The DOI matches its Crossref record; 151 of the 151 references it cites were found in a registry or an index.
Nanoscale Drug Delivery and Hyperthermia: The Materials Design and Preclinical and Clinical Testing of Low Temperature-Sensitive Liposomes Used in Combination with Mild Hyperthermia in the Treatment of Local Cancer
Open accessAbstract
The overall objective of liposomal drug delivery is to selectively target drug delivery to diseased tissue, while minimizing drug delivery to critical normal tissues. The purpose of this review is to provide an overview of temperature-sensitive liposomes in general and the Low Temperature-Sensitive Liposome (LTSL) in particular. We give a brief description of the material design of LTSL and highlight the likely mechanism behind temperature-triggered drug release. A complete review of the progress and results of the latest preclinical and clinical studies that demonstrate enhanced drug delivery with the combined treatment of hyperthermia and liposomes is provided as well as a clinical perspective on cancers that would benefit from hyperthermia as an adjuvant treatment for temperature-triggered chemotherapeutics. This review discusses the ideas, goals, and processes behind temperature-sensitive liposome development in the laboratory to the current use in preclinical and clinical settings.
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Cites
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Cited by
New developments in liposomal drug delivery
Pattni, B. S., Chupin, V. V., & Torchilin, V. P. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00046 · Cited by 1,600
Magnetic nanoparticle-based therapeutic agents for thermo-chemotherapy treatment of cancer
Hervault, A., & Thanh, N. T. K. (2014) · Nanoscale · doi:10.1039/c4nr03482a · Cited by 585
Thermosensitive liposomes for localized delivery and triggered release of chemotherapy
Ta, T., & Porter, T. M. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.03.036 · Cited by 403
Ramasamy, T., Ruttala, H. B., Gupta, B., Poudel, B. K., Choi, H.-G., Yong, C. S., & Kim, J. O. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.04.043 · Cited by 373
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Metadata
- Authors
- Landon, C. D.
- Venue
- The Open Nanomedicine Journal
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2011-05-25
- Volume
- 3
- Issue
- 1
- Pages
- 24-37
- ISSN
- 1875-9335 (ISSN-L)
- OpenAlex
- W1974187781
- Cited by
- 281
- References
- 151
- FWCI
- 6.67
- Type
- journal article
- Language
- en
- Open access
- diamond
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- CoChat. (2026). Citation check: Nanoscale Drug Delivery and Hyperthermia: The Materials Design and Preclinical and Clinical Testing of Low Temperature-Sensitive Liposomes Used in Combination with Mild Hyperthermia in the Treatment of Local Cancer. https://app.cochat.ai/papers/10.2174/1875933501103010038
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- Landon, C. D. (2011). Nanoscale Drug Delivery and Hyperthermia: The Materials Design and Preclinical and Clinical Testing of Low Temperature-Sensitive Liposomes Used in Combination with Mild Hyperthermia in the Treatment of Local Cancer. The Open Nanomedicine Journal. https://doi.org/10.2174/1875933501103010038
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
