The neuropharmacology of relapse to food seeking: Methodology, main findings, and comparison with relapse to drug seeking

Nair, Sunila G.; Adams-Deutsch, Tristan; Epstein, David H.; Shaham, Yavin

doi:10.1016/j.pneurobio.2009.05.003

Cited by 112Neurotransmitter Receptor Influence on BehaviorEating Disorders and BehaviorsRegulation of Appetite and Obesity

The neuropharmacology of relapse to food seeking: Methodology, main findings, and comparison with relapse to drug seeking

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Nair, Sunila G., Adams-Deutsch, Tristan, Epstein, David H., Shaham, Yavin·2009·Progress in Neurobiology

DOI 10.1016/j.pneurobio.2009.05.003PMC PMC2745723

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Abstract

Relapse to old, unhealthy eating habits is a major problem in human dietary treatments. The mechanisms underlying this relapse are unknown. Surprisingly, until recently this clinical problem has not been systematically studied in animal models. Here, we review results from recent studies in which a reinstatement model (commonly used to study relapse to abused drugs) was employed to characterize the effect of pharmacological agents on relapse to food seeking induced by either food priming (non-contingent exposure to small amounts of food), cues previously associated with food, or injections of the pharmacological stressor yohimbine. We also address methodological issues related to the use of the reinstatement model to study relapse to food seeking, similarities and differences in mechanisms underlying reinstatement of food seeking versus drug seeking, and the degree to which the reinstatement procedure provides a suitable model for studying relapse in humans. We conclude by discussing implications for medication development and future research. We offer three tentative conclusions: (1)The neuronal mechanisms of food-priming- and cue-induced reinstatement are likely different from those of reinstatement induced by the pharmacological stressor yohimbine. (2)The neuronal mechanisms of reinstatement of food seeking are possibly different from those of ongoing food-reinforced operant responding. (3)The neuronal mechanisms underlying reinstatement of food seeking overlap to some degree with those of reinstatement of drug seeking.

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Animal models show that after extinction, drug or food consumption behavior can be triggered by cue, reward, or stressor.
“Animal models of both food and drug reward have shown that after extinction, the behavior for drug or food consumption can be triggered either by exposure to the cue, the reward, or a stressor (34).”
From The Addictive Dimensionality of Obesity (2013) · cites this paper as [34]

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Science and Human Behavior
Kilzer, E., & Skinner, B. F. (1953) · The American Catholic Sociological Review · doi:10.2307/3707860 · Cited by 8,934 · see citing works
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,501 · see citing works
The neural basis of drug craving: An incentive-sensitization theory of addiction
Robinson, T. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90013-p · Cited by 7,346 · see citing works
Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80949-6 · Cited by 5,501 · see citing works
Leptin and the regulation of body weight in mammals
Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405 · see citing works
The Stress of Life
Selye, H. (1956) · Medical Entomology and Zoology · Cited by 5,224 · see citing works
The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity
de Lecea, L., Kilduff, T. S., Peyron, C., Gao, X.-B., Foye, P. E., Danielson, P. E., Fukuhara, C., Battenberg, E. L. F., Gautvik, V. T., Bartlett, F. S., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.322 · Cited by 3,878 · see citing works
Dopamine, learning and motivation.
Wise, R. A. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1406 · Cited by 3,379 · see citing works
Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun.
Morgan, J., & Curran, T. (1991) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.14.030191.002225 · Cited by 2,689 · see citing works
The Concepts of Stress and Stress System Disorders: Overview of Physical and Behavioral Homeostasis
Chrousos, G. P. (1992) · JAMA · doi:10.1001/jama.1992.03480090092034 · Cited by 2,689 · see citing works
Gut hormone PYY3-36 physiologically inhibits food intake
Batterham, R. L., Cowley, M. A., Small, C. J., Herzog, H., Cohen, M. A., Dakin, C. L., Wren, A. M., Brynes, A. E., Low, M. J., Ghatei, M. A., et al. (2002) · Nature · doi:10.1038/nature00887 · Cited by 2,351 · see citing works
Dopamine transmission in the initiation and expression of drug- and stress-induced sensitization of motor activity
Kalivas, P. W., & Stewart, J. (1991) · Brain Research Reviews · doi:10.1016/0165-0173(91)90007-u · Cited by 2,021 · see citing works
Transposable elements: targets for early nutritional effects on epigenetic gene regulation
Waterland, R. A., & Jirtle, R. L. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.15.5293-5300.2003 · Cited by 2,019 · see citing works
Brain Dopamine and Reward
Wise, R. A., & Rompre, P.-P. (1989) · Annual Review of Psychology · doi:10.1146/annurev.ps.40.020189.001203 · Cited by 1,968 · see citing works
Long-term weight loss maintenance
Wing, R. R., & Phelan, S. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.1.222s · Cited by 1,941 · see citing works
Molecular basis of long-term plasticity underlying addiction
Nestler, E. J. (2001) · Nature reviews. Neuroscience · doi:10.1038/35053570 · Cited by 1,857 · see citing works
Meta‐analysis of cue‐reactivity in addiction research
Carter, B. L., & Tiffany, S. T. (1999) · Addiction · doi:10.1046/j.1360-0443.1999.9433273.x · Cited by 1,638 · see citing works
Relationship between stress, eating behavior, and obesity
Torres, S. J., & Nowson, C. A. (2007) · Nutrition · doi:10.1016/j.nut.2007.08.008 · Cited by 1,622 · see citing works
The reinstatement model of drug relapse: history, methodology and major findings
Shaham, Y., Shalev, U., Lu, L., de Wit, H., & Stewart, J. (2003) · Psychopharmacology · doi:10.1007/s00213-002-1224-x · Cited by 1,615 · see citing works
Self-citation
The Epidemiology of Obesity
Ogden, C. L., Yanovski, S. Z., Carroll, M. D., & Flegal, K. M. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.052 · Cited by 1,561 · see citing works
How does stress increase risk of drug abuse and relapse?
Sinha, R. (2001) · Psychopharmacology · doi:10.1007/s002130100917 · Cited by 1,505 · see citing works
Epigenetic inheritance at the agouti locus in the mouse
Morgan, H. D., Sutherland, H. G. E., Martin, D. I. K., & Whitelaw, E. (1999) · Nature Genetics · doi:10.1038/15490 · Cited by 1,476 · see citing works
The Neuroscience of Natural Rewards: Relevance to Addictive Drugs
Kelley, A. E., & Berridge, K. C. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03306.2002 · Cited by 1,465 · see citing works
Chronic stress and obesity: a new view of “comfort food”
Dallman, M. F., Pecoraro, N., Akana, S. F., la Fleur, S. E., Gomez, F., Houshyar, H., Bell, M. E., Bhatnagar, S., Laugero, K. D., & Manalo, S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1934666100 · Cited by 1,369 · see citing works
Evidence for sugar addiction: Behavioral and neurochemical effects of intermittent, excessive sugar intake
Avena, N. M., Rada, P., & Hoebel, B. G. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.04.019 · Cited by 1,358 · see citing works
A role for melanin-concentrating hormone in the central regulation of feeding behaviour
Qu, D., Ludwig, D. S., Gammeltoft, S., Piper, M., Pelleymounter, M. A., Cullen, M. J., Mathes, W. F., Przypek, J., Kanarek, R. B., & Maratos–Flier, E. (1996) · Nature · doi:10.1038/380243a0 · Cited by 1,320 · see citing works
A role for lateral hypothalamic orexin neurons in reward seeking
Harris, G. C., Wimmer, M., & Aston-Jones, G. (2005) · Nature · doi:10.1038/nature04071 · Cited by 1,311 · see citing works
Measuring reward with the conditioned place preference paradigm: a comprehensive review of drug effects, recent progress and new issues
Tzschentke, T. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00060-4 · Cited by 1,254 · see citing works
The Need to Feed
Saper, C. B., Chou, T. C., & Elmquist, J. K. (2002) · Neuron · doi:10.1016/s0896-6273(02)00969-8 · Cited by 1,120 · see citing works
How can drug addiction help us understand obesity?
Volkow, N. D., & Wise, R. A. (2005) · Nature Neuroscience · doi:10.1038/nn1452 · Cited by 1,089 · see citing works
Role of unconditioned and conditioned drug effects in the self-administration of opiates and stimulants.
Stewart, J., de Wit, H., & Eikelboom, R. (1984) · Psychological Review · doi:10.1037//0033-295x.91.2.251 · Cited by 1,064 · see citing works
Role of unconditioned and conditioned drug effects in the self-administration of opiates and stimulants.
Stewart, J., de Wit, H., & Eikelboom, R. (1984) · Psychological Review · doi:10.1037/0033-295x.91.2.251 · Cited by 1,062 · see citing works
TASTE PREFERENCES AND FOOD INTAKE
Drewnowski, A. (1997) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.17.1.237 · Cited by 1,045 · see citing works
Dopamine receptor pharmacology
Seeman, P. M., & Tol, H. H. M. V. (1994) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(94)90323-9 · Cited by 969 · see citing works
Ventral striatal control of appetitive motivation: role in ingestive behavior and reward-related learning
Kelley, A. E. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2003.11.015 · Cited by 942 · see citing works
Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin
Rothman, R. B., Baumann, M. H., Dersch, C. M., Romero, D. V., Rice, K. C., Carroll, F. I., & Partilla, J. S. (2000) · Synapse · doi:10.1002/1098-2396(20010101)39:1 · Cited by 934 · see citing works
Reinstatement of cocaine-reinforced responding in the rat
de Wit, H., & Stewart, J. (1981) · Psychopharmacology · doi:10.1007/bf00432175 · Cited by 928 · see citing works
Patient compliance with paper and electronic diaries
Stone, A. A., Shiffman, S., Schwartz, J. E., Broderick, J. E., & Hufford, M. R. (2003) · Controlled Clinical Trials · doi:10.1016/s0197-2456(02)00320-3 · Cited by 910 · see citing works
The circuitry mediating cocaine-induced reinstatement of drug-seeking behavior
McFarland, K., & Kalivas, P. W. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-21-08655.2001 · Cited by 905 · see citing works
Leptin Receptor Signaling in Midbrain Dopamine Neurons Regulates Feeding
Hommel, J. D., Trinko, R., Sears, R. M., Georgescu, D., Liu, Z.-W., Gao, X.-B., Thurmon, J. J., Marinelli, M., & DiLeone, R. J. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.023 · Cited by 902 · see citing works
Neurobiology of relapse to heroin and cocaine seeking: a review
Shalev, U., Grimm, J. W., & Shaham, Y. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.1.1 · Cited by 880 · see citing works
Self-citation
Anxiety, restraint, and eating behavior.
Herman, C. P., & Polivy, J. (1975) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.84.6.666 · Cited by 860 · see citing works
The role of dopamine in locomotor activity and learning
Beninger, R. J. (1983) · Brain Research Reviews · doi:10.1016/0165-0173(83)90038-3 · Cited by 848 · see citing works
Contextual control of the extinction of conditioned fear
Bouton, M. E., & Bolles, R. C. (1979) · Learning and Motivation · doi:10.1016/0023-9690(79)90057-2 · Cited by 796 · see citing works
Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving
Conrad, K. L., Tseng, K. Y., Uejima, J. L., Reimers, J. M., Heng, L.-J., Shaham, Y., Marinelli, M., & Wolf, M. E. (2008) · Nature · doi:10.1038/nature06995 · Cited by 790 · see citing works
Self-citation
Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse
Baker, D. L., McFarland, K., LAKE, R. W., Shen, H., Tang, X., Toda, S., & Kalivas, P. W. (2003) · Nature Neuroscience · doi:10.1038/nn1069 · Cited by 740 · see citing works
Stress-induced relapse to heroin and cocaine seeking in rats: a review
Shaham, Y., Erb, S. M., & Stewart, J. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00024-2 · Cited by 703 · see citing works
Self-citation
Unveiling the Functions of Presynaptic Metabotropic Glutamate Receptors in the Central Nervous System
Schoepp, D. D. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29296-x · Cited by 693 · see citing works
Perceived Effects of Stress on Food Choice
Oliver, G. D., & WARDLE, J. (1999) · Physiology & Behavior · doi:10.1016/s0031-9384(98)00322-9 · Cited by 684 · see citing works
Role of dopamine in the behavioural actions of nicotine related to addiction
Chiara, G. D. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00122-9 · Cited by 680 · see citing works
The role of stress in drug self-administration
Piazza, P. V., & Moal, M. L. (1998) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(97)01115-2 · Cited by 674 · see citing works
Isolation of two novel candidate hormones using a chemical method for finding naturally occurring polypeptides
Tatemoto, K., & Mutt, V. (1980) · Nature · doi:10.1038/285417a0 · Cited by 663 · see citing works
II. New evidence for a locus coeruleus-norepinephrine connection with anxiety
Redmond, D. E., & Huang, Y. H. (1979) · Life Sciences · doi:10.1016/0024-3205(79)90087-0 · Cited by 662 · see citing works
Dynamics of Drug Dependence
Wikler, A. (1973) · Archives of General Psychiatry · doi:10.1001/archpsyc.1973.01750350005001 · Cited by 650 · see citing works
Toward a model of drug relapse: an assessment of the validity of the reinstatement procedure
Epstein, D., Preston, K., Stewart, J., & Shaham, Y. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0529-6 · Cited by 634 · see citing works
Self-citation
Brain circuitry and the reinstatement of cocaine-seeking behavior
Kalivas, P., & McFarland, K. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1393-2 · Cited by 613 · see citing works
A motivational view of learning, performance, and behavior modification.
Bindra, D. (1974) · Psychology Review · doi:10.1037/h0036330 · Cited by 580 · see citing works
Promotion of sleep by targeting the orexin system in rats, dogs and humans
Roch, C., Dingemanse, J., Koberstein, R., Hoever, P., Aissaoui, H., Flores, S., Mueller, C., Nayler, O., van Gerven, J., de Haas, S. L., et al. (2007) · Nature Medicine · doi:10.1038/nm1544 · Cited by 578 · see citing works
Noradrenergic mechanisms in stress and anxiety: I. preclinical studies
Bremner, J., Krystal, J., Southwick, S., & Charney, D. (1996) · Synapse · doi:10.1002/(sici)1098-2396(199605)23:1 · Cited by 571 · see citing works
Obesity and Eating
Schachter, S. (1968) · Science · doi:10.1126/science.161.3843.751 · Cited by 561 · see citing works
Glutamate Transmission in the Nucleus Accumbens Mediates Relapse in Cocaine Addiction
Cornish, J. L., & Kalivas, P. W. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-15-j0006.2000 · Cited by 546 · see citing works
Evidence That Intermittent, Excessive Sugar Intake Causes Endogenous Opioid Dependence
Colantuoni, C., Rada, P. V., McCarthy, J., Patten, C. S., Avena, N. M., Chadeayne, A., & Hoebel, B. G. (2002) · Obesity Research · doi:10.1038/oby.2002.66 · Cited by 544 · see citing works
A Historical View of the Stress Field
Mason, J. W. (1975) · Journal of Human Stress · doi:10.1080/0097840x.1975.9940399 · Cited by 532 · see citing works
Behavior, Health, and Environmental Stress
Cohen, S., Evans, G. W., Stokols, D., & Krantz, D. S. (1986) · Springer eBooks · doi:10.1007/978-1-4757-9380-2 · Cited by 521 · see citing works
Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior
Boutrel, B., Kenny, P. J., Specio, S. E., Martin-Fardon, R., Markou, A., Koob, G. F., & de Lecea, L. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507480102 · Cited by 520 · see citing works
The Role of the Dorsomedial Prefrontal Cortex, Basolateral Amygdala, and Dorsal Hippocampus in Contextual Reinstatement of Cocaine Seeking in Rats
Fuchs, R. A., Evans, K. A., Ledford, C. C., Parker, M. P., Case, J. M., Mehta, R. H., & See, R. E. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300579 · Cited by 517 · see citing works
Neuroplasticity in the mesolimbic dopamine system and cocaine addiction
Thomas, M. J., Kalivas, P. W., & Shaham, Y. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.77 · Cited by 513 · see citing works
Self-citation
The antipsychotic aripiprazole is a potent, partial agonist at the human 5-HT1A receptor
Jordan, S., Koprivica, V., Chen, R., Tottori, K., Kikuchi, T., & Altar, C. A. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01532-7 · Cited by 512 · see citing works
Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist
Borowsky, B., Durkin, M. M., Ogozalek, K. L., Marzabadi, M. R., DeLeon, J., Heurich, R. O., Lichtblau, H., Shaposhnik, Z., Daniewska, I., Blackburn, T. P., et al. (2002) · Nature Medicine · doi:10.1038/nm741 · Cited by 506 · see citing works
Context-induced relapse to drug seeking: a review
Crombag, H. S., Bossert, J. M., Koya, E., & Shaham, Y. (2008) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2008.0090 · Cited by 498 · see citing works
Self-citation
Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1
Chambers, J. K., Ames, R. S., Bergsma, D. J., Muir, A. I., Fitzgerald, L. R., Hervieu, G. J., Dytko, G. M., Foley, J. J., Martin, J., Liu, W., et al. (1999) · Nature · doi:10.1038/22313 · Cited by 495 · see citing works
Opposite Modulation of Cocaine-Seeking Behavior by D <sub>1</sub> - and D <sub>2</sub> -Like Dopamine Receptor Agonists
Self, D. W., Barnhart, W. J., Lehman, D. A., & Nestler, E. J. (1996) · Science · doi:10.1126/science.271.5255.1586 · Cited by 492 · see citing works
PYY modulation of cortical and hypothalamic brain areas predicts feeding behaviour in humans
Batterham, R. L., Ffytche, D. H., Rosenthal, J., Zelaya, F. O., Barker, G. J., Withers, D. J., & Williams, S. (2007) · Nature · doi:10.1038/nature06212 · Cited by 474 · see citing works
Excessive sugar intake alters binding to dopamine and mu-opioid receptors in the brain
Colantuoni, C., Schwenker, J., McCarthy, J., Rada, P., Ladenheim, B., Cadet, J.-L., Schwartz, G. J., Moran, T. H., & Hoebel, B. G. (2001) · Neuroreport · doi:10.1097/00001756-200111160-00035 · Cited by 471 · see citing works
Incubation of cocaine craving after withdrawal: a review of preclinical data
Lü, L., Grimm, J. W., Hope, B. T., & Shaham, Y. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.06.027 · Cited by 446 · see citing works
Self-citation
Haloperidol and nucleus accumbens dopamine depletion suppress lever pressing for food but increase free food consumption in a novel food choice procedure
Salamone, J. D., Steinpreis, R. E., McCullough, L. D., Smith, P., Grebel, D., & Mahan, K. (1991) · Psychopharmacology · doi:10.1007/bf02245659 · Cited by 436 · see citing works
A cannabinoid mechanism in relapse to cocaine seeking
Vries, T. J. D., Shaham, Y., Homberg, J. R., Crombag, H. S., Schuurman, K. G., Dieben, J., Vanderschuren, L. J. M. J., & Schoffelmeer, A. N. M. (2001) · Nature Medicine · doi:10.1038/nm1001-1151 · Cited by 433 · see citing works
Self-citation
Maintenance and relapse after weight loss in women: behavioral aspects
Kayman, S., Bruvold, W. H., & Stern, J. (1990) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/52.5.800 · Cited by 433 · see citing works
α 2 -Adrenoceptor-Mediated Hyperpolarization of Locus Coeruleus Neurons: Intracellular Studies in Vivo
Aghajanian, G. K., & VanderMaelen, C. P. (1982) · Science · doi:10.1126/science.6278591 · Cited by 431 · see citing works
The neurocircuitry of addiction: an overview
Feltenstein, M. W., & See, R. E. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.51 · Cited by 421 · see citing works
Control of cocaine-seeking behavior by drug-associated stimuli in rats: Effects on recovery of extinguished operant-responding and extracellular dopamine levels in amygdala and nucleus accumbens
Weiss, F., Maldonado-Vlaar, C. S., Parsons, L. H., Kerr, T. M., Smith, D. L., & Ben‐Shahar, O. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.8.4321 · Cited by 416 · see citing works
A role for the prefrontal cortex in stress- and cocaine-induced reinstatement of cocaine seeking in rats
Capriles, N., Rodaros, D., Sorge, R. E., & Stewart, J. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1283-z · Cited by 414 · see citing works
STRESSES AND STRAINS OF HOMEOSTASIS
Cannon, W. B. (1935) · The American Journal of the Medical Sciences · doi:10.1097/00000441-193501000-00001 · Cited by 412 · see citing works
What predicts weight regain in a group of successful weight losers?
McGuire, M. T., Wing, R. R., Klem, M. L., Lang, W., & Hill, J. O. (1999) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.67.2.177 · Cited by 412 · see citing works
Neurobiology of craving, conditioned reward and relapse
Weiss, F. (2005) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2004.11.001 · Cited by 411 · see citing works
Stress reinstates cocaine-seeking behavior after prolonged extinction and a drug-free period
Erb, S. M., Shaham, Y., & Stewart, J. (1996) · Psychopharmacology · doi:10.1007/s002130050150 · Cited by 406 · see citing works
Self-citation
Concomitant characterization of behavioral and striatal neurotransmitter response to amphetamine using in vivo microdialysis
Kuczenski, R. T., & Segal, D. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-06-02051.1989 · Cited by 398 · see citing works
3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]- pyridine: A Potent and Highly Selective Metabotropic Glutamate Subtype 5 Receptor Antagonist with Anxiolytic Activity
Cosford, N. D. P., Tehrani, L. R., Roppe, J. R., Schweiger, E. J., Smith, N. D., Anderson, J., Bristow, L. J., Brodkin, J. D., Jiang, X., McDonald, I. A., et al. (2002) · Journal of Medicinal Chemistry · doi:10.1021/jm025570j · Cited by 397 · see citing works
The orexin system regulates alcohol-seeking in rats
Lawrence, A. J., Cowen, M. S., Yang, H., Chen, F., & Oldfield, B. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706789 · Cited by 392 · see citing works
Selective inactivation of the dorsomedial prefrontal cortex and the basolateral amygdala attenuates conditioned-cued reinstatement of extinguished cocaine-seeking behavior in rats
McLaughlin, J., & See, R. E. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1196-x · Cited by 392 · see citing works
Expression of the melanin‐concentrating hormone (MCH) receptor mRNA in the rat brain
Saito, Y., Cheng, M., Leslie, F. M., & Civelli, O. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1191 · Cited by 381 · see citing works
Renewal of drug seeking by contextual cues after prolonged extinction in rats.
Crombag, H. S., & Shaham, Y. (2002) · Behavioral Neuroscience · doi:10.1037/0735-7044.116.1.169 · Cited by 380 · see citing works
Self-citation
Long-term follow-up of behavioral treatment for obesity: patterns of weight regain among men and women.
Kramer, F. M., Jeffery, R. W., Forster, J. L., & Snell, M. K. (1989) · PubMed · Cited by 378 · see citing works
Fos: An immediate‐early transcription factor in neurons
Curran, T., & Morgan, J. I. (1995) · Journal of Neurobiology · doi:10.1002/neu.480260312 · Cited by 377 · see citing works
Cocaine-induced cocaine craving
Jaffe, J. H., Cascella, N. G., Kumor, K. M., & Sherer, M. A. (1989) · Psychopharmacology · doi:10.1007/bf00443414 · Cited by 373 · see citing works
Cocaine Experience Establishes Control of Midbrain Glutamate and Dopamine by Corticotropin-Releasing Factor: A Role in Stress-Induced Relapse to Drug Seeking
Wang, B., Shaham, Y., Zitzman, D., Azari, S., Wise, R. A., & You, Z.-B. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0955-05.2005 · Cited by 369 · see citing works
Self-citation
Chapter 19 The determinants of stress-induced activation of the prefrontal cortical dopamine system
(1991) · Progress in Brain Research · doi:10.1016/s0079-6123(08)62691-6 · Cited by 364 · see citing works
Pathways to relapse: the neurobiology of drug- and stress-induced relapse to drug-taking.
Stewart, J. (2000) · PubMed Central · Cited by 361 · see citing works
Stress reinstates heroin-seeking in drug-free animals: An effect mimicking heroin, not withdrawal
Shaham, Y., & Stewart, J. (1995) · Psychopharmacology · doi:10.1007/bf02246300 · Cited by 361 · see citing works
Self-citation
Sources of relapse after extinction in Pavlovian and instrumental learning
Bouton, M. E., & Swartzentruber, D. (1991) · Clinical Psychology Review · doi:10.1016/0272-7358(91)90091-8 · Cited by 349 · see citing works
Yohimbine induced anxiety and increased noradrenergic function in humans: Effects of diazepam and clonidine
Charney, D. S., Heninger, G. R., & Redmond, D. E. (1983) · Life Sciences · doi:10.1016/0024-3205(83)90707-5 · Cited by 348 · see citing works
A Role for the Bed Nucleus of the Stria Terminalis, But Not the Amygdala, in the Effects of Corticotropin-Releasing Factor on Stress-Induced Reinstatement of Cocaine Seeking
Erb, S. M., & Stewart, J. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-20-j0006.1999 · Cited by 347 · see citing works
Characterization of hippocampal norepinephrine release as measured by microdialysis perfusion: pharmacological and behavioral studies.
Abercrombie, E., Keller, R., & Zigmond, M. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90192-3 · Cited by 342 · see citing works
Drug‐induced reinstatement of heroin‐ and cocaine‐seeking behaviour following long‐term extinction is associated with expression of behavioural sensitization
Vries, T. J. D., Schoffelmeer, A. N. M., Binnekade, R., Mulder, A. H., & Vanderschuren, L. J. M. J. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00368.x · Cited by 332 · see citing works
The Role of Corticotropin-Releasing Factor and Corticosterone in Stress- and Cocaine-Induced Relapse to Cocaine Seeking in Rats
Erb, S. M., Shaham, Y., & Stewart, J. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-14-05529.1998 · Cited by 329 · see citing works
Self-citation
Involvement of cAMP-dependent protein kinase in the nucleus accumbens in cocaine self-administration and relapse of cocaine-seeking behavior
Self, D. W., Genova, L. M., Hope, B. T., Barnhart, W. J., Spencer, J. J., & Nestler, E. J. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-05-01848.1998 · Cited by 325 · see citing works
Cocaine-induced conditioned place preference: reinstatement by priming injections of cocaine after extinction
Mueller, D. T., & Stewart, J. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00239-4 · Cited by 324 · see citing works
Extinction-induced upregulation in AMPA receptors reduces cocaine-seeking behaviour
Sutton, M. A., Schmidt, E. F., Choi, K.-H., Schad, C. A., Whisler, K., Simmons, D. L., Karanian, D. A., Monteggia, L. M., Neve, R. L., & Self, D. W. (2003) · Nature · doi:10.1038/nature01249 · Cited by 322 · see citing works
"Craving" and Relapse to Drink
Ludwig, A. M., & Wikler, A. (1974) · Quarterly Journal of Studies on Alcohol · doi:10.15288/qjsa.1974.35.108 · Cited by 322 · see citing works
Reinstatement of alcohol-seeking by priming injections of alcohol and exposure to stress in rats
Lê, A. D., Quan, B. H., Juzytsch, W., Fletcher, P. J., Joharchi, N., & Shaham, Y. (1998) · Psychopharmacology · doi:10.1007/s002130050498 · Cited by 319 · see citing works
Self-citation
Weight maintenance and relapse in obesity: a qualitative study
Byrne, S., Cooper, Z., & Fairburn, C. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802305 · Cited by 318 · see citing works
Physiology: Does gut hormone PYY3–36 decrease food intake in rodents?
Tschöp, M., Castañeda, T. R., Joost, H., Thöne-Reineke, C., Ortmann, S., Klaus, S., Hagan, M. M., Chandler, P. C., Oswald, K., Benoit, S. C., et al. (2004) · Nature · doi:10.1038/nature02665 · Cited by 311 · see citing works
The role of corticotrophin-releasing factor in stress-induced relapse to alcohol-seeking behavior in rats
Lê, A. D., Harding, S. E., Juzytsch, W., Watchus, J., Shalev, U., & Shaham, Y. (2000) · Psychopharmacology · doi:10.1007/s002130000411 · Cited by 310 · see citing works
Self-citation
Cocaine Administered into the Medial Prefrontal Cortex Reinstates Cocaine-Seeking Behavior by Increasing AMPA Receptor-Mediated Glutamate Transmission in the Nucleus Accumbens
Park, W.-K., Bari, A., Jey, A. R., Anderson, S. M., Spealman, R. D., Rowlett, J. K., & Pierce, R. C. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02916.2002 · Cited by 310 · see citing works
Corticotropin-Releasing Factor, But Not Corticosterone, Is Involved in Stress-Induced Relapse to Heroin-Seeking in Rats
Shaham, Y., Funk, D., Erb, S., Brown, T. J., Walker, C.-D., & Stewart, J. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-07-02605.1997 · Cited by 308 · see citing works
Self-citation
Second-order schedules of drug reinforcement in rats and monkeys: measurement of reinforcing efficacy and drug-seeking behaviour
Everitt, B. J., & Robbins, T. W. (2000) · Psychopharmacology · doi:10.1007/s002130000566 · Cited by 306 · see citing works
Excitotoxic lesions of the basolateral amygdala impair the acquisition of cocaine-seeking behaviour under a second-order schedule of reinforcement.
Whitelaw, R. B., Markou, A., Robbins, T. W., & Everitt, B. J. (1996) · PubMed · Cited by 306 · see citing works
Autonomic and psychic effects of yohimbine hydrochloride
Holmberg, G., & Gershon, S. (1961) · Psychopharmacology · doi:10.1007/bf00592678 · Cited by 303 · see citing works
Real-Time Electronic Diary Reports of Cue Exposure and Mood in the Hours Before Cocaine and Heroin Craving and Use
Epstein, D. H., Willner‐Reid, J., Vahabzadeh, M., Mezghanni, M., Lin, J., & Preston, K. L. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2008.509 · Cited by 301 · see citing works
Self-citation
Psychosocial Factors in Athletic Injuries: Development and Application of the Social and Athletic Readjustment Rating Scale (SARRS)
Bramwell, S. T., Masuda, M., Wagner, N. N., & Holmes, T. H. (1975) · Journal of Human Stress · doi:10.1080/0097840x.1975.9940404 · Cited by 297 · see citing works
The anxiogenic drug yohimbine reinstates methamphetamine seeking in a rat model of drug relapse
Shepard, J. D., Bossert, J. M., Liu, S. Y., & Shaham, Y. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.02.032 · Cited by 295 · see citing works
Self-citation
CaMKII: a biochemical bridge linking accumbens dopamine and glutamate systems in cocaine seeking
Anderson, S. M., Famous, K. R., Sadri-Vakili, G., Kumaresan, V., Schmidt, H. D., Bass, C. E., Terwilliger, E. F., Cha, J.-H. J., & Pierce, R. C. (2008) · Nature Neuroscience · doi:10.1038/nn2054 · Cited by 295 · see citing works
Differential Effects of Blockade of Dopamine D 1 -Family Receptors in Nucleus Accumbens Core or Shell on Reinstatement of Heroin Seeking Induced by Contextual and Discrete Cues
Bossert, J. M., Poles, G. C., Wihbey, K. A., Koya, E., & Shaham, Y. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3926-07.2007 · Cited by 292 · see citing works
Self-citation
Effect of environmental stressors on opiate and psychostimulant reinforcement, reinstatement and discrimination in rats: a review
Lü, L., Shepard, J. D., Hall, F. S., & Shaham, Y. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(03)00073-3 · Cited by 277 · see citing works
Self-citation
The validity of the reinstatement model of craving and relapse to drug use
Katz, J. L., & Higgins, S. T. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1441-y · Cited by 273 · see citing works
Priming effects with drugs and other reinforcers.
de Wit, H. (1996) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.4.1.5 · Cited by 272 · see citing works
Neurobiology of relapse to heroin and cocaine seeking: An update and clinical implications
Bossert, J. M., Ghitza, U. E., Lü, L., Epstein, D. H., & Shaham, Y. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.09.030 · Cited by 271 · see citing works
Self-citation
Alpha-2 Adrenergic Receptor Agonists Block Stress-Induced Reinstatement of Cocaine Seeking
Erb, S. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00158-x · Cited by 270 · see citing works
Distress and eating: why do dieters overeat?
Polivy, J., & Herman, C. (1999) · International Journal of Eating Disorders · doi:10.1002/(sici)1098-108x(199909)26:2 · Cited by 268 · see citing works
Noradrenergic agonists and antagonists: Effects on conditioned fear as measured by the potentiated startle paradigm
Davis, M., Redmond, D. E., & Baraban, J. M. (1979) · Psychopharmacology · doi:10.1007/bf00433036 · Cited by 258 · see citing works
Cocaine-but not food-seeking behavior is reinstated by stress after extinction
Ahmed, S. H., & Koob, G. F. (1997) · Psychopharmacology · doi:10.1007/s002130050347 · Cited by 257 · see citing works
The hardship of obesity: a soft-wired hypothalamus
Horváth, T. L. (2005) · Nature Neuroscience · doi:10.1038/nn1453 · Cited by 257 · see citing works
Role of alpha-2 adrenoceptors in stress-induced reinstatement of alcohol seeking and alcohol self-administration in rats
L�, A. D., Harding, S., Juzytsch, W., Funk, D. R., & Shaham, Y. (2004) · Psychopharmacology · doi:10.1007/s00213-004-2036-y · Cited by 254 · see citing works
Self-citation
The receptor for the orexigenic peptide melanin-concentrating hormone is a G-protein-coupled receptor
Lembo, P. M. C., Grazzini, E., Cao, J., Hubatsch, D. A., Pelletier, M., Hoffert, C., St-Onge, S., Pou, C., Labrecque, J., Groblewski, T., et al. (1999) · Nature Cell Biology · doi:10.1038/12978 · Cited by 253 · see citing works
Role of conditioned reinforcers in the initiation, maintenance and extinction of drug-seeking behavior
Davis, W. M., & Smith, S. G. (1976) · Pavlovian Journal of Biological Science · doi:10.1007/bf03000316 · Cited by 251 · see citing works
The cerebral ventricles as the avenue for the dipsogenic action of intracranial angiotensin
Johnson, A. K., & Epstein, A. N. (1975) · Brain Research · doi:10.1016/0006-8993(75)90891-4 · Cited by 250 · see citing works
Gut Peptides in the Regulation of Food Intake and Energy Homeostasis
Murphy, K. G., Dhillo, W. S., & Bloom, S. R. (2006) · Endocrine Reviews · doi:10.1210/er.2006-0028 · Cited by 243 · see citing works
Differential involvement of the core and shell subregions of the nucleus accumbens in conditioned cue-induced reinstatement of cocaine seeking in rats
Fuchs, R. A., Evans, K. A., Parker, M. P., & See, R. E. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1895-6 · Cited by 242 · see citing works
A Role of Ventral Tegmental Area Glutamate in Contextual Cue-Induced Relapse to Heroin Seeking
Bossert, J. M., Liu, S. Y., Lu, L., & Shaham, Y. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3207-04.2004 · Cited by 241 · see citing works
Self-citation
Preferential Effects of the Metabotropic Glutamate 2/3 Receptor Agonist LY379268 on Conditioned Reinstatement versus Primary Reinforcement: Comparison between Cocaine and a Potent Conventional Reinforcer
Baptista, M. A. S., Martin‐Fardon, R., & Weiss, F. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0176-04.2004 · Cited by 235 · see citing works
Mental activity in relaxed wakefulness.
Foulkes, D., & Fleisher, S. (1975) · Journal of Abnormal Psychology · doi:10.1037/h0076164 · Cited by 234 · see citing works
Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long-Evans rats
Richards, J. K., Simms, J. A., Steensland, P., Taha, S. A., Borgland, S. L., Bonci, A., & Bartlett, S. E. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1136-5 · Cited by 234 · see citing works
Role of ventral medial prefrontal cortex in incubation of cocaine craving
Koya, E., Uejima, J. L., Wihbey, K. A., Bossert, J. M., Hope, B. T., & Shaham, Y. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.04.022 · Cited by 229 · see citing works
Self-citation
Neural substrates of cocaine-cue associations that trigger relapse
See, R. E. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.09.034 · Cited by 228 · see citing works
Excitotoxic lesions of the basolateral amygdala impair the acquisition of cocaine-seeking behaviour under a second-order schedule of reinforcement
Whitelaw, R. B., Markou, A., Robbins, T. W., & Everitt, B. J. (1996) · Psychopharmacology · doi:10.1007/bf02805996 · Cited by 228 · see citing works
Conditioned cued recovery of responding following prolonged withdrawal from self-administered cocaine in rats: an animal model of relapse.
Meil, W. M., & See, R. E. (1996) · PubMed · Cited by 225 · see citing works
D1 or D2 antagonism in nucleus accumbens core or dorsomedial shell suppresses lever pressing for food but leads to compensatory increases in chow consumption
Nowend, K. L., Arizzi, M. N., Carlson, B. B., & Salamone, J. D. (2001) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00524-x · Cited by 223 · see citing works
Rate-dependent effects of drugs: A review of the literature
Sanger, D. J., & Blackman, D. E. (1976) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(76)90178-7 · Cited by 222 · see citing works
Critical assessment of how to study addiction and its treatment: Human and non-human animal models
O’Brien, C. P., & Gardner, E. L. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.06.018 · Cited by 221 · see citing works
Lateral hypothalamic neuropeptides in reward and drug addiction
Dileone, R., Georgescu, D., & Nestler, E. J. (2003) · Life Sciences · doi:10.1016/s0024-3205(03)00408-9 · Cited by 220 · see citing works
Microdialysis Studies of Brain Norepinephrine, Serotonin, and Dopamine Release During Ingestive Behavior Theoretical and Clinical Implicationsa
HOEBEL, B. G., HERNANDEZ, L., SCHWARTZ, D. H., MARK, G. P., & HUNTER, G. A. (1989) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1989.tb53242.x · Cited by 220 · see citing works
Cannabinoid CB1 receptors control conditioned drug seeking
Vries, T. J. D., & Schoffelmeer, A. N. M. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.06.002 · Cited by 219 · see citing works
Dissociation of Primary and Secondary Reward-Relevant Limbic Nuclei in an Animal Model of Relapse
Grimm, J. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00157-8 · Cited by 215 · see citing works
Antidopaminergic properties of yohimbine.
Scatton, B., Živković, B., & Dedek, J. (1980) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)32325-6 · Cited by 211 · see citing works
Reinstatement of heroin and cocaine self-administration behavior in the rat by intracerebral application of morphine in the ventral tegmental area
Stewart, J. (1984) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(84)90017-0 · Cited by 210 · see citing works
Enduring Resistance to Extinction of Cocaine-Seeking Behavior Induced by Drug-Related Cues
Weiss, F. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00238-x · Cited by 207 · see citing works
Expanding the Scales: The Multiple Roles of MCH in Regulating Energy Balance and Other Biological Functions
Pissios, P., Bradley, R. L., & Maratos–Flier, E. (2006) · Endocrine Reviews · doi:10.1210/er.2006-0021 · Cited by 206 · see citing works
Stress reinstates nicotine seeking but not sucrose solution seeking in rats
Buczek, Y., Lê, A. D., Wang, A., Stewart, J., & Shaham, Y. (1999) · Psychopharmacology · doi:10.1007/s002130050992 · Cited by 206 · see citing works
Self-citation
Peptide YY(1-36) and Peptide YY(3-36): Part I. Distribution, Release and Actions
Ballantyne, G. H. (2006) · Obesity Surgery · doi:10.1381/096089206776944959 · Cited by 205 · see citing works
The neural circuitry underlying reinstatement of heroin-seeking behavior in an animal model of relapse
Rogers, J. L., Ghee, S. M., & See, R. E. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.10.012 · Cited by 204 · see citing works
Comparison of 2-Year Weight Loss Trends in Behavioral Treatments of Obesity
Skender, M. L., Goodrick, G. K., del Junco, D. J., Reeves, R. S., Darnell, L. S., Gotto, A. M., & Foreyt, J. P. (1996) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(96)00096-x · Cited by 201 · see citing works
Clonidine blocks stress-induced reinstatement of heroin seeking in rats: an effect independent of locus coeruleus noradrenergic neurons
Shaham, Y., Highfield, D., Delfs, J., Leung, S., & Stewart, J. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00899.x · Cited by 201 · see citing works
Self-citation
Dopamine D1- and D2-Like Receptor Mechanisms in Relapse to Cocaine-Seeking Behavior: Effects of Selective Antagonists and Agonists
Khroyan, T. V., Barrett-Larimore, R. L., Rowlett, J. K., & Spealman, R. D. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39122-0 · Cited by 198 · see citing works
Stress and relapse to drug seeking in rats: studies on the generality of the effect
Shalev, U., Highfield, D. A., Yap, J. J., & Shaham, Y. (2000) · Psychopharmacology · doi:10.1007/s002130000441 · Cited by 198 · see citing works
Self-citation
Cannabinoid modulation of the reinforcing and motivational properties of heroin and heroin-associated cues in rats
Vries, T. J. D., Homberg, J. R., Binnekade, R., Raasø, H. S., & Schoffelmeer, A. N. M. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1422-1 · Cited by 197 · see citing works
Relapse to Cocaine- and Heroin-Seeking Behavior Mediated by Dopamine D2 Receptors Is Time-Dependent and Associated with Behavioral Sensitization
Vries, T. J. D. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00293-7 · Cited by 195 · see citing works
Corticosteroids and the Control of Function in the Hypothalamo‐Pituitary‐Adrenal (HPA) Axisa
Dallman, M. F., Akana, S. F., LEVIN, N., Walker, C. D., BRADBURY, M. J., Suemaru, S., & SCRIBNER, K. S. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb39206.x · Cited by 195 · see citing works
Observational analysis of feeding induced by Δ9-THC and anandamide
Williams, C. M., & Kirkham, T. C. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00725-4 · Cited by 194 · see citing works
Effects of opioid and dopamine receptor antagonists on relapse induced by stress and re-exposure to heroin in rats
Shaham, Y., & Stewart, J. (1996) · Psychopharmacology · doi:10.1007/bf02246022 · Cited by 194 · see citing works
Self-citation
Metabotropic Glutamate 2/3 Receptors in the Ventral Tegmental Area and the Nucleus Accumbens Shell Are Involved in Behaviors Relating to Nicotine Dependence
Liechti, M. E., Lhuillier, L., Kaupmann, K., & Markou, A. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.1766-07.2007 · Cited by 193 · see citing works
Basolateral amygdala inactivation abolishes conditioned stimulus- and heroin-induced reinstatement of extinguished heroin-seeking behavior in rats
Fuchs, R. A., & See, R. E. (2002) · Psychopharmacology · doi:10.1007/s00213-001-0997-7 · Cited by 193 · see citing works
Systemic and Central Amygdala Injections of the mGluR2/3 Agonist LY379268 Attenuate the Expression of Incubation of Cocaine Craving
Lü, L., Uejima, J. L., Gray, S. M., Bossert, J. M., & Shaham, Y. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.04.011 · Cited by 192 · see citing works
Self-citation
Erratum: Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist
Borowsky, B., Durkin, M. M., Ogozalek, K. L., Marzabadi, M. R., DeLeon, J., Heurich, R. O., Lichtblau, H., Shaposhnik, Z., Daniewska, I., Blackburn, T. P., et al. (2002) · Nature Medicine · doi:10.1038/nm0902-1039b · Cited by 192 · see citing works
The CRF1 receptor antagonist antalarmin attenuates yohimbine-induced increases in operant alcohol self-administration and reinstatement of alcohol seeking in rats
Marinelli, P. W., Funk, D. R., Juzytsch, W., Harding, S. E., Rice, K. C., Shaham, Y., & Lê, A. D. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0905-x · Cited by 191 · see citing works
Self-citation
Serotonin and Dopamine Sensitization in the Nucleus Accumbens, Ventral Tegmental Area, and Dorsal Raphe Nucleus Following Repeated Cocaine Administration
Parsons, L. H., & Justice, J. B. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb09794.x · Cited by 190 · see citing works
The group II metabotropic glutamate receptor agonist, LY379268, inhibits both cocaine- and food-seeking behavior in rats
Peters, J., & Kalivas, P. W. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0372-9 · Cited by 190 · see citing works
Regulation of drug-taking and-seeking behaviors by neuroadaptations in the mesolimbic dopamine system
Self, D. W. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.07.005 · Cited by 189 · see citing works
Characterization of recombinant human orexin receptor pharmacology in a Chinese hamster ovary cell‐line using FLIPR
Smart, D., Jerman, J. C., Brough, S. J., Rushton, S. L., Murdock, P. R., Jewitt, F., Elshourbagy, N. A., Ellis, C. E., Middlemiss, D. N., & Brown, F. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702780 · Cited by 189 · see citing works
The neural correlates and role of D1 dopamine receptors in renewal of extinguished alcohol-seeking
Hamlin, A. S., Newby, J. M., & McNally, G. P. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.01.063 · Cited by 185 · see citing works
Leptin Attenuates Acute Food Deprivation-Induced Relapse to Heroin Seeking
Shalev, U., Yap, J. J., & Shaham, Y. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-04-j0001.2001 · Cited by 183 · see citing works
Self-citation
Therapeutic and adverse actions of serotonin transporter substrates
Rothman, R. B., & Baumann, M. H. (2002) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(02)00234-6 · Cited by 183 · see citing works
Modulation by high-fat diets of gastrointestinal function and hormones associated with the regulation of energy intake: implications for the pathophysiology of obesity
Little, T. J., Horowitz, M., & Feinle‐Bisset, C. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.3.531 · Cited by 182 · see citing works
Drugs of abuse: behavioural principles, methods and terms
Stolerman, I. P. (1992) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(92)90059-f · Cited by 182 · see citing works
Renewal of Extinguished Lever-Press Responses upon Return to the Training Context
Nakajima, S., Tanaka, S., Urushihara, K., & Imada, H. (2000) · Learning and Motivation · doi:10.1006/lmot.2000.1064 · Cited by 181 · see citing works
Opioids and consummatory behavior
Levine, A. S., Morley, J. E., Gosnell, B. A., Billington, C. J., & Bartness, T. J. (1985) · Brain Research Bulletin · doi:10.1016/0361-9230(85)90116-9 · Cited by 180 · see citing works
Amygdala and "emotional" modulation of the relative use of multiple memory systems.
Packard, M., & Wingard, J. C. (2004) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2004.06.008 · Cited by 179 · see citing works
Administration of the D1-like dopamine receptor antagonist SCH-23390 into the medial nucleus accumbens shell attenuates cocaine priming-induced reinstatement of drug-seeking behavior in rats
Anderson, S. M., Bari, A. A., & Pierce, R. C. (2003) · Psychopharmacology · doi:10.1007/s00213-002-1298-5 · Cited by 178 · see citing works
Pharmacological and Environmental Determinants of Relapse to Cocaine-Seeking Behavior
Spealman, R. D., Barrett-Larimore, R. L., Rowlett, J. K., Platt, D. M., & Khroyan, T. V. (1999) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(99)00049-0 · Cited by 173 · see citing works
Bromocriptine self-administration and bromocriptine-reinstatement of cocaine-trained and heroin-trained lever pressing in rats
Wise, R. A., Murray, A., & Bozarth, M. A. (1990) · Psychopharmacology · doi:10.1007/bf02244606 · Cited by 173 · see citing works
Clinical significance of adaptive thermogenesis
Major, G., Doucet, É., Trayhurn, P., Astrup, A. V., & Tremblay, A. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803523 · Cited by 170 · see citing works
Anatomy and pharmacology of cocaine priming-induced reinstatement of drug seeking
Schmidt, H. D., Anderson, S. M., Famous, K. R., Kumaresan, V., & Pierce, R. C. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.09.068 · Cited by 170 · see citing works
Effect of the cannabinoid CB1 receptor antagonist SR-141716A on ethanol self-administration and ethanol-seeking behaviour in rats
Economidou, D., Mattioli, L., Cifani, C., Perfumi, M. C., Massi, M., Cuomo, V., Trabace, L., & Ciccocioppo, R. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0199-9 · Cited by 169 · see citing works
Nicotine increases alcohol self-administration and reinstates alcohol seeking in rats
Lê, A. D., Wang, A. A., Harding, S. E., Juzytsch, W., & Shaham, Y. (2003) · Psychopharmacology · doi:10.1007/s00213-002-1330-9 · Cited by 169 · see citing works
Self-citation
Pharmacological Treatment of the Overweight Patient
Bray, G. A., & Greenway, F. L. (2007) · Pharmacological Reviews · doi:10.1124/pr.59.2.2 · Cited by 167 · see citing works
Comparison of the ?-adrenoceptor antagonist profiles of idazoxan (RX 781094), yohimbine, rauwolscine and corynanthine
Doxey, J. C., Lane, A. C., Roach, A. G., & Virdce, N. K. (1984) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00506193 · Cited by 166 · see citing works
Relapse crises and coping among dieters.
Grilo, C. M., Shiffman, S., & Wing, R. R. (1989) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.57.4.488 · Cited by 165 · see citing works
Renewal of extinguished cocaine-seeking
Hamlin, A. S., Clemens, K. J., & McNally, G. P. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.11.018 · Cited by 164 · see citing works
Medications development: Successes and challenges
Vocci, F. J., & Ling, W. W. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.06.010 · Cited by 161 · see citing works
Manipulation of dopamine d1-like receptor activation in the rat medial prefrontal cortex alters stress- and cocaine-induced reinstatement of conditioned place preference behavior
Sanchez, C. J., Bailie, T. M., Wu, W.-R., Li, N., & Sorg, B. A. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00078-2 · Cited by 160 · see citing works
Midbrain dopamine system electrophysiological functioning: A review and new hypothesis
Bunney, B. S., Chiodo, L. A., & Grace, A. A. (1991) · Synapse · doi:10.1002/syn.890090202 · Cited by 160 · see citing works

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Research works printed but not linked: 4

Baker A H S Bouton M Contexual conditioning and Reinstatement of Extinguished Instrumental Responding The Quarterly Journal of Experimental Psychology 1991 43B 199 218
Bremner JD Krystal JH Southwick SM Charney DS Noradrenergic mechanisms in stress and anxiety: II.clinical studies Synapse 1996b 23 39 51 8723134
Cohen F Horowitz MJ Lazarus RS Moos RH Robbins LN Rose RM Rutter M Eliott GR Eisdorfer C Panel report on psychosocial and modifiers of stress Stress and human health 1982 New York Springer Publishing Co. 147 188
Pavlov IP Conditioned reflexes 1927 Oxford Oxford University Press

Sorted by citations

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Stress-induced reinstatement of drug seeking: 20 years of progress
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Self-citation
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Self-citation
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Self-citation
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Self-citation
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Self-citation
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Self-citation
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Self-citation
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Self-citation
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Self-citation
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Ball, K. T., Combs, T. A., & Beyer, D. N. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.03.064 · Cited by 24 · see citing works
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Brenes, J. C., & Schwarting, R. K. W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102414 · Cited by 23 · see citing works
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Virtual Reality
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Adams, W. K., Barrus, M. M., Zeeb, F. D., Cocker, P. J., Benoit, J., & Winstanley, C. A. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.03.034 · Cited by 20 · see citing works
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Wiss, D. A. (2019) · The Assessment and Treatment of Addiction · doi:10.1016/b978-0-323-54856-4.00002-x · Cited by 20 · see citing works
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Ziółkowska, B., Kiełbiński, M., Gieryk, A., Sòria, G., Maldonado, R. J., & Przewłocki, R. (2011) · Journal of Neural Transmission · doi:10.1007/s00702-011-0583-z · Cited by 20 · see citing works
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Fogger, S. A., & McGuinness, T. M. (2011) · Perspectives In Psychiatric Care · doi:10.1111/j.1744-6163.2010.00298.x · Cited by 17 · see citing works
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Hauser, S. R., Wilden, J. A., Deehan, G. A., McBride, W. J., & Rodd, Z. A. (2014) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12540 · Cited by 17 · see citing works
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Disulfiram inhibits chocolate self-administration and reinstatement to chocolate seeking in rats
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Addiction au sucre
Chapelot, D. (2018) · Médecine des Maladies Métaboliques · doi:10.1016/s1957-2557(18)30117-2 · Cited by 2 · see citing works

The use of the reinstatement model to study relapse to palatable food seeking during dieting
Calu, D. J., Chen, Y., Kawa, A. B., Nair, S. G., & Shaham, Y. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.04.030 · Cited by 73 · see citing works
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Gooden, S. (2025) · Works - Scholarship, Research, & Creative Expression (Swarthmore College)
Role of food type in yohimbine- and pellet-priming-induced reinstatement of food seeking
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Self-citation
Effect of fenfluramine on reinstatement of food seeking in female and male rats: implications for the predictive validity of the reinstatement model
Pickens, C. L., Cifani, C., Navarre, B. M., Eichenbaum, H., Theberge, F. R. M., Baumann, M. H., Calu, D. J., & Shaham, Y. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2585-9 · Cited by 35 · see citing works
Self-citation
Effect of Fenfluramine on yohimbine- and pellet priming-induced reinstatement of food seeking in female rats: Implications for the predictive validity of the reinstatement model
Navarre, B. M., MH, B., Calu, D., Y., S., & CIFANI, C. (2011) · Unicam Scientific Publications (University of Camerino)

Authors: Nair, S. G., Adams-Deutsch, T., Epstein, D. H., & Shaham, Y.
Affiliations: National Institute on Drug Abuse (US)
Corresponding author: Shaham, Yavin
ORCID: Nair, Sunila G.
Epstein, David H.
Shaham, Yavin
Venue: Progress in Neurobiology
Publisher: Elsevier BV
Published: 2009-09
Volume: 89
Issue: 1
Pages: 18-45
ISSN: 0301-0082 (ISSN-L)
DOI: 10.1016/j.pneurobio.2009.05.003
PMC: PMC2745723
OpenAlex: W1974100279
Cited by: 112
References: 358
Citations by year: 2025: 1 · 2023: 2 · 2022: 2 · 2021: 7 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 9 · 2016: 7 · 2015: 7 · 2014: 13 · 2013: 19 · 2012: 9
FWCI: 1.04
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Progress in Neurobiology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute on Drug Abuse (Z01DA000434)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: food cues, yohimbine, reinstatement of drug seeking, neuropharmacology, dietary therapy, food addiction, neural mechanisms, pharmacological stress
MeSH terms: Animals, Feeding and Eating Disorders, Behavior, Animal, Disease Models, Animal, Feeding Behavior, Food Preferences, Humans, Neuropharmacology, Yohimbine, Behavior, Addictive

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The neuropharmacology of relapse to food seeking: Methodology, main findings, and comparison with relapse to drug seeking

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