Significance of P2X7 Receptor Variants to Human Health and Disease

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

Ghiringhelli, F., Apetoh, L., Tesniere, A., Aymeric, L., Ma, Y., Ortiz, C., Vermaelen, K., Panaretakis, T., Mignot, G., Ullrich, E., et al. (2009) · Nature Medicine · doi:10.1038/nm.2028 · Cited by 1,898 · see citing works

The Cytolytic P _2Z Receptor for Extracellular ATP Identified as a P _2X Receptor (P2X ₇ )

Surprenant, A., Rassendren, F., Kawashima, E., North, R. A., & Buell, G. (1996) · Science · doi:10.1126/science.272.5262.735 · Cited by 1,739 · see citing works

Nucleotide- and nucleoside-converting ectoenzymes: Important modulators of purinergic signalling cascade

Yegutkin, G. G. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.01.024 · Cited by 1,155 · see citing works

Purine and pyrimidine receptors

Burnstock, G. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-6497-0 · Cited by 929 · see citing works

Cellular Distribution and Functions of P2 Receptor Subtypes in Different Systems

Burnstock, G., & Knight, G. E. (2004) · International review of cytology · doi:10.1016/s0074-7696(04)40002-3 · Cited by 796 · see citing works

Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain

Chessell, I. P., Hatcher, J. P., Bountra, C., Michel, A. D., Hughes, J. P., Green, P., Egerton, J., Murfin, M., Richardson, J. C., Peck, W. L., et al. (2005) · Pain · doi:10.1016/j.pain.2005.01.002 · Cited by 790 · see citing works

Crystal structure of the ATP-gated P2X4 ion channel in the closed state

Kawate, T., Michel, J. J. C., Birdsong, W. T., & Gouaux, E. (2009) · Nature · doi:10.1038/nature08198 · Cited by 739 · see citing works

Signaling at Purinergic P2X Receptors

Surprenant, A., & North, R. A. (2008) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.113006.100630 · Cited by 547 · see citing works

COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord

Yiangou, Y., Facer, P., Durrenberger, P., Chessell, I. P., Naylor, A., Bountra, C., Banati, R. R., & Anand, P. (2006) · BMC Neurology · doi:10.1186/1471-2377-6-12 · Cited by 509 · see citing works

Liaisons dangereuses: P2X7 and the inflammasome

Di Virgilio, F. (2007) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2007.07.002 · Cited by 493 · see citing works

Absence of the P2X7 Receptor Alters Leukocyte Function and Attenuates an Inflammatory Response

Labasi, J. M., Petrushova, N., Donovan, C. B., McCurdy, S. P., Lira, P. D., Payette, M. M., Brissette, W. H., Wicks, J. R., Audoly, L., & Gabel, C. A. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.12.6436 · Cited by 490 · see citing works

The Permeabilizing ATP Receptor, P2X7

Rassendren, F., Buell, G. N., Virginio, C., Collo, G., North, R. A., & Surprenant, A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.9.5482 · Cited by 479 · see citing works

A-740003 [N-(1-{[(Cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a Novel and Selective P2X7 Receptor Antagonist, Dose-Dependently Reduces Neuropathic Pain in the Rat

Honoré, P., Donnelly‐Roberts, D. L., Namovic, M. T., Hsieh, G. C., Zhu, C., Mikusa, J. P., Hernandez, G., Zhong, C., Gauvin, D. M., Chandran, P., et al. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.111559 · Cited by 418 · see citing works

Hetero-oligomeric Assembly of P2X Receptor Subunits

Torres, G. E., Egan, T. M., & Voigt, M. M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.10.6653 · Cited by 414 · see citing works

ATP-gated P2X cation-channels

Jarvis, M. F., & Khakh, B. S. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.06.067 · Cited by 327 · see citing works

A Glu-496 to Ala Polymorphism Leads to Loss of Function of the Human P2X7 Receptor

Gu, B. J., Zhang, W., Worthington, R. A., Sluyter, R., Dao‐Ung, P., Petrou, S., Barden, J. A., & Wiley, J. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010353200 · Cited by 314 · see citing works

Deletion of the P2X7Nucleotide Receptor Reveals Its Regulatory Roles in Bone Formation and Resorption

Ke, H. Z., Qi, H., Weidema, A. F., Zhang, Q. H., Panupinthu, N., Crawford, D. T., GRASSER, W. A., Paralkar, V. M., Li, M., Audoly, L., et al. (2003) · Molecular Endocrinology · doi:10.1210/me.2003-0021 · Cited by 283 · see citing works

Molecular genetics of bipolar disorder and depression

Kato, T. (2007) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2007.01604.x · Cited by 282 · see citing works

Chemotherapy induces ATP release from tumor cells

Martins, I., Tesnière, A., Kepp, O., Michaud, M., Schlemmer, F., Senovilla, L., Séror, C., Métivier, D., Perfettini, J., Zitvogel, L., et al. (2009) · Cell Cycle · doi:10.4161/cc.8.22.10026 · Cited by 278 · see citing works

Discovery of P2X7 receptor‐selective antagonists offers new insights into P2X7 receptor function and indicates a role in chronic pain states

Donnelly‐Roberts, D. L., & Jarvis, M. F. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707265 · Cited by 267 · see citing works

P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder

Lucae, S., Salyakina, D., Barden, N., Harvey, M., Gagné, B., Labbé, M., Binder, E. B., Uhr, M., Paez-Pereda, M., Sillaber, I., et al. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl166 · Cited by 261 · see citing works

Trophic activity of a naturally occurring truncated isoform of the P2X7 receptor

Adinolfi, E., Cirillo, M., Woltersdorf, R., Falzoni, S., Chiozzi, P., Pellegatti, P., Callegari, M. G., Sandonà, D., Markwárdt, F., Schmalzing, G., et al. (2010) · The FASEB Journal · doi:10.1096/fj.09-153601 · Cited by 254 · see citing works

P2 receptors and cancer

White, N. F., & Burnstock, G. (2006) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2006.02.004 · Cited by 251 · see citing works

Evidence for Functional P2X4/P2X7 Heteromeric Receptors

Guo, C. Y., Masin, M., Qureshi, O. S., & Murrell‐Lagnado, R. D. (2007) · Molecular Pharmacology · doi:10.1124/mol.107.035980 · Cited by 239 · see citing works

Structure−Activity Relationship Studies on a Series of Novel, Substituted 1-Benzyl-5-phenyltetrazole P2X7Antagonists

Nelson, D. W., Gregg, R. J., Kort, M. E., Perez‐Medrano, A., Voight, E. A., Wang, Y., Grayson, G. K., Namovic, M. T., Donnelly‐Roberts, D. L., Niforatos, W., et al. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm051202e · Cited by 235 · see citing works

Altered P2X7‐receptor level and function in mouse models of Huntington's disease and therapeutic efficacy of antagonist administration

Dı́az-Hernández, M., Diez-Zaera, M., Sánchez‐Nogueiro, J., Gómez‐Villafuertes, R., Canals, J. M., Alberch, J., Miras‐Portugal, M. T., & Lucas, J. J. (2009) · The FASEB Journal · doi:10.1096/fj.08-122275 · Cited by 224 · see citing works

Emerging challenges of assigning P2X7 receptor function and immunoreactivity in neurons

Anderson, C. M., & Nedergaard, M. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.03.003 · Cited by 207 · see citing works

Identification and characterization of splice variants of the human P2X7 ATP channel

Cheewatrakoolpong, B., Gilchrest, H., Anthes, J. C., & Greenfeder, S. A. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.04.087 · Cited by 207 · see citing works

Expression of P2X7 purinoceptors on human lymphocytes and monocytes: evidence for nonfunctional P2X7 receptors

Gu, B. J., Zhang, W. Y., Bendall, L. J., Chessell, I. P., Buell, G. N., & Wiley, J. S. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.279.4.c1189 · Cited by 204 · see citing works

A Polymorphism in the P2X7 Gene Increases Susceptibility to Extrapulmonary Tuberculosis

Fernando, S. L., Saunders, B. M., Sluyter, R., Skarratt, K. K., Goldberg, H., Marks, G. B., Wiley, J. S., & Britton, W. J. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200607-970oc · Cited by 203 · see citing works

Analysis of single nucleotide polymorphisms in genes in the chromosome 12Q24.31 region points to P2RX7 as a susceptibility gene to bipolar affective disorder

Barden, N., Harvey, M., Gagné, B., Shink, É., Tremblay, M., Raymond, C., Labbé, M., Villeneuve, A., Rochette, D., Bordeleau, L., et al. (2006) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30303 · Cited by 201 · see citing works

A Functional P2X7 Splice Variant with an Alternative Transmembrane Domain 1 Escapes Gene Inactivation in P2X7 Knock-out Mice

Nicke, A., Kuan, Y., Masin, M., Rettinger, J., Marquez-Klaka, B., Bender, O., Górecki, D. C., Murrell‐Lagnado, R. D., & Soto, F. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.033134 · Cited by 187 · see citing works

Molecular properties of P2X receptors

Roberts, J. A., Vial, C., Digby, H. R., Agboh, K. C., Wen, H., Atterbury-Thomas, A. E., & Evans, R. J. (2006) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-006-0073-6 · Cited by 176 · see citing works

Two haplotypes of the P2X 7 receptor containing the Ala‐348 to Thr polymorphism exhibit a gain‐of‐function effect and enhanced interleukin‐1β secretion

Stokes, L., Fuller, S. J., Sluyter, R., Skarratt, K. K., Gu, B. J., & Wiley, J. S. (2010) · The FASEB Journal · doi:10.1096/fj.09-150862 · Cited by 174 · see citing works

A Thr357 to Ser Polymorphism in Homozygous and Compound Heterozygous Subjects Causes Absent or Reduced P2X7 Function and Impairs ATP-induced Mycobacterial Killing by Macrophages

Shemon, A. N., Sluyter, R., Fernando, S. L., Clarke, A. L., Dao‐Ung, L., Skarratt, K. K., Saunders, B. M., Tan, K. S., Gu, B. J., Fuller, S. J., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507816200 · Cited by 173 · see citing works

P2x7 deficiency suppresses development of experimental autoimmune encephalomyelitis

Sharp, A. J., Polak, P. E., Simonini, M. V., Lin, S. X., Richardson, J. C., Bongarzone, E. R., & Feinstein, D. L. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-33 · Cited by 167 · see citing works

An Ile-568 to Asn Polymorphism Prevents Normal Trafficking and Function of the Human P2X7 Receptor

Wiley, J. S., Dao‐Ung, L., Li, C., Shemon, A. N., Gu, B. J., Smart, M. L., Fuller, S. J., Barden, J. A., Petrou, S., & Sluyter, R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212759200 · Cited by 166 · see citing works

A loss-of-function polymorphic mutation in the cytolytic P2X7 receptor gene and chronic lymphocytic leukaemia: a molecular study

Wiley, J. S., Dao‐Ung, L., Gu, B. J., Sluyter, R., Shemon, A. N., Li, C., Taper, J., Gallo, J. H., & Manoharan, A. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08156-4 · Cited by 166 · see citing works

A His-155 to Tyr Polymorphism Confers Gain-of-Function to the Human P2X7 Receptor of Human Leukemic Lymphocytes

Cabrini, G., Falzoni, S., Forchap, S., Pellegatti, P., Balboni, A., Agostini, P., Cuneo, A., Castoldi, G., Baricordi, O. R., & Virgilio, F. D. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.1.82 · Cited by 164 · see citing works

Rapid ATP-induced release of matrix metalloproteinase 9 is mediated by the P2X7 receptor

Gu, B. J., & Wiley, J. S. (2006) · Blood · doi:10.1182/blood-2005-07-2994 · Cited by 160 · see citing works

Human primary fibroblasts in vitro express a purinergic P2X7 receptor coupled to ion fluxes, microvesicle formation and IL-6 release

Solini, A., Chiozzi, P., Morelli, A., Fellin, R., & Virgilio, F. D. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.3.297 · Cited by 159 · see citing works

ADP and AMP Induce Interleukin-1β Release from Microglial Cells through Activation of ATP-Primed P2X7 Receptor Channels

Chakfe, Y., Seguin, R. M., Antel, J. P., Morissette, C., Malo, D., Henderson, D. J., & Séguéla, P. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03061.2002 · Cited by 158 · see citing works

A Truncated P2X7 Receptor Variant (P2X7-j) Endogenously Expressed in Cervical Cancer Cells Antagonizes the Full-length P2X7 Receptor through Hetero-oligomerization

Feng, Y., Li, X., Wang, L., Zhou, L., & Gorodeski, G. I. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602999200 · Cited by 152 · see citing works

Glu496 to Ala Polymorphism in the P2X7 Receptor Impairs ATP-Induced IL-1β Release from Human Monocytes

Sluyter, R., Shemon, A. N., & Wiley, J. S. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.6.3399 · Cited by 151 · see citing works

Adenosine Triphosphate–Induced Shedding of CD23 and L-Selectin (CD62L) From Lymphocytes Is Mediated by the Same Receptor but Different Metalloproteases

Gu, B. J., Bendall, L. J., & Wiley, J. S. (1998) · Blood · doi:10.1182/blood.v92.3.946.415a24_946_951 · Cited by 148 · see citing works

An Arg307 to Gln Polymorphism within the ATP-binding Site Causes Loss of Function of the Human P2X7 Receptor

Gu, B. J., Sluyter, R., Skarratt, K. K., Shemon, A. N., Dao‐Ung, L., Fuller, S. J., Barden, J. A., Clarke, A. L., Petrou, S., & Wiley, J. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313902200 · Cited by 145 · see citing works

Expression of P2 receptors in bone and cultured bone cells

Hoebertz, A., Townsend‐Nicholson, A., Glass, R., et al. (2000) · Bone · doi:10.1016/s8756-3282(00)00351-3 · Cited by 144 · see citing works

Antagonists of the P2X7Receptor. From Lead Identification to Drug Development

Guile, S. D., Alcaraz, L., Birkinshaw, T. N., Bowers, K. C., Ebden, M. R., Furber, M., & Stocks, M. J. (2009) · Journal of Medicinal Chemistry · doi:10.1021/jm801528x · Cited by 142 · see citing works

Variations in FKBP5 and BDNF genes are suggestively associated with depression in a Swedish population-based cohort

Lavebratt, C., Åberg, E., Sjöholm, L. K., & Forsell, Y. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.02.113 · Cited by 140 · see citing works

P2X7: a growth-promoting receptor—implications for cancer

Virgilio, F. D., Ferrari, D., & Adinolfi, E. (2009) · Purinergic Signalling · doi:10.1007/s11302-009-9145-3 · Cited by 140 · see citing works

Association of a Polymorphism in the P2X7Gene with Tuberculosis in a Gambian Population

Li, C. M., Campbell, S. J., Kumararatne, D. S., Bellamy, R., Ruwende, C., McAdam, K. P. W. J., Hill, A. V. S., & Lammas, D. A. (2002) · The Journal of Infectious Diseases · doi:10.1086/344351 · Cited by 137 · see citing works

P2X7 receptors: Properties and relevance to CNS function

Duan, S., & Neary, J. T. (2006) · Glia · doi:10.1002/glia.20397 · Cited by 136 · see citing works

MicroRNAs miR-186 and miR-150 Down-regulate Expression of the Pro-apoptotic Purinergic P2X7 Receptor by Activation of Instability Sites at the 3′-Untranslated Region of the Gene That Decrease Steady-state Levels of the Transcript

Zhou, L., Qi, X., Potashkin, J. A., Abdul-Karim, F. W., & Gorodeski, G. I. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802663200 · Cited by 135 · see citing works

Expression of a P2X7 Receptor by a Subpopulation of Human Osteoblasts

Gartland, A., Hipskind, R. A., Gallagher, J. A., & Bowler, W. B. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.5.846 · Cited by 134 · see citing works

P2X7 Receptor-Mediated Killing of an Intracellular Parasite, Toxoplasma gondii , by Human and Murine Macrophages

Lees, M. P., Fuller, S. J., McLeod, R. L., Boulter, N. R., Miller, C., Zakrzewski, A. M., Mui, E. J., Witola, W. H., Coyne, J. J., Hargrave, A. C., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000012 · Cited by 132 · see citing works

Single nucleotide polymorphisms that were identified in affective mood disorders affect ATP-activated P2X7 receptor functions

Roger, S., Mei, Z.-Z., Baldwin, J. M., Dong, L., Bradley, H., Baldwin, S. A., Surprenant, A., & Jiang, L. (2009) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.10.005 · Cited by 131 · see citing works

P2X7 receptors regulate multiple types of membrane trafficking responses and non-classical secretion pathways

Qu, Y., & Dubyak, G. (2009) · Purinergic Signalling · doi:10.1007/s11302-009-9132-8 · Cited by 130 · see citing works

Exacerbation of Experimental Autoimmune Encephalomyelitis in P2X7R−/− Mice: Evidence for Loss of Apoptotic Activity in Lymphocytes

Chen, L., & Brosnan, C. F. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.5.3115 · Cited by 130 · see citing works

P2X7 Receptor-Mediated Release of Cathepsins from Macrophages Is a Cytokine-Independent Mechanism Potentially Involved in Joint Diseases

López‐Castejón, G., Theaker, J., Pelegrı́n, P., Clifton, A. D., Braddock, M., & Surprenant, A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000436 · Cited by 126 · see citing works

A Loss-of-Function Polymorphism in the Human P2X7 Receptor Abolishes ATP-Mediated Killing of Mycobacteria

Saunders, B. M., Fernando, S. L., Sluyter, R., Britton, W. J., & Wiley, J. S. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.10.5442 · Cited by 126 · see citing works

Genetics of the P2X7 receptor and human disease

Fuller, S. J., Stokes, L., Skarratt, K. K., Gu, B. J., & Wiley, J. S. (2009) · Purinergic Signalling · doi:10.1007/s11302-009-9136-4 · Cited by 125 · see citing works

Inhibition of Neutrophil Apoptosis by ATP Is Mediated by the P2Y11 Receptor

Vaughan, K., Stokes, L., Prince, L. R., Marriott, H. M., Meis, S., Kassack, M. U., Bingle, C. D., Sabroe, I., Surprenant, A., & Whyte, M. K. B. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.12.8544 · Cited by 125 · see citing works

ADP‐ribosylation at R125 gates the P2X7 ion channel by presenting a covalent ligand to its nucleotide binding site

Adriouch, S., Bannas, P., Schwarz, N., Fliegert, R., Guse, A. H., Séman, M., Haag, F., & Koch‐Nolte, F. (2007) · The FASEB Journal · doi:10.1096/fj.07-9294com · Cited by 123 · see citing works

Involvement of microglial P2X7 receptors and downstream signaling pathways in long-term potentiation of spinal nociceptive responses

Chu, Y., Zhang, Y., Zhang, Y., & Zhao, Z.-Q. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.06.001 · Cited by 117 · see citing works

Case–control studies show that a non-conservative amino-acid change from a glutamine to arginine in the P2RX7 purinergic receptor protein is associated with both bipolar- and unipolar-affective disorders

McQuillin, A., Bass, N. J., Choudhury, K., Puri, V., Kosmin, M., Lawrence, J., Curtis, D., & Gurling, H. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.6 · Cited by 117 · see citing works

Early prostate cancer detected using expression of non‐functional cytolytic P2X7 receptors

Slater, M., Danieletto, S., Gidley-Baird, A. A., Teh, L. C., & Barden, J. A. (2004) · Histopathology · doi:10.1111/j.0309-0167.2004.01798.x · Cited by 116 · see citing works

Homotrimeric complexes are the dominant assembly state of native P2X7 subunits

Nicke, A. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.10.042 · Cited by 110 · see citing works

Single nucleotide polymorphisms in the P2X7 gene are associated to fracture risk and to effect of estrogen treatment

Ohlendorff, S. D., Tofteng, C. L., Jensen, J. B., et al. (2007) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0b013e3280951625 · Cited by 109 · see citing works

Polymorphism in the P2X7 receptor gene and survival in chronic lymphocytic leukaemia

Thunberg, U., Tobin, G., Johnson, A., Söderberg, O., Padyukov, L., Hultdin, M., Klareskog, L., Enblad, G., Sundström, C., Roos, G., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11917-9 · Cited by 106 · see citing works

Evidence for associations between the purinergic receptor P2X7 (P2RX7) and toxoplasmosis

Jamieson, S., Rangel, A. L. P., Hargrave, A. C., de Roubaix, L.-A., Mui, E. J., Boulter, N. R., Miller, E. N., Fuller, S. J., Wiley, J. S., Castellucci, L. C., et al. (2010) · Genes and Immunity · doi:10.1038/gene.2010.31 · Cited by 105 · see citing works

γ-Irradiation induces P2X7 receptor-dependent ATP release from B16 melanoma cells

Ohshima, Y., Tsukimoto, M., Takenouchi, T., et al. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.10.008 · Cited by 104 · see citing works

P2X7 receptor polymorphism impairs extracellular adenosine 5′-triphosphate-induced interleukin-18 release from human monocytes

Sluyter, R., Dalitz, J., & Wiley, J. S. (2004) · Genes and Immunity · doi:10.1038/sj.gene.6364127 · Cited by 100 · see citing works

Association between depression and the Gln460Arg polymorphism of P2RX7 gene: A dimensional approach

Hejjas, K., Szekely, A., Domotor, E., Halmai, Z., Balogh, G., Schilling, B., Sarosi, A., Faludi, G., Sasvari‐Szekely, M., & Nemoda, Z. (2009) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30799 · Cited by 100 · see citing works

Functional evidence for the expression of P2X1, P2X4 and P2X7 receptors in human lung mast cells

Wareham, K., Vial, C., Wykes, R. C., Bradding, P. H., & Seward, E. P. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00287.x · Cited by 96 · see citing works

Association of polymorphisms in P2RX7 and CaMKKb with anxiety disorders

Erhardt, A., Lucae, S., Unschuld, P. G., Ising, M., Kern, N., Salyakina, D., Lieb, R., Uhr, M., Binder, E. B., Keck, M. E., et al. (2007) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.11.016 · Cited by 87 · see citing works

Extracellular ATP and Cancer—An Overview with Special Reference to P2 Purinergic Receptors

Deli, T., & Csernoch, L. (2008) · Pathology & Oncology Research · doi:10.1007/s12253-008-9071-7 · Cited by 82 · see citing works

P2X7 and NRAMP1/SLC11 A1 gene polymorphisms in Mexican mestizo patients with pulmonary tuberculosis

Niño-Moreno, P., Portales‐Pérez, D. P., Hernández-Castro, B., Portales‐Cervantes, L., Flores-Meraz, V., Baranda, L., Gómez‐Gómez, A., Acuña-Alonzo, V., Granados, J., & González-Amaro, R. (2007) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2007.03359.x · Cited by 81 · see citing works

Polymorphisms in the P2X7 receptor gene are associated with low lumbar spine bone mineral density and accelerated bone loss in post-menopausal women

Gartland, A., Skarratt, K. K., Hocking, L. J., et al. (2012) · European Journal of Human Genetics · doi:10.1038/ejhg.2011.245 · Cited by 78 · see citing works

The role of P2X7 in pain and inflammation

Hughes, J. P., Hatcher, J. P., & Chessell, I. P. (2007) · Purinergic Signalling · doi:10.1007/s11302-006-9031-1 · Cited by 77 · see citing works

Extracellular ATP Increases Cation Fluxes in Human Erythrocytes by Activation of the P2X7 Receptor

Sluyter, R., Shemon, A. N., Barden, J. A., & Wiley, J. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405631200 · Cited by 76 · see citing works

P2 purinergic receptors of human eosinophils: characterization and coupling to oxygen radical production

Ferrari, D., Idzko, M., Dichmann, S., Purlis, D., Virchow, C., Norgauer, J., Chiozzi, P., Virgilio, F. D., & Luttmann, W. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)02306-1 · Cited by 76 · see citing works

Differentiation between Cancerous and Normal Hyperplastic Lobules in Breast Lesions

Slater, M. D., Danieletto, S., Pooley, M., et al. (2004) · Breast Cancer Research and Treatment · doi:10.1023/b:brea.0000010670.85915.0f · Cited by 76 · see citing works

Recent Patents on Novel P2X7 Receptor Antagonists and their Potential for Reducing Central Nervous System Inflammation

Friedle, S. A., Curet, M., & Watters, J. J. (2009) · Recent Patents on CNS Drug Discovery · doi:10.2174/157488910789753530 · Cited by 71 · see citing works

P2RX7: A bipolar and unipolar disorder candidate susceptibility gene?

Green, E., Grozeva, D., Raybould, R., Elvidge, G. P., MacGregor, S., Craig, I., FARMER, A. E., McGuffin, P., Forty, L., Jones, L. A., et al. (2009) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30931 · Cited by 66 · see citing works

Glu496Ala polymorphism of human P2X7receptor does not affect its electrophysiological phenotype

Boldt, W., Klapperstück, M., Büttner, C., Sadtler, S., Schmalzing, G., & Markwárdt, F. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00042.2002 · Cited by 66 · see citing works

P2X receptor characterization and IL‐1/IL‐1Ra release from human endothelial cells

Wilson, H. L., Varcoe, R. W., Stokes, L., Holland, K., Francis, S., Dower, S., Surprenant, A., & Crossman, D. C. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707213 · Cited by 65 · see citing works

Gene Dosage Determines the Negative Effects of Polymorphic Alleles of the P2X7Receptor on Adenosine Triphosphate–Mediated Killing of Mycobacteria by Human Macrophages

Fernando, S. L., Saunders, B. M., Sluyter, R., Skarratt, K. K., Wiley, J. S., & Britton, W. J. (2005) · The Journal of Infectious Diseases · doi:10.1086/430622 · Cited by 61 · see citing works

A 5′ intronic splice site polymorphism leads to a null allele of the P2X7 gene in 1–2% of the Caucasian population

Skarratt, K. K., Fuller, S. J., Sluyter, R., Dao‐Ung, L., Gu, B. J., & Wiley, J. S. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.03.091 · Cited by 60 · see citing works

Ambulatory Blood Pressure Is Associated With Polymorphic Variation in P2X Receptor Genes

Palomino-Doza, J., Rahman, T., Avery, P. J., Mayosi, B. M., Farrall, M., Watkins, H. C., Edwards, C. R. W., & Keavney, B. D. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.113282 · Cited by 58 · see citing works

Expression and function of the P2X7 purinergic receptor in patients with systemic lupus erythematosus and rheumatoid arthritis

Portales‐Cervantes, L., Niño-Moreno, P., Doníz-Padilla, L., Baranda-Candido, L., García-Hernández, M. H., Salgado‐Bustamante, M., González‐Amaro, R., & Portales‐Pérez, D. P. (2010) · Human Immunology · doi:10.1016/j.humimm.2010.05.008 · Cited by 57 · see citing works

The P2X7 receptor and intracellular pathogens: a continuing struggle

Coutinho‐Silva, R., Corrêa, G., Sater, A. A. A., & Ojcius, D. M. (2009) · Purinergic Signalling · doi:10.1007/s11302-009-9130-x · Cited by 57 · see citing works

Identification and characterization of a novel variant of the human P2X7 receptor resulting in gain of function

Sun, C., Chu, J., Singh, S. G., & Salter, R. D. (2009) · Purinergic Signalling · doi:10.1007/s11302-009-9168-9 · Cited by 56 · see citing works

P2X7 and phospholipid signalling: The search of the “missing link” in epithelial cells

Garcia‐Marcos, M., Pochet, S., Marino, A., & Dehaye, J. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2006.05.008 · Cited by 56 · see citing works

Extracellular adenosine 5'-triphosphate induces a loss of CD23 from human dendritic cells via activation of P2X7 receptors

Sluyter, R. (2002) · International Immunology · doi:10.1093/intimm/dxf111 · Cited by 56 · see citing works

Variation in P2RX7 candidate gene (rs2230912) is not associated with bipolar I disorder and unipolar major depression in four European samples

Grigoroiu‐Serbânescu, M., Herms, S., Mühleisen, T. W., Georgi, A., Diaconu, C. C., Strohmaier, J., Czerski, P. M., Hauser, J., Leszczyńska-Rodziewicz, A., Jamra, R. A., et al. (2009) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30952 · Cited by 55 · see citing works

Point mutations confer loss of ATP‐induced human P2X7 receptor function

Worthington, R. A., Smart, M. L., Gu, B. J., Williams, D. A., Petrou, S., Wiley, J. S., & Barden, J. A. (2002) · FEBS Letters · doi:10.1016/s0014-5793(01)03311-7 · Cited by 53 · see citing works

Human Epidermal and Monocyte-Derived Langerhans Cells Express Functional P2X7 Receptors

Georgiou, J. G., Skarratt, K. K., Fuller, S. J., Martin, C. J., Christopherson, R. I., Wiley, J. S., & Sluyter, R. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23835.x · Cited by 51 · see citing works

Human P2X7 Pore Function Predicts Allele Linkage Disequilibrium

Denlinger, L. C., Coursin, D. B., Schell, K. A., Angelini, G., Green, D. N., Guadarrama, A. G., Halsey, J., Prabhu, U., Hogan, K. J., & Bertics, P. J. (2006) · Clinical Chemistry · doi:10.1373/clinchem.2005.065425 · Cited by 49 · see citing works

P2X7 receptor-mediated reactive oxygen and nitrogen species formation: from receptor to generators

Hewinson, J., & MacKenzie, A. B. (2007) · Biochemical Society Transactions · doi:10.1042/bst0351168 · Cited by 49 · see citing works

Increased expression of apoptotic markers in melanoma

Slater, M. D., Scolyer, R. A., Gidley-Baird, A. A., et al. (2003) · Melanoma Research · doi:10.1097/00008390-200304000-00005 · Cited by 49 · see citing works

1513A>C Polymorphism in the P2X7 Receptor Gene in Patients with Papillary Thyroid Cancer: Correlation with Histological Variants and Clinical Parameters

Dardano, A., Falzoni, S., Caraccio, N., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1322 · Cited by 49 · see citing works

Detection of Human P2X7 Nucleotide Receptor Polymorphisms by a Novel Monocyte Pore Assay Predictive of Alterations in Lipopolysaccharide-Induced Cytokine Production

Denlinger, L. C., Angelini, G., Schell, K. A., Green, D. N., Guadarrama, A. G., Prabhu, U., Coursin, D. B., Bertics, P. J., & Hogan, K. J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.7.4424 · Cited by 48 · see citing works

P2X7 polymorphism and chronic lymphocytic leukaemia: lack of correlation with incidence, survival and abnormalities of chromosome 12

Zhang, L. Y., Ibbotson, R. E., Orchard, J., et al. (2003) · Leukemia · doi:10.1038/sj.leu.2403125 · Cited by 48 · see citing works

The P2X7 receptor gene polymorphism 1513 A→C has no effect on clinical prognostic markers, in vitro sensitivity to fludarabine, Bcl‐2 family protein expression or survival in B‐cell chronic lymphocytic leukaemia

Starczynski, J., Pepper, C. J., Pratt, G., et al. (2003) · British Journal of Haematology · doi:10.1046/j.1365-2141.2003.04563.x · Cited by 48 · see citing works

P2RX7 Gln460Arg polymorphism is associated with depression among diabetic patients

Nagy, G., Rónai, Z., Somogyi, A., Sasvári‐Székely, M., Rahman, O. A., Máté, A., Varga, T., & Nemoda, Z. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.08.021 · Cited by 47 · see citing works

P2X7 receptor activation induces cell death and CD23 shedding in human RPMI 8226 multiple myeloma cells

Farrell, A. W., Gadeock, S., Pupovac, A., Wang, B., Jalilian, I., Ranson, M., & Sluyter, R. (2010) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2010.07.001 · Cited by 47 · see citing works

Genetic susceptibility to different clinical forms of tuberculosis in the Peruvian population

Taype, C. A., Shamsuzzaman, S., Accinelli, R. A., et al. (2010) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2010.02.011 · Cited by 46 · see citing works

Mycobacterium tuberculosis co-existence with humans: making an imprint on the macrophage P2X7 receptor gene?

Mokrousov, I. V., Валентиновна, С. Н., & Narvskaya, O. V. (2008) · Journal of Medical Microbiology · doi:10.1099/jmm.0.47455-0 · Cited by 46 · see citing works

P2X7 gene polymorphisms and risk assessment for pulmonary tuberculosis in Asian Indians.

Venkatasubramanian, S., Murthy, K. J. R., Reddy, R., et al. (2010) · PubMed · doi:10.3233/dma-2010-0682 · Cited by 44 · see citing works

A Comparative Study of Interleukin-1β Production and P2x7 Expression After Atp Stimulation by Peripheral Blood Mononuclear Cells Isolated From Rheumatoid Arthritis Patients and Normal Healthy Controls

Al-Shukaili, A. K., Alkaabi, J., & Hassan, B. (2007) · Inflammation · doi:10.1007/s10753-007-9052-0 · Cited by 43 · see citing works

CD21 and CD62L shedding are both inducible via P2X7Rs

Sengstake, S., Boneberg, E., & Illges, H. (2006) · International Immunology · doi:10.1093/intimm/dxl051 · Cited by 40 · see citing works

P2X 7 -mediated chemoprevention of epithelial cancers

Gorodeski, G. I. (2009) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728220903277249 · Cited by 38 · see citing works

Association of P2X7 receptor +1513 (A-->C) polymorphism with tuberculosis in a Punjabi population.

Sharma, S., Kumar, V., Khosla, R., et al. (2010) · PubMed · Cited by 38 · see citing works

P2X7 receptor polymorphism and clinical outcomes in HLA-matched sibling allogeneic hematopoietic stem cell transplantation

Lee, K. H., Park, S. S., Kim, I., Kim, J. H., K., E., Yoon, S., Hong, Y., Park, S., & Kim, B. K. (2007) · Haematologica · doi:10.3324/haematol.10810 · Cited by 37 · see citing works

Attenuated P2X7 Pore Function as a Risk Factor for Virus-induced Loss of Asthma Control

Denlinger, L. C., Shi, L., Guadarrama, A. G., Schell, K., Green, D., Morrin, A., Hogan, K. J., Sorkness, R. L., Busse, W. W., & Gern, J. E. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200802-293oc · Cited by 36 · see citing works

Current advances in the human lupus genetics

Shen, N., & Tsao, B. P. (2004) · Current Rheumatology Reports · doi:10.1007/s11926-004-0014-3 · Cited by 35 · see citing works

Lack of association between polymorphisms in the P2X7gene and tuberculosis in a Chinese Han population

Xiao, J., Sun, L., Jiao, W., et al. (2008) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2008.00508.x · Cited by 35 · see citing works

POLYMORPHISM IN THE P2X7 GENE INCREASES SUSCEPTIBILITY TO EXTRAPULMONARY TUBERCULOSIS IN TURKISH CHILDREN

Tekin, D., Kayaaltı, Z., Dalgıç, N., Çakır, E., Söylemezoğlu, T., Kutlubay, B. I., & Kılıç, B. A. (2010) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0b013e3181d9932e · Cited by 35 · see citing works

1513A/C polymorphism in the P2X7 receptor gene in chronic lymphocytic leukemia: absence of correlation with clinical outcome

Nückel, H., Frey, U. H., Dürig, J., et al. (2004) · European Journal Of Haematology · doi:10.1111/j.0902-4441.2003.00210.x · Cited by 35 · see citing works

Association of the 1513C polymorphism in the P2X7 gene with familial forms of chronic lymphocytic leukaemia

Dao‐Ung, L., Fuller, S. J., Sluyter, R., et al. (2004) · British Journal of Haematology · doi:10.1111/j.1365-2141.2004.04976.x · Cited by 34 · see citing works

Metaanalysis of P2X7 gene polymorphisms and tuberculosis susceptibility

Xiao, J., Sun, L., Yan, H., et al. (2010) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2010.00735.x · Cited by 34 · see citing works

Regulation of P2X7 gene transcription

Zhou, L., Luo, L., Qi, X., Li, X., & Gorodeski, G. I. (2009) · Purinergic Signalling · doi:10.1007/s11302-009-9167-x · Cited by 33 · see citing works

The P2X7 receptor mediates the uptake of organic cations in canine erythrocytes and mononuclear leukocytes: comparison to equivalent human cell types

Stevenson, R. O., Taylor, R. M., Wiley, J. S., & Sluyter, R. (2009) · Purinergic Signalling · doi:10.1007/s11302-009-9163-1 · Cited by 32 · see citing works

A quantitative method for routine measurement of cell surface P2X7 receptor function in leucocyte subsets by two-colour time-resolved flow cytometry

Jursik, C., Sluyter, R., Georgiou, J. G., Fuller, S. J., Wiley, J. S., & Gu, B. J. (2007) · Journal of Immunological Methods · doi:10.1016/j.jim.2007.06.002 · Cited by 32 · see citing works

Variation in the purinergic P2RX7 receptor gene and schizophrenia

Hansen, T. F., Jakobsen, K. D., Fenger, M., Nielsen, J., Krane, K., Fink‐Jensen, A., Lublin, H., Ullum, H., Timm, S., Wang, A. G., et al. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.05.026 · Cited by 31 · see citing works

Specific detection of non‐functional human P2X7 receptors in HEK293 cells and B‐lymphocytes

Barden, J. A., Sluyter, R., Gu, B. J., & Wiley, J. S. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00172-8 · Cited by 29 · see citing works

Analysis of a polymorphic microRNA target site in the purinergic receptor P2RX7 gene

Rahman, O. A., Sasvari‐Szekely, M., Szekely, A., Faludi, G., Guttman, A., & Nemoda, Z. (2010) · ELECTROPHORESIS · doi:10.1002/elps.200900664 · Cited by 28 · see citing works

The P2X7 Receptor Gene A1513C Polymorphism Does Not Contribute to Risk of Familial or Sporadic Chronic Lymphocytic Leukemia

Sellick, G. S., Rudd, M. F., Eve, P. D., et al. (2004) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.1065.13.6 · Cited by 28 · see citing works

P2X7 receptor activation causes phosphatidylserine exposure in human erythrocytes

Sluyter, R., Shemon, A. N., & Wiley, J. S. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.01.124 · Cited by 27 · see citing works

Functional variants of the P2RX7 gene, aseptic osteolysis, and revision of the total hip arthroplasty: A preliminary study

Mrázek, F., Gallo, J., Stahelova, A., & Petřek, M. (2009) · Human Immunology · doi:10.1016/j.humimm.2009.10.013 · Cited by 27 · see citing works

Regulation of calcium binding proteins calreticulin and calsequestrin during differentiation in the myogenic cell line L6

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Human neutrophils do not express purinergic P2X7 receptors

Martel‐Gallegos, G., Rosales-Saavedra, M. T., Reyes, J. P., et al. (2010) · Purinergic Signalling · doi:10.1007/s11302-010-9178-7 · Cited by 24 · see citing works

Rottlerin inhibits P2X7 receptor‐stimulated phospholipase D activity in chronic lymphocytic leukaemia B‐lymphocytes

Shemon, A. N., Sluyter, R., & Wiley, J. S. (2006) · Immunology and Cell Biology · doi:10.1038/sj.icb.7100005 · Cited by 23 · see citing works

Circulating interleukin-18 concentrations and a loss-of-function P2X7 polymorphism in heart failure

Eslick, G. D., Thampan, B. V., Nalos, M., et al. (2008) · International Journal of Cardiology · doi:10.1016/j.ijcard.2008.05.017 · Cited by 22 · see citing works

The P2X7 receptor gene polymorphism 1513 A→C has no effect on clinical prognostic markers and survival in multiple myeloma

Paneesha, S., Starczynski, J., Pepper, C. J., et al. (2005) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428190500305901 · Cited by 21 · see citing works

Functional P2X7 Receptor Polymorphisms (His155Tyr, Arg307Gln, Glu496Ala) in Patients with Crohn's Disease

Haas, S., Ruether, A., Singer, M. V., et al. (2006) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2006.01876.x · Cited by 19 · see citing works

No Association Between Hip Geometry and Four Common Polymorphisms Associated with Fracture: The Danish Osteoporosis Prevention Study

Nissen, N., Madsen, J. S., Bladbjerg, E., et al. (2009) · Calcified Tissue International · doi:10.1007/s00223-009-9219-9 · Cited by 18 · see citing works

Functional significance of P2RX7 polymorphisms associated with affective mood disorders

Sluyter, R., Stokes, L., Fuller, S. J., Skarratt, K. K., Gu, B. J., & Wiley, J. S. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.04.013 · Cited by 17 · see citing works

P2X7 gene polymorphisms do not appear to be a susceptibility gene locus in sporadic cases of systemic lupus erythematosus

Forchap, S., Anandacoomarasamy, A., Wicks, J. R., et al. (2008) · Tissue Antigens · doi:10.1111/j.1399-0039.2008.01136.x · Cited by 15 · see citing works

Standardized method to minimize variability in a functional P2X7 flow cytometric assay for a multi‐center clinical trial

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A novel assay to detect nucleotide receptor P2X7 genetic polymorphisms influencing numerous innate immune functions

Denlinger, L. C., Schell, K. A., Angelini, G., et al. (2004) · Journal of Endotoxin Research · doi:10.1177/09680519040100020101 · Cited by 8 · see citing works

The P2X7 Receptor in Infection and Inflammation

Di Virgilio, F., Dal Ben, D., Sarti, A. C., Giuliani, A. L., & Falzoni, S. (2017) · Immunity · doi:10.1016/j.immuni.2017.06.020 · Cited by 1,267 · see citing works

The P2X7 Receptor

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The P2X7 Receptor: Central Hub of Brain Diseases

Andrejew, R., Oliveira-Giacomelli, Á., Ribeiro, D. E., Glaser, T., Arnaud-Sampaio, V. F., Lameu, C., & Ulrich, H. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00124 · Cited by 162 · see citing works

Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology

Ribeiro, D. E., Oliveira-Giacomelli, Á., Glaser, T., Arnaud-Sampaio, V. F., Andrejew, R., Dieckmann, L., Baranova, J., Lameu, C., Ratajczak, M. Z., & Ulrich, H. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-00965-3 · Cited by 145 · see citing works

P2X7 on Mouse T Cells: One Channel, Many Functions

Rissiek, B., Haag, F., Boyer, O., Koch-Nolte, F., & Adriouch, S. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00204 · Cited by 116 · see citing works

Heterozygosity for the mood disorder-associated variant Gln460Arg alters P2X7 receptor function and sleep quality

Metzger, M. W., Walser, S. M., Dedic, N., Aprile-Garcia, F., Jakubcakova, V., Adamczyk, M., Webb, K. J., Uhr, M., Refojo, D., Schmidt, M. V., et al. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.3487-16.2017 · Cited by 59 · see citing works

Associations between depression severity and purinergic receptor P2RX7 gene polymorphisms

Halmai, Z., Dome, P., Vereczkei, A., Abdul-Rahman, O., Szekely, A., Gonda, X., Faludi, G., Sasvari-Szekely, M., & Nemoda, Z. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.02.033 · Cited by 55 · see citing works

[Progress on role of extracellular ATP and its metabolite adenosine in immunoregulation: Review].

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Dimerization of G protein-coupled purinergic receptors: increasing the diversity of purinergic receptor signal responses and receptor functions

Nakata, H., Suzuki, T., Namba, K., & Oyanagi, K. (2010) · Journal of Receptors and Signal Transduction · doi:10.3109/10799893.2010.509729 · Cited by 28 · see citing works

ATP- and Adenosine-Mediated Signaling in the Central Nervous System: Purinergic Receptor Complex: Generating Adenine Nucleotide-Sensitive Adenosine Receptors

Yoshioka, K., & Nakata, H. (2004) · Journal of Pharmacological Sciences · doi:10.1254/jphs.94.88 · Cited by 23 · see citing works

Comparative Analysis of the Efficacy of A1 Adenosine Receptor Activation of Gi/oα G Proteins following Coexpression of Receptor and G Protein and Expression of A1 Adenosine Receptor−Gi/oα Fusion Proteins

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Exploring The Role Of Purinergic Signaling In T Cell Activation

Bhate, M. M. (2011)