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Cited by 379Stress Responses and CortisolNeurotransmitter Receptor Influence on BehaviorNeuropeptides and Animal Physiology

The CRF system, stress, depression and anxiety—insights from human genetic studies

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Binder, E B, Nemeroff, C B·2010·Molecular Psychiatry
DOI 10.1038/mp.2009.141PMC PMC3666571
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Abstract

A concatenation of findings from preclinical and clinical studies support a preeminent function for the corticotropin-releasing factor (CRF) system in mediating the physiological response to external stressors and in the pathophysiology of anxiety and depression. Recently, human genetic studies have provided considerable support to several long-standing hypotheses of mood and anxiety disorders, including the CRF hypothesis. These data, reviewed in this report, are congruent with the hypothesis that this system is of paramount importance in mediating stress-related psychopathology. More specifically, variants in the gene encoding the CRF(1) receptor interact with adverse environmental factors to predict risk for stress-related psychiatric disorders. In-depth characterization of these variants will likely be important in furthering our understanding of the long-term consequences of adverse experience.

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  • In psychiatry, depression is conceptualized as heterogeneous, multifactorial in causation, and believed to arise from cumulative effects of genetics, adverse events in childhood, and ongoing life stressors.

    “Moreover, in psychiatry depression is conceptualized as heterogeneous, multifactorial in causation, and it is believed to arise from the cumulative effects [56–58] of genetics [59–62], adverse events in childhood [63–66], and ongoing life stressors [67–70].”

    From The Need to Separate Chronic Traumatic Encephalopathy Neuropathology from Clinical Features (2017) · cites this paper as [59]

    The Human genetic studies section (page unavailable) says susceptibility to depression reflects the combined effects of genes and environment. The CRHR1 locus section links genetic variants and childhood abuse to adult depressive symptoms, and the Conclusions discuss the impact of life stress. The paper does not explicitly characterize depression as heterogeneous or establish the claimed cumulative effect of all three factors. (LLM, conf=0.82)

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Cited by

Sorted by citations

Authors
Binder, E. B., & Nemeroff, C. B.
Affiliations
  • Max Planck Institute of Psychiatry (DE)
  • University of Miami (US)
Corresponding author
Binder, E B
ORCID
Venue
Molecular Psychiatry
Publisher
Springer Science and Business Media LLC
Published
2009-12-15
Volume
15
Issue
6
Pages
574-588
ISSN
  • 1359-4184 (ISSN-L)
  • 1476-5578
DOI
10.1038/mp.2009.141
PMC
PMC3666571
OpenAlex
W2058410379
Cited by
379
References
16
Citations by year
2026: 13 · 2025: 14 · 2024: 19 · 2023: 18 · 2022: 27 · 2021: 16 · 2020: 21 · 2019: 35 · 2018: 27 · 2017: 35 · 2016: 23 · 2015: 28 · 2014: 26 · 2013: 22 · 2012: 19
FWCI
0.97
Type
journal article
Language
en
Open access
Licence
Locations
  • Molecular Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Max Planck Institute for Plasma Physics (submittedVersion)
Funders
  • National Institutes of Health (5u19mh069056-10, UL1TR000454)
  • National Institute of Mental Health (R01MH042088, U19-MH069056, P50MH058922, MH58922, MH42088, MH 69056)
  • National Center for Research Resources (UL1RR025008, RR25008)
  • National Center for Advancing Translational Sciences
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
corticotropin-releasing factor, CRF1 receptor, stress response, depression, anxiety disorders, genetic variants, gene-environment interaction, mood disorders, psychopathology
MeSH terms
CRF Receptor, Type 1, Anxiety Disorders, Corticotropin-Releasing Hormone, Depression, Humans, Models, Biological, Stress, Psychological, Genetic Variation, Signal Transduction, Receptors, Corticotropin-Releasing Hormone, Genetic Association Studies

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