Cited by 112Epigenetics and DNA MethylationPosttraumatic Stress Disorder ResearchChild Abuse and Trauma

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Traumatic Stress and Human DNA Methylation: A Critical Review

Vinkers, Christiaan H, Kalafateli, Aimilia Lydia, Rutten, Bart PF, Kas, Martien J, Kaminsky, Zachary, Turner, Jonathan D, Boks, Marco PM·2015·Epigenomics

DOI 10.2217/epi.15.11

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Abstract

Animal studies have identified persistent and functional effects of traumatic stress on the epigenome. This review discusses the clinical evidence for trauma-induced changes in DNA methylation across the life span in humans. Studies are reviewed based on reports of trauma exposure during the prenatal period (13 studies), early life (20 studies), and adulthood (ten studies). Even though it is apparent that traumatic stress influences the human epigenome, there are significant drawbacks in the existing human literature. These include a lack of longitudinal studies, methodological heterogeneity, selection of tissue type, and the influence of developmental stage and trauma type on methylation outcomes. These issues are discussed in order to present a way in which future studies can gain more insight into the functional relevance of trauma-related DNA methylation changes. Epigenetic studies investigating the detrimental effects of traumatic stress have great potential for an improved detection and treatment of trauma-related psychiatric disorders.

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Authors: Vinkers, C. H., Kalafateli, A. L., Rutten, B. P., Kas, M. J., Kaminsky, Z., Turner, J. D., & Boks, M. P.
Affiliations: University Medical Center Utrecht (NL)
Yale University (US)
Maastricht University Medical Centre (NL)
Brain Center Rudolf Magnus, Department of Translational Neuroscience, Utrecht, The Netherlands
Johns Hopkins University (US)
Laboratoire National de Santé (LU)
ORCID: Vinkers, Christiaan H
Kalafateli, Aimilia Lydia
Rutten, Bart PF
Kas, Martien J
Kaminsky, Zachary
Turner, Jonathan D
Boks, Marco PM
Venue: Epigenomics
Publisher: Informa UK Limited
Published: 2015-06
Volume: 7
Issue: 4
Pages: 593-608
ISSN: 1750-1911 (ISSN-L)
1750-192X
DOI: 10.2217/epi.15.11
OpenAlex: W1869592690
Cited by: 112
References: 89
Citations by year: 2026: 5 · 2025: 6 · 2024: 7 · 2023: 8 · 2022: 10 · 2021: 13 · 2020: 15 · 2019: 10 · 2018: 12 · 2017: 12 · 2016: 12 · 2015: 2
FWCI: 1.23
Type: journal article
Language: en
Open access: closed
Locations: Epigenomics (publishedVersion)
PubMed (publishedVersion)
Research Publications (Maastricht University) (publishedVersion)
Research Publications (Maastricht University) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Funders: Neuroscience and Cognition initiative from the University Utrecht
VENI (451.13.001)
The Netherlands Organisation for Scientific Research
Netherlands B rain Foundation Fellowship (F2013(1) -216)
Brain Foundation Fellowship (916.11.086)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Keywords: traumatic stress, DNA methylation, epigenetics, trauma exposure, prenatal trauma, early trauma, adult trauma, tissue type, developmental stages, longitudinal study
MeSH terms: Animals, Base Sequence, Humans, Molecular Sequence Data, DNA Methylation, Stress Disorders, Traumatic, Epigenesis, Genetic

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Traumatic Stress and Human DNA Methylation: A Critical Review

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