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Cited by 434

The DOI matches its Crossref record; 106 of the 106 references it cites were found in a registry or an index.

Hypoxemia in patients with COPD: cause, effects, and disease progression

Open access
McNicholas, Walter, Kent, Mitchell·2011·International Journal of Chronic Obstructive Pulmonary Disease
DOI 10.2147/copd.s10611
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Abstract

Chronic obstructive pulmonary disease (COPD) is a leading cause of death and disability internationally. Alveolar hypoxia and consequent hypoxemia increase in prevalence as disease severity increases. Ventilation/perfusion mismatch resulting from progressive airflow limitation and emphysema is the key driver of this hypoxia, which may be exacerbated by sleep and exercise. Uncorrected chronic hypoxemia is associated with the development of adverse sequelae of COPD, including pulmonary hypertension, secondary polycythemia, systemic inflammation, and skeletal muscle dysfunction. A combination of these factors leads to diminished quality of life, reduced exercise tolerance, increased risk of cardiovascular morbidity, and greater risk of death. Concomitant sleep-disordered breathing may place a small but significant subset of COPD patients at increased risk of these complications. Long-term oxygen therapy has been shown to improve pulmonary hemodynamics, reduce erythrocytosis, and improve survival in selected patients with severe hypoxemic respiratory failure. However, the optimal treatment for patients with exertional oxyhemoglobin desaturation, isolated nocturnal hypoxemia, or mild-to-moderate resting daytime hypoxemia remains uncertain.

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Metadata

Authors
McNicholas, W., Kent, & Mitchell
Venue
International Journal of Chronic Obstructive Pulmonary Disease
Publisher
Informa UK Limited
Published
2011-03
Volume
6
Pages
199
ISSN
  • 1176-9106 (ISSN-L)
  • 1178-2005
DOI
10.2147/copd.s10611
OpenAlex
W1977925028
Cited by
434
References
106
FWCI
15.59
Type
journal article
Language
en
Open access
gold

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Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.