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Cited by 90Exercise and Physiological ResponsesCardiovascular and exercise physiologyT-cell and B-cell Immunology

Latent Cytomegalovirus infection amplifies CD8 T-lymphocyte mobilisation and egress in response to exercise

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Turner, James E., Aldred, Sarah, Witard, Oliver C., Drayson, Mark T., Moss, Paul M., Bosch, Jos A.·2010·Brain, Behavior, and Immunity
DOI 10.1016/j.bbi.2010.07.239
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Abstract

Exercise induces mobilisation of CD8(+) T lymphocytes (CD8TL) into the peripheral blood. This response is largely confined to effector-memory CD8TLs: antigen experienced cells which have a strong tissue-homing and effector potential. This study investigated whether effector-memory cells also account for the CD8TL egress from peripheral blood following exercise. As latent Cytomegalovirus (CMV) infection is associated with a robust expansion in the number and proportion of effector-memory CD8TLs, we also investigated if CMV serostatus was a determinant of the CD8TL responses to exercise. Fourteen males (Mean age 35, SD ± 14 yrs), half of whom were CMV seropositive (CMV(+)), ran on a treadmill for 60 min at 80% VO(2) max. Blood was collected at baseline, during the final minute of exercise, and 15 min and 60 min thereafter. CD8TL memory subsets were characterised by flow cytometry, using the cell-surface markers CD45RA, CD27, and CD28. The results confirmed that CD8TLs with an effector-memory phenotype (CD27(-)CD28(-)CD45RA(+/-)) exhibited the largest increase during exercise (+200% to +250%), and also showed the largest egress from blood 60 min post-exercise (down to 40% of baseline values). Strikingly, the mobilisation and subsequent egress of total CD8TLs was nearly twice as large in CMV(+) individuals. This effect appeared specific to CD8TLs, and was not seen for CD4(+) T lymphocytes or total lymphocytes. This effect of CMV serostatus was largely driven by the higher numbers of exercise-responsive effector-memory CD8TLs in the CMV(+) participants. This is the first study to demonstrate that infection history is a determinant of immune system responses to exercise.

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Authors
Turner, J. E., Aldred, S., Witard, O. C., Drayson, M. T., Moss, P. M., & Bosch, J. A.
Affiliations
  • University of Birmingham (GB)
  • Heidelberg University (DE)
Corresponding author
Bosch, Jos A.
ORCID
Venue
Brain, Behavior, and Immunity
Publisher
Elsevier BV
Published
2010-11
Volume
24
Issue
8
Pages
1362-1370
ISSN
0889-1591 (ISSN-L)
DOI
10.1016/j.bbi.2010.07.239
OpenAlex
W2066448873
Cited by
90
References
77
Citations by year
2026: 2 · 2025: 3 · 2024: 6 · 2023: 2 · 2022: 5 · 2021: 5 · 2020: 1 · 2019: 2 · 2018: 6 · 2017: 7 · 2016: 7 · 2015: 8 · 2014: 3 · 2013: 13 · 2012: 7
FWCI
10.96
Type
journal article
Language
en
Open access
Licence
Locations
  • Brain Behavior and Immunity (publishedVersion)
  • PubMed (publishedVersion)
  • The University of Bath Online Publications Store (The University of Bath) (submittedVersion)
  • Stirling Online Research Repository (University of Stirling) (submittedVersion, public-domain)
  • Pure Amsterdam UMC (submittedVersion)
  • University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
  • Pure (University of Bath) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords
CD8+ T cells, physical activity, effector memory T cells, T cell egress, CMV serostatus, CD45RA, CD27, CD28, lymphocyte homing
MeSH terms
Adult, Cytomegalovirus Infections, Exercise Test, Flow Cytometry, Humans, Immunologic Memory, Immunologic Surveillance, Male, Anaerobic Threshold, Exercise, CD4-Positive T-Lymphocytes, Virus Latency, CD8-Positive T-Lymphocytes, Lymphocyte Count

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