Analysis of individual items on the attention-deficit/hyperactivity disorder symptom rating scale in children and adults: the effects of age and sex in pivotal trials of lisdexamfetamine dimesylate
Open accessAbstract
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) symptom presentation across age and sex has not been fully elucidated. The present post hoc analyses qualitatively explored the baseline levels of ADHD symptomatology across subgroups in two clinical trials of children and adults with ADHD to elucidate differences in participant presentation. The response to treatment was examined to determine patterns of response among items of the ADHD Rating Scale IV. METHODS: Exploratory post hoc analyses of ADHD Rating Scale IV item scores were conducted on data from two 4-week placebo-controlled trials in children (6-12 years) and in adults (18-55 years) with ADHD. Baseline and endpoint mean item scores were determined for subgroups defined by age (6-9, 10-12, 18-39, and 40-55 years) and sex. RESULTS: The baseline mean item scores were generally numerically similar for all age-by-sex subgroups. The inattention (IA) items were numerically higher than hyperactivity/impulsivity (H/I) items among older children and adults. The endpoint mean item scores were numerically lower after lisdexamfetamine dimesylate treatment for IA and H/I items in all subgroups. CONCLUSION: These results suggest that regardless of age or sex, baseline IA and H/I symptom profiles were comparable; however, IA vs H/I symptoms were more severe in older participants. In all age-by-sex subgroups, IA and H/I symptoms appeared to decrease after active treatment.
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In a post hoc analysis of Biederman et al, at week 6 compared with placebo, LDX was associated with significantly lower DBQ errors (P < .02) and lapses (P < .02).
“At week 6, compared with placebo, LDX was associated with significantly lower DBQ errors (P < .02) and lapses (P < .02).”
From Review of Lisdexamfetamine Dimesylate in Adults With Attention-Deficit/Hyperactivity Disorder (2017) · cites this paper as [44]
The Methods (Study overview; page unavailable) describe two 4-week trials, and the reported outcomes are ADHD-RS-IV item scores, not DBQ errors or lapses. Searches for “DBQ errors lapses week 6” and “Biederman driving behavior questionnaire” found no passage reporting the claimed week-6 comparison or P values. (LLM, conf=0.78)
Experimental — accuracy not yet measuredIn the same post hoc analysis, a decrease in DBQ violations was noted, although not significant (P = .16).
“A decrease in DBQ violations was also noted, although not significant (P = .16).”
From Review of Lisdexamfetamine Dimesylate in Adults With Attention-Deficit/Hyperactivity Disorder (2017) · cites this paper as [44]
The Methods (Statistical analyses; page not provided) describe a post hoc analysis of ADHD-RS-IV symptom items, and the Results (Participants; page not provided) report changes in those items. Searches for DBQ violations, driving behavior, and P = .16 found no passage addressing the claimed outcome. (LLM, conf=0.78)
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- Authors
- Weisler, R., Childress, A., Adler, L., Kollins, S., Goodman, D., Hamdani, & Dirks, B.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- VA NY Harbor Healthcare System (US)
- Duke Medical Center (US)
- Johns Hopkins University (US)
- Corresponding author
- Weisler, Richard
- Venue
- Neuropsychiatric Disease and Treatment
- Publisher
- Informa UK Limited
- Published
- 2013-12
- Volume
- 10
- Pages
- 1
- ISSN
- 1176-6328 (ISSN-L)
- PMC
- PMC3862743
- OpenAlex
- W1967848183
- Cited by
- 16
- References
- 41
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2018: 1 · 2017: 4 · 2016: 3 · 2015: 1 · 2014: 1
- FWCI
- 1.19
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Neuropsychiatric Disease and Treatment (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- UNC Libraries
- Funders
- Eli Lilly and Company
- Pfizer
- Purdue University
- Sunovion
- York University
- Shionogi
- National Institutes of Health
- National Institute on Drug Abuse
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Developmental and Educational Neuropsychology
- Keywords
- attention deficit hyperactivity disorder, lisdexamfetamine dimesylate, ADHD Rating Scale-IV, inattention, hyperactivity/impulsivity, age differences, sex differences, children, adults, treatment response, presenting symptoms
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