Lymphocyte oxidative DNA damage and plasma antioxidants in Alzheimer disease
Abstract
CONTEXT: A large body of experimental evidence suggests that in Alzheimer disease (AD) pathogenesis an important role is played by oxidative stress, but there is still a lack of data on in vivo markers of free radical-induced damage. OBJECTIVES: To evaluate levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG), a marker of oxidative damage to DNA, in peripheral lymphocytes; to measure plasma concentrations of several nonenzymatic antioxidants; and to assess the relationships between any observed changes in lymphocyte DNA 8-OHdG content and plasma antioxidant levels in patients with AD and healthy aged control subjects. SUBJECTS: Forty elderly outpatients with AD and 39 healthy age- and sex-matched controls were studied. MAIN OUTCOME MEASURES: The level of 8-OHdG was determined in DNA extracted from lymphocytes and plasma levels of vitamin C, vitamin A, vitamin E, and carotenoids (zeaxanthin, beta-cryptoxanthin, lycopene, lutein, and alpha- and beta-carotene) were measured by high-performance liquid chromatography. RESULTS: Lymphocyte DNA 8-OHdG content was significantly higher and plasma levels of antioxidants (with the exception of lutein) were significantly lower in patients with AD compared with controls. In patients with AD, a significant inverse relationship between lymphocyte DNA 8-OHdG content and plasma levels of lycopene, lutein, alpha-carotene, and beta-carotene, respectively, was observed. CONCLUSIONS: Markers of oxidative damage are increased in AD and correlate with decreased levels of plasma antioxidants. These findings suggest that lymphocyte DNA 8-OHdG content in patients with AD reflects a condition of increased oxidative stress related to a poor antioxidant status.
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Nonenzymatic antioxidants such as vitamin C, vitamin A, vitamin E, and carotenoids are lower in the plasma of patients with AD compared with controls and are associated with increased levels of oxidative damage markers.
“In addition, several nonenzymatic antioxidants such as vitamin C, vitamin A, vitamin E, and carotenoids were lower in the plasma of patients with AD compared with controls and are associated to increased levels of oxidative damage markers [155].”
From Role of Oxidative Damage in Alzheimer’s Disease and Neurodegeneration: From Pathogenic Mechanisms to Biomarker Discovery (2021) · cites this paper as [155]
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- Authors
- Mecocci, P.
- Affiliations
- University of Perugia (IT)
- Corresponding author
- Mecocci, Patrizia
- ORCID
- Mecocci, Patrizia
- Venue
- Archives of Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 2002-05-01
- Volume
- 59
- Issue
- 5
- Pages
- 794
- ISSN
- 0003-9942 (ISSN-L)
- OpenAlex
- W2130940521
- Cited by
- 229
- References
- 53
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 11 · 2023: 4 · 2022: 9 · 2021: 9 · 2020: 7 · 2019: 9 · 2018: 9 · 2017: 5 · 2016: 8 · 2015: 6 · 2014: 7 · 2013: 15 · 2012: 8
- FWCI
- 7.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, oxidative stress, 8-hydroxy-2'-deoxyguanosine, lymphocyte DNA damage, plasma antioxidants, carotenoids, lycopene, lutein, vitamin C, vitamin E, vitamin A, oxidative damage, biomarkers
- MeSH terms
- 8-Hydroxy-2'-Deoxyguanosine, Aged, Aged, 80 and over, Alzheimer Disease, Antioxidants, Deoxyguanosine, DNA Damage, Female, Humans, Lymphocytes, Male, Oxidation-Reduction, Linear Models, Oxidative Stress
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