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Cited by 1,039Wound Healing and TreatmentsDermatologic Treatments and ResearchLiver physiology and pathology

The DOI matches its Crossref record; 75 of the 76 references it cites were found in a registry or an index.

Fibroblasts and myofibroblasts in wound healing

Open access
Desmouliere, Alexis, Darby, Ian Andrew, Laverdet, Betty, Bonté, Frédéric·2014·Clinical, Cosmetic and Investigational Dermatology
DOI 10.2147/ccid.s50046PMC PMC4226391
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Abstract

(Myo)fibroblasts are key players for maintaining skin homeostasis and for orchestrating physiological tissue repair. (Myo)fibroblasts are embedded in a sophisticated extracellular matrix (ECM) that they secrete, and a complex and interactive dialogue exists between (myo)fibroblasts and their microenvironment. In addition to the secretion of the ECM, (myo)fibroblasts, by secreting matrix metalloproteinases and tissue inhibitors of metalloproteinases, are able to remodel this ECM. (Myo)fibroblasts and their microenvironment form an evolving network during tissue repair, with reciprocal actions leading to cell differentiation, proliferation, quiescence, or apoptosis, and actions on growth factor bioavailability by binding, sequestration, and activation. In addition, the (myo)fibroblast phenotype is regulated by mechanical stresses to which they are subjected and thus by mechanical signaling. In pathological situations (excessive scarring or fibrosis), or during aging, this dialogue between the (myo)fibroblasts and their microenvironment may be altered or disrupted, leading to repair defects or to injuries with damaged and/or cosmetic skin alterations such as wrinkle development. The intimate dialogue between the (myo)fibroblasts and their microenvironment therefore represents a fascinating domain that must be better understood in order not only to characterize new therapeutic targets and drugs able to prevent or treat pathological developments but also to interfere with skin alterations observed during normal aging or premature aging induced by a deleterious environment.

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Metadata

Authors
Desmouliere, A., Darby, I. A., Laverdet, B., & Bonté, F.
Affiliations
  • RMIT University (AU)
  • Université de Limoges (FR)
  • LVMH (France) (FR)
ORCID
Venue
Clinical, Cosmetic and Investigational Dermatology
Publisher
Informa UK Limited
Published
2014-11
Volume
7
Pages
301
ISSN
1178-7015 (ISSN-L)
DOI
10.2147/ccid.s50046
PMC
PMC4226391
OpenAlex
W2023805473
Cited by
1,039
References
76
Citations by year
2026: 43 · 2025: 98 · 2024: 103 · 2023: 115 · 2022: 121 · 2021: 123 · 2020: 117 · 2019: 108 · 2018: 91 · 2017: 61 · 2016: 37 · 2015: 21
FWCI
4.89
Type
journal article
Language
en
Open access
Licence
Locations
  • Clinical Cosmetic and Investigational Dermatology (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • RMIT Research Repository (RMIT University Library) (submittedVersion)
  • Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
  • Figshare (submittedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Wound Healing and Treatments
  • Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Keywords
fibroblasts, myofibroblasts, wound healing, skin homeostasis, extracellular matrix, matrix metalloproteinases, tissue inhibitors of metalloproteinases, extracellular matrix remodeling, growth factor bioavailability, mechanical signaling, fibrosis, scar formation, skin aging, wrinkle formation, cell-microenvironment interactions

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