Cited by 25Antifungal resistance and susceptibilityFungal and yeast genetics researchBacterial Identification and Susceptibility Testing

Diagnostics and Susceptibility Testing in Aspergillus

Bernal-Martínez, Leticia, Alastruey-Izquierdo, Ana, Cuenca-Estrella, Manuel·2016·Future Microbiology

Abstract

UNLABELLED: Invasive aspergillosis is a major cause of morbidity and mortality in immunosuppressed patients. Early diagnosis and correct antifungal treatment have a direct impact on patient survival. A number of newer diagnostic procedures have been developed as alternatives to conventional microbiological methods. The detection of fungal components, largely antigens and DNA, are used in clinical laboratories to diagnose invasive aspergillosis. Other rapid diagnostic tests have been recently developed with promising results. However, antifungal resistance is becoming an emerging problem. The detection of this resistance is important to administer the proper antifungal agent. This text reviews the novelties on new diagnostics Aspergillus spp. PROCEDURES: Intrinsic antifungal resistance and mechanisms of secondary resistance to triazoles in A. fumigatus are also reviewed.

Integrity signals

Registry

Crossref · 10.2217/fmb.15.140

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139 of 139 references verified0 citation errors · 0 not checkable

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  • β1,3 glucan is a fungal polysaccharide not specific for Aspergillus.

    “The detection of β1,3 glucan, a fungal polysaccharide not specific for Aspergillus, is based on a very different approach (132–134).”

    From Aspergillus fumigatus and Aspergillosis in 2019 (2019) · cites this paper as [132]

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Authors
Bernal-Martínez, L., Alastruey-Izquierdo, A., & Cuenca-Estrella, M.
Affiliations
Mycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain; Spanish Network for the Research in Infectious Diseases (REIPI RD12/0015), Instituto de Salud Carlos III, Madrid, Spain
Venue
Future Microbiology
Published
2016-02
Volume
11
Issue
2
Pages
315-328
ISSN
  • 1746-0913 (ISSN-L)
  • 1746-0921
OpenAlex
W2270529090
Cited by
25
References
139
Citations by year
2026: 1 · 2025: 3 · 2024: 2 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 5 · 2018: 3 · 2017: 5 · 2016: 1
FWCI
0.72
Type
journal article
Language
en
Open access
closed
Locations
  • Future Microbiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Spanish Network for Research in Infectious Diseases (RD12/0015)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Bacterial Identification and Susceptibility Testing
Keywords
invasive aspergillosis, Aspergillus, antifungal susceptibility testing, antifungal resistance, Aspergillus fumigatus, triazole resistance, rapid diagnostic tests, fungal antigens, fungal DNA detection, immunocompromised patients
MeSH terms
Antifungal Agents, Aspergillosis, Aspergillus, Humans, Microbial Sensitivity Tests, Microbiological Techniques, Biomarkers, Drug Resistance, Fungal

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