P2X7 on Mouse T Cells: One Channel, Many Functions

Rissiek, BjÃ¶rn; Haag, Friedrich; Boyer, Olivier; Koch-Nolte, Friedrich; Adriouch, Sahil

doi:10.3389/fimmu.2015.00204

Cited by 116Adenosine and Purinergic SignalingCalcium signaling and nucleotide metabolismBiochemical and Molecular Research

P2X7 on Mouse T Cells: One Channel, Many Functions

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Rissiek, BjÃ¶rn, Haag, Friedrich, Boyer, Olivier, Koch-Nolte, Friedrich, Adriouch, Sahil·2015·Frontiers in Immunology

DOI 10.3389/fimmu.2015.00204PMC PMC4436801

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Abstract

The P2X7 receptor is an adenosine triphosphate (ATP)-gated cation channel that is expressed by several cells of the immune system. P2X7 is best known for its proinflammatory role in promoting inflammasome formation and release of mature interleukin (IL)-1β by innate immune cells. Mounting evidence indicates that P2X7 is also an important regulatory receptor of murine and human T cell functions. Murine T cells express a sensitive splice variant of P2X7 that can be activated either by non-covalent binding of ATP or, in the presence of nicotinamide adenine dinucleotide, by its covalent ADP-ribosylation catalyzed by the ecto-ADP-ribosyltransferase ARTC2.2. Prolonged activation of P2X7 by either one of these pathways triggers the induction of T cell death. Conversely, lower concentrations of ATP can activate P2X7 to enhance T cell proliferation and production of IL-2. In this review, we will highlight the molecular and cellular consequences of P2X7 activation on mouse T cells and its versatile role in T cell homeostasis and activation. Further, we will discuss important differences in the function of P2X7 on human and murine T cells.

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Activation of the danger receptor P2RX7 by extracellular NAD or ATP, released by dying cells during processing, can lead to shedding of surface molecules such as CD62L and CD27, the masking of CD8β and the induction of cell death in susceptible cells like Treg, NKT, and Trm cells.
“For example, activation of the danger receptor P2RX7 by extracellular NAD or ATP, released by dying cells during processing, can lead to shedding of surface molecules such as CD62L and CD27, the masking of CD8β and the induction of cell death in susceptible cells like Treg, NKT, and Trm cells [286-288].”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [286]
The sections on ex vivo murine T-cell preparations and Figure 2 (pages not provided) report NAD+ release during preparation, P2X7-dependent CD27 and CD62L shedding, and cell death in Tregs and liver NKT cells. The paper also describes ATP-dependent P2X7 activation, but the passages do not support CD8β masking or identify Trm cells as a susceptible population. (LLM, conf=0.87)
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Technical Advance: A new cell preparation strategy that greatly improves the yield of vital and functional Tregs and NKT cells
Rissiek, B., Danquah, W., Haag, F., & Koch‐Nolte, F. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.0713407 · Cited by 55 · see citing works
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ADP-Ribosylation of P2X7: A Matter of Life and Death for Regulatory T Cells and Natural Killer T Cells
Rissiek, B., Haag, F., Boyer, O., Koch‐Nolte, F., & Adriouch, S. (2014) · Current topics in microbiology and immunology · doi:10.1007/82_2014_420 · Cited by 53 · see citing works
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Nanobodies as modulators of inflammation: potential applications for acute brain injury
Rissiek, B., Koch‐Nolte, F., & Magnus, T. U. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00344 · Cited by 53 · see citing works
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Pannexin1 channels act downstream of P2X 7 receptors in ATP-induced murine T-cell death
Shoji, K. F., Sáez, P. J., Harcha, P. A., Aguila, H. L., & Sáez, J. C. (2014) · Channels · doi:10.4161/chan.28122 · Cited by 51 · see citing works
Lymphocytes from P2X7-deficient mice exhibit enhanced P2X7 responses
Taylor, S. R. J., González–Begne, M., Sojka, D. K., Richardson, J. C., Sheardown, S. A., Harrison, S. M., Pusey, C. D., Tam, F. W. K., & Elliott, J. I. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0408251 · Cited by 49 · see citing works
Identification of Thr283 as a key determinant of P2X7 receptor function
Young, M. T., Pelegrı́n, P., & Surprenant, A. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706880 · Cited by 46 · see citing works
Genetic Background Strongly Influences the Bone Phenotype of P2X7 Receptor Knockout Mice
Syberg, S., Petersen, S., Jensen, J. B., Gartland, A., Teilmann, J., Chessell, I. P., Steinberg, T. H., Schwarz, P., & Jørgensen, N. R. (2012) · Journal of Osteoporosis · doi:10.1155/2012/391097 · Cited by 41 · see citing works
Activation of the P2X7 ion channel by soluble and covalently bound ligands
Schwarz, N., Fliegert, R., Adriouch, S., Séman, M., Guse, A. H., Haag, F., & Koch‐Nolte, F. (2009) · Purinergic Signalling · doi:10.1007/s11302-009-9135-5 · Cited by 38 · see citing works
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Purinergic P2X7 Receptor Drives T Cell Lineage Choice and Shapes Peripheral γδ Cells
Frascoli, M., Marcandalli, J., Schenk, U., & Grassi, F. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1101582 · Cited by 37 · see citing works
A recombinant heavy chain antibody approach blocks ART2 mediated deletion of an iNKT cell population that upon activation inhibits autoimmune diabetes
Scheuplein, F., Rissiek, B., Driver, J. P., Chen, Y., Koch‐Nolte, F., & SERREZE, D. V. (2009) · Journal of Autoimmunity · doi:10.1016/j.jaut.2009.08.012 · Cited by 36 · see citing works
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CD39 is a negative regulator of P2X7-mediated inflammatory cell death in mast cells
Kuhny, M., Hochdörfer, T., Ayata, C. K., Idzko, M., & Huber, M. (2014) · Cell Communication and Signaling · doi:10.1186/s12964-014-0040-3 · Cited by 33 · see citing works
Involvement of Sodium in Early Phosphatidylserine Exposure and Phospholipid Scrambling Induced by P2X7 Purinoceptor Activation in Thymocytes
Courageot, M.-P., Lépine, S., Hours, M. C., Giraud, F., & Sulpice, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401426200 · Cited by 32 · see citing works
T Cells of Different Developmental Stages Differ in Sensitivity to Apoptosis Induced by Extracellular NAD
Haag, F., Freese, D., Scheublein, F., Ohlrogge, W., Adriouch, S., Séman, M., & Koch‐Nolte, F. (2002) · Journal of Immunology Research · doi:10.1080/10446670310001593514 · Cited by 19 · see citing works
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Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)
Cossarizza, A., Chang, H., Radbruch, A., Acs, A., Adam, D., Adam‐Klages, S., Agace, W. W., Aghaeepour, N., Akdiş, M., Allez, M., et al. (2019) · European Journal of Immunology · doi:10.1002/eji.201970107 · Cited by 982 · see citing works
CD8+ T cell metabolism in infection and cancer
Reina‐Campos, M., Scharping, N. E., & Goldrath, A. W. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00537-8 · Cited by 630 · see citing works
Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)
Cossarizza, A., Chang, H., Radbruch, A., Abrignani, S., Addo, R., Akdis, M., Andrä, I., Andreata, F., Annunziato, F., Arranz, E., et al. (2021) · European Journal of Immunology · doi:10.1002/eji.202170126 · Cited by 531 · see citing works
Danger signals in stroke and their role on microglia activation after ischemia
Gülke, E., Gelderblom, M., & Magnus, T. (2018) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756286418774254 · Cited by 321 · see citing works
ADP-Ribosylation, a Multifaceted Posttranslational Modification Involved in the Control of Cell Physiology in Health and Disease
Lüscher, B., Bütepage, M., Eckei, L., Krieg, S., Verheugd, P., & Shilton, B. H. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00122 · Cited by 258 · see citing works
The purinergic receptor P2RX7 directs metabolic fitness of long-lived memory CD8+ T cells
da Silva, H. B., Beura, L. K., Wang, H., Hanse, E. A., Gore, R., Scott, M. C., Walsh, D., Block, K. E., Fonseca, R., Yan, Y., et al. (2018) · Nature · doi:10.1038/s41586-018-0282-0 · Cited by 258 · see citing works
The P2X7 Receptor
Sluyter, R. (2017) · Advances in Experimental Medicine and Biology · doi:10.1007/5584_2017_59 · Cited by 235 · see citing works
P2X7 Interactions and Signaling – Making Head or Tail of It
Kopp, R., Krautloher, A., Ramírez-Fernández, A., & Nicke, A. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00183 · Cited by 217 · see citing works
T RM maintenance is regulated by tissue damage via P2RX7
Stark, R., Wesselink, T. H., Behr, F. M., Kragten, N. A. M., Arens, R., Koch-Nolte, F., van Gisbergen, K. P. J. M., & van Lier, R. A. W. (2018) · Science Immunology · doi:10.1126/sciimmunol.aau1022 · Cited by 141 · see citing works
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Sensing of ATP via the Purinergic Receptor P2RX7 Promotes CD8+ Trm Cell Generation by Enhancing Their Sensitivity to the Cytokine TGF-β
da Silva, H. B., Peng, C., Wang, H.-G., Wanhainen, K. M., Ma, C.-Y., Lopez, S., Khoruts, A., Zhang, N., & Jameson, S. (2020) · Immunity · doi:10.1016/j.immuni.2020.06.010 · Cited by 115 · see citing works
P2RX7 Purinoceptor as a Therapeutic Target—The Second Coming?
Young, C., & Górecki, D. C. (2018) · Frontiers in Chemistry · doi:10.3389/fchem.2018.00248 · Cited by 95 · see citing works
Modulation of innate and adaptive immunity by P2X ion channels
Virgilio, F. D., Sarti, A. C., & Grassi, F. (2018) · Current Opinion in Immunology · doi:10.1016/j.coi.2018.03.026 · Cited by 89 · see citing works
Non-nucleotide Agonists Triggering P2X7 Receptor Activation and Pore Formation
Virgilio, F. D., Giuliani, A. L., Vultaggio-Poma, V., Falzoni, S., & Sarti, A. C. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00039 · Cited by 90 · see citing works
Purinergic Receptors in Adipose Tissue As Potential Targets in Metabolic Disorders
Tozzi, M., & Novak, I. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00878 · Cited by 87 · see citing works
Regulation of P2X7 receptor expression and function in the brain
Jimenez-Mateos, E. M., Smith, J., Nicke, A., & Engel, T. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.12.008 · Cited by 79 · see citing works
Single-cell protein expression profiling resolves circulating and resident memory T cell diversity across tissues and infection contexts.
Evrard, M., Becht, E., Fonseca, R., Obers, A., Park, S. L., Ghabdan-Zanluqui, N., Schroeder, J., Christo, S. N., Schienstock, D., Lai, J.-Y., et al. (2023) · Immunity · doi:10.1016/j.immuni.2023.06.005 · Cited by 73 · see citing works
Graft-Infiltrating Macrophages Adopt an M2 Phenotype and Are Inhibited by Purinergic Receptor P2X7 Antagonist in Chronic Rejection
Wu, C., Zhao, Y., Xiao, X., Fan, Y., Kloc, M., Liu, W., Ghobrial, R. M., Lan, P., He, X., & Li, X. C. (2016) · American Journal of Transplantation · doi:10.1111/ajt.13808 · Cited by 75 · see citing works
P2X7 Receptors in Neurodegeneration: Potential Therapeutic Applications From Basic to Clinical Approaches
Territo, P. R., & Zarrinmayeh, H. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.617036 · Cited by 68 · see citing works
CD39 is upregulated during activation of mouse and human T cells and attenuates the immune response to Listeria monocytogenes
Raczkowski, F., Rissiek, A., Ricklefs, I., Heiß, K., Schumacher, V., Wundenberg, K., Haag, F., Koch‐Nolte, F., Tolosa, E., & Mittrücker, H. (2018) · PLoS ONE · doi:10.1371/journal.pone.0197151 · Cited by 63 · see citing works
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Oxidative stress as a therapeutic target for the prevention and treatment of early age-related macular degeneration
Jabbehdari, S., & Handa, J. T. (2020) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2020.09.002 · Cited by 60 · see citing works
P2X4 and P2X7 are essential players in basal T cell activity and Ca 2+ signaling milliseconds after T cell activation
Brock, V. J., Wolf, I. M. A., Er-Lukowiak, M., Lory, N. C., Stähler, T., Woelk, L.-M., Mittrücker, H., Müller, C. E., Koch‐Nolte, F., Rissiek, B., et al. (2022) · Science Advances · doi:10.1126/sciadv.abl9770 · Cited by 59 · see citing works
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ARTC2.2/P2RX7 signaling during cell isolation distorts function and quantification of tissue-resident CD8+ T cell and iNKT subsets
da Silva, H. B., Wang, H.-G., Qian, L. J., Hogquist, K., & Jameson, S. (2019) · Journal of Immunology · doi:10.4049/jimmunol.1801613 · Cited by 60 · see citing works
Structure, function and techniques of investigation of the P2X7 receptor (P2X7R) in mammalian cells
Virgilio, F. D., Jiang, L., Roger, S., Falzoni, S., Sarti, A. C., Vultaggio-Poma, V., Chiozzi, P., & Adinolfi, E. (2019) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2019.07.043 · Cited by 59 · see citing works
Skin and gut imprinted helper T cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity
Hiltensperger, M., Beltrán, E., Kant, R., Tyystjärvi, S., Lepennetier, G., Moreno, H. D., Bauer, I., Grassmann, S. A., Jarosch, S., Schober, K., et al. (2021) · Nature Immunology · doi:10.1038/s41590-021-00948-8 · Cited by 57 · see citing works
P2X7 Receptor at the Crossroads of T Cell Fate
Rivas-Yáñez, E., Barrera-Avalos, C., Parra-Tello, B., Briceño, P., Rosemblatt, M., Saavedra-Almarza, J., Rosemblatt, M., Acuña-Castillo, C., Bono, M., & Sauma, D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144937 · Cited by 52 · see citing works
P2X7-pannexin-1 and amyloid β-induced oxysterol input in human retinal cell: Role in age-related macular degeneration?
Olivier, E., Dutot, M., Regazzetti, A., Léguillier, T., Dargère, D., Auzeil, N., Laprévôte, O., & Rat, P. (2016) · Biochimie · doi:10.1016/j.biochi.2016.04.014 · Cited by 53 · see citing works
Contraction of intestinal effector T cells by retinoic acid-induced purinergic receptor P2X7
Hashimoto‐Hill, S., Friesen, L., Kim, M., & Kim, C. H. (2016) · Mucosal Immunology · doi:10.1038/mi.2016.109 · Cited by 52 · see citing works
Dynamic Metabolic State of Tissue Resident CD8 T Cells
Konjar, Š., & Veldhoen, M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01683 · Cited by 50 · see citing works
Blocking P2X7 by intracerebroventricular injection of P2X7-specific nanobodies reduces stroke lesions
Wilmes, M., Pinto-Espinoza, C., Ludewig, P., Stabernack, J., Liesz, A., Nicke, A., Gelderblom, M., Gerloff, C. P., Falzoni, S., Tolosa, E., et al. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02601-z · Cited by 49 · see citing works
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Pleiotropic Roles of P2X7 in the Central Nervous System
Kanellopoulos, J. M., & Delarasse, C. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00401 · Cited by 48 · see citing works
The P2X7 Receptor as Regulator of T Cell Development and Function
Grassi, F. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01179 · Cited by 40 · see citing works
In Vivo Blockade of Murine ARTC2.2 During Cell Preparation Preserves the Vitality and Function of Liver Tissue-Resident Memory T Cells
Rissiek, B., Lukowiak, M., Raczkowski, F., Magnus, T., Mittrücker, H.-W., & Koch-Nolte, F. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01580 · Cited by 45 · see citing works
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Physical tuning of galectin-3 signaling
Farhadi, S. A., Liu, R., Becker, M. W., Phelps, E. A., & Hudalla, G. A. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2024117118 · Cited by 47 · see citing works
Alternative splicing of P2RX7 pre-messenger RNA in health and diseases: Myth or reality?
Benzaquen, J., Heeke, S., Hreich, S. J. D., Douguet, L., Marquette, C., Hofman, P. M., & Vouret‐Craviari, V. (2019) · Biomedical Journal · doi:10.1016/j.bj.2019.05.007 · Cited by 42 · see citing works
The role of the P2X7 receptor in murine cutaneous leishmaniasis: aspects of inflammation and parasite control
Figliuolo, V. R., Chaves, S. P., Savio, L. E. B., Thorstenberg, M. L., de Salles, É. M., Takiya, C. M., Lima, M. R. D., Guedes, H. L. D. M., Rossi‐Bergmann, B., & Coutinho‐Silva, R. (2016) · Purinergic Signalling · doi:10.1007/s11302-016-9544-1 · Cited by 37 · see citing works
Opposing effects of the purinergic P2X7 receptor on seizures in neurons and microglia in male mice
Alves, M., Gil, B., Villegas-Salmerón, J., Salari, V., Martins-Ferreira, R., Blázquez, M. A., Méndez, A. M., Gerbatin, R. R., Smith, J., de Diego-García, L., et al. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.05.023 · Cited by 36 · see citing works
TCR‐pMHC encounter differentially regulates transcriptomes of tissue‐resident CD8 T cells
Yoshizawa, A., Bi, K., Keskin, D. B., Zhang, G., Reinhold, B. B., & Reinherz, E. L. (2017) · European Journal of Immunology · doi:10.1002/eji.201747174 · Cited by 34 · see citing works
Activation of P2X7 Receptors in Peritoneal and Meningeal Mast Cells Detected by Uptake of Organic Dyes: Possible Purinergic Triggers of Neuroinflammation in Meninges
Nurkhametova, D., Kudryavtsev, I. V., Гусельникова, В. В., Серебрякова, М. К., Giniatullina, R., Wojciechowski, S., Töre, F., Rizvanov, A. A., Koıstınaho, J., Malm, T., et al. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00045 · Cited by 33 · see citing works
Antioxidants in Age-Related Macular Degeneration: Lights and Shadows
Parmar, U. P. S., Surico, P. L., Mori, T., Singh, R. B., Cutrupi, F., Premkishore, P., Afflitto, G. G., Zazzo, A. D., Coassin, M., & Romano, F. (2025) · Antioxidants · doi:10.3390/antiox14020152 · Cited by 30 · see citing works
P2RX7 Enhances Tumor Control by CD8+ T Cells in Adoptive Cell Therapy
Wanhainen, K. M., Peng, C., Zhou, M. H., Macedo, B. D. G., O’Flanagan, S. D., Yang, T., Kelekar, A., Burbach, B. J., da Silva, H. B., & Jameson, S. C. (2022) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-21-0691 · Cited by 29 · see citing works
P2X7 receptor as the regulator of T-cell function in intestinal barrier disruption
Jiang, Z., Wu, W. H., Hu, H.-B., Li, Z., Zhong, M., & Zhang, L. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i36.5265 · Cited by 25 · see citing works
A P2rx7 Passenger Mutation Affects the Vitality and Function of T cells in Congenic Mice
Er-Lukowiak, M., Duan, Y., Rassendren, F., Ulmann, L., Nicke, A., Ufer, F., Friese, M. A., Koch‐Nolte, F., Magnus, T. U., & Rissiek, B. (2020) · iScience · doi:10.1016/j.isci.2020.101870 · Cited by 24 · see citing works
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Purinergic Signaling in Pancreas—From Physiology to Therapeutic Strategies in Pancreatic Cancer
Novak, I., Yu, H., Magni, L., & Deshar, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228781 · Cited by 24 · see citing works
Inflammasomes in the urinary tract: a disease-based review
Purves, J. T., & Hughes, F. M. (2016) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00607.2015 · Cited by 24 · see citing works
Mechanisms underlying sensitization of P2X7 receptors in astrocytes for induction of ischemic tolerance
Hirayama, Y., Anzai, N., & Koizumi, S. (2021) · Glia · doi:10.1002/glia.23998 · Cited by 23 · see citing works
Roles of extracellular nucleotides and P2 receptors in ectodomain shedding
Pupovac, A., & Sluyter, R. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2274-2 · Cited by 23 · see citing works
Human P2Y11 Expression Level Affects Human P2X7 Receptor-Mediated Cell Death
Dreisig, K., Sund, L., Dommer, M. W., Kristensen, N. P., Boddum, K., Viste, R., Fredholm, S., Ødum, N., Jäättelä, M., Skov, S., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01159 · Cited by 23 · see citing works
eATP/P2X7R Axis: An Orchestrated Pathway Triggering Inflammasome Activation in Muscle Diseases
Panicucci, C., Raffaghello, L., Bruzzone, S., Baratto, S., Principi, E., Minetti, C., Gazzerro, E., & Bruno, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21175963 · Cited by 23 · see citing works
P2X7 receptor in skin biology and diseases
Geraghty, N. J., Watson, D., Adhikary, S. R., & Sluyter, R. (2016) · World Journal of Dermatology · doi:10.5314/wjd.v5.i2.72 · Cited by 21 · see citing works
The Role of IL-18 in P2RX7-Mediated Antitumor Immunity
Hreich, S. J. D., Hofman, P., & Vouret-Craviari, V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119235 · Cited by 16 · see citing works
Blocking the ART2.2/P2X7‐system is essential to avoid a detrimental bias in functional CD4 T cell studies
Georgiev, H., Ravens, I., Papadogianni, G., Malissen, B., Förster, R., & Bernhardt, G. (2018) · European Journal of Immunology · doi:10.1002/eji.201747420 · Cited by 19 · see citing works
P2X7 Receptor and Extracellular Vesicle Release
Golia, M. T., Gabrielli, M., & Verderio, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24129805 · Cited by 19 · see citing works
Understanding autoimmunity: The ion channel perspective
Ramakrishnan, A. M., & Sankaranarayanan, K. (2016) · Autoimmunity Reviews · doi:10.1016/j.autrev.2016.02.004 · Cited by 19 · see citing works
Ca 2+ microdomains, NAADP and type 1 ryanodine receptor in cell activation
Guse, A. H., & Wolf, I. M. A. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2016.01.014 · Cited by 19 · see citing works
Evaluation of P2X7 Receptor Function in Tumor Contexts Using rAAV Vector and Nanobodies (AAVnano)
Demeules, M., Scarpitta, A., Abad, C., Gondé, H., Hardet, R., Pinto-Espinoza, C., Eichhoff, A., Schäfer, W., Haag, F., Koch-Nolte, F., et al. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01699 · Cited by 18 · see citing works
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Long-Term Effects of Very Low Dose Particle Radiation on Gene Expression in the Heart: Degenerative Disease Risks
Garikipati, V. N. S., Arakelyan, A., Blakely, E. A., Chang, P. Y., Truongcao, M. M., Cimini, M., Mallaredy, V., Bajpai, A., Addya, S., Bisserier, M., et al. (2021) · Cells · doi:10.3390/cells10020387 · Cited by 19 · see citing works
P2X7 Receptor in Bone Marrow-Derived Cells Aggravates Tuberculosis Caused by Hypervirulent Mycobacterium bovis
Bomfim, C. C. B., Amaral, E. P., Cassado, A. D. A., de Salles, É. M., do Nascimento, R. S., Lasunskaia, E., Hirata, M. H., Álvarez, J. M., & Lima, M. R. D. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00435 · Cited by 19 · see citing works
P2X7-NLRP3-Caspase-1 signaling mediates activity-induced muscle pain in male but not female mice
Hayashi, K., Lesnak, J. B., Plumb, A. N., Rasmussen, L. A., & Sluka, K. A. (2023) · Pain · doi:10.1097/j.pain.0000000000002887 · Cited by 18 · see citing works
The impact of the P2X7 receptor on the tumor immune microenvironment and its effects on tumor progression
Zou, Y.-T., Li, J., Chai, J.-Y., Hu, Y., Zhang, W., & Zhang, Q. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.149513 · Cited by 18 · see citing works
Immunogenic cell death of dendritic cells following modified vaccinia virus Ankara infection enhances CD8+ T cell proliferation
Tappe, K. A., Budida, R., Stankov, M. V., Frenz, T., Shah, H., Volz, A., Sutter, G., Kalinke, U., & Behrens, G. M. N. (2018) · European Journal of Immunology · doi:10.1002/eji.201847632 · Cited by 18 · see citing works
Gpx4 Regulates Invariant NKT Cell Homeostasis and Function by Preventing Lipid Peroxidation and Ferroptosis
Sok, S. P. M., Pipkin, K., Popescu, N. I., Reidy, M. A., Li, B., Remmen, H. V., Kinter, M., Sun, X.-H., Fan, Z., & Zhao, M. (2024) · The Journal of Immunology · doi:10.4049/jimmunol.2400246 · Cited by 17 · see citing works
Macrophages and glia are the dominant P2X7-expressing cell types in the gut nervous system—No evidence for the role of neuronal P2X7 receptors in colitis
Jooss, T., Zhang, J., Zimmer, B., Rezzonico-Jost, T., Rissiek, B., Pelczar, P., Seehusen, F., Koch‐Nolte, F., Magnus, T. U., Zierler, S., et al. (2023) · Mucosal Immunology · doi:10.1016/j.mucimm.2022.11.003 · Cited by 17 · see citing works
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Administration of an AAV vector coding for a P2X7-blocking nanobody-based biologic ameliorates colitis in mice
Abad, C., Demeules, M., Guillou, C., Gondé, H., Zoubaïri, R., Tan, Y., Pinto-Espinoza, C., Schäfer, W., Mann, A. M., Vouret‐Craviari, V., et al. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02285-4 · Cited by 16 · see citing works
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NLRP3 inflammasome: structure, mechanism, drug-induced organ toxicity, therapeutic strategies, and future perspectives
Singh, D. D. (2025) · RSC Medicinal Chemistry · doi:10.1039/d5md00167f · Cited by 16 · see citing works
Evaluation of nanobody-based biologics targeting purinergic checkpoints in tumor models in vivo
Demeules, M., Scarpitta, A., Hardet, R., Gondé, H., Abad, C., Blandin, M., Menzel, S., Duan, Y., Rissiek, B., Magnus, T., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1012534 · Cited by 15 · see citing works
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The P2X7 receptor in immune cells
Taylor, S. (2017) · Open Research (University of Surrey)

Authors: Rissiek, B., Haag, F., Boyer, O., Koch-Nolte, F., & Adriouch, S.
Affiliations: Universität Hamburg (DE)
Inserm (FR)
Corresponding author: Adriouch, Sahil
ORCID: Haag, Friedrich
Boyer, Olivier
Adriouch, Sahil
Venue: Frontiers in Immunology
Publisher: Frontiers Media SA
Published: 2015-05-19
Volume: 6
Pages: 204-204
ISSN: 1664-3224 (ISSN-L)
DOI: 10.3389/fimmu.2015.00204
PMC: PMC4436801
OpenAlex: W1564355150
Cited by: 116
References: 81
Citations by year: 2026: 4 · 2025: 7 · 2024: 7 · 2023: 10 · 2022: 8 · 2021: 15 · 2020: 13 · 2019: 14 · 2018: 15 · 2017: 11 · 2016: 12
FWCI: 1.62
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Immunology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
HAL (submittedVersion, other-oa)
HAL (submittedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders: Deutsche Forschungsgemeinschaft (SFB 877, HA2369/5)
Institut National de la Santé et de la Recherche Médicale
Normandie Université
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
Keywords: P2X7 receptor, T cells, ATP-gated cation channels, ADP-ribosylation, T cell death, T cell proliferation, interleukin-2, T cell homeostasis, T cell activation, splice variants

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P2X7 on Mouse T Cells: One Channel, Many Functions

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