The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Efflux-Mediated Drug Resistance in Bacteria: An Update
Open accessAbstract
Drug efflux pumps play a key role in drug resistance and also serve other functions in bacteria. There has been a growing list of multidrug and drug-specific efflux pumps characterized from bacteria of human, animal, plant and environmental origins. These pumps are mostly encoded on the chromosome, although they can also be plasmid-encoded. A previous article in this journal provided a comprehensive review regarding efflux-mediated drug resistance in bacteria. In the past 5 years, significant progress has been achieved in further understanding of drug resistance-related efflux transporters and this review focuses on the latest studies in this field since 2003. This has been demonstrated in multiple aspects that include but are not limited to: further molecular and biochemical characterization of the known drug efflux pumps and identification of novel drug efflux pumps; structural elucidation of the transport mechanisms of drug transporters; regulatory mechanisms of drug efflux pumps; determining the role of the drug efflux pumps in other functions such as stress responses, virulence and cell communication; and development of efflux pump inhibitors. Overall, the multifaceted implications of drug efflux transporters warrant novel strategies to combat multidrug resistance in bacteria.
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Cites
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Cited by
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Antibiotic use in food animals worldwide, with a focus on Africa: Pluses and minuses
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Impact of multidrug-resistant Pseudomonas aeruginosa infection on patient outcomes
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Metadata
- Authors
- Li, X.-Z., & Nikaido, H.
- Venue
- Drugs
- Published
- 2009-08
- Volume
- 69
- Issue
- 12
- Pages
- 1555-1623
- ISSN
- 0012-6667 (ISSN-L)
- OpenAlex
- W2076233570
- Cited by
- 966
- References
- 14
- FWCI
- 19.28
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
