Cholesterol homeostasis failure in the brain: Implications for synaptic dysfunction and cognitive decline
Abstract
Cholesterol is one of the most important molecules in cell physiology because of its involvement in several biological processes: for instance, it determines both physical and biochemical properties of cell membranes and proteins. Disruption to cholesterol homeostasis leads to coronary heart disease, atherosclerosis and metabolic syndrome. Strong evidence suggests that cholesterol also has a crucial role in the brain as various neurological and neurodegenerative disorders, including Alzheimer's, Huntington's and Parkinson diseases are associated with disruptions to cholesterol homeostasis. Here, we summarize the current knowledge about the role cholesterol plays at synaptic junctions and the pathological consequences caused by disruptions in the homeostatic maintenance of this compound.
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Cholesterol plays a role in the proper structural organization of postsynaptic densities.
“Moreover cholesterol plays a role in the proper structural organization of postsynaptic densities [3].”
From Loss of Mevalonate/Cholesterol Homeostasis in the Brain: A Focus on Autism Spectrum Disorder and Rett Syndrome (2019) · cites this paper as [3]
Diet-derived cholesterol cannot cross the BBB and cannot compensate the low cholesterol level in the brain of SLOS patients with neurologic symptoms.
“Nevertheless, diet-derived cholesterol cannot cross the BBB and cannot compensate the low cholesterol level in the brain [3,24].”
From Loss of Mevalonate/Cholesterol Homeostasis in the Brain: A Focus on Autism Spectrum Disorder and Rett Syndrome (2019) · cites this paper as [3]
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- Authors
- Segatto, M., Leboffe, L., Trapani, L., & Pallottini, V.
- Affiliations
- Roma Tre University (IT)
- Venue
- Current Medicinal Chemistry
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2014-07-31
- Volume
- 21
- Issue
- 24
- Pages
- 2788-2802
- ISSN
- 0929-8673 (ISSN-L)
- OpenAlex
- W2108358846
- Cited by
- 65
- References
- 136
- Citations by year
- 2025: 7 · 2024: 6 · 2023: 6 · 2022: 9 · 2021: 8 · 2020: 8 · 2019: 4 · 2018: 2 · 2017: 5 · 2016: 6 · 2015: 2 · 2014: 1
- FWCI
- 4.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Medicinal Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi del Molise (submittedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- cholesterol homeostasis, brain cholesterol, synaptic dysfunction, cognitive decline, neurodegenerative diseases, Alzheimer's disease, Huntington's disease, Parkinson's disease, membrane cholesterol, lipid metabolism
- MeSH terms
- Animals, Brain, Cholesterol, Cognition Disorders, Homeostasis, Humans, Synapses, Neurodegenerative Diseases
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