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Nanotechnology Advances Proteolysis Targeting Chimeras (PROTACs): Transition From Basic Research to Clinical Application

Mu, Xupeng, Mu, Chongqiang, Wang, Mengxue, Meng, Chen, Liu, Huimin, Lu, Haibin·2025·International Journal of Nanomedicine
DOI 10.2147/ijn.s552644PMC PMC12513389
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  • PROTACs are bifunctional molecules that simultaneously bind a target protein and an E3 ubiquitin ligase, promoting ubiquitination and proteasomal degradation of the target.

    “These bifunctional molecules function as molecular matchmakers, simultaneously binding a target protein (e.g., BCL-xL) and an E3 ubiquitin ligase80. This induced proximity promotes ubiquitination of the target protein, directing it to the proteasome for complete degradation81–83.”

    From Emerging strategies in senotherapeutics: from broad-spectrum senolysis to precision reprogramming (2026) · cites this paper as [81]

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Metadata

Authors
Mu, X., Mu, C., Wang, M., Meng, C., Liu, H., & Lu, H.
Venue
International Journal of Nanomedicine
Publisher
Informa UK Limited
Published
2025-10
Volume
Volume 20
Pages
12177-12198
ISSN
1178-2013
DOI
10.2147/ijn.s552644
PMC
PMC12513389
Cited by
16
References
7
Language
en
Licence
creativecommons.org/licenses/by-nc/3.0/ (unspecified)

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