Conjugated linoleic acid and inflammatory cell signalling

Reynolds, C.M.; Roche, H.M.

doi:10.1016/j.plefa.2010.02.021

Cited by 118Fatty Acid Research and HealthInflammatory mediators and NSAID effectsEdible Oils Quality and Analysis

Conjugated linoleic acid and inflammatory cell signalling

Reynolds, C.M., Roche, H.M.·2010·Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)

DOI 10.1016/j.plefa.2010.02.021

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Abstract

Conjugated linoleic acids (CLA) are a family of polyunsaturated fatty acids (PUFA), some isomers occurring naturally in beef and dairy products and others being formed as a result of bihydrogenation of vegetable oils to form margarine. Synthetic and natural sources of CLA may have beneficial effects in a range of inflammatory conditions including colitis, atherosclerosis, metabolic syndrome and rheumatoid arthritis. Most of the biological effects have been attributed to the cis9, trans11- (c9, t11-) and the trans10, cis12- (t10, c12-) isomers. Evidence suggests that c9, t11-CLA is responsible for the anti-inflammatory effect attributed to CLA while t10, t12-CLA appears to be responsible for anti-adipogenic effects. This review will focus on the effects of CLA on the inflammatory components associated with insulin resistance, atherosclerosis and Th1 mediated inflammatory disease, at a cellular, systemic and clinical level. Whist CLA may ameliorate certain aspects of the inflammatory response, particularly within cellular and animal models, the relevance of this has yet to be clarified within the context of human health.

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cLA consists of positional isomers of linoleic acid having conjugated dienes in the cis and trans configurations.
“cLA consists of positional isomers of linoleic acid having conjugated dienes in the cis and trans configurations [39], [51], [52].”
From Olives and olive oil are sources of electrophilic fatty acid nitroalkenes (2014) · cites this paper as [51]
Conjugated linoleic acid displays immune-modulatory and anti-inflammatory effects, with proposed mechanisms including reduction of pro-inflammatory cytokine levels via inhibition of NF-κB-dependent gene expression and activation of PPAR-regulated gene expression.
“Conjugated linoleic acid displays immune-modulatory and anti-inflammatory effects [51], [52], with the mechanisms accounting for these actions proposed to include the reduction of pro-inflammatory cytokine levels via inhibition of NF-κB-dependent gene expression and activation of PPAR-regulated gene expression [51], [52].”
From Olives and olive oil are sources of electrophilic fatty acid nitroalkenes (2014) · cites this paper as [51]

Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041 · see citing works
The metabolic syndrome—a new worldwide definition
Alberti, K. G. M., Zimmet, P., & Shaw, J. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67402-8 · Cited by 9,352 · see citing works
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199 · see citing works
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518 · see citing works
Immunobiology of Dendritic Cells
Banchereau, J., Brière, F., Caux, C., Davoust, J. M., Lebecque, S., Liu, Y., Pulendran, B., & Palucka, K. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.767 · Cited by 6,612 · see citing works
Metabolic syndrome—a new world‐wide definition. A Consensus Statement from the International Diabetes Federation
Alberti, K. G. M. M., Zimmet, P., & Shaw, J. (2006) · Diabetic Medicine · doi:10.1111/j.1464-5491.2006.01858.x · Cited by 6,597 · see citing works
Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans
Cinti, S., Mitchell, G., Barbatelli, G., Murano, I., Ceresi, E., Faloia, E., Wang, S., Fortier, M., Greenberg, A. S., & Obin, M. S. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500294-jlr200 · Cited by 2,529 · see citing works
IL-10: The Master Regulator of Immunity to Infection
Couper, K. N., Blount, D. G., & Riley, E. M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.9.5771 · Cited by 2,220 · see citing works
Atherosclerosis is an inflammatory disease
Ross, R. (1999) · American Heart Journal · doi:10.1016/s0002-8703(99)70266-8 · Cited by 1,458 · see citing works
Metabolic syndrome: A comprehensive perspective based on interactions between obesity, diabetes, and inflammation
Dandona, P., Aljada, A., Chaudhuri, A., Mohanty, P., & Garg, R. (2005) · Circulation · doi:10.1161/01.cir.0000158483.13093.9d · Cited by 1,263 · see citing works
Effect of conjugated linoleic acid on body composition in mice
Park, Y., Albright, K. J., Liu, W., Storkson, J. M., Cook, M. E., & Pariza, M. W. (1997) · Lipids · doi:10.1007/s11745-997-0109-x · Cited by 1,163 · see citing works
A Model-Based Method for Assessing Insulin Sensitivity From the Oral Glucose Tolerance Test
Mari, A., Pacini, G., Murphy, E., Ludvik, B. H., & Nolan, J. J. (2001) · Diabetes Care · doi:10.2337/diacare.24.3.539 · Cited by 805 · see citing works
Intermediates and Products of the Biohydrogenation of Linoleic Acid by Butyrivibrio fibrisolvens
Kepler, C. R., Hirons, K. P., McNeill, J. J., & Tove, S. B. (1966) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)96781-5 · Cited by 693 · see citing works
Biological effects of conjugated linoleic acids in health and disease
Bhattacharya, A., Banu, J., Rahman, M., Causey, J., & Fernandes, G. (2006) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2006.02.009 · Cited by 663 · see citing works
Pathogen-specific T Regulatory 1 Cells Induced in the Respiratory Tract by a Bacterial Molecule that Stimulates Interleukin 10 Production by Dendritic Cells
McGuirk, P., McCann, C., & Mills, K. H. G. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011288 · Cited by 617 · see citing works
Resistin, Adiponectin, Ghrelin, Leptin, and Proinflammatory Cytokines: Relationships in Obesity
Vendrell, J. J., Broch, M., Vilarrasa, N., Molina, A., Gómez, J. M., Gutiérrez, C., Simón, I., Soler, J., & Richart, C. (2004) · Obesity Research · doi:10.1038/oby.2004.118 · Cited by 552 · see citing works
Monocyte Chemoattractant Protein-1 Release Is Higher in Visceral than Subcutaneous Human Adipose Tissue (AT): Implication of Macrophages Resident in the AT
Bruun, J. M., Lihn, A. S., Pedersen, S. B., & Richelsen, B. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1696 · Cited by 535 · see citing works
Effects of conjugated linoleic acid on body fat and energy metabolism in the mouse
West, D. B., DeLany, J. P., Camet, P. M., Blohm, F., Truett, A. A., & Scimeca, J. A. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.275.3.r667 · Cited by 468 · see citing works
Activation of PPAR γ and δ by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease
Bassaganya-Riera, J., Reynolds, K., Martino‐Catt, S. J., Cui, Y., Hennighausen, L. G., Gonzalez, F. J., Rohrer, J., Uribe-Benninghoff, A., & Hontecillas, R. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.06.049 · Cited by 393 · see citing works
Dietary trans-10,cis-12 conjugated linoleic acid induces hyperinsulinemia and fatty liver in the mouse
Clément, L. C., Poirier, H., Niot, I., Bocher, V., Guerre-Millo, M., Krief, S., Staels, B., & Besnard, P. (2002) · Journal of Lipid Research · doi:10.1194/jlr.m20008-jlr200 · Cited by 356 · see citing works
Estimation of Conjugated Linoleic Acid Intake by Written Dietary Assessment Methodologies Underestimates Actual Intake Evaluated by Food Duplicate Methodology
Ritzenthaler, K. L., McGuire, M. K., Shultz, T. D., Falen, R., Dasgupta, N., & McGuire, M. A. (2001) · Journal of Nutrition · doi:10.1093/jn/131.5.1548 · Cited by 326 · see citing works
Efficacy of conjugated linoleic acid for reducing fat mass: a meta-analysis in humans
Whigham, L. D., Watras, A. C., & Schoeller, D. A. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.5.1203 · Cited by 312 · see citing works
Conjugated linoleic acid decreases production of pro-inflammatory products in macrophages: evidence for a PPARγ-dependent mechanism
Yu, Y.-B., Correll, P. H., & Heuvel, J. P. V. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(02)00126-9 · Cited by 311 · see citing works
Opposing effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid on blood lipids in healthy humans
Tricon, S., Burdge, G. C., Kew, S., Banerjee, T., Russell, J. J., Jones, E. L., Grimble, R. F., Williams, C. M., Yaqoob, P., & Calder, P. C. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.3.614 · Cited by 294 · see citing works
Macrophage Activation in Atherosclerosis: Pathogenesis and Pharmacology of Plaque Rupture
Boyle, J. (2005) · Current Vascular Pharmacology · doi:10.2174/1570161052773861 · Cited by 291 · see citing works
Conjugated linoleic acid (CLA) reduced abdominal adipose tissue in obese middle-aged men with signs of the metabolic syndrome: a randomised controlled trial
Risérus, U., Berglund, L., & Vessby, B. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801659 · Cited by 284 · see citing works
Immunomodulatory properties of conjugated linoleic acid
O’Shea, M., Bassaganya-Riera, J., & Mohede, I. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.6.1199s · Cited by 262 · see citing works
Conjugated linoleic acid supplementation, insulin sensitivity, and lipoprotein metabolism in patients with type 2 diabetes mellitus
Moloney, F., Yeow, T.-P., Mullen, A., Nolan, J. J., & Roche, H. M. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.4.887 · Cited by 247 · see citing works
Effects of cis-9,trans-11 conjugated linoleic acid supplementation on insulin sensitivity, lipid peroxidation, and proinflammatory markers in obese men
Risérus, U., Vessby, B. O., Ärnlöv, J., & Basu, S. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.2.279 · Cited by 243 · see citing works
The effect of dietary supplementation using isomeric blends of conjugated linoleic acid on lipid metabolism in healthy human subjects
Noone, E., Roche, H. M., Nugent, A. P., & Gibney, M. J. (2002) · British Journal Of Nutrition · doi:10.1079/bjn2002615 · Cited by 240 · see citing works
Antigen-specific regulatory T cells—their induction and role in infection
Mills, K. H. G., & McGuirk, P. (2004) · Seminars in Immunology · doi:10.1016/j.smim.2003.12.006 · Cited by 236 · see citing works
CLA and n-3 PUFA differentially modulate clinical activity and colonic PPAR-responsive gene expression in a pig model of experimental IBD
Bassaganya-Riera, J., & Hontecillas, R. (2006) · Clinical Nutrition · doi:10.1016/j.clnu.2005.12.008 · Cited by 220 · see citing works
Trans-Vaccenic Acid Is Desaturated to Conjugated Linoleic Acid in Mice
Santora, J. E., Palmquist, D. L., & Roehrig, K. L. (2000) · Journal of Nutrition · doi:10.1093/jn/130.2.208 · Cited by 204 · see citing works
cis-9, trans-11 CLA Derived Endogenously from trans-11 18:1 Reduces Cancer Risk in Rats
Corl, B. A., Barbano, D. M., Bauman, D. E., & Ip, C. C. Y. (2003) · Journal of Nutrition · doi:10.1093/jn/133.9.2893 · Cited by 195 · see citing works
Effects of cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid (CLA) isomers on immune function in healthy men
Albers, R., van der Wielen, R. P. J., Brink, E. J., Hendriks, H., Dorovska‐Taran, V., & Mohede, I. (2003) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601585 · Cited by 183 · see citing works
Nutritional Supplementation Withtrans-10,cis-12–Conjugated Linoleic Acid Induces Inflammation of White Adipose Tissue
Poirier, H., Shapiro, J. S., Kim, R. J., & Lazar, M. A. (2006) · Diabetes · doi:10.2337/db06-0036 · Cited by 176 · see citing works
Dietary conjugated linoleic acid and body composition
Wang, Y., & Jones, P. J. H. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.6.1153s · Cited by 175 · see citing works
Effects of dairy products naturally enriched with cis-9,trans-11 conjugated linoleic acid on the blood lipid profile in healthy middle-aged men
Tricon, S., Burdge, G. C., Jones, E. L., Russell, J. J., El-Khazen, S., Moretti, E., Hall, W. L., Gerry, A. B., Leake, D. S., Grimble, R. F., et al. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.4.744 · Cited by 165 · see citing works
Distribution of conjugated linoleic acid and metabolites in different lipid fractions in the rat liver
Banni, S., Carta, G., Angioni, E., Murru, E., Scanu, P., Melis, M. P., Bauman, D. E., Fischer, S. M., & Ip, C. C. Y. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31594-7 · Cited by 159 · see citing works
Antidiabetic Effects of cis-9, trans-11–Conjugated Linoleic Acid May Be Mediated via Anti-Inflammatory Effects in White Adipose Tissue
Moloney, F., Toomey, S., Noone, E., Nugent, A. P., Allan, B. B., Loscher, C. E., & Roche, H. M. (2007) · Diabetes · doi:10.2337/db06-0384 · Cited by 157 · see citing works
Conjugated Linoleic Acid Suppresses NF-κB Activation and IL-12 Production in Dendritic Cells through ERK-Mediated IL-10 Induction
Loscher, C. E., Draper, E., Leavy, O., Kelleher, D., Mills, K. H. G., & Roche, H. M. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.8.4990 · Cited by 148 · see citing works
Conjugated linoleic acid isomer effects in atherosclerosis: Growth and regression of lesions
Kritchevsky, D., Tepper, S. A., Wright, S., Czarnecki, S. K., Wilson, T. A., & Nicolosi, R. J. (2004) · Lipids · doi:10.1007/s11745-004-1273-8 · Cited by 147 · see citing works
Supplementation with trans10cis12-conjugated linoleic acid induces hyperproinsulinaemia in obese men: close association with impaired insulin sensitivity
Ris�rus, U., Vessby, B., Arner, P., & Zethelius, B. (2004) · Diabetologia · doi:10.1007/s00125-004-1421-8 · Cited by 139 · see citing works
Profound resolution of early atherosclerosis with conjugated linoleic acid
Toomey, S., Harhen, B., Roche, H. M., Fitzgerald, D. J., & Belton, O. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.08.024 · Cited by 134 · see citing works
Effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid on immune cell function in healthy humans
Tricon, S., Burdge, G. C., Kew, S., Banerjee, T., Russell, J. J., Grimble, R. F., Williams, C. M., Calder, P. C., & Yaqoob, P. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.6.1626 · Cited by 111 · see citing works
Fatores de risco no desenvolvimento da aterosclerose na infância e adolescência
dos Santos, M. G., Pegoraro, M., Sandrini, F., & Macuco, E. C. (2008) · Arquivos Brasileiros de Cardiologia · doi:10.1590/s0066-782x2008000400012 · Cited by 107 · see citing works
Cis-9, trans-11-Conjugated Linoleic Acid Inhibits Allergic Sensitization and Airway Inflammation via a PPAR γ-Related Mechanism in Mice3
Jaudszus, A., Krokowski, M., Möckel, P., Darcan, Y., Avagyan, A., Matricardi, P. M., Jahreis, G., & Hamelmann, E. H. (2008) · Journal of Nutrition · doi:10.1093/jn/138.7.1336 · Cited by 104 · see citing works
The effects of conjugated linoleic acid on human health-related outcomes
Tricon, S., Burdge, G. C., Williams, C. M., Calder, P. C., & Yaqoob, P. (2005) · Proceedings of The Nutrition Society · doi:10.1079/pns2005418 · Cited by 104 · see citing works
Trans-10, cis-12 conjugated linoleic acid causes inflammation and delipidation of white adipose tissue in mice: a microarray and histological analysis
LaRosa, P. C., Miner, J. L., Xia, Y., Zhou, Y., Kachman, S. D., & Fromm, M. (2006) · Physiological Genomics · doi:10.1152/physiolgenomics.00076.2006 · Cited by 103 · see citing works
Selective effect of conjugated linoleic acid isomers on atherosclerotic lesion development in apolipoprotein E knockout mice
Arbonés-Mainar, J. M., Navarro, M. Á., Guzmán, M., Arnal, C., Surra, J. C., Acı́n, S., Carnicer, R., Osada, J., & Roche, H. M. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.01.015 · Cited by 102 · see citing works
Rosiglitazone Reduces the Development and Rupture of Experimental Aortic Aneurysms
Jones, A., Deb, R., Torsney, E., Howe, F. A., Dunkley, M., Gnaneswaran, Y., Gaze, D. C., Nasr, H. H., Loftus, I. M., Thompson, M. M., et al. (2009) · Circulation · doi:10.1161/circulationaha.109.852467 · Cited by 97 · see citing works
Trans-11–18: 1 is effectively δ9-desaturated compared withTrans-12–18: 1 in humans
Kuhnt, K., Kraft, J., Moeckel, P., & Jahreis, G. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20051680 · Cited by 97 · see citing works
Biosynthesis of Conjugated Linoleic Acid (CLA): A Review
Khanal, R. C., & Dhiman, T. R. (2004) · Pakistan Journal of Nutrition · doi:10.3923/pjn.2004.72.81 · Cited by 92 · see citing works
An Oil Mixture with Trans-10, Cis-12 Conjugated Linoleic Acid Increases Markers of Inflammation and in Vivo Lipid Peroxidation Compared with Cis-9, Trans-11 Conjugated Linoleic Acid in Postmenopausal Women
Tholstrup, T., Raff, M., Straarup, E. M., Lund, P., Basu, S., & Bruun, J. M. (2008) · Journal of Nutrition · doi:10.1093/jn/138.8.1445 · Cited by 91 · see citing works
Differential effects of conjugated linoleic acid isomers in insulin-resistant female C57Bl/6J mice
Halade, G. V., Rahman, M. M., & Fernandes, G. (2009) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.01.006 · Cited by 77 · see citing works
Divergent mechanisms of cis 9, trans 11 ‐ and trans 10 , cis 12 ‐ conjugated linoleic acid affecting insulin resistance and inflammation in apolipoprotein E knockout mice: a proteomics approach
de Roos, B., Rucklidge, G. J., Reid, M., Ross, K., Duncan, G., Navarro, M. Á., Arbonés-Mainar, J. M., Guzmán-García, M. A., Osada, J., Browne, J., et al. (2005) · The FASEB Journal · doi:10.1096/fj.05-3953fje · Cited by 76 · see citing works
Effect of conjugated linoleic acid isomers on insulin resistance and mRNA levels of genes regulating energy metabolism in high-fat–fed rats
Choi, J. S., Jung, M. H., Park, H. S., & Song, J. (2004) · Nutrition · doi:10.1016/j.nut.2004.08.009 · Cited by 74 · see citing works
Daily intake of conjugated linoleic acid-enriched yoghurts: effects on energy metabolism and adipose tissue gene expression in healthy subjects
Nazare, J., de la Perrière, A. B., Bonnet, F., Desage, M., Peyrat, J., Maitrepierre, C., Louche‐Pélissier, C., Bruzeau, J., Goudable, J., Lassel, T. S., et al. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507191911 · Cited by 73 · see citing works
Conjugated linoleic acid increased C-reactive protein in human subjects
Smedman, A., Basu, S., Jovinge, S. V., Fredrikson, G. N., & Vessby, B. O. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20041419 · Cited by 73 · see citing works
Trans-10, cis-12- and cis-9, trans-11-Conjugated Linoleic Acid Isomers Selectively Modify HDL-Apolipoprotein Composition in Apolipoprotein E Knockout Mice
Arbonés-Mainar, J. M., Navarro, M. Á., Acı́n, S., Guzmán, M., Arnal, C., Surra, J. C., Carnicer, R., Roche, H. M., & Osada, J. (2006) · Journal of Nutrition · doi:10.1093/jn/136.2.353 · Cited by 73 · see citing works
Conjugated linoleic acid fails to worsen insulin resistance but induces hepatic steatosis in the presence of leptin in ob/ob mice
Wendel, A. A., Purushotham, A., Liu, L.-F., & Belury, M. A. (2007) · Journal of Lipid Research · doi:10.1194/jlr.m700195-jlr200 · Cited by 71 · see citing works
The effects of conjugated linoleic acid supplementation on immune function in healthy volunteers
Nugent, A. P., Roche, H. M., Noone, E. J., Long, A., Kelleher, D. K., & Gibney, M. J. (2005) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602132 · Cited by 71 · cited 1× · see citing works
“A recent study [64] investigated the effects of c9, t11-CLA and t10, c12-CLA in ApoE deficient mice.”
Background
Dietary supplementation with conjugated linoleic acid increased its concentration in human peripheral blood mononuclear cells, but did not alter their function
Kelley, D. S., Simon, V. A., Taylor, P. C., Rudolph, I. L., Benito, P., Nelson, G. J., Mackey, B. E., & Erickson, K. L. (2001) · Lipids · doi:10.1007/s11745-001-0771-z · Cited by 70 · see citing works
Macrophages: Promising Targets for the Treatment of Atherosclerosis
Wilson, H. M., Barker, R. N., & Erwig, L. (2009) · Current Vascular Pharmacology · doi:10.2174/157016109787455635 · Cited by 67 · see citing works
cis-9,trans-11-Conjugated linoleic acid down-regulates phorbol ester-induced NF- B activation and subsequent COX-2 expression in hairless mouse skin by targeting I B kinase and PI3K-Akt
Hwang, D.-M., Kundu, J. K., Shin, J., Lee, J.-C., Lee, H. W., & Surh, Y. (2006) · Carcinogenesis · doi:10.1093/carcin/bgl151 · Cited by 65 · see citing works
Conjugated Linoleic Acid (CLA) Prevents Body Fat Accumulation and Weight Gain in an Animal Model
Park, Y., ALBRIGHT, K. J., STORKSON, J. M., Liu, W., & Pariza, M. W. (2007) · Journal of Food Science · doi:10.1111/j.1750-3841.2007.00477.x · Cited by 63 · see citing works
Dietary conjugated linoleic acid increases PPARγ gene expression in adipose tissue of obese rat, and improves insulin resistance
Zhou, X., Sun, C., Liu, J., & Zhao, D. (2008) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2008.01.001 · Cited by 62 · see citing works
Atherogenic Effect of Interleukin-2 and Antiatherogenic Effect of Interleukin-2 Antibody in Apo-E-Deficient Mice
Upadhya, S., Mooteri, S., Peckham, N. H., & Pai, R. G. (2004) · Angiology · doi:10.1177/000331970405500308 · Cited by 59 · see citing works
The metabolic syndrome and cardiovascular disease: part 2.
Jiamsripong, P., Mookadam, M., Alharthi, M. S., Khandheria, B., & Mookadam, F. (2008) · Preventive Cardiology · doi:10.1111/j.1751-7141.2008.00002.x · Cited by 56 · see citing works
Conjugated linoleic acid modulation of risk factors associated with atherosclerosis
Nakamura, Y., Flintoff‐Dye, N. L., & Omaye, S. T. (2008) · Nutrition & Metabolism · doi:10.1186/1743-7075-5-22 · Cited by 56 · see citing works
Conjugated Linoleic Acid Reduces Body Fat Accretion and Lipogenic Gene Expression in Neonatal Pigs Fed Low- or High-Fat Formulas3
Corl, B. A., Oliver, S. A. M., Lin, X., Oliver, W. T., Ma, Y., Harrell, R. J., & Odle, J. (2008) · Journal of Nutrition · doi:10.1093/jn/138.3.449 · Cited by 53 · see citing works
Dietary conjugated linoleic acid decreases adipocyte size and favorably modifies adipokine status and insulin sensitivity in obese, insulin-resistant rats
Noto, A. D., Zahradka, P. C., Yurkova, N., Xie, X., Truong, H., Nitschmann, E. P., Ogborn, M. R., & Taylor, C. G. (2007) · Metabolism · doi:10.1016/j.metabol.2007.06.025 · Cited by 48 · see citing works
Effects of the individual isomers cis‐9,trans‐11 vs. trans‐10,cis‐12 of conjugated linoleic acid (CLA) on inflammation parameters in moderately overweight subjects with LDL‐phenotype B
Ramakers, J. D., Plat, J., Sébédio, J., & Mensink, R. P. (2005) · Lipids · doi:10.1007/s11745-005-1451-8 · Cited by 47 · see citing works
Cis-9,trans-11-conjugated linoleic acid but not its precursortrans-vaccenic acid attenuate inflammatory markers in the human colonic epithelial cell line Caco-2
Reynolds, C. M., Loscher, C. E., MOLONEY, A. P., & Roche, H. M. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508894329 · Cited by 46 · see citing works
Self-citation
Conjugated linoleic acid isomers reduce blood cholesterol levels but not aortic cholesterol accumulation in hypercholesterolemic hamsters
Wilson, T. A., Nicolosi, R. J., Saati, A., Kotyla, T., & Kritchevsky, D. (2006) · Lipids · doi:10.1007/s11745-006-5068-8 · Cited by 45 · see citing works
A mechanistic approach to understanding conjugated linoleic acid's role in inflammation using murine models of rheumatoid arthritis
Bütz, D. E., Li, G., Huebner, S. M., & Cook, M. E. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00005.2007 · Cited by 44 · see citing works
Variation of trans fatty acids in milk fats
Precht, D. (1995) · Zeitschrift für Ernährungswissenschaft · doi:10.1007/bf01612782 · Cited by 41 · see citing works
Conjugated linoleic acid supplementation reduces peripheral blood mononuclear cell interleukin-2 production in healthy middle-aged males
Mullen, A., Moloney, F., Nugent, A. P., Doyle, L., Cashman, K. D., & Roche, H. M. (2007) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2006.12.008 · Cited by 37 · see citing works
Conjugated Linoleic Acids Can Change Phagocytosis of Human Monocytes/Macrophages by Reduction in Cox‐2 Expression
Stachowska, E., Baśkiewicz‐Masiuk, M., Dziedziejko, V., Adler, G., Bober, J., Machaliński, B., & Chlubek, D. (2007) · Lipids · doi:10.1007/s11745-007-3072-2 · Cited by 37 · see citing works
Effects of Selection and Crossbreeding Strategies on Industry Profit in the New Zealand Dairy Industry
Lopez-Villalobos, N., Garrick, D. J., Holmes, C. W., Blair, H. T., & Spelman, R. J. (2000) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(00)74867-3 · Cited by 35 · see citing works
cis-9,trans-11-Conjugated Linoleic Acid Activates AMP-Activated Protein Kinase in Attenuation of Insulin Resistance in C2C12 Myotubes
Qin, H., Liu, Y., Lu, N., Li, Y., & Sun, C. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf900534w · Cited by 34 · see citing works
Peroxisome proliferator‐activated receptor α,γ coagonist LY465608 inhibits macrophage activation and atherosclerosis in apolipoprotein E knockout mice
Zuckerman, S. H., Kauffman, R. F., & Evans, G. F. (2002) · Lipids · doi:10.1007/s11745-002-0922-2 · Cited by 30 · see citing works
Conjugated linoleic acid can prevent tumor necrosis factor gene expression by inhibiting nuclear factor binding activity in peripheral blood mononuclear cells from weaned pigs challenged with lipopolysaccharide
Zhao, L., Yin, J., Li, D., Lai, C., Chen, X., & Ma, D. (2005) · Archives of Animal Nutrition · doi:10.1080/17450390500353333 · Cited by 26 · see citing works
NF-κB independent inhibition of lipopolysaccharide-induced cyclooxygenase by a conjugated linoleic acid cognate, conjugated nonadecadienoic acid
Li, G., Dong, B., Bütz, D. E., Park, Y., Pariza, M. W., & Cook, M. E. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2006.07.014 · Cited by 19 · see citing works
Effects of dietary conjugated linoleic acid isomers on several functional properties of macrophages and heterophils in laying hens
Politis, I., Dimopoulou, M., Voudouri, A., NOIKOKYRIS, P. N., & Feggeros, K. (2003) · British Poultry Science · doi:10.1080/0007166031000088316 · Cited by 14 · see citing works
Dietary fat and atherosclerosis
Kritchevsky, D. (2002) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(02)00189-4 · Cited by 5 · see citing works

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Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling
Hansen, A. L., Buchan, G. J., Rühl, M., Mukai, K., Salvatore, S. R., Ogawa, E., Andersen, S. D., Iversen, M. B., Thielke, A. L., Gunderstofte, C., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1806239115 · Cited by 311 · see citing works
Milk fatty acids and potential health benefits: An updated vision
Gómez‐Cortés, P., Juárez, M., & de la Fuente, M. Á. (2018) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2018.08.014 · Cited by 260 · see citing works
Pathways of polyunsaturated fatty acid utilization: Implications for brain function in neuropsychiatric health and disease
Liu, J. J., Green, P., Mann, J. J., Rapoport, S. I., & Sublette, M. E. (2014) · Brain Research · doi:10.1016/j.brainres.2014.11.059 · Cited by 234 · see citing works
PPARs and lipid ligands in inflammation and metabolism
Harmon, G. S., Lam, M. T., & Glass, C. K. (2011) · Chemical Reviews · doi:10.1021/cr2001355 · Cited by 216 · see citing works
Bioactivity and health effects of ruminant meat lipids. Invited Review
Vahmani, P., Ponnampalam, E. N., Kraft, J., Mapiye, C., Bermingham, E. N., Watkins, P. J., Proctor, S. D., & Dugan, M. E. R. (2020) · Meat Science · doi:10.1016/j.meatsci.2020.108114 · Cited by 168 · see citing works
Conjugated linoleic acid is a preferential substrate for fatty acid nitration
Bonacci, G., Baker, P. R. S., Salvatore, S. R., Shores, D., Khoo, N. K. H., Koenitzer, J. R., Vitturi, D. A., Woodcock, S. R., Golin-Bisello, F., Cole, M. P., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.401356 · Cited by 147 · see citing works
Invited review: The anti-inflammatory properties of dairy lipids
Lordan, R., & Zabetakis, I. (2017) · Journal of Dairy Science · doi:10.3168/jds.2016-12224 · Cited by 146 · see citing works
The Health Promoting Properties of the Conjugated Isomers of α‐Linolenic Acid
Hennessy, A. A., Ross, R. P., Devery, R., & Stanton, C. (2010) · Lipids · doi:10.1007/s11745-010-3501-5 · Cited by 142 · see citing works
Conjugated linoleic acid (CLA) as a functional food: Is it beneficial or not?
Badawy, S., Liu, Y., Guo, M., Liu, Z., Xie, C., Marawan, M. A., Arés, I., López-Torres, B., Martínez, M., Maximiliano, J.-E., et al. (2023) · Food Research International · doi:10.1016/j.foodres.2023.113158 · Cited by 135 · see citing works
Olives and olive oil are sources of electrophilic fatty acid nitroalkenes
Fazzari, M., Trostchansky, A., Schopfer, F. J., Salvatore, S. R., Sánchez-Calvo, B., Vitturi, D., Valderrama, R., Barroso, J. B., Radi, R., Freeman, B. A., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0084884 · Cited by 114 · see citing works
Fatty Acids - Induced Lipotoxicity and Inflammation
Savary, S., Trompier, D., Andreoletti, P., Le Borgne, F., Demarquoy, J., & Lizard, G. (2012) · Current Drug Metabolism · doi:10.2174/138920012803762729 · Cited by 111 · see citing works
Long chain fatty acids and gene expression in inflammation and immunity
Calder, P. C. (2013) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3283620616 · Cited by 106 · see citing works
The Microbiota–Gut–Brain Axis in Alzheimer’s Disease: A Review of Taxonomic Alterations and Potential Avenues for Interventions
Murray, E. R., Kemp, M., & Nguyen, T. T. (2022) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acac008 · Cited by 98 · see citing works
Dietary Conjugated Linoleic Acid and Hepatic Steatosis: Species-Specific Effects on Liver and Adipose Lipid Metabolism and Gene Expression
Vyas, D., Kadegowda, A. K. G., & Erdman, R. A. (2011) · Journal of Nutrition and Metabolism · doi:10.1155/2012/932928 · Cited by 92 · see citing works
New insights into the role of fatty acids in the pathogenesis and resolution of inflammatory bowel disease
Shores, D. R., Binion, D. G., Freeman, B. Α., & Baker, P. R. S. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21560 · Cited by 84 · see citing works
Role of the Lower and Upper Intestine in the Production and Absorption of Gut Microbiota-Derived PUFA Metabolites
Druart, C., Neyrinck, A. M., Vlaeminck, B., Fievez, V., Cani, P. D., & Delzenne, N. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087560 · Cited by 81 · see citing works
Intake of butter naturally enriched with cis9,trans11 conjugated linoleic acid reduces systemic inflammatory mediators in healthy young adults
Penedo, L. A., Nunes, J. C., da Gama, M. A. S., Leite, P. E. C., Quírico‐Santos, T., & Torres, A. G. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.08.006 · Cited by 79 · see citing works
Modulation of Peroxisome Proliferator-Activated Receptor gamma (PPAR γ) by Conjugated Fatty Acid in Obesity and Inflammatory Bowel Disease
Yuan, G., Chen, X., & Li, D. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf505050c · Cited by 76 · see citing works
Ability of the gut microbiota to produce PUFA‐derived bacterial metabolites: Proof of concept in germ‐free versus conventionalized mice
Druart, C., Bindels, L. B., Schmaltz, R. J., Neyrinck, A. M., Cani, P. D., Walter, J., Ramer‐Tait, A. E., & Delzenne, N. M. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500014 · Cited by 69 · see citing works
Functional yogurt with strawberries and chia seeds
Kowaleski, J., Quast, L. B., Steffens, J., Lovato, F., Rodrigues dos Santos, L., Zambiazi da Silva, S., Maschio de Souza, D., & Felicetti, M. A. (2020) · Food Bioscience · doi:10.1016/j.fbio.2020.100726 · Cited by 68 · see citing works
The effect of conjugated linoleic acids on inflammation, oxidative stress, body composition and physical performance: a comprehensive review of putative molecular mechanisms
Putera, H. D., Doewes, R. I., Shalaby, M. N., Ramírez‐Coronel, A. A., Clayton, Z. S., Abdelbasset, W. K., Murtazaev, S. S., Jalil, A. T., Rahimi, P., Nattagh‐Eshtivani, E., et al. (2023) · Nutrition & Metabolism · doi:10.1186/s12986-023-00758-9 · Cited by 67 · see citing works
Modulatory role of dietary polyunsaturated fatty acids in Nrf2-mediated redox homeostasis
Abrescia, P., Treppiccione, L., Rossi, M., & Bergamo, P. (2020) · Progress in Lipid Research · doi:10.1016/j.plipres.2020.101066 · Cited by 64 · see citing works
Effects of fatty acids on T cell function: role in atherosclerosis
Reilly, N. A., Lutgens, E., Kuiper, J., Heijmans, B. T., & Jukema, J. W. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00582-9 · Cited by 64 · see citing works
Gut Microbial Metabolites of Polyunsaturated Fatty Acids Correlate with Specific Fecal Bacteria and Serum Markers of Metabolic Syndrome in Obese Women
Druart, C., Dewulf, E. M., Cani, P. D., Neyrinck, A. M., Thissen, J., & Delzenne, N. M. (2014) · Lipids · doi:10.1007/s11745-014-3881-z · Cited by 63 · see citing works
Bovine haptoglobin as an adipokine: Serum concentrations and tissue expression in dairy cows receiving a conjugated linoleic acids supplement throughout lactation
Saremi, B., Al‐Dawood, A., Winand, S., Müller, U., Pappritz, J., von Soosten, D., Rehage, J., Dänicke, S., Häussler, S., Mielenz, M., et al. (2012) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2012.03.011 · Cited by 62 · see citing works
A Maternal High Fat Diet Programmes Endothelial Function and Cardiovascular Status in Adult Male Offspring Independent of Body Weight, Which is Reversed by Maternal Conjugated Linoleic Acid (CLA) Supplementation
Gray, C. L., Vickers, M. H., Segovia, S. A., Zhang, X. D., & Reynolds, C. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0115994 · Cited by 60 · see citing works
Self-citation
The Preventive Effect of Lactobacillus plantarum ZS62 on DSS‐Induced IBD by Regulating Oxidative Stress and the Immune Response
Pan, Y., Ning, Y., Hu, J. Y., Wang, Z., Chen, X., & Zhao, X. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/9416794 · Cited by 59 · see citing works
Retracted
Effects of short- and long-chain fatty acids on the expression of stearoyl-CoA desaturase and other lipogenic genes in bovine mammary epithelial cells
Jacobs, A. A. A., Dijkstra, J., Liesman, J. S., VandeHaar, M. J., Lock, A. L., van Vuuren, A. M., Hendriks, W. H., & van Baal, J. (2013) · animal · doi:10.1017/s175173111300061x · Cited by 57 · see citing works
Longitudinal Profiling of the Tissue-Specific Expression of Genes Related with Insulin Sensitivity in Dairy Cows during Lactation Focusing on Different Fat Depots
Saremi, B., Winand, S., Friedrichs, P., Kinoshita, A., Rehage, J., Dänicke, S., Häussler, S., Breves, G., Mielenz, M., & Sauerwein, H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086211 · Cited by 56 · see citing works
c9,t11-Conjugated linoleic acid ameliorates steatosis by modulating mitochondrial uncoupling and Nrf2 pathway
Mollica, M. P., Trinchese, G., Cavaliere, G., Filippo, C. D., Cocca, E., Gaita, M., Della-Gatta, A., Marano, A., Mazzarella, G., & Bergamo, P. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m044032 · Cited by 55 · see citing works
Cross-sectional study of conjugated linoleic acid in adipose tissue and risk of diabetes
Castro‐Webb, N., Ruiz-Narváez, E., & Campos, H. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.011858 · Cited by 53 · see citing works
Intake of milk, but not total dairy, yogurt, or cheese, is negatively associated with the clustering of cardiometabolic risk factors in adolescents
Abreu, S., Moreira, P. A. M., Moreira, C. M. M., Mota, J. A. P. S., Moreira-Silva, I., Santos, P. C., & Santos, R. (2013) · Nutrition Research · doi:10.1016/j.nutres.2013.10.008 · Cited by 53 · see citing works
Acylpeptide Hydrolase Inhibition as Targeted Strategy to Induce Proteasomal Down-Regulation
Palmieri, G., Bergamo, P., Luini, A., Ruvo, M., Gogliettino, M., Langella, E., Saviano, M., Hegde, R. N., Sandomenico, A., & Rossi, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025888 · Cited by 52 · see citing works
Anti-inflammatory effects of conjugated linoleic acid isomers and essential fatty acids in bovine mammary epithelial cells
Dipasquale, D., Basiricò, L., Morera, P., Primi, R., Tröscher, A., & Bernabucci, U. (2018) · animal · doi:10.1017/s1751731117003676 · Cited by 51 · see citing works
Vaccenic acid-mediated reduction in cytokine production is independent of c9,t11-CLA in human peripheral blood mononuclear cells
Jaudszus, A., Jahreis, G., Schlörmann, W., Fischer, J., Krämer, R., Degen, C., Rohrer, C., Röth, A., Gabriel, H. W., Barz, D., et al. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.06.010 · Cited by 47 · see citing works
Health potential of fermented goat dairy products: composition comparison with fermented cow milk, probiotics selection, health benefits and mechanisms
Chen, L., Bagnicka, E., Chen, H., & Shu, G. (2023) · Food & Function · doi:10.1039/d3fo00413a · Cited by 51 · see citing works
Cancer Chemopreventive Ability of Conjugated Linolenic Acids
Tanaka, T., Hosokawa, M., Yasui, Y., Ishigamori, R., & Miyashita, K. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12117495 · Cited by 46 · see citing works
Genetics of Omega-3 Long-Chain Polyunsaturated Fatty Acid Metabolism and Meat Eating Quality in Tattykeel Australian White Lambs
Pewan, S. B., Otto, J. R., Huerlimann, R., Budd, A. M., Mwangi, F. W., Edmunds, R. C., Holman, B. W. B., Henry, M. L. E., Kinobe, R. T., Adegboye, O. A., et al. (2020) · Genes · doi:10.3390/genes11050587 · Cited by 42 · see citing works
Lactobacillus plantarum ZS2058 produces CLA to ameliorate DSS-induced acute colitis in mice
Wang, J., Chen, H., Yang, B. K., Gu, Z., Zhang, H., Chen, W., & Chen, Y. Q. (2016) · RSC Advances · doi:10.1039/c5ra24491a · Cited by 42 · see citing works
Inhibitory Effect of Methotrexate on Rheumatoid Arthritis Inflammation and Comprehensive Metabolomics Analysis Using Ultra-Performance Liquid Chromatography-Quadrupole Time of Flight-Mass Spectrometry (UPLC-Q/TOF-MS)
Pang, Z., Wang, G., Ran, N., Lin, H., Wang, Z., Guan, X., Yuan, Y., Fang, K., Liu, J., & Wang, F. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19102894 · Cited by 42 · see citing works
Post-Translational Modification of Proteins Mediated by Nitro-Fatty Acids in Plants: Nitroalkylation
Aranda‐Caño, L., Sánchez-Calvo, B., Begara-Morales, J. C., Chaki, M., Mata-Pérez, C., Padilla, M. N., Valderrama, R., & Barroso, J. B. (2019) · Plants · doi:10.3390/plants8040082 · Cited by 42 · see citing works
Dietary Conjugated Linoleic Acid Activates PPARγ and the Intestinal Trefoil Factor in SW480 Cells and Mice with Dextran Sulfate Sodium-Induced Colitis3
Borniquel, S., Jädert, C., & Lundberg, J. O. (2012) · Journal of Nutrition · doi:10.3945/jn.112.163931 · Cited by 41 · see citing works
Current issues surrounding the definition of trans-fatty acids: implications for health, industry and food labels
Wang, Y., & Proctor, S. D. (2013) · British Journal Of Nutrition · doi:10.1017/s0007114513001086 · Cited by 36 · see citing works
Conjugated linoleic acid-enriched butter improved memory and up-regulated phospholipase A2 encoding-genes in rat brain tissue
da Gama, M. A. S., Raposo, N. R. B., Mury, F. B., Lopes, F. C. F., Dias‐Neto, E., Talib, L. L., & Gattaz, W. F. (2015) · Journal of Neural Transmission · doi:10.1007/s00702-015-1401-9 · Cited by 29 · see citing works
Conjugated Linoleic Acid Supplementation During Pregnancy and Lactation Reduces Maternal High-Fat-Diet-Induced Programming of Early-Onset Puberty and Hyperlipidemia in Female Rat Offspring1
Reynolds, C. M., Segovia, S. A., Zhang, X. D., Gray, C. L., & Vickers, M. H. (2014) · Biology of Reproduction · doi:10.1095/biolreprod.114.125047 · Cited by 29 · see citing works
Self-citation
Dietary cis-9, trans-11-conjugated linoleic acid reduces amyloid β-protein accumulation and upregulates anti-inflammatory cytokines in an Alzheimer’s disease mouse model
Fujita, Y., Kano, K., Kishino, S., Nagao, T., Shen, X., Sato, C., Hatakeyama, H., Ota, Y., Niibori, S., Nomura, A., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-88870-9 · Cited by 31 · see citing works
Diabetes Mellitus, Nonalcoholic Fatty Liver Disease, and Conjugated Linoleic Acid (Omega 6): What Is the Link?
Hegazy, M., Elsayed, N. M., Ali, H., Hassan, H. G., & Rashed, L. A. (2019) · Journal of Diabetes Research · doi:10.1155/2019/5267025 · Cited by 27 · see citing works
Conjugated linoleic acid induces an atheroprotective macrophage MΦ2 phenotype and limits foam cell formation
de Gaetano, M., Alghamdi, K. S., Marcone, S., & Belton, O. (2015) · Journal of Inflammation · doi:10.1186/s12950-015-0060-9 · Cited by 27 · see citing works
Decreased Metabolic Flexibility in Skeletal Muscle of Rat Fed with a High-Fat Diet Is Recovered by Individual CLA Isomer Supplementation via Converging Protective Mechanisms
Trinchese, G., Cavaliere, G., Cimmino, F., Catapano, A., Carta, G., Pirozzi, C., Murru, E., Lama, A., Meli, R., Bergamo, P., et al. (2020) · Cells · doi:10.3390/cells9040823 · Cited by 26 · see citing works
Oleanolic Acid Acetate Exerts Anti-Inflammatory Activity via IKKα/β Suppression in TLR3-Mediated NF-κB Activation
Lim, H. J., Jang, H., Kim, M. H., Lee, S., Lee, S., Lee, S. W., & Rho, M. (2019) · Molecules · doi:10.3390/molecules24214002 · Cited by 24 · see citing works
Probiotic suppression of the H. pylori-induced responses by conjugated linoleic acids in a gastric epithelial cell line
Hwang, S. W., Kim, N., Kim, J. M., Huh, C. S., Ahn, Y. T., Park, S. H., Shin, C. M., Park, J. H., Lee, M. K., Nam, R. H., et al. (2012) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2012.04.002 · Cited by 24 · see citing works
t10,c12-CLA decreases adiposity in peripubertal mice without dose-related detrimental effects on mammary development, inflammation status, and metabolism
Foote, M. R., Giesy, S. L., Bernal-Santos, G., Bauman, D. E., & Boisclair, Y. R. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00445.2010 · Cited by 24 · see citing works
Maternal conjugated linoleic acid supplementation reverses high-fat diet-induced skeletal muscle atrophy and inflammation in adult male rat offspring
Pileggi, C. A., Segovia, S. A., Markworth, J. F., Gray, C., Zhang, X. D., Milan, A. M., Mitchell, C. J., Barnett, M. P. G., Roy, N. C., Vickers, M. H., et al. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00351.2015 · Cited by 24 · see citing works
Self-citation
Perspectives of gene editing for cattle farming in tropical and subtropical regions
Camargo, L. S. A., Saraiva, N. Z., Oliveira, C. S., Carmickle, A. T., de Lemos, D. R., Siqueira, L. G. B., & Denicol, A. C. (2022) · Animal Reproduction · doi:10.1590/1984-3143-ar2022-0108 · Cited by 24 · see citing works
Effects of conjugated linoleic acid isomers on monocyte, macrophage and foam cell phenotype in atherosclerosis
Mooney, D., McCarthy, C., & Belton, O. (2012) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2011.12.006 · Cited by 23 · see citing works
The association between dairy products and the risk of COVID-19
Darand, M., Hassanizadeh, S., Marzban, A., Mirzaei, M., & Hosseinzadeh, M. (2022) · European Journal of Clinical Nutrition · doi:10.1038/s41430-022-01149-8 · Cited by 20 · see citing works
Inter‐organ proteomic analysis reveals insights into the molecular mechanisms underlying the anti‐diabetic effects of cis‐9, trans‐11‐conjugated linoleic acid in ob/ob mice
Rungapamestry, V., McMonagle, J., Reynolds, C. M., Rucklidge, G. J., Reid, M., Duncan, G., Ross, K., Horgan, G. W., Toomey, S., MOLONEY, A. P., et al. (2011) · PROTEOMICS · doi:10.1002/pmic.201100312 · Cited by 19 · see citing works
Self-citation
Beneficial Effects of a Low-dose of Conjugated Linoleic Acid on Body Weight Gain and other Cardiometabolic Risk Factors in Cafeteria Diet-fed Rats
Martín‐González, M. Z., Palacios, H. H., Rodriguez, M. A., Arola, L., Aragonès, G., & Muguerza, B. (2020) · Nutrients · doi:10.3390/nu12020408 · Cited by 17 · see citing works
Bioactive Conjugated Linoleic Acid (CLA) in Milk
Kee, J.-I., Ganesan, P., & Kwak, H. (2010) · Korean Journal for Food Science of Animal Resources · doi:10.5851/kosfa.2010.30.6.879 · Cited by 17 · see citing works
Breastmilk fatty acids in relation to sensitization – the ALADDIN birth cohort
Rosenlund, H., Fagerstedt, S., Alm, J. S., & Mie, A. (2016) · Allergy · doi:10.1111/all.12896 · Cited by 17 · see citing works
Positive effects of conjugated linoleic acid (CLA) on the PGC1-α expression under the inflammatory conditions induced by TNF-α in the C2C12 cell line
Mohammadi, I., Mahdavi, A. H., Rabiee, F., Nasr‐Esfahani, M. H., & Ghaedi, K. (2020) · Gene · doi:10.1016/j.gene.2020.144394 · Cited by 17 · see citing works
Preeclampsia prevention: a case-control study nested in a cohort.
Alzate, A., Herrera, R., & Pineda, L. M. (2015) · PubMed Central · Cited by 14 · see citing works
Goat Milk
Zervas, G. P., & Tsiplakou, E. (2013) · doi:10.1002/9781118534168.ch23 · Cited by 15 · see citing works
Hepatic and extrahepatic expression of serum amyloid A3 during lactation in dairy cows
Saremi, B., Mielenz, M., Rahman, M. M., Hosseini, A., Kopp, C., Dänicke, S., Ceciliani, F., & Sauerwein, H. (2013) · Journal of Dairy Science · doi:10.3168/jds.2013-6495 · Cited by 14 · see citing works
Effect of supplementation with an 80:20 cis9,trans11 conjugated linoleic acid blend on the human platelet proteome
Bachmair, E., Bots, M. L., Mennen, L. I., Kelder, T., Evelo, C. T., Horgan, G. W., Ford, I., & de Roos, B. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100763 · Cited by 14 · see citing works
Oligosaccharide profiles as potential biomarkers for detecting adulteration of caprine dairy products with bovine dairy products
Wang, H., Zhang, X., Yao, Y., Huo, Z., Cui, X., Liu, M., Zhao, L., & Ge, W. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.138551 · Cited by 12 · see citing works
La prevención de la preeclampsia: un estudio de casos y controles anidado en una cohorte
Alzate, A., Herrera, R., & Pineda, L. M. (2015) · Colombia medica · doi:10.25100/cm.v46i4.1887 · Cited by 12 · see citing works
Twelve-week-conjugated linoleic acid supplementation has no effects on the selected markers of atherosclerosis in obese and overweight women
Duś-Żuchowska, M., Mądry, E., Krzyżanowska-Jankowska, P., Bogdański, P., & Walkowiak, J. (2016) · Food & Nutrition Research · doi:10.3402/fnr.v60.32776 · Cited by 12 · see citing works
Fermented goat milk consumption improves iron status and evokes inflammatory signalling during anemia recovery
López‐Aliaga, I., García-Pedro, J. D., Moreno‐Fernández, J., Alférez, M. J. M., López‐Frías, M., & Díaz‐Castro, J. (2018) · Food & Function · doi:10.1039/c8fo00552d · Cited by 12 · see citing works
Regulation of platelet function by natural bioactive compounds
Fernandez-Rojas, M., Rodríguez, L., Trostchansky, A., & Eduardo Fuentes, Q. (2022) · Food Bioscience · doi:10.1016/j.fbio.2022.101742 · Cited by 12 · see citing works
Trans-10, cis-12-conjugated linoleic acid attenuates tumor necrosis factor-α production by lipopolysaccharide-stimulated porcine peripheral blood mononuclear cells through induction of interleukin-10
Kim, K.-H., Kim, D., Kim, S., Jung, E., Kang, J., Jeung, E., & Yang, M. (2011) · Cytokine · doi:10.1016/j.cyto.2011.06.019 · Cited by 11 · see citing works
Fermented goat milk consumption improves cardiovascular health during anemia recovery
Alférez, M. J. M., Muñoz‐García, A., Moreno‐Fernández, J., López‐Aliaga, I., & Díaz‐Castro, J. (2018) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.9210 · Cited by 11 · see citing works
ÁCIDO LINOLEICO CONJUGADO: ESTRUTURA QUÍMICA, EFEITOS SOBRE A SAÚDE HUMANA E ANÁLISE EM LÁCTEOS
Lucatto, J. N., de Brandão, S. N. T. G., & Drunkler, D. A. (2014) · Revista do Instituto de Latícinios Cândido Tostes · doi:10.14295/2238-6416.v69i3.282 · Cited by 11 · see citing works
Effect of sunflower oil supplementation and milking frequency reduction on sheep milk production and composition1
Prieto, N., Bodas, R., López-Campos, Ó., Andrés, S., López, S., & Giráldez, F. J. (2012) · Journal of Animal Science · doi:10.2527/jas.2012-5187 · Cited by 11 · see citing works
Soybean oil modulates the fatty acid synthesis in the mammary gland, improving nutritional quality of the goat milk
Silva, L. S. E., Cavalcanti, J. V. F. L., Magalhães, A. L. R., Santoro, K. R., Gonçalves, G. D., Santana, L. P. V., da Silva, J. K. B., & de Almeida, O. C. (2019) · Small Ruminant Research · doi:10.1016/j.smallrumres.2019.106041 · Cited by 11 · see citing works
Ácidos grasos trans y ácido linoleico conjugado en alimentos: origen y propiedades biológicas
Juárez, M., Gómez‐Cortés, P., & de la Fuente, M. Á. (2018) · Nutrición Hospitalaria · doi:10.20960/nh.2466 · Cited by 10 · see citing works
Foods for protection against COVID-19: An overview
Kaushal, K., Bhatt, K., Thakur, A., Thakur, A., Gautam, S., Shambhvi, S., & Barthwal, R. (2022) · Annals of Phytomedicine An International Journal · doi:10.54085/ap.2022.11.1.3 · Cited by 8 · see citing works
Isomers of conjugated linoleic acid induce insulin resistance through a mechanism involving activation of protein kinase Cε in liver cells
Roura-Guiberna, A., Hernández-Aranda, J., Ramírez‐Flores, C. J., Mondragón‐Flores, R., Garibay-Nieto, N., Queipo-García, G. E., Laresgoiti‐Servitje, E., Soh, J., & Olivares-Reyes, J. A. (2018) · Cellular Signalling · doi:10.1016/j.cellsig.2018.10.013 · Cited by 8 · see citing works
The effect of conjugated linoleic acid supplementation in comparison with omega-6 and omega-9 on lipid profile: a graded, dose–response systematic review and meta-analysis of randomized controlled trials
Akhgarjand, C., Tavakoli, A., Samavat, S., Bagheri, A., Anoushirvani, A. A., Mirzababaei, A., Amini, M. R., Ghorbi, M. D., Valisoltani, N., Mansour, A., et al. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1336889 · Cited by 7 · see citing works
Equimolar mixture of c9,t11 and t9,t11 CLA inhibits the growth and induces apoptosis in Caco‐2 cells
Zhong, X., Luo, T. F., Huang, G., Deng, Z., & Lei, L. (2012) · European Journal of Lipid Science and Technology · doi:10.1002/ejlt.201100338 · Cited by 6 · see citing works
Heterologous Expression and Polyphasic Analysis of CLA-Converting Linoleic Acid Isomerase from Bifidobacterium breve JKL2022
Elnar, A. G., Jang, Y., & Kim, G. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c05746 · Cited by 5 · see citing works
Peroxisome proliferator-activated receptor-γ agonistic effect of Chrysanthemum indicum capitulum and its active ingredients
Makino, T., Zhang, F., Iwaki, A., Ishiuchi, K., Sugiyama, A., & Ohsawa, M. (2018) · Pharmacognosy Magazine · doi:10.4103/pm.pm_607_17 · Cited by 5 · see citing works
Short communication: Localization and expression of monocyte chemoattractant protein-1 in different subcutaneous and visceral adipose tissues of early-lactating dairy cows
Häussler, S., Sacré, C., Friedauer, K., Dänicke, S., & Sauerwein, H. (2015) · Journal of Dairy Science · doi:10.3168/jds.2014-9256 · Cited by 4 · see citing works
Detection of 11 beta‐hydroxysteroid dehydrogenase type 1, the glucocorticoid and mineralocorticoid receptor in various adipose tissue depots of dairy cows supplemented with conjugated linoleic acids
Friedauer, K., Dänicke, S., Schulz, K., Sauerwein, H., & Häussler, S. (2014) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/jpn.12268 · Cited by 4 · see citing works
Nitro-Fatty Acids: Synthesis, Properties, and Role in Biological System
Rubbo, H., & Trostchansky, A. (2014) · Springer eBooks · doi:10.1007/978-3-319-06710-0_9 · Cited by 4 · see citing works
Diet and Microbes in the Pathogenesis of Lupus
Luo, X., Edwards, M. R., Reilly, C. M., Mu, Q., & Ahmed, S. A. (2017) · InTech eBooks · doi:10.5772/68110 · Cited by 4 · see citing works
10,12-Conjugated linoleic acid alleviates lipid accumulation in primary chicken hepatocytes via the ERK1/2-AMPK pathway
Liu, X., Yan, P., Zhang, H., Gao, Q., Shang, Y., & Fu, C. (2025) · Poultry Science · doi:10.1016/j.psj.2025.105904 · Cited by 3 · see citing works
CLA isomer t10,c12 induce oxidation and apoptosis in 3t3 adipocyte cells in a similar effect as omega-3 linolenic acid and DHA.
Meadus, W. J., Vahmani, P., Duff, P., Zantinge, J. L., Turner, T. D., & Dugan, M. E. R. (2017) · Functional Foods in Health and Disease · doi:10.31989/ffhd.v7i2.288 · Cited by 3 · see citing works
Developmentally programmed obesity: Is there a role for anti‐inflammatory nutritional strategies?
Kearns, M. L., & Reynolds, C. M. (2023) · Experimental Physiology · doi:10.1113/ep091209 · Cited by 3 · see citing works
Self-citation
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Elnar, A. G., & Kim, G. (2025) · Microbial Cell Factories · doi:10.1186/s12934-025-02766-1 · Cited by 2 · see citing works
Milk and Chronic-Degenerative Diseases
Grosso, G. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809868-4.00030-3 · Cited by 2 · see citing works
Relationship Between Dairy Intake and Hospitalization Risk and Disease Severity in Patients With COVID-19
Abbas‐Hashemi, S. A., Yari, Z., Soltanieh, S., Salavatizadeh, M., Karimi, S., Ardestani, S. K., Salehi, M., Jahromi, S. R., Ghazanfari, T., & Hekmatdoost, A. (2023) · Clinical Nutrition Research · doi:10.7762/cnr.2023.12.4.283 · Cited by 2 · see citing works
Physicochemical characterization, fatty acids profile and lipid quality of Gorgonzola cheeses
Laurindo, J., Picinatto, M. B., Melati, J., Morés, S., & Tonial, I. B. (2022) · Conjecturas · doi:10.53660/conj-724-a19 · Cited by 1 · see citing works
Involvement of the PKC–NF–κB signaling pathway in the regulation of T lymphocytes proliferation of chickens by conjugated linoleic acids
Long, F., Yang, X., Liu, D., Guo, Y., & Wang, Z. (2015) · Food and Agricultural Immunology · doi:10.1080/09540105.2015.1079590 · Cited by 1 · see citing works
Nitro-fatty acids as novel Virgin olive oil quality markers
Rubbo, H., Trostchansky, A., & Sánchez-Calvo, B. (2023) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2023.105680 · Cited by 1 · see citing works
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Zhang, X., Gao, Y., Mai, Z., Li, Y., Wang, J., Zhao, X., & Zhang, Y. (2024) · Animals · doi:10.3390/ani14131933 · Cited by 1 · see citing works
The causal relationship between circulating metabolites and gestational hypertension, pre-eclampsia, eclampsia: A bidirectional two-sample Mendelian randomization study
Guo, S., Su, Y.-T., Li, Y., Li, C., & Pan, L. (2025) · Clinical and Experimental Hypertension · doi:10.1080/10641963.2025.2508787 · Cited by 1 · see citing works
Dairy Foods and Cardiovascular Diseases
Correa‐Matos, N. J., & Vaghefi, S. B. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-396485-4.00018-9 · Cited by 1 · see citing works
ÓLEO DE SOJA COMO SUPLEMENTAÇÃO LIPÍDICA PARA RUMINANTES LEITEIROS E PRECURSOR DE FATOR ANTIOBESIDADE NO LEITE
Silva, L. S. E. (2022) · SCIENCE AND ANIMAL HEALTH · doi:10.15210/sah.v8i2.18372 · Cited by 1 · see citing works
Diet and inflammation : the role of nitrate and conjugated linoleic acid
Jädert, C. (2014) · Figshare

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Viladomiu, M., Hontecillas, R., & Bassaganya-Riera, J. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.03.095 · Cited by 174 · see citing works
Biological effects of conjugated linoleic acids in health and disease
Bhattacharya, A., Banu, J., Rahman, M., Causey, J., & Fernandes, G. (2006) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2006.02.009 · Cited by 663 · see citing works
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Al-Muharrami, K. (2010) · Figshare · doi:10.25401/cardiffmet.20941966
Conjugated linoleic acids and inflammation: isomer- and tissue-specific responses
Belda, B. J., Lee, Y., & Heuvel, J. P. V. (2010) · Clinical Lipidology · doi:10.2217/clp.10.54 · Cited by 7 · see citing works
The effect of conjugated linoleic acid and its 9:11 and 10:12 isomers on the inflamatory profiles on monocytic/macrophage and endothelial cell systems
Al-Muharrami, K. (2010) · Cardiff Metropolitan Research Repository (Cardiff Metropolitan University) · Cited by 1 · see citing works

Authors: Reynolds, C. M., & Roche, H. M.
Affiliations: University College Dublin (IE)
ORCID: Reynolds, C.M.
Roche, H.M.
Venue: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)
Publisher: Elsevier BV
Published: 2010-04
Volume: 82
Issue: 4-6
Pages: 199-204
ISSN: 0952-3278 (ISSN-L)
DOI: 10.1016/j.plefa.2010.02.021
OpenAlex: W2055518254
Cited by: 118
References: 86
Citations by year: 2026: 3 · 2025: 5 · 2024: 4 · 2023: 6 · 2022: 7 · 2021: 3 · 2020: 7 · 2019: 6 · 2018: 9 · 2017: 5 · 2016: 4 · 2015: 10 · 2014: 13 · 2013: 11 · 2012: 14
FWCI: 1.29
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Prostaglandins Leukotrienes and Essential Fatty Acids (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
Keywords: conjugated linoleic acid, polyunsaturated fatty acids, anti-inflammatory activity, insulin resistance, atherosclerosis, Th1-mediated inflammation, c9,t11-CLA, adipogenesis, colitis, rheumatoid arthritis, metabolic syndrome
MeSH terms: Animals, Dendritic Cells, Humans, Inflammation, Models, Biological, Signal Transduction, Cytokines, NF-kappa B, Linoleic Acids, Conjugated, PPAR gamma

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Conjugated linoleic acid and inflammatory cell signalling

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