see citing works

Drug delivery to the central nervous system

Nance, E. A., Pun, S. H., Saigal, R., & Sellers, D. L. (2021) · Nature Reviews Materials · doi:10.1038/s41578-021-00394-w · Cited by 436 · see citing works

On a highway to the brain: A review on nose-to-brain drug delivery using nanoparticles

Formica, M. L., Real, D. A., Picchio, M. L., Catlin, E. J., Donnelly, R. F., & Paredes, A. J. (2022) · Applied Materials Today · doi:10.1016/j.apmt.2022.101631 · Cited by 282 · see citing works

Nanoemulsions for “Nose-to-Brain” Drug Delivery

Bonferoni, M. C., Rossi, S., Sandri, G., Ferrari, F., Gavini, E., Rassu, G., & Giunchedi, P. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11020084 · Cited by 269 · see citing works

Nanoparticle crossing of blood-brain barrier: A road to new therapeutic approaches to central nervous system diseases

Ceña, V., & Játiva, P. (2018) · Nanomedicine · doi:10.2217/nnm-2018-0139 · Cited by 232 · see citing works

Endo-lysosomal dysregulations and late-onset Alzheimer’s disease: impact of genetic risk factors

Van Acker, Z. P., Bretou, M., & Annaert, W. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0323-7 · Cited by 222 · see citing works

Nanotherapeutics for Nose-to-Brain Drug Delivery: An Approach to Bypass the Blood Brain Barrier

Lee, D., & Minko, T. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13122049 · Cited by 219 · see citing works

Recent advances in nanomaterials for sonodynamic therapy

Xu, T., Zhao, S., Lin, C., Zheng, X., & Lan, M. (2020) · Nano Research · doi:10.1007/s12274-020-2992-5 · Cited by 156 · see citing works

Surface-modified lipid nanocarriers for crossing the blood-brain barrier (BBB): A current overview of active targeting in brain diseases

Teixeira, M. I., Lopes, C. M., Amaral, M. H., & Costa, P. C. (2022) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2022.112999 · Cited by 155 · see citing works

Chitosan coated human serum albumin nanoparticles: A promising strategy for nose-to-brain drug delivery

Piazzini, V., Landucci, E., D’Ambrosio, M., Fasiolo, L. T., Cinci, L., Colombo, G., Pellegrini-Giampietro, D. E., Bilia, A. R., Luceri, C., & Bergonzi, M. C. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.02.005 · Cited by 147 · see citing works

Chitosan-Coated Nanoparticles: Effect of Chitosan Molecular Weight on Nasal Transmucosal Delivery

Bruinsmann, F. A., Pigana, S., Aguirre, T. A. S., Souto, G. D., Pereira, G. G., Bianchera, A., Fasiolo, L. T., Colombo, G., Marques, M. D. S., Pohlmann, A. R., et al. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11020086 · Cited by 140 · see citing works

Polymeric Nanoparticles for Nasal Drug Delivery to the Brain: Relevance to Alzheimer's Disease

Rabiee, N., Ahmadi, S., Afshari, R., Khalaji, S., Rabiee, M., Bagherzadeh, M., Fatahi, Y., Dinarvand, R., Tahriri, M., Tayebi, L., et al. (2020) · Advanced Therapeutics · doi:10.1002/adtp.202000076 · Cited by 140 · see citing works

Chitosan-coated PLGA nanoparticles for the nasal delivery of ropinirole hydrochloride: In vitro and ex vivo evaluation of efficacy and safety

Chatzitaki, A., Jesus, S., Karavasili, C., Andreadis, D., Fatouros, D. G., & Borges, O. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119776 · Cited by 137 · see citing works

Pharmacokinetics and Pharmacodynamics of Intranasal Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Nose-to-Brain Delivery

Nguyen, T., & Maeng, H. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14030572 · Cited by 131 · see citing works

Nasal Drug Delivery of Anticancer Drugs for the Treatment of Glioblastoma: Preclinical and Clinical Trials

Bruinsmann, F. A., Vaz, G. R., Alves, A. D. C. S., Aguirre, T. A. S., Pohlmann, A. R., Guterres, S. S., & Sonvico, F. (2019) · Molecules · doi:10.3390/molecules24234312 · Cited by 117 · see citing works

Structure and Fate of Nanoparticles Designed for the Nasal Delivery of Poorly Soluble Drugs

Clementino, A., Pellegrini, G., Banella, S., Colombo, G., Cantú, L., Sonvico, F., & Favero, E. D. (2021) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.1c00366 · Cited by 116 · see citing works

Recent Advances in Intranasal Liposomes for Drug, Gene, and Vaccine Delivery

Duong, V., Nguyen, T., & Maeng, H. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15010207 · Cited by 114 · see citing works

Recent progress in nanocarriers for direct nose to brain drug delivery

Emad, N. A., Ahmed, B., Alhalmi, A., Alzobaidi, N., & Al-Kubati, S. S. (2021) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2021.102642 · Cited by 109 · see citing works

Progress and perspectives of brain-targeting lipid-based nanosystems via the nasal route in Alzheimer’s disease

Akel, H., Ismail, R., & Csóka, I. (2020) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2019.12.014 · Cited by 110 · see citing works

A Reevaluation of Chitosan-Decorated Nanoparticles to Cross the Blood-Brain Barrier

Cortés, H., Alcalá-Alcalá, S., Caballero-Florán, I. H., Bernal-Chávez, S. A., Ávalos‐Fuentes, A., González‐Torres, M., Carmen, M. G., Figueroa‐González, G., Reyes‐Hernández, O. D., Florán, B., et al. (2020) · Membranes · doi:10.3390/membranes10090212 · Cited by 108 · see citing works

Development and Study of Nanoemulsions and Nanoemulsion-Based Hydrogels for the Encapsulation of Lipophilic Compounds

Demisli, S., Mitsou, E., Pletsa, V., Xenakis, A., & Papadimitriou, V. (2020) · Nanomaterials · doi:10.3390/nano10122464 · Cited by 108 · see citing works

Using the Intranasal Route to Administer Drugs to Treat Neurological and Psychiatric Illnesses: Rationale, Successes, and Future Needs

Lofts, A., Abu-Hijleh, F. A., Rigg, N., Mishra, R. K., & Hoare, T. R. (2022) · CNS Drugs · doi:10.1007/s40263-022-00930-4 · Cited by 108 · see citing works

Increased Nose-to-Brain Delivery of Melatonin Mediated by Polycaprolactone Nanoparticles for the Treatment of Glioblastoma

de Oliveira, E. R., Nascimento, T. L., Salomão, M. A., da Silva, A. C. G., Valadares, M. C., & Lima, E. M. (2019) · Pharmaceutical Research · doi:10.1007/s11095-019-2662-z · Cited by 102 · see citing works

Recent advancement and development of chitin and chitosan-based nanocomposite for drug delivery: Critical approach to clinical research

Ahmad, A., Mubarak, N. M., Naseem, K., Tabassum, H., Rizwan, M., Najda, A., Kashif, M., Bin-Jumah, M. N., Hussain, A., Shaheen, A., et al. (2020) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2020.10.019 · Cited by 101 · see citing works

Formulation Strategies to Improve Nose-to-Brain Delivery of Donepezil

Espinoza, L. C., Silva-Abreu, M., Clares, B., Rodríguez-Lagunas, M. J., Halbaut, L., Cañas, M.-A., & Calpena, A. C. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11020064 · Cited by 99 · see citing works

Focused ultrasound combined with microbubble-mediated intranasal delivery of gold nanoclusters to the brain

Ye, D., Zhang, X., Yue, Y., Raliya, R., Biswas, P., Taylor, S. J., Tai, Y., Rubin, J. B., Liu, Y., & Chen, H. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.07.020 · Cited by 98 · see citing works

Nanosized Transferosome-Based Intranasal In Situ Gel for Brain Targeting of Resveratrol: Formulation, Optimization, In Vitro Evaluation, and In Vivo Pharmacokinetic Study

Salem, H. F., Kharshoum, R. M., Abou‐Taleb, H. A., & Naguib, D. M. (2019) · AAPS PharmSciTech · doi:10.1208/s12249-019-1353-8 · Cited by 96 · see citing works

Design and Development of Nanomaterial-Based Drug Carriers to Overcome the Blood–Brain Barrier by Using Different Transport Mechanisms

Song, J., Lu, C. T., Leszek, J., & Zhang, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221810118 · Cited by 95 · see citing works

How to characterize a nasal product. The state of the art of in vitro and ex vivo specific methods

Salade, L., Wauthoz, N., Goole, J., & Amighi, K. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.02.026 · Cited by 92 · see citing works

Nasal Formulations for Drug Administration and Characterization of Nasal Preparations in Drug Delivery

Scherließ, R. (2020) · Therapeutic Delivery · doi:10.4155/tde-2019-0086 · Cited by 92 · see citing works

Brain drug delivery and neurodegenerative diseases: Polymeric PLGA-based nanoparticles as a forefront platform

Pinto, M., Silva, V., Barreiro, S., Silva, R. V. D. S., Remião, F., Borges, F., & Fernandes, C. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101658 · Cited by 94 · see citing works

Intranasal Nanoparticulate Systems as Alternative Route of Drug Delivery

Alshweiat, A., Ambrus, R., & Csóka, I. (2019) · Current Medicinal Chemistry · doi:10.2174/0929867326666190827151741 · Cited by 85 · see citing works

Bioactive 2D nanomaterials for neural repair and regeneration

He, X., Zhu, Y., Ma, B., Xu, X., Huang, R., Cheng, L., & Zhu, R. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114379 · Cited by 84 · see citing works

Micro- and nanotechnology approaches to improve Parkinson's disease therapy

Torres-Ortega, P. V., Saludas, L., Hanafy, A. S., Garbayo, E., & Blanco‐Prieto, M. J. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.12.036 · Cited by 83 · see citing works

In situ-gelling starch nanoparticle (SNP)/O-carboxymethyl chitosan (CMCh) nanoparticle network hydrogels for the intranasal delivery of an antipsychotic peptide

Majcher, M. J., Babar, A., Lofts, A., Leung, A., Li, X., Abu-Hijleh, F. A., Smeets, N. M. B., Mishra, R. K., & Hoare, T. R. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.12.050 · Cited by 79 · see citing works

Nose-to-Brain Delivery

Giunchedi, P., Gavini, E., & Bonferoni, M. C. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12020138 · Cited by 78 · see citing works

Brain Targeting of Duloxetine HCL via Intranasal Delivery of Loaded Cubosomal Gel: In vitro Characterization, ex vivo Permeation, and in vivo Biodistribution Studies

Elsenosy, F. M., Abdelbary, G. A., Elshafeey, A. H., Elsayed, I., & Fares, A. R. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s277352 · Cited by 77 · see citing works

A comparison study of lipid and polymeric nanoparticles in the nasal delivery of meloxicam: Formulation, characterization, and in vitro evaluation

Akel, H., Ismail, R., Katona, G., Sabir, F., Ambrus, R., & Csóka, I. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.120724 · Cited by 78 · see citing works

Quality by Design Based Formulation Study of Meloxicam-Loaded Polymeric Micelles for Intranasal Administration

Sipos, B., Szabó‐Révész, P., Csóka, I., Pallagi, E., Dobó, D. G., Bélteky, P., Kónya, Z., Deák, Á., Janovák, L., & Katona, G. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12080697 · Cited by 73 · see citing works

Management of epileptic disorders using nanotechnology-based strategies for nose-to-brain drug delivery

Shringarpure, M., Gharat, S., Momin, M. M., & Omri, A. (2020) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2021.1823965 · Cited by 70 · see citing works

Targeting Small Molecule Delivery to the Brain and Spinal Cord via Intranasal Administration of Rabies Virus Glycoprotein (RVG29)-Modified PLGA Nanoparticles

Chung, E. P., Cotter, J. D., Prakapenka, A. V., Cook, R. L., DiPerna, D. M., & Sirianni, R. W. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12020093 · Cited by 69 · see citing works

Nose-to-brain drug delivery mediated by polymeric nanoparticles: influence of PEG surface coating

de Oliveira, E. R., dos Santos, L. C. R., Salomão, M. A., Nascimento, T. L., Oliveira, G. D. A. R., Lião, L. M., & Lima, E. M. (2020) · Drug Delivery and Translational Research · doi:10.1007/s13346-020-00816-2 · Cited by 69 · see citing works

Nose-to-Brain (N2B) Delivery: An Alternative Route for the Delivery of Biologics in the Management and Treatment of Central Nervous System Disorders

Patharapankal, E. J., Ajiboye, A. L., Mattern, C., & Trivedi, V. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics16010066 · Cited by 69 · see citing works

Chitosan-coated liposome dry-powder formulations loaded with ghrelin for nose-to-brain delivery

Salade, L., Wauthoz, N., Vermeersch, M., Amighi, K., & Goole, J. (2018) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2018.06.011 · Cited by 69 · see citing works

RVG29-modified microRNA-loaded nanoparticles improve ischemic brain injury by nasal delivery

Hao, R., Sun, B., Yang, L., Ma, C., & Li, S. (2020) · Drug Delivery · doi:10.1080/10717544.2020.1760960 · Cited by 67 · see citing works

Nanoparticle-Guided Brain Drug Delivery: Expanding the Therapeutic Approach to Neurodegenerative Diseases

Riccardi, C., Napolitano, F., Montesarchio, D., Sampaolo, S., & Melone, M. A. B. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13111897 · Cited by 66 · see citing works

Spray dried powders for nasal delivery: Process and formulation considerations

Henriques, P., Fortuna, A. C., & Doktorovová, S. (2022) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2022.05.002 · Cited by 64 · see citing works

Primary Studies on Construction and Evaluation of Ion-Sensitive in situ Gel Loaded with Paeonol-Solid Lipid Nanoparticles for Intranasal Drug Delivery

Sun, Y., Li, L., Xie, H., Wang, Y., Gao, S., Zhang, L., Bo, F., Yang, S., & Feng, A. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s247935 · Cited by 63 · see citing works

Development and Evaluation of Optimized Thiolated Chitosan Proniosomal Gel Containing Duloxetine for Intranasal Delivery

Khatoon, M., Sohail, M. F., Shahnaz, G., Rehman, F. U., Din, F. U., Rehman, A. U., Ullah, N., Amin, U., Khan, G. M., & Shah, K. U. (2019) · AAPS PharmSciTech · doi:10.1208/s12249-019-1484-y · Cited by 62 · see citing works

In Vitro Comparative Study of Solid Lipid and PLGA Nanoparticles Designed to Facilitate Nose-to-Brain Delivery of Insulin

Akel, H., Csóka, I., Ambrus, R., Bocsik, A., Gróf, I., Mészáros, M., Szecskó, A., Kozma, G., Veszelka, S., Deli, M. A., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413258 · Cited by 62 · see citing works

Nanocarrier-Based Drug Delivery to Brain: Interventions of Surface Modification

Sharma, S., & Dang, S. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220706121412 · Cited by 64 · see citing works

Lipid-based nanoparticles via nose-to-brain delivery: a mini review

Xinchen, Y., Jing, T., & Jiaoqiong, G. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1214450 · Cited by 62 · see citing works

Acrylated Eudragit® E PO as a novel polymeric excipient with enhanced mucoadhesive properties for application in nasal drug delivery

Porfiryeva, N. N., Nasibullin, S. F., Абдуллина, С. Г., Tukhbatullina, I. K., Moustafine, R. I., & Khutoryanskiy, V. V. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.03.027 · Cited by 62 · see citing works

Shortcut Approaches to Substance Delivery into the Brain Based on Intranasal Administration Using Nanodelivery Strategies for Insulin

Tashima, T. (2020) · Molecules · doi:10.3390/molecules25215188 · Cited by 61 · see citing works

Micro/nanosystems for controllable drug delivery to the brain

Tian, M., Ma, Z., & Yang, G. (2023) · The Innovation · doi:10.1016/j.xinn.2023.100548 · Cited by 60 · see citing works

Chitosan/poly(lactic-co-glycolic)acid Nanoparticle Formulations with Finely-Tuned Size Distributions for Enhanced Mucoadhesion

Yang, F., Cabe, M. H., Nowak, H. A., & Langert, K. A. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14010095 · Cited by 58 · see citing works

The Potential Benefits of Nanotechnology in Treating Alzheimer’s Disease

Ling, T. S., Chandrasegaran, S., Low, Z. X., Suan, T. L., Elaine, E., Nathan, D. V., Chai, Y. H., Gunasekaran, B., & Salvamani, S. (2021) · BioMed Research International · doi:10.1155/2021/5550938 · Cited by 57 · see citing works

Nose to Brain Delivery of Phenytoin Sodium Loaded Nano Lipid Carriers: Formulation, Drug Release, Permeation and In Vivo Pharmacokinetic Studies

Nair, S. C., Vinayan, K. P., & Mangalathillam, S. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13101640 · Cited by 57 · see citing works

Core-shell lipoplexes inducing active macropinocytosis promote intranasal delivery of c-Myc siRNA for treatment of glioblastoma

Hu, Y., Jiang, K., Wang, D., Yao, S.-Y., Lu, L., Wang, H., Song, J., Zhou, J., Fan, X., Wang, Y., et al. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.10.042 · Cited by 57 · see citing works

Design and development of chitosan-insulin-transfersomes (Transfersulin) as effective intranasal nanovesicles for the treatment of Alzheimer’s disease: In vitro, in vivo, and ex vivo evaluations

Nojoki, F., Ebrahimi-Hosseinzadeh, B., Hatamian-Zarmi, A., Khodagholi, F., & Khezri, K. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113450 · Cited by 55 · see citing works

Development of Meloxicam-Human Serum Albumin Nanoparticles for Nose-to-Brain Delivery via Application of a Quality by Design Approach

Katona, G., Balogh, G. T., Dargó, G., Gáspár, R., Márki, Á., Ducza, E., Sztojkov‐Ivanov, A., Tömösi, F., Kecskeméti, G., Janáky, T., et al. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12020097 · Cited by 55 · see citing works

Sesame Oil-Based Nanostructured Lipid Carriers of Nicergoline, Intranasal Delivery System for Brain Targeting of Synergistic Cerebrovascular Protection

Abourehab, M. A. S., Khames, A., Genedy, S., Mostafa, S., Khaleel, M. A., Omar, M. M., & Sisi, A. M. E. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13040581 · Cited by 55 · see citing works

Development of a microemulsion for encapsulation and delivery of gallic acid. The role of chitosan

Mitsou, E., Pletsa, V., Sotiroudis, G. T., Panine, P., Zoumpanioti, M., & Xenakis, A. (2020) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2020.110974 · Cited by 54 · see citing works

Convolutions in the rendition of nose to brain therapeutics from bench to bedside: Feats & fallacies

Goel, H., Kalra, V., Verma, S. K., Dubey, S. K., & Tiwary, A. K. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.12.009 · Cited by 52 · see citing works

Intranasal Delivery of Granisetron to the Brain via Nanostructured Cubosomes-Based In Situ Gel for Improved Management of Chemotherapy-Induced Emesis

Eissa, E. M., Elkomy, M. H., Eid, H. M., Ali, A. A., Abourehab, M. A. S., Alsubaiyel, A. M., Naguib, I. A., Alsalahat, I., & Hassan, A. H. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14071374 · Cited by 50 · see citing works

Usefulness of cell-penetrating peptides and penetration accelerating sequence for nose-to-brain delivery of glucagon-like peptide-2

Akita, T., Kimura, R., Akaguma, S., Nagai, M., Nakao, Y., Tsugane, M., Suzuki, H., Oka, J., & Yamashita, C. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.06.007 · Cited by 50 · see citing works

Direct nose to the brain nanomedicine delivery presents a formidable challenge

Yokel, R. A. (2021) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1767 · Cited by 49 · see citing works

Drug Nanocrystals: Focus on Brain Delivery from Therapeutic to Diagnostic Applications

Zingale, E., Bonaccorso, A., Carbone, C., Musumeci, T., & Pignatello, R. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14040691 · Cited by 49 · see citing works

Design of experiment (DoE) as a quality by design (QbD) tool to optimise formulations of lipid nanoparticles for nose-to-brain drug delivery

Correia, A. C., Moreira, J. N., Lobo, J. M. S., & Silva, A. C. (2023) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2023.2274902 · Cited by 50 · see citing works

Highlights in poloxamer-based drug delivery systems as strategy at local application for vaginal infections

Carvalho, G. C., Araújo, V. H. S., Fonseca‐Santos, B., de Araújo, J. T. C., de Souza, M. P. C., Duarte, J. L., & Chorilli, M. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.120635 · Cited by 47 · see citing works

Zolmitriptan Intranasal Spanlastics for Enhanced Migraine Treatment; Formulation Parameters Optimized via Quality by Design Approach

Saleh, A., Khalifa, M. K. A., Shawky, S., Bani-Ali, A., & Eassa, H. A. (2021) · Scientia Pharmaceutica · doi:10.3390/scipharm89020024 · Cited by 46 · see citing works

The uses of resveratrol for neurological diseases treatment and insights for nanotechnology based-drug delivery systems

Fonseca‐Santos, B., & Chorilli, M. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119832 · Cited by 46 · see citing works

Flavonoid-Based Nanomedicines in Alzheimer’s Disease Therapeutics: Promises Made, a Long Way To Go

Prasanna, P., & Upadhyay, A. (2021) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.0c00224 · Cited by 46 · see citing works

Application of the QbD-based approach in the early development of liposomes for nasal administration

Pallagi, E., Jójárt‐Laczkovich, O., Németh, Z., Szabó‐Révész, P., & Csóka, I. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.03.021 · Cited by 45 · see citing works

Design and Development of A Commercially Viable In Situ Nanoemulgel for The Treatment of Postmenopausal Osteoporosis

Zakir, F., Ahmad, A. N., Farooq, U., Mirza, M. A., Tripathi, A., Singh, D. R., Shakeel, F., Mohapatra, S., Ahmad, F. J., & Kohli, K. (2020) · Nanomedicine · doi:10.2217/nnm-2020-0079 · Cited by 45 · see citing works

Nose-to-brain delivery of simvastatin mediated by chitosan-coated lipid-core nanocapsules allows for the treatment of glioblastoma in vivo

Bruinsmann, F. A., Alves, A. D. C. S., Dias, A. D. F., Silva, L. F. L., Visioli, F., Pohlmann, A. R., Figueiró, F., Sonvico, F., & Guterres, S. S. (2022) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2022.121563 · Cited by 44 · see citing works

Functionalized Nanomaterials as Tailored Theranostic Agents in Brain Imaging

Thangam, R., Paulmurugan, R., & Kang, H. (2021) · Nanomaterials · doi:10.3390/nano12010018 · Cited by 43 · see citing works

Nasal biocompatible powder of Geraniol oil complexed with cyclodextrins for neurodegenerative diseases: physicochemical characterization and in vivo evidences of nose to brain delivery

Truzzi, E., Rustichelli, C., de Oliveira, E. R., Ferraro, L., Maretti, E., Graziani, D., Botti, G., Beggiato, S., Iannuccelli, V., Lima, E. M., et al. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.05.020 · Cited by 43 · see citing works

Development and evaluation of protamine-coated PLGA nanoparticles for nose-to-brain delivery of tacrine: In-vitro and in-vivo assessment

Shamarekh, K. S., Gad, H. A., Soliman, M. E., & Sammour, O. A. (2020) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2020.101724 · Cited by 42 · see citing works

Toll-like Receptor-4 (TLR4) Agonist-Based Intranasal Nanovaccine Delivery System for Inducing Systemic and Mucosal Immunity

Bakkari, M. A., Valiveti, C. K., Kaushik, R. S., & Tummala, H. (2021) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.0c01256 · Cited by 42 · see citing works

PLGA nanoparticles for nasal drug delivery

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Post-injury Nose-to-Brain Delivery of Activin A and SerpinB2 Reduces Brain Damage in a Mouse Stroke Model

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Mixed Mucoadhesive Amphiphilic Polymeric Nanoparticles Cross a Model of Nasal Septum Epithelium in Vitro

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Design and optimization of pH-sensitive Eudragit nanoparticles for improved oral delivery of triclabendazole

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Nanomedicine in the Face of Parkinson’s Disease: From Drug Delivery Systems to Nanozymes

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Green nanomedicine: the path to the next generation of nanomaterials for diagnosing brain tumors and therapeutics?

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Polymeric nanotherapeutics acting at special regions of body

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Design and evaluation of thermo-responsive nasal in situ gelling system dispersed with piribedil loaded lecithin-chitosan hybrid nanoparticles for improved brain availability

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Intranasal delivery of N-terminal modified leptin-pluronic conjugate for treatment of obesity

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Oxidized Alginate Dopamine Conjugate: In Vitro Characterization for Nose-to-Brain Delivery Application

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Thin film hydration versus modified spraying technique to fabricate intranasal spanlastic nanovesicles for rasagiline mesylate brain delivery: Characterization, statistical optimization, and in vivo pharmacokinetic evaluation

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Novel O/W nanoemulsions for nasal administration: Structural hints in the selection of performing vehicles with enhanced mucopenetration

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Formulation strategies for nose-to-brain delivery of therapeutic molecules

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Ginkgo Biloba and Long COVID: In Vivo and In Vitro Models for the Evaluation of Nanotherapeutic Efficacy

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Recent advances in nanotechnology for Intra-nasal drug delivery and clinical applications

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Nose-to-Brain Drug Delivery and Physico-Chemical Properties of Nanosystems: Analysis and Correlation Studies of Data from Scientific Literature

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Intranasal delivery of mucoadhesive nanocarriers: a viable option for Parkinson’s disease treatment?

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Quality by Design Approach for the Development of Liposome Carrying Ghrelin for Intranasal Administration

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Enhanced nose-to-brain delivery of tranilast using liquid crystal formulations

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The Role of Natural Compounds and their Nanocarriers in the Treatment of CNS Inflammation

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Nanoparticle-Mediated Nose-to-Brain Drug Delivery Systems: A Promising Approach for CNS Therapeutics

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Functionalized Nanoparticles in Drug Delivery: Strategies to Enhance Direct Nose-to-Brain Drug Delivery via Integrated Nerve Pathways

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Updated Progress of Nanocarrier-Based Intranasal Drug Delivery Systems for Treatment of Brain Diseases

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Formulation and Optimization of Nose to Brain targeted system for Drug Delivery

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