A Review of Preclinical Research Demonstrating that Drug and Non-Drug ReinforcersDifferentially Affect Behavior

N. Kearns, David; A. Gomez-Serrano, Maria; J. Tunstall, Brendan

doi:10.2174/1874473711104040261

Cited by 22Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and OutcomesNeural and Behavioral Psychology Studies

A Review of Preclinical Research Demonstrating that Drug and Non-Drug ReinforcersDifferentially Affect Behavior

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N. Kearns, David, A. Gomez-Serrano, Maria, J. Tunstall, Brendan·2011·Current Drug Abuse Reviewse

DOI 10.2174/1874473711104040261PMC PMC3717264

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Abstract

This review describes and summarizes current preclinical research revealing important differences between drug and non-drug reinforcers in terms of their effects on behavior. Despite research showing that drugs are not especially strong reinforcers in animals, a number of other behavioral differences potentially relevant to addiction have been reported in studies that have compared drug and non-drug reinforcers. Several of these effects appear only after long-term access to drugs. These include an escalation of drug intake, an increased persistence in responding for the drug, and a decreased sensitivity to the effects of punishers or other suppressors of drug seeking. Further differences between drug and non-drug reinforcers include the effects that reinforcer-paired stimuli have on behavior. Drug cues, as compared to food cues, have been shown to exert greater control over reinforcer-seeking behavior after periods of abstinence. Similarly, behavior previously reinforced by drugs, but not food, has been shown to be susceptible to stress-induced reinstatement after extinction. The behavioral differences between drug and non-drug reinforcers reviewed here may identify special features of drugs that lead to addiction.

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Once extinguished, drug-reinforced behaviours are far more susceptible to stress-induced reinstatement than food-reinforced behaviours.
“once extinguished, drug-reinforced behaviours are far more susceptible to stress-induced reinstatement than food-reinforced behaviours (58).”
From Obesity and addiction: Neurobiological overlaps (2013) · cites this paper as [58]
Drug cues are more powerful triggers of reinforcer-seeking behaviour after abstinence than food cues, at least in animals that have not been food deprived.
“when compared to food cues, drug cues are more powerful triggers of reinforcer-seeking behaviour following a period of abstinence, at least in the case of animals that have not been food deprived (58).”
From Obesity and addiction: Neurobiological overlaps (2013) · cites this paper as [58]
Once extinguished, drug-reinforced behaviors are more susceptible to stress-induced reinstatement than food-reinforced behaviors.
“Thus, once extinguished, drug-reinforced behaviors are far more susceptible to stress-induced reinstatement than food-reinforced behaviors (56).”
From The Addictive Dimensionality of Obesity (2013) · cites this paper as [56]

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Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
The reinstatement model of drug relapse: history, methodology and major findings
Shaham, Y., Shalev, U., Lu, L., de Wit, H., & Stewart, J. (2003) · Psychopharmacology · doi:10.1007/s00213-002-1224-x · Cited by 1,615 · see citing works
Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats
Johnson, P. M., & Kenny, P. J. (2010) · Nature Neuroscience · doi:10.1038/nn.2519 · Cited by 1,495 · see citing works
Impulsivity as a vulnerability marker for substance-use disorders: Review of findings from high-risk research, problem gamblers and genetic association studies
Verdejo‐García, A., Lawrence, A. J., & Clark, L. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.11.003 · Cited by 1,414 · see citing works
Evidence for sugar addiction: Behavioral and neurochemical effects of intermittent, excessive sugar intake
Avena, N. M., Rada, P., & Hoebel, B. G. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.04.019 · Cited by 1,358 · see citing works
Some quantitative properties of anxiety.
Estes, W. K., & Skinner, B. F. (1941) · Journal of Experimental Psychology · doi:10.1037/h0062283 · Cited by 1,350 · see citing works
Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement
Dalley, J. W., Fryer, T. D., Brichard, L., Robinson, E. S. J., Theobald, D. E. H., Lääne, K., Peña, Y., Murphy, E. R., Shah, Y., Probst, K., et al. (2007) · Science · doi:10.1126/science.1137073 · Cited by 1,188 · see citing works
Transition from Moderate to Excessive Drug Intake: Change in Hedonic Set Point
Ahmed, S. H., & Koob, G. F. (1998) · Science · doi:10.1126/science.282.5387.298 · Cited by 1,159 · see citing works
Evidence for Addiction-like Behavior in the Rat
Deroche-Gamonet, V., Belin, D., & Piazza, P. V. (2004) · Science · doi:10.1126/science.1099020 · Cited by 1,135 · see citing works
Toward a behavioral economic understanding of drug dependence: delay discounting processes
Bickel, W. K., & Marsch, L. A. (2001) · Addiction · doi:10.1046/j.1360-0443.2001.961736.x · Cited by 1,117 · see citing works
Incubation of cocaine craving after withdrawal
Grimm, J. W., Hope, B. T., Wise, R. A., & Shaham, Y. (2001) · Nature · doi:10.1038/35084134 · Cited by 1,003 · see citing works
High Impulsivity Predicts the Switch to Compulsive Cocaine-Taking
Belin, D., Mar, A. C., Dalley, J. W., Robbins, T. W., & Everitt, B. J. (2008) · Science · doi:10.1126/science.1158136 · Cited by 989 · see citing works
The circuitry mediating cocaine-induced reinstatement of drug-seeking behavior
McFarland, K., & Kalivas, P. W. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-21-08655.2001 · Cited by 905 · see citing works
Prefrontal Glutamate Release into the Core of the Nucleus Accumbens Mediates Cocaine-Induced Reinstatement of Drug-Seeking Behavior
McFarland, K., Lapish, C. C., & Kalivas, P. W. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03531.2003 · Cited by 884 · see citing works
Neurobiology of relapse to heroin and cocaine seeking: a review
Shalev, U., Grimm, J. W., & Shaham, Y. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.1.1 · Cited by 880 · see citing works
Reward mechanisms in obesity: new insights and future directions
Kenny, P. J. (2011) · Neuron · doi:10.1016/j.neuron.2011.02.016 · Cited by 748 · see citing works
Heroin and cocaine abusers have higher discount rates for delayed rewards than alcoholics or non-drug-using controls.
Kirby, K., & Petry, N. (2004) · Addiction · doi:10.1111/j.1360-0443.2003.00669.x · Cited by 737 · see citing works
Drug Seeking Becomes Compulsive After Prolonged Cocaine Self-Administration
Vanderschuren, L. J. M. J., & Everitt, B. J. (2004) · Science · doi:10.1126/science.1098975 · Cited by 733 · see citing works
Applying extinction research and theory to cue‐exposure addiction treatments
Conklin, C. A., & Tiffany, S. T. (2002) · Addiction · doi:10.1046/j.1360-0443.2002.00014.x · Cited by 702 · see citing works
Impulsivity and rapid discounting of delayed hypothetical rewards in cocaine-dependent individuals.
Coffey, S., Gudleski, G., Saladin, M., & Brady, K. (2003) · Experimental and clinical psychopharmacology · doi:10.1037//1064-1297.11.1.18 · Cited by 655 · see citing works
Toward a model of drug relapse: an assessment of the validity of the reinstatement procedure
Epstein, D., Preston, K., Stewart, J., & Shaham, Y. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0529-6 · Cited by 634 · see citing works
Intense Sweetness Surpasses Cocaine Reward
Lenoir, M., Serre, F., Cantin, L., & Ahmed, S. H. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000698 · Cited by 608 · see citing works
Addiction as a Computational Process Gone Awry
Redish, A. D. (2004) · Science · doi:10.1126/science.1102384 · Cited by 534 · see citing works
Imaging stress‐ and cue‐induced drug and alcohol craving: association with relapse and clinical implications
SINHA, R., & LI, C. ‐. R. (2007) · Drug and Alcohol Review · doi:10.1080/09595230601036960 · Cited by 497 · see citing works
THE FORM OF THE AUTO‐SHAPED RESPONSE WITH FOOD OR WATER REINFORCERS1
Jenkins, H. M., & Moore, B. R. (1973) · Journal of the Experimental Analysis of Behavior · doi:10.1901/jeab.1973.20-163 · Cited by 492 · see citing works
Contemporary Learning Theories: Pavlovian Conditioning and the Status of Traditional Learning Theory
Kehoe, E. J., Klein, S. B., & Mowrer, R. R. (1991) · The American Journal of Psychology · doi:10.2307/1423162 · Cited by 483 · see citing works
Incubation of cocaine craving after withdrawal: a review of preclinical data
Lü, L., Grimm, J. W., Hope, B. T., & Shaham, Y. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.06.027 · Cited by 446 · see citing works
Neurobiological evidence for hedonic allostasis associated with escalating cocaine use
Ahmed, S. H., Kenny, P. J., Koob, G. F., & Markou, A. (2002) · Nature Neuroscience · doi:10.1038/nn872 · Cited by 389 · see citing works
A motivational learning hypothesis of the role of mesolimbic dopamine in compulsive drug use
Chiara, G. D. (1998) · Journal of Psychopharmacology · doi:10.1177/026988119801200108 · Cited by 346 · see citing works
Compulsive drug seeking by rats under punishment: effects of drug taking history
Pelloux, Y., Everitt, B. J., & Dickinson, A. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0805-0 · Cited by 323 · see citing works
Reinstatement of alcohol-seeking by priming injections of alcohol and exposure to stress in rats
Lê, A. D., Quan, B. H., Juzytsch, W., Fletcher, P. J., Joharchi, N., & Shaham, Y. (1998) · Psychopharmacology · doi:10.1007/s002130050498 · Cited by 319 · see citing works
What Can Long‐term Follow‐up Teach us About Relapse and Prevention of Relapse in Addiction?
Vaillant, G. E. (1988) · British Journal of Addiction · doi:10.1111/j.1360-0443.1988.tb03021.x · Cited by 312 · see citing works
Long-lasting increase in the set point for cocaine self-administration after escalation in rats
Ahmed, S. H., & Koob, G. F. (1999) · Psychopharmacology · doi:10.1007/s002130051121 · Cited by 303 · see citing works
Cocaine-but not food-seeking behavior is reinstated by stress after extinction
Ahmed, S. H., & Koob, G. F. (1997) · Psychopharmacology · doi:10.1007/s002130050347 · Cited by 257 · see citing works
Effects of increasing the magnitude of an alternative reinforcer on drug choice in a discrete-trials choice procedure
Nader, M. A., & Woolverton, W. L. (1991) · Psychopharmacology · doi:10.1007/bf02244304 · Cited by 253 · see citing works
Three decision‐making tasks in cocaine‐dependent patients: do they measure the same construct?
Monterosso, J. R., Ehrman, R. N., Napier, K. L., O'Brien, C. P., & Childress, A. R. (2001) · Addiction · doi:10.1046/j.1360-0443.2001.9612182512.x · Cited by 251 · see citing works
Validation crisis in animal models of drug addiction: Beyond non-disordered drug use toward drug addiction
Ahmed, S. H. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.04.005 · Cited by 240 · see citing works
Escalation of methamphetamine self-administration in rats: a dose–effect function
Kitamura, O., Wee, S., Specio, S. E., Koob, G. F., & Pulvirenti, L. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0353-z · Cited by 218 · see citing works
Sugar-dependent rats show enhanced responding for sugar after abstinence: Evidence of a sugar deprivation effect
Avena, N. M., Long, K. A., & Hoebel, B. G. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.12.016 · Cited by 215 · see citing works
Effects of extended access to high versus low cocaine doses on self-administration, cocaine-induced reinstatement and brain mRNA levels in rats
Mantsch, J. R., Yuferov, V. P., Mathieu-Kia, A.-M., Ho, A., & Kreek, M. J. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1778-x · Cited by 214 · see citing works
EFFECTS OF PUNISHMENT INTENSITY DURING VARIABLE‐INTERVAL REINFORCEMENT
Azrin, N. H. (1960) · Journal of the Experimental Analysis of Behavior · doi:10.1901/jeab.1960.3-123 · Cited by 214 · see citing works
Stress reinstates nicotine seeking but not sucrose solution seeking in rats
Buczek, Y., Lê, A. D., Wang, A., Stewart, J., & Shaham, Y. (1999) · Psychopharmacology · doi:10.1007/s002130050992 · Cited by 206 · see citing works
Increased motivation for self-administered cocaine after escalated cocaine intake
Paterson, N. E., & Markou, A. (2003) · Neuroreport · doi:10.1097/00001756-200312020-00019 · Cited by 203 · see citing works
Rapid Assessment of Choice between Cocaine and Food in Rhesus Monkeys: Effects of Environmental Manipulations and Treatment with d-Amphetamine and Flupenthixol
Negus, S. S. (2002) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300096 · Cited by 203 · see citing works
Conditioned reinforcing properties of stimuli paired with self-administered cocaine, heroin or sucrose: implications for the persistence of addictive behaviour
Ciano, P. D., & Everitt, B. J. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.06.005 · Cited by 193 · see citing works
The group II metabotropic glutamate receptor agonist, LY379268, inhibits both cocaine- and food-seeking behavior in rats
Peters, J., & Kalivas, P. W. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0372-9 · Cited by 190 · see citing works
Cocaine Is Low on the Value Ladder of Rats: Possible Evidence for Resilience to Addiction
Cantin, L., Lenoir, M., Augier, E., Vanhille, N., Dubreucq, S., Serre, F., Vouillac‐Mendoza, C., & Ahmed, S. H. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011592 · Cited by 190 · see citing works
Impulsivity predicts the escalation of cocaine self-administration in rats
Anker, J. J., Perry, J. L., Gliddon, L. A., & Carroll, M. E. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.05.013 · Cited by 188 · see citing works
Conditioned Approach and Contact Behavior toward Signals for Food or Brain-Stimulation Reinforcement
Peterson, G. B., Ackilt, J. E., Frommer, G. P., & Hearst, E. S. (1972) · Science · doi:10.1126/science.177.4053.1009 · Cited by 186 · see citing works
Influence of an alternative reinforcer on human cocaine self-administration
Higgins, S. T., Bickel, W. K., & Hughes, J. R. (1994) · Life Sciences · doi:10.1016/0024-3205(94)00878-7 · Cited by 175 · see citing works
The attribution of incentive salience to a stimulus that signals an intravenous injection of cocaine
Uslaner, J. M., Acerbo, M. J., Jones, S., & Robinson, T. E. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.02.001 · Cited by 167 · see citing works
FIXED‐RATIO PUNISHMENT1
Azrin, N. H., Holz, W. C., & Hake, D. F. (1963) · Journal of the Experimental Analysis of Behavior · doi:10.1901/jeab.1963.6-141 · Cited by 163 · see citing works
Self-administered cocaine causes long-lasting increases in impulsive choice in a delay discounting task.
Mendez, I. A., Simon, N. W., Hart, N., Mitchell, M. R., Nation, J. R., Wellman, P. J., & Setlow, B. (2010) · Behavioral Neuroscience · doi:10.1037/a0020458 · Cited by 135 · see citing works
Explaining the Escalation of Drug Use in Substance Dependence: Models and Appropriate Animal Laboratory Tests
Zernig, G., Ahmed, S. H., Cardinal, R. N., Morgan, D., Acquas, E., Foltin, R. W., Vezina, P., Negus, S. S., Crespo, J. A., Stöckl, P., et al. (2007) · Pharmacology · doi:10.1159/000103923 · Cited by 131 · see citing works
CRF1 receptor antagonists attenuate escalated cocaine self-administration in rats
Specio, S. E., Wee, S., O’Dell, L. E., Boutrel, B., Zorrilla, E. P., & Koob, G. F. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0983-9 · Cited by 129 · see citing works
Pavlovian Conditioning with Heat Reinforcement Produces Stimulus-Directed Pecking in Chicks
Wasserman, E. A. (1973) · Science · doi:10.1126/science.181.4102.875 · Cited by 127 · see citing works
Differential control over drug-seeking behavior by drug-associated conditioned reinforcers and discriminative stimuli predictive of drug availability.
Ciano, P. D., & Everitt, B. J. (2003) · Behavioral Neuroscience · doi:10.1037/0735-7044.117.5.952 · Cited by 118 · see citing works
Extended methamphetamine self-administration enhances reinstatement of drug seeking and impairs novel object recognition in rats
Rogers, J. L., Santis, S. D., & See, R. E. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1187-7 · Cited by 118 · see citing works
Stimuli associated with a single cocaine experience elicit long-lasting cocaine-seeking
Ciccocioppo, R., Martin‐Fardon, R., & Weiss, F. (2004) · Nature Neuroscience · doi:10.1038/nn1219 · Cited by 117 · see citing works
The neuropharmacology of relapse to food seeking: Methodology, main findings, and comparison with relapse to drug seeking
Nair, S. G., Adams-Deutsch, T., Epstein, D. H., & Shaham, Y. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.05.003 · Cited by 112 · see citing works
Ketoconazole blocks the stress-induced reinstatement of cocaine-seeking behavior in rats: relationship to the discriminative stimulus effects of cocaine
Mantsch, J. R., & Goeders, N. E. (1999) · Psychopharmacology · doi:10.1007/s002130050905 · Cited by 109 · see citing works
Effects of increasing response requirement on choice between cocaine and food in rhesus monkeys
Nader, M. A., & Woolverton, W. L. (1992) · Psychopharmacology · doi:10.1007/bf02245115 · Cited by 108 · see citing works
P300 Event-Related Potential Amplitude and Impulsivity in Cocaine-Dependent Subjects
Moeller, F. G., Barratt, E. S., Fischer, C. J., Dougherty, D. M., Reilly, E. L., Mathias, C. W., & Swann, A. C. (2004) · Neuropsychobiology · doi:10.1159/000079110 · Cited by 104 · see citing works
Supply of a Nondrug Substitute Reduces Escalated Heroin Consumption
Lenoir, M., & Ahmed, S. H. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301602 · Cited by 96 · see citing works
Demand for cocaine and food over time
Christensen, C. J., Silberberg, A. M., Hursh, S. R., et al. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.07.009 · Cited by 80 · see citing works
Escalation patterns of varying periods of heroin access
Vendruscolo, L. F., Schlosburg, J. E., Misra, K., Chen, S. A., Greenwell, T. N., & Koob, G. F. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.03.004 · Cited by 79 · see citing works
Essential value of cocaine and food in rats: tests of the exponential model of demand
Christensen, C. J., Silberberg, A. M., Hursh, S. R., Huntsberry, M. E., & Riley, A. L. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1120-0 · Cited by 75 · see citing works
Trait impulsivity predicts escalation of sucrose seeking and hypersensitivity to sucrose-associated stimuli.
Diergaarde, L., Pattij, T., Nawijn, L., Schoffelmeer, A. N. M., & Vries, T. J. D. (2009) · Behavioral Neuroscience · doi:10.1037/a0016504 · Cited by 72 · see citing works
Effects of antipsychotic compounds in rhesus monkeys given a choice between cocaine and food
Woolverton, W. L., & Balster, R. L. (1981) · Drug and Alcohol Dependence · doi:10.1016/0376-8716(81)90088-0 · Cited by 64 · see citing works
Attenuated incubation of cocaine seeking in male rats trained to self-administer cocaine during periadolescence
Li, C., & Frantz, K. J. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1502-y · Cited by 63 · see citing works
The Influence of Subthalamic Nucleus Lesions on Sign-Tracking to Stimuli Paired with Food and Drug Rewards: Facilitation of Incentive Salience Attribution?
Uslaner, J. M., Dell’Orco, J., Pevzner, A., & Robinson, T. E. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301653 · Cited by 61 · see citing works
The generalized matching law as a predictor of choice between cocaine and food in rhesus monkeys
Anderson, K. G., Velkey, A. J., & Woolverton, W. L. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1012-7 · Cited by 59 · see citing works
Incentive-sensitization and drug ?wanting?
Robinson, T. E., & Berridge, K. C. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1602-z · Cited by 58 · see citing works
Do vertical shifts in dose-response rate-relationships in operant conditioning procedures indicate ?sensitization? to ?drug wanting??
Zernig, G., Wakonigg, G., Madlung, E., et al. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1601-0 · Cited by 56 · see citing works
Effects of delay to reinforcement on the choice between cocaine and food in rhesus monkeys
Woolverton, W. L., & Anderso, K. G. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0355-x · Cited by 53 · see citing works
Contingent access to stimuli associated with cocaine self-administration is required for reinstatement of drug-seeking behavior
Grimm, J. W., Kruzich, P. J., & See, R. E. (2000) · Psychobiology · doi:10.3758/bf03331995 · Cited by 50 · see citing works
Sign-tracking (autoshaping) in rats: A comparison of cocaine and food as unconditioned stimuli
Kearns, D. N., & Weiss, S. J. (2004) · Learning & Behavior · doi:10.3758/bf03196042 · Cited by 50 · see citing works
Measures of cocaine-seeking behavior using a multiple schedule of food and drug self-administration in rats
Weissenborn, R. (1995) · Drug and Alcohol Dependence · doi:10.1016/0376-8716(95)01107-a · Cited by 47 · see citing works
Behavioral effects of chronic oral administration of levo -alpha-acetylmethadol in the rat
Aigner, T. G., & Balster, R. L. (1978) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(78)90393-3 · Cited by 43 · see citing works
One hour, but not six hours, of daily access to self-administered cocaine results in elevated levels of the dopamine transporter
Ben‐Shahar, O., Moscarello, J. M., & Ettenberg, A. (2006) · Brain Research · doi:10.1016/j.brainres.2006.04.002 · Cited by 43 · see citing works
Demand for food and cocaine in Fischer and Lewis rats.
Christensen, C. J., Kohut, S. J., Handler, S. L., Silberberg, A. M., & Riley, A. L. (2009) · Behavioral Neuroscience · doi:10.1037/a0013736 · Cited by 42 · see citing works
Escalation of food-maintained responding and sensitivity to the locomotor stimulant effects of cocaine in mice
Goeders, J. E., Murnane, K. S., Banks, M. L., & Fantegrossi, W. E. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.04.008 · Cited by 35 · see citing works
Monetary alternative reinforcers more effectively decrease intranasal cocaine choice than food alternative reinforcers
Stoops, W. W., Lile, J. A., & Rush, C. R. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.01.003 · Cited by 33 · see citing works
Differential effects of allopregnanolone on the escalation of cocaine self-administration and sucrose intake in female rats
Anker, J. J., Zlebnik, N. E., & Carroll, M. E. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1968-7 · Cited by 32 · see citing works
Wheel access duration in rats: II. Day-night and within-session changes.
Eikelboom, R., & Lattanzio, S. B. (2003) · Behavioral Neuroscience · doi:10.1037/0735-7044.117.4.825 · Cited by 30 · see citing works
Interaction of Extinguished Cocaine-Conditioned Stimuli and Footshock on Reinstatement in Rats
Shelton, K. L., & Beardsley, P. M. (2005) · International Journal of Comparative Psychology · doi:10.46867/ijcp.2005.18.02.02 · Cited by 30 · see citing works
Conditioned suppression of behavior maintained by cocaine self-administration
Kearns, D. N., Weiss, S. J., & Panlilio, L. V. (2002) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(01)00167-3 · Cited by 26 · see citing works
Comparison of plasma cocaine levels during a "binge" pattern of cocaine administration in male and female rhesus monkeys
Mello, N. K., Bowen, C. A., & Mendelson, J. H. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1188-x · Cited by 21 · see citing works
Motivational properties of conditioned suppression
Millenson, J. R., & de Villiers, P. A. (1972) · Learning and Motivation · doi:10.1016/0023-9690(72)90033-1 · Cited by 21 · see citing works
Time-dependent increases in cue-induced reinstatement of sucrose seeking after sucrose self-administration in adolescence
Li, C., & Frantz, K. J. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.04.011 · Cited by 17 · see citing works
The utility of ?tolerance? as a concept in the study of drug self-administration
Negus, S. S., Mello, N. K., & Caine, S. B. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1606-8 · Cited by 8 · see citing works
What juxtaposition, tradition and parsimony can do to vertical shifts in drug self-administration dose?response functions
Piazza, P. V., & Deroche, V. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1604-x · Cited by 6 · see citing works

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Obesity and addiction: Neurobiological overlaps
Volkow, N. D., Wang, G. ‐., Tomasi, D., & Baler, R. D. (2013) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.01031.x · Cited by 800 · see citing works
The Addictive Dimensionality of Obesity
Volkow, N. D., Wang, G.-J., Tomasi, D., & Baler, R. D. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.12.020 · Cited by 380 · see citing works

Authors: N. Kearns, D., A. Gomez-Serrano, M., & J. Tunstall, B.
Venue: Current Drug Abuse Reviewse
Publisher: Bentham Science Publishers Ltd.
Published: 2011-12-01
Volume: 4
Issue: 4
Pages: 261-269
ISSN: 1874-4737 (ISSN-L)
DOI: 10.2174/1874473711104040261
PMC: PMC3717264
OpenAlex: W2020978729
Cited by: 22
References: 92
Citations by year: 2025: 1 · 2023: 1 · 2022: 1 · 2019: 2 · 2018: 2 · 2017: 4 · 2015: 1 · 2014: 4 · 2013: 3 · 2012: 3
FWCI: 1.31
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Current Drug Abuse Reviews (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Drug Abuse (R01DA008651)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: food reinforcement, drug-seeking behavior, drug cues, food cues, stress, abstinence, addiction
MeSH terms: Animals, Behavior, Animal, Cues, Disease Models, Animal, Drug Evaluation, Preclinical, Humans, Reinforcement, Psychology, Self Administration, Substance-Related Disorders

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A Review of Preclinical Research Demonstrating that Drug and Non-Drug ReinforcersDifferentially Affect Behavior

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