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Cited by 228Exercise and Physiological ResponsesAdipokines, Inflammation, and Metabolic DiseasesCardiovascular and exercise physiology

Muscle-derived interleukin-6: lipolytic, anti-inflammatory and immune regulatory effects

Pedersen, Bente Klarlund, Steensberg, Adam, Keller, Pernille, Keller, Charlotte, Fischer, Christian, Hiscock, Natalie, van Hall, Gerrit, Plomgaard, Peter +1 more·2003·Pflügers Archiv - European Journal of Physiology
DOI 10.1007/s00424-002-0981-z
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Abstract

Interleukin-6 (IL-6) is produced locally in working skeletal muscle and can account for the exercise-induced increase in plasma IL-6. The transcription rate for IL-6 in muscle nuclei isolated from muscle biopsies during exercise is very high and is enhanced further when muscle glycogen content is low. Furthermore, cultured human primary muscle cells can increase IL-6 mRNA when incubated with the calcium ionophore ionomycin and it is likely that myocytes produce IL-6 in response to muscle contraction. The biological roles of muscle-derived IL-6 have been investigated in studies in which human recombinant IL-6 was infused in healthy volunteers to mimic closely the IL-6 concentrations observed during prolonged exercise. Using stable isotopes, we have demonstrated that physiological concentrations of IL-6 induce lipolysis. Although we have yet to determine the precise biological action of muscle-derived IL-6, our data support the hypothesis that the role of IL-6 released from contracting muscle during exercise is to act in a hormone-like manner to mobilize extracellular substrates and/or augment substrate delivery during exercise. In addition, IL-6 inhibits low-level TNF-alpha production, and IL-6 produced during exercise probably inhibits TNF-alpha-induced insulin resistance in peripheral tissues. Hence, IL-6 produced by skeletal muscle during contraction may play an important role in the beneficial health effects of exercise

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  • Physical inactivity is associated with low-grade chronic inflammation, especially when associated with obesity.

    “Physical inactivity is associated with low-grade chronic inflammation, not least when a physical inactive lifestyle is associated with obesity (29, 142, 144, 145, 207-210).”

    From Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020) · cites this paper as [209]

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Authors
Pedersen, B. K., Steensberg, A., Keller, P., Keller, C., Fischer, C., Hiscock, N., van Hall, G., Plomgaard, P., & Febbraio, M. A.
Affiliations
University of Copenhagen (DK)
Corresponding author
Pedersen, Bente Klarlund
ORCID
Venue
Pflügers Archiv - European Journal of Physiology
Publisher
Springer Science and Business Media LLC
Published
2003-02-18
Volume
446
Issue
1
Pages
9-16
ISSN
  • 0031-6768 (ISSN-L)
  • 1432-2013
DOI
10.1007/s00424-002-0981-z
OpenAlex
W1561143321
Cited by
228
References
102
Citations by year
2026: 7 · 2025: 6 · 2024: 5 · 2023: 8 · 2022: 5 · 2021: 9 · 2020: 8 · 2019: 9 · 2018: 10 · 2017: 7 · 2016: 7 · 2015: 10 · 2014: 15 · 2013: 13 · 2012: 13
FWCI
2.51
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Pflügers Archiv - European Journal of Physiology (publishedVersion)
  • PubMed (publishedVersion)
  • RMIT Research Repository (RMIT University Library) (submittedVersion)
  • Figshare (submittedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Topics
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords
skeletal muscle, physical activity, lipolysis, anti-inflammatory activity, anti-TNF therapy, insulin resistance, muscle contraction, substrate mobilization
MeSH terms
Animals, Anti-Inflammatory Agents, Glucose, Glycogen, Humans, Insulin Resistance, Lipolysis, Muscle Contraction, Tumor Necrosis Factor-alpha, Signal Transduction, Exercise, Interleukin-6, Muscle, Skeletal

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