Cited by 65Cholesterol and Lipid MetabolismAlzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Cholesterol homeostasis failure in the brain: Implications for synaptic dysfunction and cognitive decline

Segatto, Marco, Leboffe, Loris, Trapani, Laura, Pallottini, Valentina·2014·Current Medicinal Chemistry

Abstract

Cholesterol is one of the most important molecules in cell physiology because of its involvement in several biological processes: for instance, it determines both physical and biochemical properties of cell membranes and proteins. Disruption to cholesterol homeostasis leads to coronary heart disease, atherosclerosis and metabolic syndrome. Strong evidence suggests that cholesterol also has a crucial role in the brain as various neurological and neurodegenerative disorders, including Alzheimer's, Huntington's and Parkinson diseases are associated with disruptions to cholesterol homeostasis. Here, we summarize the current knowledge about the role cholesterol plays at synaptic junctions and the pathological consequences caused by disruptions in the homeostatic maintenance of this compound.

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Crossref · 10.2174/0929867321666140303142902

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136 of 136 references verified0 citation errors · 0 not checkable

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Authors
Segatto, M., Leboffe, L., Trapani, L., & Pallottini, V.
Affiliations
Roma Tre University (IT)
Venue
Current Medicinal Chemistry
Published
2014-07-31
Volume
21
Issue
24
Pages
2788-2802
ISSN
0929-8673 (ISSN-L)
OpenAlex
W2108358846
Cited by
65
References
136
Citations by year
2025: 7 · 2024: 6 · 2023: 6 · 2022: 9 · 2021: 8 · 2020: 8 · 2019: 4 · 2018: 2 · 2017: 5 · 2016: 6 · 2015: 2 · 2014: 1
FWCI
4.63
Type
journal article
Language
en
Open access
closed
Locations
  • Current Medicinal Chemistry (publishedVersion)
  • PubMed (publishedVersion)
  • Archivio Istituzionale della Ricerca - Università degli Studi del Molise (submittedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
cholesterol homeostasis, brain cholesterol, synaptic dysfunction, cognitive decline, neurodegenerative diseases, Alzheimer's disease, Huntington's disease, Parkinson's disease, membrane cholesterol, lipid metabolism
MeSH terms
Animals, Brain, Cholesterol, Cognition Disorders, Homeostasis, Humans, Synapses, Neurodegenerative Diseases

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