Cited by 39Malaria Research and ControlNanoparticle-Based Drug DeliveryPharmacology and Nanomedicine Research

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Nanomedicine Against Malaria

Urban, Patricia, Fernandez-Busquets, Xavier·2014·Current Medicinal Chemistry

DOI 10.2174/09298673113206660292

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Abstract

Malaria is arguably one of the main medical concerns worldwide because of the numbers of people affected, the severity of the disease and the complexity of the life cycle of its causative agent, the protist Plasmodium sp. The clinical, social and economic burden of malaria has led for the last 100 years to several waves of serious efforts to reach its control and eventual eradication, without success to this day. With the advent of nanoscience, renewed hopes have appeared of finally obtaining the long sought-after magic bullet against malaria in the form of a nanovector for the targeted delivery of antimalarial drugs exclusively to Plasmodium-infected cells. Different types of encapsulating structure, targeting molecule, and antimalarial compound will be discussed for the assembly of Trojan horse nanocapsules capable of targeting with complete specificity diseased cells and of delivering inside them their antimalarial cargo with the objective of eliminating the parasite with a single dose. Nanotechnology can also be applied to the discovery of new antimalarials through single-molecule manipulation approaches for the identification of novel drugs targeting essential molecular components of the parasite. Finally, methods for the diagnosis of malaria can benefit from nanotools applied to the design of microfluidic-based devices for the accurate identification of the parasite's strain, its precise infective load, and the relative content of the different stages of its life cycle, whose knowledge is essential for the administration of adequate therapies. The benefits and drawbacks of these nanosystems will be considered in different possible scenarios, including cost-related issues that might be hampering the development of nanotechnology-based medicines against malaria with the dubious argument that they are too expensive to be used in developing areas.

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Authors: Urban, P., & Fernandez-Busquets, X.
Venue: Current Medicinal Chemistry
Publisher: Bentham Science Publishers Ltd.
Published: 2014-01-31
Volume: 21
Issue: 5
Pages: 605-629
ISSN: 0929-8673 (ISSN-L)
DOI: 10.2174/09298673113206660292
OpenAlex: W2325546659
Cited by: 39
References: 313
Citations by year: 2026: 1 · 2025: 2 · 2024: 6 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 4 · 2015: 2 · 2014: 3
FWCI: 4.29
Type: journal article
Language: en
Open access: closed
Locations: Current Medicinal Chemistry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Pharmacology and Nanomedicine Research
Keywords: malaria, Plasmodium, nanomedicine, targeted drug delivery, nanocapsules, antimalarial drugs, single-molecule manipulation, drug discovery, malaria diagnosis, microfluidics, parasite developmental stages, developing countries
MeSH terms: Amino Alcohols, Antimalarials, Drug Carriers, Humans, Malaria, Plasmodium, Quinolines, Drug Design, Dendrimers, Nanomedicine

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