Surface-Modified Nanocarriers for Nose-To-Brain Delivery: From Bioadhesion to Targeting

Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues

Lai, S. K., Wang, Y.-Y., & Hanes, J. S. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.11.002 · Cited by 1,863

Barrier properties of mucus

Cone, R. A. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.09.008 · Cited by 1,459

Intranasal delivery to the central nervous system: Mechanisms and experimental considerations

Dhuria, S. V., Hanson, L. R., & Frey, W. H. (2010) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21924 · Cited by 1,239

Nasal drug delivery—possibilities, problems and solutions

Illum, L. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00363-2 · Cited by 1,139

Modern methods for delivery of drugs across the blood–brain barrier

Chen, Y., & Liu, L. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.11.010 · Cited by 1,036

Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration

Thorne, R. G., Pronk, G. J., Padmanabhan, V., & Frey, W. H. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.05.029 · Cited by 958

Transport of drugs from the nasal cavity to the central nervous system

Illum, L. (2000) · European Journal of Pharmaceutical Sciences · doi:10.1016/s0928-0987(00)00087-7 · Cited by 907

Intranasal insulin improves cognition and modulates β-amyloid in early AD

Reger, M. A., Watson, G. S., Green, P. S., Wilkinson, C. W., Baker, L. D., Cholerton, B., Fishel, M. A., Plymate, S. R., Breitner, J. C. S., DeGroodt, W., et al. (2008) · Neurology · doi:10.1212/01.wnl.0000265401.62434.36 · Cited by 830

Approaches to transport therapeutic drugs across the blood–brain barrier to treat brain diseases

Gabathuler, R. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.07.028 · Cited by 829

Nanoparticles for direct nose-to-brain delivery of drugs

Mistry, A., Stolnik, S., & Illum, L. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.06.019 · Cited by 734

Intranasal Drug Delivery: How, Why and What For?

Pires, A., Fortuna, A., Alves, G., & Falcão, A. (2009) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.18433/j3nc79 · Cited by 641

Addressing the PEG Mucoadhesivity Paradox to Engineer Nanoparticles that “Slip” through the Human Mucus Barrier

Wang, Y., Lai, S. K., Suk, J. S., Pace, A., Cone, R. A., & Hanes, J. S. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200803526 · Cited by 605

Impact of Surface Polyethylene Glycol (PEG) Density on Biodegradable Nanoparticle Transport in Mucus ex Vivo and Distribution in Vivo

Xu, Q., Ensign, L. M., Boylan, N. J., Schön, A., Gong, X., Yang, J.-C., Lamb, N. W., Cai, S., Yu, T., Freire, E., et al. (2015) · ACS Nano · doi:10.1021/acsnano.5b03876 · Cited by 568

Recent advances in the use of cell-penetrating peptides for medical and biological applications☆

Fonseca, S. B., Pereira, M. P., & Kelley, S. O. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.06.001 · Cited by 563

Nasal drug delivery devices: characteristics and performance in a clinical perspective—a review

Djupesland, P. G. (2013) · Drug Delivery and Translational Research · doi:10.1007/s13346-012-0108-9 · Cited by 563

Nasal mucoadhesive drug delivery: Background, applications, trends and future perspectives

Ugwoke, M. I., Agu, R. U., Verbeke, N., & Kinget, R. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2005.07.009 · Cited by 559

The applications of Vitamin E TPGS in drug delivery

Guo, Y., Luo, J., Tan, S., Otieno, B. O., & Zhang, Z. (2013) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2013.02.006 · Cited by 523

Polysaccharide-decorated nanoparticles

Lemarchand, C., Gref, R., & Couvreur, P. (2004) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2004.02.016 · Cited by 500

Mucoadhesive polymers in the design of nano-drug delivery systems for administration by non-parenteral routes: A review

Sosnik, A., das Neves, J., & Sarmento, B. F. C. C. (2014) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2014.07.010 · Cited by 495

Nanotechnological advances for the delivery of cns therapeutics.

Wong, H. L., Wu, X. Y., & Bendayan, R. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.10.007 · Cited by 488

Direct nose to brain drug delivery via integrated nerve pathways bypassing the blood–brain barrier: an excellent platform for brain targeting

Pardeshi, C. V., & Belgamwar, V. S. (2013) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2013.790887 · Cited by 482 · cited 1×

Nanoparticle diffusion in respiratory mucus from humans without lung disease

Schuster, B. S., Suk, J. S., Woodworth, G. F., & Hanes, J. S. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.01.064 · Cited by 478

Nasal mucociliary clearance as a factor in nasal drug delivery

Marttin, E., Schipper, N. G. M., Verhoef, J. C., & Merkus, F. W. H. M. (1998) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(97)00059-8 · Cited by 469 · cited 1×

Chitosan in nasal delivery systems for therapeutic drugs

Casettari, L., & Illum, L. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.05.003 · Cited by 448

Is nose-to-brain transport of drugs in man a reality?

Illum, L. (2004) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357022539 · Cited by 439

Intranasal nanoemulsion based brain targeting drug delivery system of risperidone

Kumar, M., Misra, A., Babbar, A. K., Mishra, A. K., Mishra, P., & Pathak, K. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2008.03.029 · Cited by 435

Permeability issues in nasal drug delivery

Arora, P., Sharma, S., & Garg, S. (2002) · Drug Discovery Today · doi:10.1016/s1359-6446(02)02452-2 · Cited by 426

Strategy for effective brain drug delivery

Alam, M. I., Beg, S., Samad, A., Baboota, S., Kohli, K., Ali, J., Ahuja, A., & Akbar, M. (2010) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2010.05.003 · Cited by 415

Lectin-mediated drug targeting: history and applications

Bies, C., Lehr, C., & Woodley, J. F. (2003) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2003.10.030 · Cited by 414

Biological hydrogels as selective diffusion barriers

Lieleg, O., & Ribbeck, K. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.06.002 · Cited by 387 · cited 2×

Potential use of tight junction modulators to reversibly open membranous barriers and improve drug delivery

Deli, M. A. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2008.09.016 · Cited by 385

Lactoferrin

Suzuki, Y. A., López, V., & Lönnerdal, B. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5371-1 · Cited by 384

Development and evaluation of rivastigmine loaded chitosan nanoparticles for brain targeting

Fazil, M., Md, S., Haque, S., Kumar, M., Baboota, S., Sahni, J. K., & Ali, J. (2012) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2012.04.013 · Cited by 379

Comparative Uptake Studies of Bioadhesive and Non-Bioadhesive Nanoparticles in Human Intestinal Cell Lines and Rats: The Effect of Mucus on Particle Adsorption and Transport

Behrens, I., Pena, A. I. V., Alonso, M. J., & Kissel, T. (2002) · Pharmaceutical Research · doi:10.1023/a:1019854327540 · Cited by 377

Quantitative analysis of the olfactory pathway for drug delivery to the brain

Thorne, R. G., Emory, C. R., Ala, T. A., & Frey, W. H. (1995) · Brain Research · doi:10.1016/0006-8993(95)00637-6 · Cited by 352

Quantitative analysis of drug delivery to the brain via nasal route

Kozlovskaya, L., Abou-Kaoud, M., & Stepensky, D. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.06.053 · Cited by 345

Stealth Properties to Improve Therapeutic Efficacy of Drug Nanocarriers

Salmaso, S., & Caliceti, P. (2013) · Journal of Drug Delivery · doi:10.1155/2013/374252 · Cited by 340

Effects of Regular and Long-Acting Insulin on Cognition and Alzheimer’s Disease Biomarkers: A Pilot Clinical Trial

Craft, S., Claxton, A., Baker, L. D., Hanson, A. J., Cholerton, B., Trittschuh, E. H., Dahl, D., Caulder, E., Neth, B., Montine, T. J., et al. (2017) · Journal of Alzheimer’s Disease · doi:10.3233/jad-161256 · Cited by 335

Nanotechnology-based drug delivery systems for the treatment of Alzheimer’s disease

Fonseca‐Santos, B., Chorilli, M., & Gremião, M. P. D. (2015) · International Journal of Nanomedicine · doi:10.2147/ijn.s87148 · Cited by 320

Intranasal Treatment of Central Nervous System Dysfunction in Humans

Chapman, C. D., Frey, W. H., Craft, S., Danielyan, L., Hallschmid, M., Schiöth, H. B., & Benedict, C. (2013) · Pharmaceutical Research · doi:10.1007/s11095-012-0915-1 · Cited by 310

Bromocriptine loaded chitosan nanoparticles intended for direct nose to brain delivery: Pharmacodynamic, Pharmacokinetic and Scintigraphy study in mice model

Md, S., Khan, R. A., Mustafa, G., Chuttani, K., Baboota, S., Sahni, J. K., & Ali, J. (2012) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2012.12.007 · Cited by 307

Lectin-conjugated PEG–PLA nanoparticles: Preparation and brain delivery after intranasal administration

Gao, X., Tao, W., Lü, W., Zhang, Q., Zhang, Y., Jiang, X., & Fu, S. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.01.038 · Cited by 300

Davunetide in patients with progressive supranuclear palsy: a randomised, double-blind, placebo-controlled phase 2/3 trial

Boxer, A. L., Lang, A. E., Grossman, M., Knopman, D. S., Miller, B. L., Schneider, L. S., Doody, R. S., Lees, A., Golbe, L. I., Williams, D. R., et al. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70088-2 · Cited by 294

Neurological impacts from inhalation of pollutants and the nose–brain connection

Lucchini, R. G., Dorman, D. C., Elder, A., & Veronesi, B. (2012) · NeuroToxicology · doi:10.1016/j.neuro.2011.12.001 · Cited by 283

Mucus as a barrier to lipophilic drugs

Sigurðsson, H. H., Kirch, J., & Lehr, C. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.05.040 · Cited by 280

Nanosystem drug targeting: Facing up to complex realities

Ruenraroengsak, P., Cook, J. M., & Florence, A. T. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.10.032 · Cited by 269

Tight junction modulation by chitosan nanoparticles: Comparison with chitosan solution

Vllasaliu, D., Exposito-Harris, R., Heras, Á., Casettari, L., Garnett, M. C., Illum, L., & Stolnik, S. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.08.020 · Cited by 253

Transport of PLA-PEG particles across the nasal mucosa: effect of particle size and PEG coating density

Vila, A., Gill, H., McCallion, O. N. M., & Alonso, M. J. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.04.026 · Cited by 249

Delivery of siRNA to the brain using a combination of nose-to-brain delivery and cell-penetrating peptide-modified nano-micelles

Kanazawa, T., Akiyama, F., Kakizaki, S., Takashima, Y., & Seta, Y. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.08.036 · Cited by 242

Odorranalectin-conjugated nanoparticles: Preparation, brain delivery and pharmacodynamic study on Parkinson's disease following intranasal administration

Wen, Z., Yan, Z., Hu, K., Pang, Z., Cheng, X., Guo, L., Zhang, Q., Jiang, X., Fang, L., & Lai, R. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.02.022 · Cited by 241

Nose-to-brain delivery of BACE1 siRNA loaded in solid lipid nanoparticles for Alzheimer’s therapy

Rassu, G., Soddu, E., Posadino, A. M., Pintus, G., Sarmento, B., Giunchedi, P., & Gavini, E. (2017) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2017.01.031 · Cited by 239

Nanosystems in nose-to-brain drug delivery: A review of non-clinical brain targeting studies

Pires, P. C., & Santos, A. O. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.11.047 · Cited by 228

Development and evaluation of thymoquinone-encapsulated chitosan nanoparticles for nose-to-brain targeting: a pharmacoscintigraphic study

Alam, S., Mustafa, G., Khan, Z. I., Islam, F., Bhatnagar, A., Ahmad, F. J., & Kumar (2012) · International Journal of Nanomedicine · doi:10.2147/ijn.s35329 · Cited by 219

Lactoferrin-modified PEG-co-PCL nanoparticles for enhanced brain delivery of NAP peptide following intranasal administration

Liu, Z., Jiang, M., Kang, T., Miao, D., Gu, G., Song, Q., Yao, L., Hu, Q., Tu, Y., Pang, Z., et al. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.02.003 · Cited by 219

Nanoemulsion-based intranasal drug delivery system of saquinavir mesylate for brain targeting

Mahajan, H. S., Mahajan, M. S., Nerkar, P. P., & Agrawal, A. (2014) · Drug Delivery · doi:10.3109/10717544.2013.838014 · Cited by 212

Nose to brain transport pathways an overview: potential of nanostructured lipid carriers in nose to brain targeting

Selvaraj, K., Kuppusamy, G., & Karri, V. V. S. R. (2017) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2017.1420073 · Cited by 211

Brain delivery of vasoactive intestinal peptide enhanced with the nanoparticles conjugated with wheat germ agglutinin following intranasal administration

Gao, X., Wu, B., Zhang, Q., Chen, J., Zhu, J., Zhang, W., Rong, Z., Chen, H., & Jiang, X. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.05.026 · Cited by 207

Pramipexole dihydrochloride loaded chitosan nanoparticles for nose to brain delivery: Development, characterization and in vivo anti-Parkinson activity

Raj, R., Wairkar, S., Sridhar, V., & Gaud, R. S. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.12.056 · Cited by 205

Intranasal delivery of rotigotine to the brain with lactoferrin-modified PEG-PLGA nanoparticles for Parkinson’s disease treatment

Bi, C., Wang, A., Chu, Y., Liu, S., Mu, H., Liu, W., Wu, Z., Sun, K., & Li, Y. (2016) · International Journal of Nanomedicine · doi:10.2147/ijn.s120939 · Cited by 203

Evidence of nose-to-brain delivery of nanoemulsions: Cargoes but not vehicles

Ahmad, E., Feng, Y., Qi, J., Fan, W., Ma, Y., He, H., Xia, F., Dong, X., Zhao, W., Lu, Y., et al. (2017) · Nanoscale · doi:10.1039/c6nr07581a · Cited by 194

Optical tweezers reveal relationship between microstructure and nanoparticle penetration of pulmonary mucus

Kirch, J., Schneider, A., Abou, B., Hopf, A., Schaefer, U. F., Schneider, M., Schall, C., Wagner, C., & Lehr, C. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1214066109 · Cited by 190

Risks from accidental exposures to engineered nanoparticles and neurological health effects: A critical review

Simkó, M., & Mattsson, M. (2010) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-7-42 · Cited by 189

Nose-to-Brain Delivery: Investigation of the Transport of Nanoparticles with Different Surface Characteristics and Sizes in Excised Porcine Olfactory Epithelium

Mistry, A., Stolnik, S., & Illum, L. (2015) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5b00088 · Cited by 185

Nose-to-brain peptide delivery – The potential of nanotechnology

Samaridou, E., & Alonso, M. J. (2017) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2017.11.001 · Cited by 183

Endocytic and exocytic pathways of the neuronal secretory process and trans synaptic transfer of wheat germ agglutinin‐horseradish peroxidase in vivo

Broadwell, R. D., & Balin, B. J. (1985) · The Journal of Comparative Neurology · doi:10.1002/cne.902420410 · Cited by 181

Helping oxytocin deliver: considerations in the development of oxytocin-based therapeutics for brain disorders

MacDonald, K., & Feifel, D. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00035 · Cited by 181

Filamentous phage as vector-mediated antibody delivery to the brain

Frenkel, D., & Solomon, B. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.072027199 · Cited by 178

Systematic Approach for the Formulation and Optimization of Solid Lipid Nanoparticles of Efavirenz by High Pressure Homogenization Using Design of Experiments for Brain Targeting and Enhanced Bioavailability

Gupta, S. K., Kesarla, R., Chotai, N., Misra, A. R., & Omri, A. (2017) · BioMed Research International · doi:10.1155/2017/5984014 · Cited by 172

Neurotoxicity of nanoscale materials

Karmakar, A., Zhang, Q., & Zhang, Y. (2014) · Journal of Food and Drug Analysis · doi:10.1016/j.jfda.2014.01.012 · Cited by 171

Cell-Penetrating Peptide-Modified Block Copolymer Micelles Promote Direct Brain Delivery via Intranasal Administration

Kanazawa, T., Taki, H., Tanaka, K., Takashima, Y., & Okada, H. (2011) · Pharmaceutical Research · doi:10.1007/s11095-011-0440-7 · Cited by 166

Formulations for Intranasal Delivery of Pharmacological Agents to Combat Brain Disease: A New Opportunity to Tackle GBM?

Woensel, M. V., Wauthoz, N., Rosière, R., Amighi, K., Mathieu, V., Lefranc, F., Gool, S. V., & Vleeschouwer, S. D. (2013) · Cancers · doi:10.3390/cancers5031020 · Cited by 162

A study of rivastigmine liposomes for delivery into the brain through intranasal route

Arumugam, K., Subramanian, G., Mallayasamy, S., Averineni, R. K., Reddy, M. S., & Udupa, N. (2008) · Acta Pharmaceutica · doi:10.2478/v10007-008-0014-3 · Cited by 162

Venlafaxine loaded chitosan NPs for brain targeting: Pharmacokinetic and pharmacodynamic evaluation

Haque, S., Md, S., Fazil, M., Kumar, M., Sahni, J. K., Ali, J., & Baboota, S. (2012) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2012.02.051 · Cited by 161

Development, characterization and nasal delivery of rosmarinic acid-loaded solid lipid nanoparticles for the effective management of Huntington’s disease

Bhatt, R., Singh, D., Prakash, A. K., & Mishra, N. (2014) · Drug Delivery · doi:10.3109/10717544.2014.880860 · Cited by 160

Fabrication of an ionic-sensitive in situ gel loaded with resveratrol nanosuspensions intended for direct nose-to-brain delivery

Hao, J., Zhao, J., Zhang, S., Tong, T., Zhuang, Q., Jin, K., Chen, W., & Tang, H. (2016) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2016.08.011 · Cited by 160

Low molecular weight protamine-functionalized nanoparticles for drug delivery to the brain after intranasal administration

Xia, H., Gao, X., Gu, G., Liu, Z., Zeng, N., Hu, Q., Song, Q., Yao, L., Pang, Z., Jiang, X., et al. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.09.004 · Cited by 152

Drug carrier nanoparticles that penetrate human chronic rhinosinusitis mucus

Lai, S. K., Suk, J. S., Pace, A., Wang, Y.-Y., Yang, M., Mert, O., Chen, J., Kim, J., & Hanes, J. S. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.05.008 · Cited by 146

NAP: Research and Development of a Peptide Derived from Activity-Dependent Neuroprotective Protein (ADNP)

Gozes, I., Morimoto, B. H., Tiong, J., Fox, A. W., Sutherland, K., Dangoor, D., Holser-Cochav, M., Vered, K., Newton, P. E., Aisen, P. S. S., et al. (2006) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2005.tb00053.x · Cited by 144

Effect of surface charge on the brain delivery of nanostructured lipid carriers in situ gels via the nasal route

Gabal, Y. M., Kamel, A. O., Sammour, O. A., & Elshafeey, A. H. (2014) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2014.07.025 · Cited by 144

Brain Targeting of Temozolomide via the Intranasal Route Using Lipid-Based Nanoparticles: Brain Pharmacokinetic and Scintigraphic Analyses

Khan, A. S., Imam, S. S., Aqil, M., Ahad, A., Sultana, Y., Ali, A., & Khan, K. M. (2016) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.6b00586 · Cited by 144

Albumin nanoparticles carrying cyclodextrins for nasal delivery of the anti-Alzheimer drug tacrine

Luppi, B., Bigucci, F., Corace, G., Delucca, A., Cerchiara, T., Sorrenti, M., Catenacci, L., Pietra, A. M. D., & Zecchi, V. (2011) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2011.10.002 · Cited by 143

Intranasal brain-targeted clonazepam polymeric micelles for immediate control of status epilepticus: in vitro optimization, ex vivo determination of cytotoxicity, in vivo biodistribution and pharmacodynamics studies

Nour, S. A. E.-K., Abdelmalak, N. S., Naguib, M. J., Rashed, H. M., & Ibrahim, A. B. (2016) · Drug Delivery · doi:10.1080/10717544.2016.1223216 · Cited by 141

Brain targeting of olanzapine via intranasal delivery of core–shell difunctional block copolymer mixed nanomicellar carriers: In vitro characterization, ex vivo estimation of nasal toxicity and in vivo biodistribution studies

Abdelbary, G. A., & Tadros, M. I. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.04.084 · Cited by 138

Intranasal agomelatine solid lipid nanoparticles to enhance brain delivery: formulation, optimization and in vivo pharmacokinetics

Fatouh, A. M., Elshafeey, A. H., & Abdelbary, A. (2017) · Drug Design Development and Therapy · doi:10.2147/dddt.s102500 · Cited by 138

Optimization of nanostructured lipid carriers of lamotrigine for brain delivery:in vitrocharacterization andin vivoefficacy in epilepsy

Alam, T., Pandit, J., Vohora, D., Aqil, M., Ali, A., & Sultana, Y. (2014) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2014.945416 · Cited by 132

Effect of physicochemical properties on intranasal nanoparticle transit into murine olfactory epithelium

Mistry, A., Glud, S. Z., Kjems, J., Randel, J., Howard, K. A., Stolnik, S., & Illum, L. (2009) · Journal of drug targeting · doi:10.1080/10611860903055470 · Cited by 131

Design, characterization, and evaluation of intranasal delivery of ropinirole-loaded mucoadhesive nanoparticles for brain targeting

Jafarieh, O., Md, S., Ali, M., Baboota, S., Sahni, J. K., Kumar, B., Bhatnagar, A., & Ali, J. (2014) · Drug Development and Industrial Pharmacy · doi:10.3109/03639045.2014.991400 · Cited by 131

Trans-nasal zolmitriptan novasomes: in-vitro preparation, optimization and in-vivo evaluation of brain targeting efficiency

Abd-Elal, R. M. A., Shamma, R. N., Rashed, H. M., & Bendas, E. R. (2016) · Drug Delivery · doi:10.1080/10717544.2016.1183721 · Cited by 131

Nose-To-Brain Delivery of PLGA-Diazepam Nanoparticles

Sharma, D., Sharma, R. K., Sharma, N., Gabrani, R., Sharma, S. K., Ali, J., & Dang, S. (2015) · AAPS PharmSciTech · doi:10.1208/s12249-015-0294-0 · Cited by 127

An update on the role of nanovehicles in nose-to-brain drug delivery

Feng, Y., He, H., Li, F., Lü, Y., Qi, J., & Wu, W. (2018) · Drug Discovery Today · doi:10.1016/j.drudis.2018.01.005 · Cited by 127

Nanoparticle penetration of human cervicovaginal mucus: The effect of polyvinyl alcohol

Yang, M., Lai, S. K., Yu, T., Wang, Y.-Y., Happe, C., Zhong, W., Zhang, M., Anonuevo, A., Fridley, C., Hung, A., et al. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.07.045 · Cited by 126

Emerging Insights for Translational Pharmacokinetic and Pharmacokinetic-Pharmacodynamic Studies: Towards Prediction of Nose-to-Brain Transport in Humans

Ruigrok, M. J. R., & de Lange, E. C. M. (2015) · The AAPS Journal · doi:10.1208/s12248-015-9724-x · Cited by 126

Scalable method to produce biodegradable nanoparticles that rapidly penetrate human mucus

Xu, Q., Boylan, N. J., Cai, S., Miao, B., Patel, H., & Hanes, J. S. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.05.035 · Cited by 124

Brain targeted nanoparticulate drug delivery system of rasagiline via intranasal route

Mittal, D., Md, S., Hasan, Q., Fazil, M., Ali, A., Baboota, S., & Ali, J. (2014) · Drug Delivery · doi:10.3109/10717544.2014.907372 · Cited by 120

Surface engineered nanostructured lipid carriers for efficient nose to brain delivery of ondansetron HCl using Delonix regia gum as a natural mucoadhesive polymer

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Nanotechnology-mediated nose to brain drug delivery for Parkinson's disease: a mini review

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Sodium hyaluronate as a mucoadhesive component in nasal formulation enhances delivery of molecules to brain tissue

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Phytochemical-loaded mesoporous silica nanoparticles for nose-to-brain olfactory drug delivery

Lungare, S., Hallam, K., & Badhan, R. K. S. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.09.042 · Cited by 117

Thiolated chitosan nanoparticles for the nasal administration of leuprolide: Bioavailability and pharmacokinetic characterization

Shahnaz, G., Vetter, A., Barthelmes, J., Rahmat, D., Laffleur, F., Iqbal, J., Perera, G., Schlocker, W., Dünnhaput, S., Augustijns, P., et al. (2012) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2012.02.044 · Cited by 116

A Double-Blind, Placebo-Controlled, Ascending-Dose, Randomized Study to Evaluate the Safety, Tolerability and Effects on Cognition of AL-108 after 12 Weeks of Intranasal Administration in Subjects with Mild Cognitive Impairment

Morimoto, B. H., Schmechel, D., Hirman, J., Blackwell, A., Keith, J., Gold, M., & on behalf of the AL-108-211 Study Investigators (2013) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000348347 · Cited by 115

Uptake and bio-reactivity of polystyrene nanoparticles is affected by surface modifications, ageing and LPS adsorption: in vitro studies on neural tissue cells

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A poly(ethylene glycol)-based surfactant for formulation of drug-loaded mucus penetrating particles

Mert, O., Lai, S. K., Ensign, L. M., Yang, M., Wang, Y.-Y., Wood, J., & Hanes, J. S. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.08.032 · Cited by 114

Gelatin nanostructured lipid carriers-mediated intranasal delivery of basic fibroblast growth factor enhances functional recovery in hemiparkinsonian rats

Zhao, Y., Li, X., Lu, C., Lin, M., Chen, L., Xiang, Q., Zhang, M., Jin, R., Jiang, X., Shen, X., et al. (2013) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2013.10.009 · Cited by 114

Phospholipid based colloidal poloxamer–nanocubic vesicles for brain targeting via the nasal route

Ha, S., Mahmoud, A. A. K., Kamel, A. O., Hady, M. A., & Awad, G. A. S. (2012) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2012.05.010 · Cited by 113

Quantum Dots Bearing Lectin-Functionalized Nanoparticles as a Platform for In Vivo Brain Imaging

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Dose-dependent social-cognitive effects of intranasal oxytocin delivered with novel Breath Powered device in adults with autism spectrum disorder: a randomized placebo-controlled double-blind crossover trial

Quintana, D. S., Westlye, L. T., Hope, S., Nærland, T., Elvsåshagen, T., Dørum, E., Rustan, Ø., Valstad, M., Rezvaya, L., Lishaugen, H., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.103 · Cited by 111

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Distribution and clearance of bioadhesive formulations from the olfactory region in man: Effect of polymer type and nasal delivery device

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Intranasal delivery of dopamine to the striatum using glycol chitosan/sulfobutylether-β-cyclodextrin based nanoparticles

Gioia, S. D., Trapani, A., Mandracchia, D., Giglio, E. D., Cometa, S., Mangini, V., Arnesano, F., Belgiovine, G., Castellani, S., Pace, L., et al. (2015) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2015.05.019 · Cited by 104

Is there a clinical future for polymeric nanoparticles as brain-targeting drug delivery agents?

Costantino, L., & Boraschi, D. (2011) · Drug Discovery Today · doi:10.1016/j.drudis.2011.10.028 · Cited by 103

Characterization of lactoferrin as a targeting ligand for nonviral gene delivery to airway epithelial cells

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Haloperidol-loaded intranasally administered lectin functionalized poly(ethylene glycol)–block-poly(d,l)-lactic-co-glycolic acid (PEG–PLGA) nanoparticles for the treatment of schizophrenia

Piazza, J. E., Hoare, T. R., Molinaro, L., Terpstra, K. J., Bhandari, J., Selvaganapathy, P. R., Gupta, B. P., & Mishra, R. K. (2014) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2014.02.007 · Cited by 100

Evaluation of neuropeptide loaded trimethyl chitosan nanoparticles for nose to brain delivery

Kumar, M., Pandey, R. S., Patra, K. C., Jain, S. K., Soni, M. L., Dangi, J. S., & Madan, J. (2013) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2013.06.041 · Cited by 99

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Response surface optimization, Ex vivo and In vivo investigation of nasal spanlastics for bioavailability enhancement and brain targeting of risperidone

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Micellar Nanocarriers: Potential Nose-to-Brain Delivery of Zolmitriptan as Novel Migraine Therapy

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Receptor-based Targeting of Therapeutics

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Solanum tuberosumlectin-conjugated PLGA nanoparticles for nose-to-brain delivery:in vivoandin vitroevaluations

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Nanoparticle transport across in vitro olfactory cell monolayers

Gartziandia, O., Egusquiaguirre, S. P., Bianco, J. I., Pedraz, J. L., Igartúa, M., Hernández, R. M., Véronique Préat, A., & Beloqui, A. (2015) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2015.12.046 · Cited by 97

UEA I-bearing nanoparticles for brain delivery following intranasal administration

Gao, X., Chen, J., Tao, W.-Q., ZHU, J., Zhang, Q., CHEN, H., & JIANG, X. (2007) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.03.039 · Cited by 95

Rivastigmine-loadedin situgelling nanostructured lipid carriers for nose to brain delivery

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The brain targeting efficiency following nasally applied MPEG-PLA nanoparticles in rats

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Nose-to-brain delivery of macromolecules mediated by cell-penetrating peptides

Lin, T., Liu, E., He, H., Shin, M. C., Moon, C., Yang, V. C.-M., & Huang, Y. (2016) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2016.04.001 · Cited by 85

Nose-to-Brain Transport Pathways of Wheat Germ Agglutinin Conjugated PEG-PLA Nanoparticles

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The nasal delivery of nanoencapsulated statins – an approach for brain delivery

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Brain distribution of ribavirin after intranasal administration

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Attenuation of Kindled Seizures by Intranasal Delivery of Neuropeptide-Loaded Nanoparticles

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Role of serum albumin as a nanoparticulate carrier for nose-to-brain delivery of R-flurbiprofen: implications for the treatment of Alzheimer's disease

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Nanoneurotherapeutics approach intended for direct nose to brain delivery

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Increased brain radioactivity by intranasal 32P-labeled siRNA dendriplexes within in situ-forming mucoadhesive gels

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Intranasal Delivery of Camptothecin-Loaded Tat-Modified Nanomicells for Treatment of Intracranial Brain Tumors

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Comfort, C., Garrastazu, G., Pozzoli, M., & Sonvico, F. (2015) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026615666150108144655 · Cited by 69

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SLN approach for nose-to-brain delivery of alprazolam

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Nose-to-Brain Delivery: Evaluation of Polymeric Nanoparticles on Olfactory Ensheathing Cells Uptake

Musumeci, T., Pellitteri, R., Spatuzza, M., & Puglisi, G. (2014) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.23836 · Cited by 67

Pharmacological evaluation of nasal delivery of selegiline hydrochloride-loaded thiolated chitosan nanoparticles for the treatment of depression

Singh, D., Rashid, M., Hallan, S. S., Mehra, N. K., Prakash, A. K., & Mishra, N. (2015) · Artificial Cells Nanomedicine and Biotechnology · doi:10.3109/21691401.2014.998824 · Cited by 66

Nasal-to-CNS Drug Delivery: Where are We Now and Where are We heading? an Industrial Perspective

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A potential non-invasive glioblastoma treatment: Nose-to-brain delivery of farnesylthiosalicylic acid incorporated hybrid nanoparticles

Şekerdağ, E., Lüle, S., Pehlivan, S. B., Öztürk, N., Kara, A., Kaffashi, A., Vural, İ., Işıkay, İ., Yavuz, B., Oğuz, K. K., et al. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.06.032 · Cited by 64

Evaluation of brain-targeting for the nasal delivery of estradiol by the microdialysis method

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Enhancement of nose-to-brain delivery of hydrophilic macromolecules with stearate- or polyethylene glycol-modified arginine-rich peptide

Kanazawa, T., Kaneko, M., Niide, T., Akiyama, F., Kakizaki, S., Ibaraki, H., Shiraishi, S., Takashima, Y., Suzuki, T., & Seta, Y. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.07.077 · Cited by 62

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Chalikwar, S. S., Mene, B. S., Pardeshi, C. V., Belgamwar, V. S., & Surana, S. J. (2013) · Polymer-Plastics Technology and Engineering · doi:10.1080/03602559.2012.751999 · Cited by 61

Biovector™ Nanoparticles Improve Antinociceptive Efficacy of Nasal Morphine

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Improved Transnasal Transport and Brain Uptake of Tizanidine HCl-Loaded Thiolated Chitosan Nanoparticles for Alleviation of Pain

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In vitro and in vivo characterization of meloxicam nanoparticles designed for nasal administration

Kürti, L., Gáspár, R., Márki, Á., Kápolna, E., Bocsik, A., Veszelka, S., Bartos, C., Ambrus, R., Vastag, M., Deli, M. A., et al. (2013) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2013.03.012 · Cited by 56

Mucoadhesive Amphiphilic Methacrylic Copolymer-Functionalized Poly(ε-caprolactone) Nanocapsules for Nose-to-Brain Delivery of Olanzapine

da Fonseca, F. N., Betti, A. H., Carvalho, F. C., Gremião, M. P. D., Dimer, F. A., Guterres, S. S., Tebaldi, M. L., Rates, S. M. K., & Pohlmann, A. R. (2014) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2015.2078 · Cited by 56

Development of coated liposomes loaded with ghrelin for nose-to-brain delivery for the treatment of cachexia

Salade, L., Wauthoz, N., Deleu, M., Vermeersch, M., Vriese, C. D., Amighi, K., & Goole, J. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s147650 · Cited by 56

In vivo toxicity and immunogenicity of wheat germ agglutinin conjugated poly(ethylene glycol)-poly(lactic acid) nanoparticles for intranasal delivery to the brain

Liu, Q., Shao, X., Chen, J., Shen, Y., Feng, C., Gao, X., Zhao, Y., Li, J., Zhang, Q., & Jiang, X. (2010) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2010.12.003 · Cited by 55

Brain targeting and toxicity study of odorranalectin-conjugated nanoparticles following intranasal administration

Wen, Z., Yan, Z., He, R., Pang, Z., Guo, L., Qian, Y. J., Jiang, X., & Fang, L. (2011) · Drug Delivery · doi:10.3109/10717544.2011.596583 · Cited by 54

Brain delivery of small interfering ribonucleic acid and drugs through intranasal administration with nano-sized polymer micelles

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Dry powder nasal drug delivery: challenges, opportunities and a study of the commercial Teijin Puvlizer Rhinocort device and formulation

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Thermosensitive PLA based nanodispersion for targeting brain tumor via intranasal route

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Formulation and Evaluation of Novel Micellar Nanocarrier for Nasal Delivery of Sumatriptan

Jain, R. D., Nabar, S., Dandekar, P. P., Hassan, P. A., Aswal, V. K., Talmon, Y., Shet, T., Borde, L. C., Ray, K., & Patravale, V. B. (2010) · Nanomedicine · doi:10.2217/nnm.10.28 · Cited by 46

Intranasal delivery of tapentadol hydrochloride–loaded chitosan nanoparticles: formulation, characterisation and itsin vivoevaluation

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Intranasal gene delivery for treating Parkinson’s disease: overcoming the blood–brain barrier

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Effects of PAMAM dendrimers in the mouse brain after a single intranasal instillation

Win‐Shwe, T., Sone, H., Kurokawa, Y., Zeng, Y., Zeng, Q., Nitta, H., & Hirano, S. (2014) · Toxicology Letters · doi:10.1016/j.toxlet.2014.04.020 · Cited by 45

Quantitative analysis of the brain-targeted delivery of drugs and model compounds using nano-delivery systems

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Study of sodium hyaluronate-based intranasal formulations containing micro- or nanosized meloxicam particles

Bartos, C., Ambrus, R., Sipos, P., Budai-Szűcs, M., Csányi, E., Gáspár, R., Márki, Á., Seres, A. B., Sztojkov‐Ivanov, A., Horváth, T., et al. (2015) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2015.06.046 · Cited by 45

Expanding the Therapeutic Potential of Statins by Means of Nanotechnology Enabled Drug Delivery Systems

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Intranasal delivery of α-asarone to the brain with lactoferrin-modified mPEG-PLA nanoparticles prepared by premix membrane emulsification

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Nasal administration of drugs as a new non-invasive strategy for efficient treatment of multiple sclerosis

Duchi, S., Ovadia, H., & Touítou, E. (2013) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2013.02.013 · Cited by 41

The nose may help the brain: intranasal drug delivery for treating neurological diseases

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Intranasal delivery of cyclobenzaprine hydrochloride-loaded thiolated chitosan nanoparticles for pain relief

Patel, D. H., Naik, S., Chuttani, K., Mathur, R., Mishra, A. K., & Misra, A. R. (2013) · Journal of drug targeting · doi:10.3109/1061186x.2013.818676 · Cited by 37

Intranasal delivery of N-terminal modified leptin-pluronic conjugate for treatment of obesity

Yuan, D., Yi, X., Zhao, Y., Poon, C., Bullock, K. M., Hansen, K. M., Salameh, T. S., Farr, S. A., Banks, W. A., & Kabanov, A. V. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.03.029 · Cited by 37

A systematic review of inhaled intranasal therapy for central nervous system neoplasms: an emerging therapeutic option

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Pharmacodynamic and pharmacokinetic investigation of cyclodextrin-mediated asenapine maleate in situ nasal gel for improved bioavailability

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A novel intranasal breath-powered delivery system for sumatriptan: a review of technology and clinical application of the investigational product AVP-825 in the treatment of migraine

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Aerosol-Stable Peptide-Coated Liposome Nanoparticles: A Proof-of-Concept Study with Opioid Fentanyl in Enhancing Analgesic Effects and Reducing Plasma Drug Exposure

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Nose to Brain Delivery of Midazolam Loaded PLGA Nanoparticles: In Vitro and In Vivo Investigations

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Nose to Brain Delivery: New Trends in Amphiphile-Based “Soft” Nanocarriers

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Nose-to-brain delivery of TS-002, prostaglandin D2 analogue

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Transferrin receptor antibody-modified α-cobrotoxin-loaded nanoparticles enable drug delivery across the blood–brain barrier by intranasal administration

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Drug Delivery to the brain: How Can Nanoencapsulated Statins Be Used in the Clinic?

Sonvico, F., Zimetti, F., Pohlmann, A. R., & Guterres, S. S. (2017) · Therapeutic Delivery · doi:10.4155/tde-2017-0044 · Cited by 14

Evaluation of intranasal delivery route of drug administration for brain targeting

Erdő, F., Bors, L. A., Farkas, D., Bajza, Á., & Gizurarson, S. S. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.10.009 · Cited by 773

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On a highway to the brain: A review on nose-to-brain drug delivery using nanoparticles

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Nanoemulsions for “Nose-to-Brain” Drug Delivery

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Surface modification of nanocarriers as a strategy to enhance the direct nose-to-brain drug delivery

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Nanoparticle-Mediated Nose-to-Brain Drug Delivery Systems: A Promising Approach for CNS Therapeutics

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Functionalized Nanoparticles in Drug Delivery: Strategies to Enhance Direct Nose-to-Brain Drug Delivery via Integrated Nerve Pathways

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