Fatty Acids - Induced Lipotoxicity and Inflammation

Savary, Stephane; Trompier, Doriane; Andreoletti, Pierre; Le Borgne, Francoise; Demarquoy, Jean; Lizard, Gerard

doi:10.2174/138920012803762729

Cited by 111Liver Disease Diagnosis and TreatmentLipid metabolism and biosynthesisFatty Acid Research and Health

Fatty Acids - Induced Lipotoxicity and Inflammation

Savary, Stephane, Trompier, Doriane, Andreoletti, Pierre, Le Borgne, Francoise, Demarquoy, Jean, Lizard, Gerard·2012·Current Drug Metabolism

DOI 10.2174/138920012803762729

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Abstract

Fatty acids are known to serve as energetic substrates, key components of membrane lipids, and as substrates for the synthesis of signaling molecules and complex lipids. They are also known to be ligands either of membrane receptors involved in cell signaling or of nuclear receptors mediating gene regulation. Accumulation of fatty acids due to altered metabolism and/or unbalanced diet has been described to be toxic for several tissues, especially liver. In numerous cell types, cell death, cytokine secretion and activation of inflammatory processes appear to be a consequence of fatty acid accumulation. This review presents the different classes of fatty acids known to trigger toxic effects and inflammation, the cellular and subcellular targets of these fatty acids in the context of non-alcoholic fatty liver disease (NAFLD), and the mechanisms by which these effects are mediated.

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Cholesterol oxide derivatives and long chain fatty acid derivatives including prostaglandins, leukotrienes and neuroprotectins are present in the brain.
“Besides them, cholesterol oxide derivatives and other long chain derivatives of fatty acids including prostaglandins, leukotrienes and neuroprotectins are present [63, 64].”
From Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease (2020) · cites this paper as [64]

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Identification of ACSL4 as a biomarker and contributor of ferroptosis
Yuan, H., Li, X., Zhang, X., Kang, R., & Tang, D. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.08.124 · Cited by 1,071 · see citing works
Decoding cell death signals in liver inflammation
Brenner, C., Galluzzi, L., Kepp, O., & Kroemer, G. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.03.033 · Cited by 1,022 · see citing works
Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease
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“Besides them, cholesterol oxide derivatives and other long chain derivatives of fatty acids including prostaglandins, leukotrienes and neuroprotectins are present [63, 64].”
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Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?
Rada, P., González‐Rodríguez, Á., García‐Monzón, C., & Valverde, Á. M. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03003-w · Cited by 522 · see citing works
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Sex matters: The effects of biological sex on adipose tissue biology and energy metabolism
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Germline Signals Deploy NHR-49 to Modulate Fatty-Acid β-Oxidation and Desaturation in Somatic Tissues of C. elegans
Ratnappan, R., Amrit, F. R. G., Chen, S.-W., Gill, H. K., Holden, K., Ward, J. D., Yamamoto, K. R., Olsen, C. P., & Ghazi, A. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004829 · Cited by 143 · see citing works
Oleate prevents palmitate-induced mitochondrial dysfunction, insulin resistance and inflammatory signaling in neuronal cells
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Lonicera caerulea Extract Attenuates Non-Alcoholic Fatty Liver Disease in Free Fatty Acid-Induced HepG2 Hepatocytes and in High Fat Diet-Fed Mice
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The peroxisome: an up-and-coming organelle in immunometabolism
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SIRT1 Mediates the Effect of GLP-1 Receptor Agonist Exenatide on Ameliorating Hepatic Steatosis
Xu, F., Li, Z., Zheng, X., Liu, H., Liang, H., Xu, H., Chen, Z., Zeng, K., & Weng, J. (2014) · Diabetes · doi:10.2337/db14-0263 · Cited by 114 · see citing works
The Biological Functions and Regulatory Mechanisms of Fatty Acid Binding Protein 5 in Various Diseases
Xu, B., Chen, L., Zhan, Y., Marquez, K. N. S., Zhuo, L., Qi, S., Zhu, J., He, Y., Chen, X., Zhang, H., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.857919 · Cited by 104 · see citing works
Attenuation of Hyperlipidemia- and Diabetes-Induced Early-Stage Apoptosis and Late-Stage Renal Dysfunction via Administration of Fibroblast Growth Factor-21 Is Associated with Suppression of Renal Inflammation
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The peroxisome: an update on mysteries 3.0
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Personalized Nutrition in the Management of Female Infertility: New Insights on Chronic Low-Grade Inflammation
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Obesity-Related Chronic Kidney Disease—The Role of Lipid Metabolism
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Adipocyte Death Preferentially Induces Liver Injury and Inflammation Through the Activation of Chemokine (C‐C Motif) Receptor 2‐Positive Macrophages and Lipolysis
Kim, S., Feng, D., Guillot, A., Dai, S., Liu, F., Hwang, S., Parker, R., Seo, W., He, Y., Godlewski, G., et al. (2019) · Hepatology · doi:10.1002/hep.30525 · Cited by 75 · see citing works
Cherry Anthocyanins Regulate NAFLD by Promoting Autophagy Pathway
Chu, Q., Zhang, S., Chen, M., Han, W., Jia, R., Chen, W., & Zheng, X. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/4825949 · Cited by 72 · see citing works
High‐Fat Diet Alters Serum Fatty Acid Profiles in Obesity Prone Rats: Implications for InVitro Studies
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Peroxisomal ABC Transporters: An Update
Tawbeh, A., Gondcaille, C., Trompier, D., & Savary, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22116093 · Cited by 68 · see citing works
“While the toxicity of VLCFAs has been recognized [88], the sequence of events leading to neurodegeneration and inflammation is still debated.”
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A Distinct Fatty Acid Profile Underlies the Reduced Inflammatory State of Metabolically Healthy Obese Individuals
Perreault, M., Zulyniak, M. A., Badoud, F., Stephenson, S., Badawi, A. F., Buchholz, A. C., & Mutch, D. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088539 · Cited by 65 · see citing works
Anti-inflammatory potentials of incretin-based therapies used in the management of diabetes
Yaribeygi, H., Maleki, M., Sathyapalan, T., Jamialahmadi, T., & Sahebkar, A. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.117152 · Cited by 66 · see citing works
Lipophagy and Alcohol-Induced Fatty Liver
Li, Y., Yang, C., Thomes, P. G., Kharbanda, K. K., Casey, C. A., McNiven, M. A., & Donohue, T. M. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00495 · Cited by 60 · see citing works
Peroxisomes in Human Health and Disease: Metabolic Pathways, Metabolite Transport, Interplay with Other Organelles and Signal Transduction
Wanders, R. J. A. (2013) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-6889-5_2 · Cited by 58 · see citing works
Chain length of saturated fatty acids regulates mitochondrial trafficking and function in sensory neurons
Rumora, A. E., LoGrasso, G., Haidar, J. A., Dolkowski, J. J., Lentz, S. I., & Feldman, E. L. (2018) · Journal of Lipid Research · doi:10.1194/jlr.m086843 · Cited by 57 · see citing works
Serum amyloid protein A in inflammatory bowel disease: from bench to bedside
Chen, R., Chen, Q., Zheng, J., Zeng, Z., Chen, M., Li, L., & Zhang, S. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01455-5 · Cited by 57 · see citing works
Prevention of 7-Ketocholesterol-Induced Overproduction of Reactive Oxygen Species, Mitochondrial Dysfunction and Cell Death with Major Nutrients (Polyphenols, ω3 and ω9 Unsaturated Fatty Acids) of the Mediterranean Diet on N2a Neuronal Cells
Yammine, A., Nury, T., Véjux, A., Latruffe, N., Fasseur, D., Samadi, M. H., Greige‐Gerges, H., Auezova, L., & Lizard, G. (2020) · Molecules · doi:10.3390/molecules25102296 · Cited by 54 · see citing works
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CRISPR/Cas9-mediated knockout of Abcd1 and Abcd2 genes in BV-2 cells: novel microglial models for X-linked Adrenoleukodystrophy
Raas, Q., Gondcaille, C., Hamon, Y., Leoni, V., Caccia, C., Ménétrier, F., Lizard, G., Trompier, D., & Savary, S. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2019.02.006 · Cited by 53 · see citing works
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Attenuation of diabetic retinopathy and neuropathy by resveratrol: Review on its molecular mechanisms of action
Ahmad, I., & Hoda, M. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117350 · Cited by 53 · see citing works
Gemfibrozil improves lipid metabolism in Nile tilapia Oreochromis niloticus fed a high-carbohydrate diet through peroxisome proliferator activated receptor-α activation
Luo, Y., Hu, C.-T., Qiao, F., Wang, X., Qin, J. G., Du, Z., & Chen, L. (2020) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2020.113537 · Cited by 49 · see citing works
Quality Evaluation Indices for Soybean Oil in Relation to Cultivar, Application of N Fertiliser and Seed Inoculation with Bradyrhizobium japonicum
Szpunar-Krok, E., & Wondołowska-Grabowska, A. (2022) · Foods · doi:10.3390/foods11050762 · Cited by 48 · see citing works
N-acetyl cysteine attenuates oxidative stress and glutathione-dependent redox imbalance caused by high glucose/high palmitic acid treatment in pancreatic Rin-5F cells
Alnahdi, A., John, A., & Raza, H. (2019) · PLoS ONE · doi:10.1371/journal.pone.0226696 · Cited by 47 · see citing works
Fatty Acid Synthase Inhibitor C75 Ameliorates Experimental Colitis
Matsuo, S., Yang, W.-L., Aziz, M., Kameoka, S., & Wang, P. (2013) · Molecular Medicine · doi:10.2119/molmed.2013.00113 · Cited by 47 · see citing works
Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cells
Sinha, R. A., Singh, B. K., Zhou, J., Xie, S. Y., Farah, B. L., Lesmana, R., Ohba, K., Tripathi, M., Ghosh, S., Hollenberg, A. N., et al. (2016) · Autophagy · doi:10.1080/15548627.2016.1235123 · Cited by 43 · see citing works
Serum metabonomics study on antidiabetic effects of fenugreek flavonoids in streptozotocin-induced rats
Jiang, W., Si, L., Li, P., Bai, B., Qu, J., Hou, B., Zou, H., Fan, X., Liu, Z., Liu, Z., et al. (2018) · Journal of Chromatography B · doi:10.1016/j.jchromb.2018.06.041 · Cited by 42 · see citing works
Evaluation of type 2 diabetic mellitus animal models via interactions between insulin and mitogen‑activated protein kinase signaling pathways induced by a high fat and sugar diet and streptozotocin
Zhuo, J., Zeng, Q., Cai, D., Zeng, X., Chen, Y., Gan, H., Huang, X., Yao, N., Huang, D., & Zhang, C. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.8504 · Cited by 38 · see citing works
Liver fibrosis is a common pathological change in the liver of dairy cows with fatty liver.
Zhang, C., Shao, Q., Liu, M.-C., Wang, X., Loor, J., Jiang, Q., Cuan, S., Li, X., Wang, J., Li, Y.-X., et al. (2023) · Journal of Dairy Science · doi:10.3168/jds.2022-22021 · Cited by 36 · see citing works
Biology, strategies, and fresh meat consequences of manipulating the fatty acid composition of meat
Burnett, D. D., Legako, J. F., Phelps, K. J., & Gonzalez, J. M. (2020) · Journal of Animal Science · doi:10.1093/jas/skaa033 · Cited by 42 · see citing works
Long‐term hepatic safety of lomitapide in homozygous familial hypercholesterolaemia
Larrey, D. G., D’Erasmo, L., O’Brien, S. L., Arca, M., & the Italian Working Group on Lomitapide (2022) · Liver International · doi:10.1111/liv.15497 · Cited by 36 · see citing works
Antioxidant Properties and Cytoprotective Effect of Pistacia lentiscus L. Seed Oil against 7β-Hydroxycholesterol-Induced Toxicity in C2C12 Myoblasts: Reduction in Oxidative Stress, Mitochondrial and Peroxisomal Dysfunctions and Attenuation of Cell Death
Ghzaiel, I., Zarrouk, A., Nury, T., Libergoli, M., Florio, F., Hammouda, S., Ménétrier, F., Avoscan, L., Yammine, A., Samadi, M. H., et al. (2021) · Antioxidants · doi:10.3390/antiox10111772 · Cited by 36 · see citing works
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A tRNA-derived fragment (tRF-3001b) aggravates the development of nonalcoholic fatty liver disease by inhibiting autophagy
Zhu, J., Cheng, M., & Zhao, X. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118125 · Cited by 34 · see citing works
Cytoprotective activities of representative nutrients from the Mediterranean diet and of Mediterranean oils against 7-ketocholesterol- and 7β-hydroxycholesterol-induced cytotoxicity: Application to age-related diseases and civilization diseases
Rezig, L., Ghzaiel, I., Ksila, M., Yammine, A., Nury, T., Zarrouk, A., Samadi, M. H., Chouaibi, M., Véjux, A., & Lizard, G. (2022) · Steroids · doi:10.1016/j.steroids.2022.109093 · Cited by 31 · see citing works
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Protective effects of milk thistle (Sylibum marianum) seed oil and α-tocopherol against 7β-hydroxycholesterol-induced peroxisomal alterations in murine C2C12 myoblasts: Nutritional insights associated with the concept of pexotherapy
Ghzaiel, I., Zarrouk, A., Essadek, S., Martine, L., Hammouda, S., Yammine, A., Ksila, M., Nury, T., Meddeb, W., Tahri-Joutey, M., et al. (2022) · Steroids · doi:10.1016/j.steroids.2022.109032 · Cited by 30 · see citing works
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Meta-Omic Platforms to Assist in the Understanding of NAFLD Gut Microbiota Alterations: Tools and Applications
CHIERICO, F. D., Gnani, D., Vernocchi, P., Petrucca, A., Alisi, A., Dallapiccola, B., Nobili, V., & Putignani, L. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15010684 · Cited by 30 · see citing works
Trans-Resveratrol Attenuates High Fatty Acid-Induced P2X7 Receptor Expression and IL-6 Release in PC12 Cells: Possible Role of P38 MAPK Pathway
Xu, H., Xiong, C., He, L., Wu, B., Peng, L., Cheng, Y., Jiang, F.-Q., Tan, L., Tang, L. F., Tu, Y., et al. (2014) · Inflammation · doi:10.1007/s10753-014-0036-6 · Cited by 30 · see citing works
Palmitate induces nitric oxide production and inflammatory cytokine expression in zebrafish
Cha, S., Hwang, Y., Kim, K., & Jun, H. (2018) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2018.05.025 · Cited by 28 · see citing works
Inhibition of lipogenesis reduces inflammation and organ injury in sepsis
Idrovo, J. P., Yang, W.-L., Jacob, A., Corbo, L., Nicastro, J. M., Coppa, G. F., & Wang, P. (2015) · Journal of Surgical Research · doi:10.1016/j.jss.2015.06.059 · Cited by 27 · see citing works
Hepatocyte‐Specific Expression of Human Carboxylesterase 1 Attenuates Diet‐Induced Steatohepatitis and Hyperlipidemia in Mice
Xu, Y., Zhu, Y., Bawa, F. N. C., Hu, S., Pan, X., Yin, L., & Zhang, Y. (2020) · Hepatology Communications · doi:10.1002/hep4.1487 · Cited by 27 · see citing works
Hypothalamic Lipids: Key Regulators of Whole Body Energy Balance
González‐García, I., Fernø, J., Diéguez, C., Nogueiras, R., & López, M. (2016) · Neuroendocrinology · doi:10.1159/000448432 · Cited by 28 · see citing works
Evidence of K+ homeostasis disruption in cellular dysfunction triggered by 7-ketocholesterol, 24S-hydroxycholesterol, and tetracosanoic acid (C24:0) in 158N murine oligodendrocytes
Bezine, M., Debbabi, M., Nury, T., Khalifa, R. B., Samadi, M. H., Cherkaoui‐Malki, M., Véjux, A., Raas, Q., Seze, J. D., Moreau, T., et al. (2017) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2017.03.006 · Cited by 26 · see citing works
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Cloning of the pks3 gene of Aurantiochytrium limacinum and functional study of the 3-ketoacyl-ACP reductase and dehydratase enzyme domains
Liu, Z., Zang, X., Cao, X., Wang, Z., Liu, C., Sun, D., Guo, Y., Zhang, F., Yang, Q., Hou, P., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0208853 · Cited by 26 · see citing works
Octadecaneuropeptide (ODN) Induces N2a Cells Differentiation through a PKA/PLC/PKC/MEK/ERK-Dependent Pathway: Incidence on Peroxisome, Mitochondria, and Lipid Profiles
Namsi, A., Nury, T., Khan, A. S., Leprince, J., Vaudry, D., Caccia, C., Leoni, V., Atanasov, A. G., Tonon, M., Masmoudi‐Kouki, O., et al. (2019) · Molecules · doi:10.3390/molecules24183310 · Cited by 25 · see citing works
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Antilipotoxicity Activity of Osmanthus fragrans and Chrysanthemum morifolium Flower Extracts in Hepatocytes and Renal Glomerular Mesangial Cells
Tsai, P., Chang, M.-L., Hsin, C.-M., Chuang, C.-C., Chuang, L., & Wu, W.-H. (2017) · Mediators of Inflammation · doi:10.1155/2017/4856095 · Cited by 22 · see citing works
Evodiamine Attenuates P2X7‐Mediated Inflammatory Injury of Human Umbilical Vein Endothelial Cells Exposed to High Free Fatty Acids
Xue, Y., Guo, T., Zou, L., Gong, Y., Wu, B., Yi, Z., Jia, T., Zhao, S., Shi, L., Li, L., et al. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/5082817 · Cited by 20 · see citing works
Treatment of cigarette smoke extract and condensate differentially potentiates palmitic acid-induced lipotoxicity and steatohepatitis in vitro
Zhou, Z., Kim, J. W., Zhao, J., Qi, J., Choi, S. J., Lim, C. W., Lee, M., Lee, K., & Kim, B. (2018) · Toxicology in Vitro · doi:10.1016/j.tiv.2018.05.017 · Cited by 19 · see citing works
Elovl2 Is Required for Robust Visual Function in Zebrafish
Dasyani, M., Gao, F., Xu, Q., Fossan, D. V., Zhang, E., Pinto, A. F. M., Saghatelian, A., Skowronska‐Krawczyk, D., & Chao, D. L. (2020) · Cells · doi:10.3390/cells9122583 · Cited by 18 · see citing works
Modulation of peroxisomes abundance by argan oil and lipopolysaccharides in acyl-CoA oxidase 1-deficient fibroblasts
Kebbaj, R. E., Kamouni, S. E., Hajj, H. I. E., Andreoletti, P., Gresti, J., Latruffe, N., Kebbaj, M. S. E., Vamecq, J., Lizard, G., Nasser, B., et al. (2013) · Health · doi:10.4236/health.2013.51009 · Cited by 17 · see citing works
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Natural and chemical compounds as protective agents against cardiac lipotoxicity
Yarmohammadi, F., Hayes, A. W., & Karimi, G. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112413 · Cited by 16 · see citing works
Polar Lipid Fraction from Golden Oyster Mushrooms (Pleurotus citrinopileatus) Suppresses Colon Injuries from Inflammatory Stresses in vivo and in vitro
Yamashita, S., Seino, T., Inobe, M., Jutanom, M., Matsumoto, S., & Kinoshita, M. (2020) · Journal of Oleo Science · doi:10.5650/jos.ess20050 · Cited by 16 · see citing works
The Tm7sf2 Gene Deficiency Protects Mice against Endotoxin-Induced Acute Kidney Injury
Gatticchi, L., Bellezza, I., SORDO, R. D., Peirce, M. J., Sidoni, A., Roberti, R., & Minelli, A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0141885 · Cited by 15 · see citing works
Palmitic Acid Inhibits Myogenic Activity and Expression of Myosin Heavy Chain MHC IIb in Muscle Cells through Phosphorylation-Dependent MyoD Inactivation
Matsuba, I., Fujita, R., & Iida, K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065847 · Cited by 14 · see citing works
Mitochondrial Homeostasis Mediates Lipotoxicity in the Failing Myocardium
Kretzschmar, T., Wu, J. M. F., & Schulze, P. C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031498 · Cited by 14 · see citing works
Short and Long-Term Impact of Lipectomy on Expression Profile of Hepatic Anabolic Genes in Rats: A High Fat and High Cholesterol Diet-Induced Obese Model
Ling, B.-L., Chiu, C., Lu, H., Lin, J.-J., Kuo, C.-Y., & Chou, F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108717 · Cited by 13 · see citing works
Tibolone Ameliorates the Lipotoxic Effect of Palmitic Acid in Normal Human Astrocytes
Martín-Jiménez, C., González, J., Vesga-Jiménez, D. J., Aristizábal-Pachón, A. F., & Barreto, G. E. (2020) · Neurotoxicity Research · doi:10.1007/s12640-020-00247-4 · Cited by 13 · see citing works
Enhanced oleate uptake and lipotoxicity associated with laurate
Kitaura, Y., Inoue, K., Kato, N., Matsushita, N., & Shimomura, Y. (2015) · FEBS Open Bio · doi:10.1016/j.fob.2015.05.008 · Cited by 13 · see citing works
Mitigation of Glucolipotoxicity-Induced Apoptosis, Mitochondrial Dysfunction, and Metabolic Stress by N-Acetyl Cysteine in Pancreatic β-Cells
Alnahdi, A., John, A., & Raza, H. (2020) · Biomolecules · doi:10.3390/biom10020239 · Cited by 13 · see citing works
Accumulation of 24S-hydroxycholesterol in neuronal SK-N-BE cells treated with hexacosanoic acid (C26:0): Argument in favor of 24S-hydroxycholesterol as a potential biomarker of neurolipotoxicity
Zarrouk, A., Hammami, M., Moreau, T., & Lizard, G. (2015) · Revue Neurologique · doi:10.1016/j.neurol.2014.10.016 · Cited by 12 · see citing works
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Effects of Dietary Ethanol Extracts from Sake Rice and Sake Lees on Intestinal Impairment in Mice
Yamashita, S., Hata, M., Kikuchi, N., Kinoshita, M., & Miyazawa, T. (2020) · Journal of Oleo Science · doi:10.5650/jos.ess20069 · Cited by 12 · see citing works
Protective Mechanism of Rice-Derived Lipids and Glucosylceramide in an In Vitro Intestinal Tract Model
Yamashita, S., Soga, M., Nguma, E., Kinoshita, M., & Miyazawa, T. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c04562 · Cited by 12 · see citing works
Selenium modulates MMP2 expression through the TGFβ1/Smad signalling pathway in human umbilical vein endothelial cells and rabbits following lipid disturbance
Xu, C., Lu, G., Li, Q., Zhang, J., Huang, Z., & Gao, X. (2017) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2017.04.006 · Cited by 12 · see citing works
Cyclophosphamide Induces Lipid and Metabolite Perturbation in Amniotic Fluid during Rat Embryonic Development
Xu, J., Fang, H., Chong, Y., Lin, L., Xie, T., Ji, J., Shen, C., Shi, C., & Shan, J. (2022) · Metabolites · doi:10.3390/metabo12111105 · Cited by 11 · see citing works
Chitosan oligosaccharide attenuates hepatic steatosis in HepG2 cells via the activation of AMP‐activated protein kinase
Li, T., Gong, H., Zhan, B., & Mao, X. (2022) · Journal of Food Biochemistry · doi:10.1111/jfbc.14045 · Cited by 11 · see citing works
Identifying Autophagy-Related lncRNAs and Potential ceRNA Networks in NAFLD
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Authors: Savary, S., Trompier, D., Andreoletti, P., Le Borgne, F., Demarquoy, J., & Lizard, G.
ORCID: Trompier, Doriane
Andreoletti, Pierre
Demarquoy, Jean
Venue: Current Drug Metabolism
Publisher: Bentham Science Publishers Ltd.
Published: 2012-10-01
Volume: 13
Issue: 10
Pages: 1358-1370
ISSN: 1389-2002 (ISSN-L)
DOI: 10.2174/138920012803762729
OpenAlex: W2028509006
Cited by: 111
References: 175
Citations by year: 2026: 7 · 2025: 8 · 2024: 4 · 2023: 5 · 2022: 12 · 2021: 7 · 2020: 13 · 2019: 9 · 2018: 9 · 2017: 6 · 2016: 6 · 2015: 8 · 2014: 8 · 2013: 8 · 2012: 1
FWCI: 5.96
Type: journal article
Language: en
Open access: closed
Locations: Current Drug Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Keywords: fatty acids, lipotoxicity, inflammation, non-alcoholic fatty liver disease, fatty acid accumulation, cell death, cytokine production, nuclear receptors, cell surface receptors, hepatotoxicity, lipid metabolism
MeSH terms: Animals, Fatty Acids, Fatty Liver, Humans, Inflammation, Oxidative Stress, Hepatocytes, Non-alcoholic Fatty Liver Disease

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Fatty Acids - Induced Lipotoxicity and Inflammation

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