High-Dose Isoflavones Do Not Improve Metabolic and Inflammatory Parameters in Androgen-Deprived Men With Prostate Cancer
Open accessAbstract
The profound hypogonadism that occurs with androgen deprivation therapy (ADT) for prostate cancer (PCa) results in complications such as diabetes and metabolic syndrome that predispose to cardiovascular disease. Because phytoestrogens have been associated with an improvement in metabolic parameters, we evaluated their role in men undergoing ADT. Our objective was to evaluate the effects of high-dose isoflavones on metabolic and inflammatory parameters in men undergoing ADT. This was a randomized, double-blind, placebo-controlled, 12-week pilot study. Participants were randomly assigned to receive 20 g of soy protein containing 160 mg of total isoflavones vs taste-matched placebo (20 g whole milk protein). The study was conducted at a tertiary care center in the United States. Thirty-three men (isoflavones = 17, placebo = 16) undergoing ADT for PCa completed this pilot study. Mean age in the 2 groups was 69 years and the majority of men were Caucasians. Mean duration of ADT in both groups was approximately 2 years (P = .70). The 2 groups were well matched at baseline. After 12 weeks of intervention, there was no significant difference in either metabolic or inflammatory parameters between the 2 groups. We found that high-dose isoflavones over a course of 12 weeks do not improve metabolic or inflammatory parameters in androgen-deprived men.
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Aerobic training decreases basal plasma IL-6 in patients with coronary artery disease.
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- Authors
- Napora, J. K., Short, R. G., Muller, D. C., Carlson, O. D., Odetunde, J. O., Xu, X., Carducci, M., Travison, T. G., Maggio, M., Egan, J. M., & Basaria, S.
- Affiliations
- National Institute on Aging (US)
- Johns Hopkins University (US)
- Boston University (US)
- University of Parma (IT)
- Corresponding author
- Basaria, S.
- ORCID
- Venue
- Journal of Andrology
- Publisher
- Wiley
- Published
- 2010-08-26
- Volume
- 32
- Issue
- 1
- Pages
- 40-48
- ISSN
- 0196-3635 (ISSN-L)
- PMC
- PMC3005077
- OpenAlex
- W2075134483
- Cited by
- 35
- References
- 47
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 4 · 2021: 4 · 2020: 4 · 2019: 1 · 2018: 4 · 2017: 1 · 2015: 2 · 2014: 3 · 2013: 3 · 2012: 1
- FWCI
- 1.52
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Andrology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (Z01AG000906)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Phytoestrogen effects and research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Keywords
- isoflavones, soy protein, androgen deprivation therapy, prostate cancer, hypogonadism, phytoestrogens, metabolic syndrome, inflammation, diabetes mellitus, cardiovascular risk
- MeSH terms
- Aged, Androgen Antagonists, Androgens, Glucose, Humans, Inflammation, Insulin Resistance, Isoflavones, Male, Metabolism, Pilot Projects, Prostatic Neoplasms, Soybean Proteins
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