Neuropeptide Y: a stressful review

Reichmann, Florian; Holzer, Peter

doi:10.1016/j.npep.2015.09.008

Cited by 490Neuropeptides and Animal PhysiologyStress Responses and CortisolNeuroendocrine regulation and behavior

Neuropeptide Y: a stressful review

Open access

Reichmann, Florian, Holzer, Peter·2016·Neuropeptides

DOI 10.1016/j.npep.2015.09.008PMC PMC4830398

Open this paper in CoChat — free account

Abstract

Stress is defined as an adverse condition that disturbs the homeostasis of the body and activates adaptation responses. Among the many pathways and mediators involved, neuropeptide Y (NPY) stands out due to its unique stress-relieving, anxiolytic and neuroprotective properties. Stress exposure alters the biosynthesis of NPY in distinct brain regions, the magnitude and direction of this effect varying with the duration and type of stress. NPY is expressed in particular neurons of the brainstem, hypothalamus and limbic system, which explains why NPY has an impact on stress-related changes in emotional-affective behaviour and feeding as well as on stress coping. The biological actions of NPY in mammals are mediated by the Y1, Y2, Y4 and Y5 receptors, Y1 receptor stimulation being anxiolytic whereas Y2 receptor activation is anxiogenic. Emerging evidence attributes NPY a role in stress resilience, the ability to cope with stress. Thus there is a negative correlation between stress-induced behavioural disruption and cerebral NPY expression in animal models of post-traumatic stress disorder. Exogenous NPY prevents the negative consequences of stress, and polymorphisms of the NPY gene are predictive of impaired stress processing and increased risk of neuropsychiatric diseases. Stress is also a factor contributing to, and resulting from, neurodegenerative diseases such as Alzheimer's, Parkinson's and Huntington's disease, in which NPY appears to play an important neuroprotective role. This review summarizes the evidence for an implication of NPY in stress-related and neurodegenerative pathologies and addresses the cerebral NPY system as a therapeutic target.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.npep.2015.09.008

Cites

184 of 184 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Nr2a encodes for NMDA receptor subunits, and the NPY protein stimulates neurogenesis and has anxiolytic effects.
“Nr2a encodes for NMDA receptor subunits, and the NPY protein stimulates neurogenesis and has anxiolytic effects (66, 67).”
From Psychedelics and Neuroplasticity: A Systematic Review Unraveling the Biological Underpinnings of Psychedelics. (2021) · cites this paper as [67]
The sections “NPY and Huntington’s disease” and “Role of NPY in anxiety” state that NPY increases neurogenesis and has anxiolytic effects. The review discusses NMDA receptors but does not state that Nr2a encodes an NMDA receptor subunit; that part of the sentence is not supported by this source. Page numbers are unavailable in our copy. (LLM, conf=0.88)
Experimental — accuracy not yet measured
There is abundant evidence that the central NPY system affects stress-related disorders such as anxiety and depression.
“There is abundant evidence that the central NPY system affects stress-related disorders such as anxiety and depression (for a review, see [181,182]).”
From Anxiety, depression, and the microbiome: A role for gut peptides (2018) · cites this paper as [182]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,501 · see citing works
A Syndrome produced by Diverse Nocuous Agents
Selye, H. (1936) · Nature · doi:10.1038/138032a0 · Cited by 3,967 · see citing works
Stress and disorders of the stress system
Chrousos, G. P. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.106 · Cited by 3,215 · see citing works
Neurocircuitry of stress: central control of the hypothalamo–pituitary–adrenocortical axis
Herman, J. P., & Cullinan, W. E. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10069-2 · Cited by 2,270 · see citing works
Neuropeptide Y—a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide
Tatemoto, K., Carlquist, M., & Mutt, V. (1982) · Nature · doi:10.1038/296659a0 · Cited by 2,254 · see citing works
Stress, eating and the reward system
Adam, T. C., & Epel, E. S. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.04.011 · Cited by 1,732 · see citing works
Neuropeptide Y Distribution in the Rat Brain
Allen, Y. S., Adrian, T. E., Allen, J. M., Tatemoto, K., Crow, T. J., Bloom, S. R., & Polak, J. M. (1983) · Science · doi:10.1126/science.6136091 · Cited by 1,097 · see citing works
A Syndrome Produced by Diverse Nocuous Agents
Selye, H. (1998) · Journal of Neuropsychiatry · doi:10.1176/jnp.10.2.230a · Cited by 925 · see citing works
Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome
Kuo, L. E., Kitlinska, J. B., Tilan, J. U., Li, L., Baker, S. B., Johnson, M. D., Lee, E. W., Burnett, M. S., Fricke, S. T., Kvetnansky, R., et al. (2007) · Nature Medicine · doi:10.1038/nm1611 · Cited by 656 · see citing works
The NPY system in stress, anxiety and depression
Heilig, M. A. (2004) · Neuropeptides · doi:10.1016/j.npep.2004.05.002 · Cited by 617 · see citing works
Increased cell proliferation and neurogenesis in the adult human Huntington's disease brain
Curtis, M., Penney, E., Pearson, A. G., van Roon-Mom, W. V., Butterworth, N., Dragunow, M., Connor, B., & Faull, R. (2003) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1532244100 · Cited by 559 · see citing works
The Concise Guide to PHARMACOLOGY 2013/14: G Protein‐Coupled Receptors
Alexander, S. P. H., Benson, H. E., Faccenda, E., Pawson, A. J., Sharman, J. L., Spedding, M., Peters, J. A., Harmar, A. J., & Collaborators, C. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12445 · Cited by 555 · see citing works
Neuropeptide, Y, peptide YY and pancreatic polypeptide in the gut-brain axis
Holzer, P., Reichmann, F., & Farzi, A. (2012) · Neuropeptides · doi:10.1016/j.npep.2012.08.005 · Cited by 501 · see citing works
Self-citation
Genetic variation in human NPY expression affects stress response and emotion
Zhou, Z., Zhu, G., Hariri, A. R., Enoch, M.-A., Scott, D., Sinha, R., Virkkunen, M., Mash, D. C., Lipsky, R. H., Hu, X.-Z., et al. (2008) · Nature · doi:10.1038/nature06858 · Cited by 455 · see citing works
Regional distribution of Y‐receptor subtype mRNAs in rat brain
Parker, R. M. C., & Herzog, H. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00553.x · Cited by 412 · see citing works
Centrally administered neuropeptide Y (NPY) produces anxiolytic-like effects in animal anxiety models
Heilig, M. A., S�derpalm, B., Engel, J. A., & Widerl�v, E. (1989) · Psychopharmacology · doi:10.1007/bf00441953 · Cited by 390 · see citing works
The neurocircuitry and receptor subtypes mediating anxiolytic-like effects of neuropeptide Y
Kask, A., Harro, J., von Hörsten, S., Redrobe, J. P., Dumont, Y., & Quirion, R. (2002) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(01)00066-5 · Cited by 358 · see citing works
Corticotropin-releasing factor and neuropeptide y: role in emotional integration
Heilig, M. A., Koob, G. F., Ekman, R., & Britton, K. T. (1994) · Trends in Neurosciences · doi:10.1016/0166-2236(94)90079-5 · Cited by 324 · see citing works
Behavioral insensitivity to restraint stress, absent fear suppression of behavior and impaired spatial learning in transgenic rats with hippocampal neuropeptide Y overexpression
Thorsell, A., Michalkiewicz, M., Dumont, Y., Quirion, R., Caberlotto, L., Rimondini, R., Mathé, A. A., & Heilig, M. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.220232997 · Cited by 315 · see citing works
Intranasal Treatment of Central Nervous System Dysfunction in Humans
Chapman, C. D., Frey, W. H., Craft, S., Danielyan, L., Hallschmid, M., Schiöth, H. B., & Benedict, C. (2013) · Pharmaceutical Research · doi:10.1007/s11095-012-0915-1 · Cited by 310 · see citing works
Neuroanatomy of the extended circadian rhythm system
Morin, L. P. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.06.026 · Cited by 309 · see citing works
The Neuropeptide Y (NPY)-ergic System is Associated with Behavioral Resilience to Stress Exposure in an Animal Model of Post-Traumatic Stress Disorder
Cohen, H., Liu, T., Kozlovsky, N., Kaplan, Z., Zohar, J., & Mathé, A. A. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.230 · Cited by 299 · see citing works
Behavioral characterization of neuropeptide Y knockout mice
Bannon, A. W., Seda, J., Carmouché, M., Francis, J. M., Norman, M. H., Karbon, B., & McCaleb, M. L. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02285-x · Cited by 288 · see citing works
The link between stress and feeding behaviour
Maniam, J., & Morris, M. J. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.04.017 · Cited by 255 · see citing works
Survival of basal ganglia neuropeptide Y-somatostatin neurones in Huntington's disease
Dawbarn, D., de Quidt, M. E., & Emson, P. C. (1985) · Brain Research · doi:10.1016/0006-8993(85)90921-7 · Cited by 251 · see citing works
The Neural Network that Regulates Energy Balance Is Responsive to Glucocorticoids and Insulin and Also Regulates HPA Axis Responsivity at a Site Proximal to CRF Neuronsa
Dallman, M. F., Akana, S. F., Strack, A. M., Hanson, E. S., & Sebastian, R. J. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb44724.x · Cited by 250 · see citing works
Low baseline and yohimbine-stimulated plasma neuropeptide Y (NPY) levels in combat-related PTSD
Rasmusson, A. M., Hauger, R. L., Morgan, C. A., Bremner, J. D., Charney, D. S., & Southwick, S. M. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00185-7 · Cited by 249 · see citing works
Plasma Neuropeptide Y Concentrations in Combat Exposed Veterans: Relationship to Trauma Exposure, Recovery from PTSD, and Coping
Yehuda, R., Brand, S. R., & Yang, R.-K. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.08.027 · Cited by 244 · see citing works
Amygdalar neuropeptide Y Y1 receptors mediate the anxiolytic-like actions of neuropeptide Y in the social interaction test
Sajdyk, T. J., Vandergriff, M. G., & Gehlert, D. R. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00018-7 · Cited by 241 · see citing works
Modifying resilience mechanisms in at-risk individuals: a controlled study of mindfulness training in Marines preparing for deployment
Johnson, D. C., Thom, N. J., Stanley, E. A., Haase, L., Simmons, A. N., Shih, P.-A. B., Thompson, W. K., Potterat, E. G., Minor, T. R., & Paulus, M. P. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.13040502 · Cited by 227 · see citing works
A possible role of neuropeptide Y in depression and stress
Morales‐Medina, J. C., Dumont, Y., & Quirion, R. (2009) · Brain Research · doi:10.1016/j.brainres.2009.09.077 · Cited by 217 · see citing works
Early neuropathology of somatostatin/NPY GABAergic cells in the hippocampus of a PS1×APP transgenic model of Alzheimer's disease
Ramos, B., Baglietto‐Vargas, D., del Río, J. C., Moreno‐González, I., Santa‐María, C., Jiménez, S., Caballero, C., Lopez-Tellez, J. F., Khan, Z. U., Ruano, D., et al. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.09.022 · Cited by 213 · see citing works
Role of hypothalamic neuropeptide Y in feeding and obesity
Gehlert, D. R. (1999) · Neuropeptides · doi:10.1054/npep.1999.0057 · Cited by 209 · see citing works
Induction of obesity and hyperleptinemia by central glucocorticoid infusion in the rat.
Zakrzewska, K. E., Cusin, I., Stricker‐Krongrad, A., Boss, O., Ricquier, D., Jeanrenaud, B., & Rohner‐Jeanrenaud, F. (1999) · Diabetes · doi:10.2337/diabetes.48.2.365 · Cited by 203 · see citing works
Comparative distribution of neuropeptide Y Y1 and Y5 receptors in the rat brain by using immunohistochemistry
Wolak, M. L., DeJoseph, M. R., Cator, A. D., Mokashi, A. S., Brownfield, M. S., & Urban, J. H. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10823 · Cited by 199 · see citing works
Expression of the neuropeptide Y Y1 receptor in the CNS of rat and of wild-type and Y1 receptor knock-out mice. Focus on immunohistochemical localization
Kopp, J., Xu, Q., Zhang, X.-Q., Pedrazzini, T., Herzog, H., Kresse, A. E., Wong, H. C., Walsh, J. H., & Hökfelt, T. G. M. (2002) · Neuroscience · doi:10.1016/s0306-4522(01)00463-8 · Cited by 196 · see citing works
Single intranasal neuropeptide Y infusion attenuates development of PTSD-like symptoms to traumatic stress in rats
Serova, L. I., Tillinger, A., Alaluf, L. G., Lauková, M., Keegan, K., & Sabban, E. L. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.01.040 · Cited by 194 · see citing works
The neuropeptide Y system: Pathophysiological and therapeutic implications in obesity and cancer
Zhang, L., Bijker, M. S., & Herzog, H. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.03.011 · Cited by 190 · see citing works
Progression of Amyloid Pathology to Alzheimer's Disease Pathology in an Amyloid Precursor Protein Transgenic Mouse Model by Removal of Nitric Oxide Synthase 2
Wilcock, D. M., Lewis, M. R., Nostrand, W. E. V., Davis, J., Previti, M. L., Gharkholonarehe, N., Vitek, M. P., & Colton, C. A. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5066-07.2008 · Cited by 187 · see citing works
Interactions between NPY and CRF in the amygdala to regulate emotionality
Sajdyk, T. J., Shekhar, A., & Gehlert, D. R. (2004) · Neuropeptides · doi:10.1016/j.npep.2004.05.006 · Cited by 183 · see citing works
Effect of restraint stress on food intake and body weight is determined by time of day
Rybkin, I. I., Zhou, Y., Vólaufová, J., Smagin, G. N., Ryan, D. H., & Harris, R. B. S. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.273.5.r1612 · Cited by 182 · see citing works
Reduced anxiety and improved stress coping ability in mice lacking NPY‐Y2 receptors
Tschenett, A., Singewald, N., Carli, M., Balducci, C., Salchner, P., Vezzani, A., Herzog, H., & Sperk, G. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02725.x · Cited by 180 · see citing works
Neuropeptide Y and corticotropin-releasing factor bi-directionally modulate inhibitory synaptic transmission in the bed nucleus of the stria terminalis
Kash, T. L., & Winder, D. G. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.06.011 · Cited by 166 · see citing works
The effect of neurodegenerative diseases on the subventricular zone
Curtis, M. A., Faull, R. L. M., & Eriksson, P. S. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2216 · Cited by 162 · see citing works
Neuropeptides in neurological disease
Beal, M. F., & Martin, J. B. (1986) · Annals of Neurology · doi:10.1002/ana.410200502 · Cited by 162 · see citing works
Behavioral and endocrine adaptation, and up-regulation of NPY expression in rat amygdala following repeated restraint stress
Thorsell, A., Carlsson, K., Ekman, R., & Heilig, M. A. (1999) · Neuroreport · doi:10.1097/00001756-199909290-00024 · Cited by 157 · see citing works
The Central and Basolateral Amygdala Are Critical Sites of Neuropeptide Y/Y2 Receptor-Mediated Regulation of Anxiety and Depression
Tasan, R. O., Nguyen, N. K., Weger, S., Sartori, S. B., Singewald, N., Heilbronn, R., Herzog, H., & Sperk, G. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0430-10.2010 · Cited by 152 · see citing works
Relevance of Neuropeptide Y (NPY) in Psychiatry
Eaton, K., Sallee, F. R., & Sah, R. (2007) · Current Topics in Medicinal Chemistry · doi:10.2174/156802607782341037 · Cited by 148 · see citing works
Neuropeptide Y in the Amygdala Induces Long-Term Resilience to Stress-Induced Reductions in Social Responses But Not Hypothalamic–Adrenal–Pituitary Axis Activity or Hyperthermia
Sajdyk, T. J., Johnson, P. L., Leitermann, R. J., Fitz, S. D., Dietrich, A. D., Morin, M., Gehlert, D. R., Urban, J. H., & Shekhar, A. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0659-07.2008 · Cited by 147 · see citing works
II. Cortical neurons immunoreactive with antisera against neuropeptide Y are altered in Alzheimer's‐type dementia
Chan‐Palay, V., Lang, W., Allen, Y. S., Haesler, U., & Polak, J. M. (1985) · The Journal of Comparative Neurology · doi:10.1002/cne.902380404 · Cited by 146 · see citing works
Low Cerebrospinal Fluid Neuropeptide Y Concentrations in Posttraumatic Stress Disorder
Sah, R., Ekhator, N. N., Strawn, J. R., Sallee, F. R., Baker, D. G., Horn, P. S., & Geracioti, T. D. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.04.037 · Cited by 145 · see citing works
The homeostatic role of neuropeptide <scp>Y</scp> in immune function and its impact on mood and behaviour
Farzi, A., Reichmann, F., & Holzer, P. (2015) · Acta Physiologica · doi:10.1111/apha.12445 · Cited by 145 · see citing works
Self-citation
Physiology and gene regulation of the brain NPY Y1 receptor
Eva, C. E., Serra, M., Mele, P., Panzica, G., & Oberto, A. (2006) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2006.07.002 · Cited by 139 · see citing works
Characterization of saturable binding sites for circulating pancreatic polypeptide in rat brain
Whitcomb, D. C., Taylor, I. L., & Vigna, S. R. (1990) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1990.259.4.g687 · Cited by 133 · see citing works
Pancreatic polypeptide immunoreactivity in rat brain is actually neuropeptide Y
DiMaggio, D. A., Chronwall, B. M., Buchanan, K. D., & O'Donohoue, T. L. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90259-3 · Cited by 131 · see citing works
Differential roles for neuropeptide Y Y1 and Y5 receptors in anxiety and sedation
Sørensen, G., Lindberg, C., Wörtwein, G., Bolwig, T. G., & Woldbye, D. P. D. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20200 · Cited by 124 · see citing works
Corticotropin-releasing hormone and animal models of anxiety: gene–environment interactions
Bakshi, V. P., & Kalin, N. H. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01082-9 · Cited by 124 · see citing works
Intranasal neuropeptide Y reverses anxiety and depressive-like behavior impaired by single prolonged stress PTSD model
Serova, L. I., Lauková, M., Alaluf, L. G., Pucillo, L., & Sabban, E. L. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.11.007 · Cited by 124 · see citing works
Neuropeptide Y: a central regulator of energy homeostasis
White, J. D. (1993) · Regulatory Peptides · doi:10.1016/0167-0115(93)90431-7 · Cited by 123 · see citing works
Neuropeptide Y-Y2 receptors mediate anxiety in the amygdala
Sajdyk, T. J., Schober, D. A., Smiley, D. L., & Gehlert, D. R. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00679-7 · Cited by 123 · see citing works
Predictable chronic mild stress in adolescence increases resilience in adulthood
Suo, L., Zhao, L., Si, J., Liu, J., Zhu, W., Chai, B., Zhang, Y., Feng, J., Ding, Z., Luo, Y., et al. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.67 · Cited by 122 · see citing works
Neuropeptide Y Produces Anxiety Via Y2-Type Receptors
Nakajima, M., Inui, A., Asakawa, A., Momose, K., Ueno, N., Teranishi, A., Baba, S., & Kasuga, M. (1998) · Peptides · doi:10.1016/s0196-9781(97)00298-2 · Cited by 119 · see citing works
Striatal neuropeptide Y neurones are under the influence of the nigrostriatal dopaminergic pathway: Immunohistochemical evidence
Goff, L. K., Bosler, O., Pelletier, G., et al. (1986) · Neuroscience Letters · doi:10.1016/0304-3940(86)90174-6 · Cited by 118 · see citing works
Emotion Processing, Major Depression, and Functional Genetic Variation of Neuropeptide Y
Mickey, B. J., Zhou, Z., Heitzeg, M. M., Heinz, E., Hodgkinson, C. A., Hsu, D. T., Langenecker, S. A., Love, T. M., Peciña, M., Shafir, T., et al. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.197 · Cited by 115 · see citing works
Neuropeptide Y and its role in CNS disease and repair
Decressac, M., & Barker, R. A. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.09.004 · Cited by 113 · see citing works
Neuropeptide Y Innervation and Neuropeptide-Y-Y1-Receptor-Expressing Neurons in the Paraventricular Hypothalamic Nucleus of the Mouse
Broberger, C., Visser, T. J., Kuhar, M. J., & Hökfelt, T. G. M. (1999) · Neuroendocrinology · doi:10.1159/000054490 · Cited by 112 · see citing works
Mouse pancreatic polypeptide modulates food intake, while not influencing anxiety in mice☆
Asakawa, A., Inui, A., Ueno, N., Fujimiya, M., Fujino, M., & Kasuga, M. (1999) · Peptides · doi:10.1016/s0196-9781(99)00155-2 · Cited by 112 · see citing works
Neuropeptide Y (NPY) gene: Impact on emotional processing and treatment response in anxious depression
Domschke, K., Dannlowski, U., Hohoff, C., Ohrmann, P., Bauer, J., Kugel, H., Zwanzger, P., Heindel, W. L., Deckert, J., Arolt, V., et al. (2009) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2009.09.006 · Cited by 110 · see citing works
Can stress trigger Parkinson's disease?
Djamshidian, A., & Lees, A. J. (2013) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2013-305911 · Cited by 105 · see citing works
Human NPY promoter variation rs16147:T>C as a moderator of prefrontal NPY gene expression and negative affect
Sommer, W. H., Lidström, J., Sun, H., Passer, D., Eskay, R. L., Parker, S. C. J., Witt, S. H., Zimmermann, U. S., Nieratschker, V., Rietschel, M., et al. (2010) · Human Mutation · doi:10.1002/humu.21299 · Cited by 104 · see citing works
Anxiolytic-like effect of neuropeptide Y (NPY) and NPY13-36 microinjected into vicinity of locus coeruleus in rats.
Kask, A., Rägo, L., & Harro, J. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00076-6 · Cited by 101 · see citing works
Effects of Altered Amygdalar Neuropeptide Y Expression on Anxiety-Related Behaviors
Primeaux, S. D., Wilson, S. P., Cusick, M. C., York, D. A., & Wilson, M. A. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300705 · Cited by 101 · see citing works
Suppressed neuropeptide Y (NPY) mRNA in rat amygdala following restraint stress
Thorsell, A., Svensson, P., Wiklund, L., Sommer, W. H., Ekman, R., & Heilig, M. A. (1998) · Regulatory Peptides · doi:10.1016/s0167-0115(98)00075-5 · Cited by 100 · see citing works
Cerebrospinal fluid neuropeptide Y in combat veterans with and without posttraumatic stress disorder
Sah, R., Ekhator, N. N., Jefferson-Wilson, L., Horn, P. S., & Geracioti, T. D. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.10.017 · Cited by 97 · see citing works
Peptide therapeutics for CNS indications
McGonigle, P. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.10.014 · Cited by 95 · see citing works
Effect of Y1 receptor deficiency on motor activity, exploration, and anxiety
Karl, T., Burne, T. H. J., & Herzog, H. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.08.019 · Cited by 95 · see citing works
Neuropeptide Y Fragments Derived from Neprilysin Processing Are Neuroprotective in a Transgenic Model of Alzheimer's Disease
Rose, J. B., Crews, L. A., Rockenstein, E. M., Adame, A., Mante, M., Hersh, L. B., Gage, F. H., Spencer, B. J., Potkar, R., Marr, R. A., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4220-08.2009 · Cited by 94 · see citing works
The Putative Neuroprotective Role of Neuropeptide Y in the Central Nervous System
Silva, A. P., Xapelli, S., Grouzmann, E., & Cavadas, C. (2005) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1568007054546153 · Cited by 92 · see citing works
Neuropeptide Y (NPY) prevents depressive-like behavior, spatial memory deficits and oxidative stress following amyloid-β (Aβ1–40) administration in mice
dos Santos, V. V., Santos, D. B., Lach, G., Rodrigues, A. L. S., Farina, M., de Lima, T. C. M., & Prediger, R. D. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.01.039 · Cited by 92 · see citing works
NPY modulates miR-30a-5p and BDNF in opposite direction in an in vitro model of Alzheimer disease: a possible role in neuroprotection?
Croce, N., Gelfo, F., Ciotti, M. T., Federici, G., Caltagirone, C., Bernardini, S., & Angelucci, F. (2013) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-013-1567-0 · Cited by 88 · see citing works
The effects of unilateral 6-OHDA lesion in medial forebrain bundle on the motor, cognitive dysfunctions and vulnerability of different striatal interneuron types in rats
Ma, Y., Zhan, M., OuYang, L., Li, Y., Chen, S. X., Wu, J., Chen, J., Luo, C., & Lei, W. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.02.039 · Cited by 83 · see citing works
Early Intervention With Intranasal NPY Prevents Single Prolonged Stress-Triggered Impairments in Hypothalamus and Ventral Hippocampus in Male Rats
Lauková, M., Alaluf, L. G., Serova, L. I., Arango, V., & Sabban, E. L. (2014) · Endocrinology · doi:10.1210/en.2014-1192 · Cited by 83 · see citing works
Reduced anxiety-like and depression-related behavior in neuropeptide Y Y4 receptor knockout mice
Painsipp, E., Wultsch, T., Edelsbrunner, M. E., Tasan, R. O., Singewald, N., Herzog, H., & Holzer, P. (2008) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2008.00389.x · Cited by 79 · see citing works
Self-citation
Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors.
Yan, H., Yang, J., Marasco, J., Yamaguchi, K., Brenner, S., Collins, F., & Karbon, W. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.10.4661 · Cited by 79 · see citing works
Anxiolytic-like effect of the selective Neuropeptide Y Y2 receptor antagonist BIIE0246 in the elevated plus-maze
Bacchi, F., Mathé, A. A., Jiménez, P., Stasi, L. P., Arban, R., Gerrard, P. A., & Caberlotto, L. (2006) · Peptides · doi:10.1016/j.peptides.2006.07.020 · Cited by 79 · see citing works
Inhibition of food intake induced by acute stress in rats is due to satiation effects
Calvez, J., Fromentin, G., Nadkarni, N. A., Darcel, N., Even, P. C., Tomé, D., Ballet, N., & Chaumontet, C. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.07.012 · Cited by 78 · see citing works
Stress-Induced Cytokines and Neuronal Dysfunction in Alzheimer's Disease
Ricci, S., Fuso, A., Ippoliti, F., & Businaro, R. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110821 · Cited by 76 · see citing works
Dextran sulfate sodium-induced colitis alters stress-associated behaviour and neuropeptide gene expression in the amygdala-hippocampus network of mice
Reichmann, F., Hassan, A. M., Farzi, A., Jain, P., Schuligoi, R., & Holzer, P. D. (2015) · Scientific Reports · doi:10.1038/srep09970 · Cited by 76 · see citing works
Self-citation
Neuroprotection by neuropeptide Y in cell and animal models of Parkinson's disease
Decressac, M., Pain, S., Chabeauti, P.-Y., Frangeul, L., Thiriet, N., Herzog, H., Vergote, J., Chalon, S., Jaber, M., & Gaillard, A. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.06.018 · Cited by 76 · see citing works
Cerebrospinal fluid norepinephrine, 3-methoxy-4-hydroxyphenylglycol and neuropeptide Y levels in Parkinson's disease, multiple system atrophy and dementia of the Alzheimer type
Martignoni, E., Blandini, F., Petraglia, F., Pacchetti, C., Bono, G., & Nappi, G. (1992) · Journal of Neural Transmission - Parkinsons Disease and Dementia Section · doi:10.1007/bf02260903 · Cited by 75 · see citing works
Neuropeptides and hippocampal neurogenesis
Zaben, M. J., & Gray, W. P. (2013) · Neuropeptides · doi:10.1016/j.npep.2013.10.002 · Cited by 75 · see citing works
Manipulating central nervous mechanisms of food intake and body weight regulation by intranasal administration of neuropeptides in man
Hallschmid, M., Benedict, C., Jan Born, A., Fehm, H., & Kern, W. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.07.023 · Cited by 75 · see citing works
Acute stress increases neuropeptide Y mRNA within the arcuate nucleus and hilus of the dentate gyrus
Conrad, C. D., & McEwen, B. S. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00105-4 · Cited by 72 · see citing works
Increased novelty-induced motor activity and reduced depression-like behavior in neuropeptide Y (NPY)-Y4 receptor knockout mice
Tasan, R. O., Lin, S., Hetzenauer, A., Singewald, N., Herzog, H., & Sperk, G. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2008.11.048 · Cited by 71 · cited 1× · see citing works
“The anxiolytic effect of Y4 receptor deletion is amplified by Y2/Y4 receptor double knockout, suggesting a positive interaction of Y2 and Y4 receptors (Tasan et al., 2009).”
Background
Characterization of NPY mRNA-expressing cells in the human brain: co-localization with Y2 but not Y1 mRNA in the cerebral cortex, hippocampus, amygdala, and striatum
Caberlotto, L., Fuxé, K., & Hurd, Y. L. (2000) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(00)00107-1 · Cited by 71 · see citing works
Regional and sub-regional differences in hippocampal GABAergic neuronal vulnerability in the TgCRND8 mouse model of Alzheimer’s disease
Albuquerque, M. S., Mahar, I., Davoli, M. A., Chabot, J.-G., Mechawar, N., Quirion, R., & Krantic, S. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00030 · Cited by 71 · see citing works
Hunger promotes fear extinction by activation of an amygdala microcircuit
Verma, D., Wood, J., Lach, G., Herzog, H., Sperk, G., & Tasan, R. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.163 · Cited by 69 · see citing works
Nicotine evoked improvement in learning and memory is mediated through NPY Y1 receptors in rat model of Alzheimer's disease
Rangani, R. J., Upadhya, M. A., Nakhate, K. T., Kokare, D. M., & Subhedar, N. K. (2012) · Peptides · doi:10.1016/j.peptides.2012.01.004 · Cited by 66 · see citing works
Trauma exposure rather than posttraumatic stress disorder is associated with reduced baseline plasma neuropeptide-Y levels
Morgan, C. A., Rasmusson, A. M., Winters, B., Hauger, R. L., Morgan, J., Hazlett, G. A., & Southwick, S. M. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00433-5 · Cited by 65 · see citing works
Psychological hardiness predicts neuroimmunological responses to stress
Sandvik, A. M., Bartone, P. T., Hystad, S. W., Phillips, T. M., Thayer, J. F., & Johnsen, B. H. (2013) · Psychology Health & Medicine · doi:10.1080/13548506.2013.772304 · Cited by 65 · see citing works
Differential regulation of agouti-related protein and neuropeptide Y in hypothalamic neurons following a stressful event
Kas, M. J., Bruijnzeel, A. W., Haanstra, J. R., Wiegant, V. M., & Adan, R. A. H. (2005) · Journal of Molecular Endocrinology · doi:10.1677/jme.1.01819 · Cited by 65 · see citing works
[ 125 I]Leu 31 , Pro 34 -PYY is a High Affinity Radioligand for Rat PP1/Y4 and Y1 Receptors: Evidence for Heterogeneity in Pancreatic Polypeptide Receptors
Gehlert, D. R., Schober, D. A., Gackenheimer, S. L., Beavers, L. S., Gadski, R. A., Lundell, I., & Larhammar, D. (1997) · Peptides · doi:10.1016/s0196-9781(96)00346-4 · Cited by 64 · see citing works
Enhanced fear recall and emotional arousal in rats recovering from chronic variable stress
McGuire, J. L., Herman, J. P., Horn, P. S., Sallee, F. R., & Sah, R. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.07.013 · Cited by 64 · see citing works
Role of NPY Y1 receptor on acquisition, consolidation and extinction on contextual fear conditioning: Dissociation between anxiety, locomotion and non-emotional memory behavior
Lach, G., & de Lima, T. C. M. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.04.005 · Cited by 64 · see citing works
Chromosome 4q31‐34 panic disorder risk locus: Association of neuropeptide Y Y5 receptor variants
Domschke, K., Hohoff, C., Jacob, C., Maier, W., Fritze, J., Bandelow, B., Krakowitzky, P., Kästner, F., Rothermundt, M., Arolt, V., et al. (2007) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30629 · Cited by 63 · see citing works
Neuropeptide Y‐family receptors Y 6 and Y 7 in chicken
Bromée, T., Sjödin, P., Fredriksson, R., Boswell, T. C., Larsson, T., Salaneck, E., Zoorob, R., Mohell, N., & Larhammar, D. (2006) · FEBS Journal · doi:10.1111/j.1742-4658.2006.05221.x · Cited by 62 · see citing works
Role of gut-brain axis in persistent abnormal feeding behavior in mice following eradication of Helicobacter pylori infection
Berčík, P., Verdu, E. F., Foster, J. A., Lu, J., Scharringa, A., Kean, I. R. L., Wang, L., Blennerhassett, P. A., & Collins, S. M. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90752.2008 · Cited by 62 · see citing works
The Novel Neuropeptide Y Y5 Receptor Antagonist Lu AA33810 [N-[[trans-4-[(4,5-Dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]-methanesulfonamide] Exerts Anxiolytic- and Antidepressant-Like Effects in Rat Models of Stress Sensitivity
Walker, M. W., Wolinsky, T. D., Jubian, V., Chandrasena, G., Zhong, H., Huang, X., Miller, S., Hegde, L. G., Marsteller, D. A., Marzabadi, M. R., et al. (2008) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.144634 · Cited by 62 · see citing works
Fear-reducing effects of intra-amygdala neuropeptide Y infusion in animal models of conditioned fear: an NPY Y1 receptor independent effect
Fendt, M., Bürki, H., Imobersteg, S., Lingenhöhl, K., McAllister, K. H., Orain, D., Uzunov, D. P., & Chaperon, F. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1610-8 · Cited by 61 · see citing works
Transcriptomic and Epigenetic Changes in the Hypothalamus Are Involved in an Increased Susceptibility to a High-Fat-Sucrose Diet in Prenatally Stressed Female Rats
Paternain, L., Batlle, M., de la Garza, A. L., Milagro, F. I., Martínez, J. A., & Campión, J. (2012) · Neuroendocrinology · doi:10.1159/000341684 · Cited by 61 · see citing works
NPY Y1 Receptors Differentially Modulate GABAA and NMDA Receptors via Divergent Signal-Transduction Pathways to Reduce Excitability of Amygdala Neurons
Molosh, A. I., Sajdyk, T. J., Truitt, W. A., Zhu, W., Oxford, G. S., & Shekhar, A. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.33 · Cited by 60 · see citing works
FunctionalNPYVariation as a Factor in Stress Resilience and Alcohol Consumption in Rhesus Macaques
Lindell, S. G., Schwandt, M. L., Sun, H., Sparenborg, J. D., Björk, K., Kasckow, J., Sommer, W. H., Goldman, D. A., Higley, J. D., Suomi, S. J., et al. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.23 · Cited by 60 · see citing works
Repeated predictable stress causes resilience against colitis-induced behavioral changes in mice
Hassan, A. M., Jain, P., Reichmann, F., Mayerhofer, R., Farzi, A., Schuligoi, R., & Holzer, P. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00386 · Cited by 59 · see citing works
Self-citation
Implication of neuropeptide-Y Y2 receptors in the effects of immune stress on emotional, locomotor and social behavior of mice
Painsipp, E., Herzog, H., & Holzer, P. D. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.05.004 · Cited by 57 · see citing works
Self-citation
Increased neuropeptide Y mRNA expression in striatum in Parkinson’s disease
Cannizzaro, C., Tel, B. C., Rose, S., et al. (2003) · Molecular Brain Research · doi:10.1016/s0169-328x(02)00555-7 · Cited by 56 · see citing works
In vitro and in vivo characterization of JNJ-31020028 (N-(4-{4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperazin-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y Y2 receptor
Shoblock, J. R., Welty, N., Nepomuceno, D. H., Lord, B., Aluisio, L. E., Fraser, I. C., Motley, S. T., Sutton, S. W., Morton, K. L., Galici, R., et al. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1726-x · Cited by 55 · see citing works
Plasma neuropeptide Y is reduced in patients with Alzheimer's disease
Koide, S., Onishi, H., Hashimoto, H., Kai, T., & Yamagami, S. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)11973-z · Cited by 55 · see citing works
Neuropeptide Y Y5 receptor antagonist CGP71683A: the effects on food intake and anxiety-related behavior in the rat
Kask, A., Vasar, E., Heidmets, L., Allikmets, L., & Wikberg, J. E. S. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)00768-3 · Cited by 55 · see citing works
NPY moderates the relation between hurricane exposure and generalized anxiety disorder in an epidemiologic sample of hurricane-exposed adults
Amstadter, A. B., Koenen, K. C., Ruggiero, K. J., Acierno, R. E., Galea, S., Kilpatrick, D. G., & Gelernter, J. E. (2009) · Depression and Anxiety · doi:10.1002/da.20648 · Cited by 55 · see citing works
An interaction between a neuropeptide Y gene polymorphism and early adversity modulates endocrine stress responses
Witt, S. H., Buchmann, A. F., Blomeyer, D., Nieratschker, V., Treutlein, J., Esser, G., Schmidt, M. H., Bidlingmaier, M., Wiedemann, K., Rietschel, M., et al. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.12.015 · Cited by 54 · see citing works
The Effect of Intrahippocampal Injection of Group II and III Metobotropic Glutamate Receptor Agonists on Anxiety; the Role of Neuropeptide Y
Śmiałowska, M., Wierońska, J. M., Domin, H., & Zieba, B. A. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301258 · Cited by 53 · see citing works
Diurnal Fluctuations in HPA and Neuropeptide Y-ergic Systems Underlie Differences in Vulnerability to Traumatic Stress Responses at Different Zeitgeber Times
Cohen, S., Vainer, E., Matar, M. A., Kozlovsky, N., Kaplan, Z., Zohar, J., Mathé, A. A., & Cohen, H. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.257 · Cited by 53 · see citing works
Neuroprotective Effect of Neuropeptide Y against Beta-Amyloid 25–35 Toxicity in SH-SY5Y Neuroblastoma Cells Is Associated with Increased Neurotrophin Production
Croce, N., Dinallo, V., Ricci, V., Federici, G., Caltagirone, C., Bernardini, S., & Angelucci, F. (2011) · Neurodegenerative Diseases · doi:10.1159/000323468 · Cited by 53 · see citing works
Support for involvement of glutamate decarboxylase 1 and neuropeptide y in anxiety susceptibility
Donner, J., Sipilä, T., Ripatti, S., Kananen, L., Chen, X., Kendler, K. S., Lönnqvist, J. K., Pirkola, S. P., Hettema, J. M., & Hovatta, I. (2012) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32029 · Cited by 52 · see citing works
Acute heat stress up-regulates neuropeptide Y precursor mRNA expression and alters brain and plasma concentrations of free amino acids in chicks
Ito, K., Bahry, M. A., Yang, H., Furuse, M., & Chowdhury, V. S. (2015) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2015.04.010 · Cited by 52 · see citing works
The Role of Ghrelin, Neuropeptide Y and Leptin Peptides in Weight Gain after Deep Brain Stimulation for Parkinson’s Disease
Markaki, E., Ellul, J., Kefalopoulou, Z. M., Trachani, E., Theodoropoulou, A., Kyriazopoulou, V. E., & Constantoyannis, C. (2012) · Stereotactic and Functional Neurosurgery · doi:10.1159/000335045 · Cited by 51 · see citing works
Neuropeptide Y modifies the disease course in the R6/2 transgenic model of Huntington's disease
Decressac, M., Wright, B. L. C., Tyers, P., Gaillard, A., & Barker, R. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.07.022 · Cited by 51 · see citing works
Neuropeptide Y Protects Rat Cortical Neurons against β-Amyloid Toxicity and Re-establishes Synthesis and Release of Nerve Growth Factor
Croce, N., Ciotti, M. T., Gelfo, F., Cortelli, S., Federici, G., Caltagirone, C., Bernardini, S., & Angelucci, F. (2012) · ACS Chemical Neuroscience · doi:10.1021/cn200127e · Cited by 50 · see citing works
Aged neuropeptide Y transgenic rats are resistant to acute stress but maintain spatial and non-spatial learning
Carvajal, C., Vercauteren, F., Dumont, Y., Michalkiewicz, M., & Quirion, R. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.01.004 · Cited by 49 · see citing works
The Characteristic Long-Term Upregulation of Hippocampal NF-κB Complex in PTSD-Like Behavioral Stress Response Is Normalized by High-Dose Corticosterone and Pyrrolidine Dithiocarbamate Administered Immediately after Exposure
Cohen, H., Kozlovsky, N., Matar, M. A., Zohar, J., & Kaplan, Z. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.118 · Cited by 49 · see citing works
Meal patterns and hypothalamic NPY expression during chronic social stress and recovery
Melhorn, S. J., Krause, E. G., Scott, K. A., Mooney, M. R., Johnson, J. D., Woods, S. C., & Sakai, R. R. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00820.2009 · Cited by 49 · see citing works
Regulatory functions of limbic Y1 receptors in body weight and anxiety uncovered by conditional knockout and maternal care
Bertocchi, I., Oberto, A., Longo, A., Mele, P., Marianna, S., Bartolomucci, A., Palanza, P., Sprengel, R., & Eva, C. E. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1109468108 · Cited by 48 · see citing works
Central administration of NPY or an NPY-Y5 selective agonist increase in vivo extracellular monoamine levels in mesocorticolimbic projecting areas
Quarta, D., Leslie, C. P., Carletti, R., Valerio, E., & Caberlotto, L. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.09.016 · Cited by 48 · see citing works
Interactions of zebrafish peptide YYb with the neuropeptide Y-family receptors Y4, Y7, Y8a, and Y8b
Sundström, G., Larsson, T., Xu, B., et al. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00029 · Cited by 48 · see citing works
Neurobiological constituents of active, passive, and variable coping strategies in rats: Integration of regional brain neuropeptide Y levels and cardiovascular responses
Hawley, D. F., Bardi, M., Everette, A. M., Higgins, T. J., Tu, K. M., Kinsley, C. H., & Lambert, K. G. (2010) · Stress · doi:10.3109/10253890903144621 · Cited by 48 · see citing works
Comparative effects of intranasal neuropeptide Y and HS014 in preventing anxiety and depressive-like behavior elicited by single prolonged stress
Sabban, E. L., Serova, L. I., Alaluf, L. G., Lauková, M., & Peddu, C. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.12.038 · Cited by 47 · see citing works
Neuropeptide Y Receptor Gene Expression in the Primate Amygdala Predicts Anxious Temperament and Brain Metabolism
Roseboom, P. H., Nanda, S. A., Fox, A. S., Oler, J. A., Shackman, A. J., Shelton, S. E., Davidson, R. J., & Kalin, N. H. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.11.012 · Cited by 46 · see citing works
The novel, selective, brain-penetrant neuropeptide Y Y2 receptor antagonist, JNJ-31020028, tested in animal models of alcohol consumption, relapse, and anxiety
Cippitelli, A., Rezvani, A. H., Robinson, J. E., Eisenberg, L., Levin, E. D., Bonaventure, P., Motley, S. T., Lovenberg, T. W., Heilig, M. A., & Thorsell, A. (2010) · Alcohol · doi:10.1016/j.alcohol.2010.09.003 · Cited by 46 · see citing works
Amygdala activation and GABAergic gene expression in hippocampal sub-regions at the interplay of stress and spatial learning
Hadad-Ophir, O., Albrecht, A., Stork, O., & Richter‐Levin, G. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00003 · Cited by 45 · see citing works
Early life stress interacts with the diet deficiency of omega-3 fatty acids during the life course increasing the metabolic vulnerability in adult rats
Bernardi, J. R., Ferreira, C. F., Senter, G., Krolow, R., de Aguiar, B. W., Portella, A. K., Kauer-Sant'Anna, M., Kapczinski, F., Dalmaz, C., Goldani, M. Z., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062031 · Cited by 43 · see citing works
Manipulating central nervous mechanisms of food intake and body weight regulation by intranasal administration of neuropeptides in man
Hallschmid, M., Benedict, C., Born, J., et al. (2004) · Physiology & Behavior · doi:10.1016/s0031-9384(04)00349-x · Cited by 43 · see citing works
Neuropeptide Y Y1 receptor hippocampal overexpression via viral vectors is associated with modest anxiolytic‐like and proconvulsant effects in mice
Olesen, M. V., Christiansen, S. H., Gøtzsche, C. R., et al. (2011) · Journal of Neuroscience Research · doi:10.1002/jnr.22770 · Cited by 42 · see citing works
Acute stress inhibits food intake and alters ghrelin signaling in the brain of tilapia (Oreochromis mossambicus)
Upton, K. R., & Riley, L. G. (2012) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2012.10.001 · Cited by 41 · see citing works
Sex-specific effects of isolation stress and consumption of palatable diet during the prepubertal period on metabolic parameters
Krolow, R., Noschang, C. G., Arcego, D. M., Huffell, A. P., Marcolin, M. L., Benitz, A. N. D., Lampert, C., Fitarelli, R. D., & Dalmaz, C. (2013) · Metabolism · doi:10.1016/j.metabol.2013.04.009 · Cited by 40 · see citing works
Individual differences in the effects of chronic stress on memory: behavioral and neurochemical correlates of resiliency
Sweis, B. M., Veverka, K. K., Dhillon, E. S., Urban, J. H., & Lucas, L. R. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.04.052 · Cited by 39 · see citing works
The Effect of Acute and Chronic Restraint on the Central Expression of Prepro‐Neuropeptide Y mRNA in Normotensive and Hypertensive Rats
Sweerts, B., Jarrott, B., & Lawrence, A. J. (2001) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2001.00674.x · Cited by 38 · see citing works
Neuropeptide Y Y 2 R blockade in the central amygdala reduces anxiety‐like behavior but not alcohol drinking in alcohol‐dependent rats
Kallupi, M., Vendruscolo, L. F., Carmichael, C. Y., George, O., Koob, G. F., & Gilpin, N. W. (2013) · Addiction Biology · doi:10.1111/adb.12059 · Cited by 38 · see citing works
Behavioral training and predisposed coping strategies interact to influence resilience in male Long-Evans rats: Implications for depression
Bardi, M., Rhone, A. P., Franssen, C. L., Hampton, J. E., Shea, E. A., Hyer, M. M., Huber, J., & Lambert, K. G. (2012) · Stress · doi:10.3109/10253890.2011.623739 · Cited by 37 · see citing works
Adult-onset hippocampal-specific neuropeptide Y overexpression confers mild anxiolytic effect in mice
Lin, E.-J. D., Lin, S., Aljanova, A., During, M. J., & Herzog, H. (2009) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2009.08.004 · Cited by 37 · see citing works
Differential Regulation of Neuropeptide Y in the Amygdala and Prefrontal Cortex during Recovery from Chronic Variable Stress
McGuire, J. L., Larke, L. E., Sallee, F. R., Herman, J. P., & Sah, R. (2011) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2011.00054 · Cited by 36 · see citing works
Plasma levels of neuropeptides in Alzheimer's disease
Proto, C., Romualdi, D., Cento, R., Spada, R., Mento, G. D., Ferri, R., & Lanzone, A. (2006) · Gynecological Endocrinology · doi:10.1080/09513590500519385 · Cited by 35 · see citing works
Cellular and molecular mechanisms involved in the selective vulnerability of striatal projection neurons in Huntington's disease.
Pérez‐Navarro, E., Canals, J. M., Ginés, S., & Alberch, J. (2006) · PubMed · doi:10.14670/hh-21.1217 · Cited by 34 · see citing works
A role for neuropeptide Y in the gender‐specific gastrointestinal, corticosterone and feeding responses to stress
Forbes, S. C., Herzog, H., & Cox, H. M. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.01939.x · Cited by 34 · see citing works
Neuroimmunomodulative properties of dipeptidyl peptidase IV/CD26 in a TNBS‐induced model of colitis in mice
Batičić, L., Detel, D., Kučić, N., Buljević, S., Pugel, E. P., & Varljen, J. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23261 · Cited by 34 · see citing works
Neuropeptide Y-Y2 receptor knockout mice: influence of genetic background on anxiety-related behaviors
Zambello, E., Zanetti, L., Hédou, G., Angelici, O., Arban, R., Tasan, R. O., Sperk, G., & Caberlotto, L. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.10.075 · Cited by 33 · see citing works
Characterization of cerebrospinal fluid (CSF) and plasma NPY levels in normal volunteers over a 24-h timeframe
Baker, D. G., Bertram, T. M., Patel, P. M., Barkauskas, D. A., Clopton, P., Patel, S., Geracioti, T. D., Haji, U., O’Connor, D. T., Nievergelt, C. M., et al. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.04.020 · Cited by 32 · see citing works
Xiaoyaosan Decoction Regulates Changes in Neuropeptide Y and Leptin Receptor in the Rat Arcuate Nucleus after Chronic Immobilization Stress
Wang, S., Chen, J., Yue, G.-X., Bai, M.-H., Kou, M.-J., & Jin, Z.-Y. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/381278 · Cited by 32 · see citing works
Exercise Enhances the Behavioral Responses to Acute Stress in an Animal Model of PTSD
HOFFMAN, J. R., OSTFELD, I., KAPLAN, Z., ZOHAR, J., & COHEN, H. (2015) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000642 · Cited by 31 · see citing works
Intranasal administration of neuropeptide Y in man: systemic absorption and functional effects
Lacroix, J. S., Ricchetti, A., Morel, D. R., Mossimann, B., Waeber, B., & Grouzmann, E. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb15647.x · Cited by 31 · see citing works
Correlation Between Clinical Characteristics and Cerebrospinal Fluid Neuropeptide Y Levels in Dementia of the Alzheimer Type and Frontotemporal Dementia
Minthon, L., Edvinsson, L. I., & Gustafson, L. (1996) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199601040-00005 · Cited by 30 · see citing works
Conditional Inactivation of Neuropeptide Y Y1 Receptors Unravels the Role of Y1 and Y5 Receptors Coexpressing Neurons in Anxiety
Longo, A., Mele, P., Bertocchi, I., Oberto, A., Bachmann, A., Bartolomucci, A., Palanza, P., Sprengel, R., & Eva, C. E. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.01.009 · Cited by 29 · see citing works
Association of age at onset in Huntington disease with functional promoter variations in NPY and NPY2R
Kloster, E., Carsten Saft, C., Akkad, D. A., Epplen, J. T., & Arning, L. (2013) · Journal of Molecular Medicine · doi:10.1007/s00109-013-1092-3 · Cited by 28 · see citing works
Altered neuropeptide Y and neurokinin messenger RNA expression and receptor binding in stress-sensitised rats
de Lange, R. P. J., Wiegant, V. M., & Stam, R. (2008) · Brain Research · doi:10.1016/j.brainres.2008.03.018 · Cited by 27 · see citing works
Cortical peptide changes in Huntington's disease may be independent of striatal degeneration
Mazurek, M. F., Garside, S., & Beal, M. F. (1997) · Annals of Neurology · doi:10.1002/ana.410410418 · Cited by 27 · see citing works
Effects of a selective Y2R antagonist, JNJ-31020028, on nicotine abstinence-related social anxiety-like behavior, neuropeptide Y and corticotropin releasing factor mRNA levels in the novelty-seeking phenotype
Aydın, Ç., Oztan, O., & Isgor, C. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.03.067 · Cited by 26 · see citing works
Change of the melanocortin system caused by bilateral subthalamic nucleus stimulation in Parkinson’s disease
Sevilla, F. E., Pérez-Navarro, M. J., Muñoz-Pasadas, M., Sáez‐Zea, C., Katati, M. J., Maroto, G. P., Ramírez-Navarro, Á., & Mínguez‐Castellanos, A. (2011) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2010.01469.x · Cited by 25 · see citing works
Differential gene expression in WKY and SHR brain following acute and chronic air-puff stress
McDougall, S. J., Widdop, R. E., & Lawrence, A. J. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.10.010 · Cited by 23 · see citing works
The effect of neuropeptide Y on cell survival and neurotrophin expression in in-vitro models of Alzheimer’s disease
Angelucci, F., Gelfo, F., Fiore, M., Croce, N., Mathé, A. A., Bernardini, S., & Caltagirone, C. (2014) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2014-0099 · Cited by 22 · see citing works
Orexigenic response to tail pinch: role of brain NPY1and corticotropin releasing factor receptors
Goebel‐Stengel, M., Stengel, A., Wang, L., & Taché, Y. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00335.2013 · Cited by 21 · see citing works
NPY‐Y1 coexpressed with NPY‐Y5 receptors modulate anxiety but not mild social stress response in mice
Longo, A., Oberto, A., Mele, P., Mattiello, L., Pisu, M. G., Palanza, P., Serra, M., & Eva, C. E. (2015) · Genes Brain & Behavior · doi:10.1111/gbb.12232 · Cited by 21 · see citing works
Modulation of orexigenic and anorexigenic peptides gene expression in the rat DVC and hypothalamus by acute immobilization stress
Chigr, F., Rachidi, F., Tardivel, C., Najimi, M., & Moyse, E. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00198 · Cited by 21 · see citing works
Y5 neuropeptide Y receptor overexpression in mice neither affects anxiety- and depression-like behaviours nor seizures but confers moderate hyperactivity
Olesen, M. V., Christiansen, S. H., Gøtzsche, C. R., et al. (2012) · Neuropeptides · doi:10.1016/j.npep.2012.01.002 · Cited by 19 · see citing works
The selective neuropeptide Y Y5 agonist [cPP1–7,NPY19–23,Ala31,Aib32,Gln34]hPP differently modulates emotional processes and body weight in the rat
Morales‐Medina, J. C., Domínguez-López, S., Gobbi, G., Beck‐Sickinger, A. G., & Quirion, R. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.05.015 · Cited by 19 · see citing works
Serum neuropeptide Y in accident survivors with depression or posttraumatic stress disorder
Nishi, D., Hashimoto, K., Noguchi, H., & Matsuoka, Y. (2014) · Neuroscience Research · doi:10.1016/j.neures.2014.03.009 · Cited by 14 · see citing works
Increased striatal neuropeptide Y immunoreactivity and its modulation by deprenyl, clonidine and L-dopa in MPTP-treated mice
Obuchowicz, E., Antkiewicz‐Michaluk, L., Romańska, I., et al. (2003) · Journal of Neural Transmission · doi:10.1007/s00702-003-0047-1 · Cited by 14 · see citing works
Lateral septal infusions of the neuropeptide Y Y2 receptor agonist, NPY13–36 differentially affect different defensive behaviors in male, Long Evans rats
Trent, N. L., & Menard, J. L. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2012.12.011 · Cited by 14 · see citing works
Mood and memory-associated behaviors in neuropeptide Y5 knockout mice
Ito, M., Dumont, Y., & Quirion, R. (2012) · Neuropeptides · doi:10.1016/j.npep.2012.10.009 · Cited by 11 · see citing works
Posttraumatic Stress Disorder From Vietnam to Today
Benedek, D. M. (2011) · The Journal of Nervous and Mental Disease · doi:10.1097/nmd.0b013e318225f0e9 · Cited by 11 · see citing works
Cell-specific expression of calcineurin immunoreactivity within the rat basolateral amygdala complex and colocalization with the neuropeptide Y Y1 receptor
Leitermann, R. J., Sajdyk, T. J., & Urban, J. H. (2012) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2012.07.005 · Cited by 11 · see citing works
Differential regulation of hypothalamic neuropeptide Y hnRNA and mRNA during psychological stress and insulin-induced hypoglycemia
Ferenczi, S., Zelei, E., Pintér-Kübler, B., Szőke, Z., & Kovács, K. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.02.036 · Cited by 11 · see citing works
Polymorphism in neuropeptide Y influences CSF cholesterol levels but is no major risk factor of Alzheimer’s disease
Kölsch, H., Lütjohann, D., Jessen, F., Urbach, H., von Bergmann, K., Maier, W., & Heun, R. (2005) · Journal of Neural Transmission · doi:10.1007/s00702-005-0319-z · Cited by 9 · see citing works
Hippocampal Y2 receptor-mediated mossy fiber plasticity is implicated in nicotine abstinence-related social anxiety-like behavior in an outbred rat model of the novelty-seeking phenotype
Aydın, Ç., Oztan, O., & Isgor, C. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.08.004 · Cited by 7 · see citing works
Hunger promotes fear extinction by activation of an amygdala microcircuit
Tasan, R. O., Verma, D., Wood, J. C., et al. (2016) · Neuropeptides · doi:10.1016/j.npep.2015.11.054 · Cited by 6 · see citing works
Untitled work
Matelli (1998) · doi:10.1002/(sici)1096-9861(19981221)402:3

Flagged first, then by citations

Research works printed but not linked: 3

[12]Bromee T Sjodin P Fredriksson R Boswell T Larsson TA Salaneck E Neuropeptide Y-family receptors Y6 and Y7 in chicken. Cloning, pharmacological characterization, tissue distribution and conserved synteny with human chromosome region FEBS J 2006 5 273 9 2048 2063 16640567
[16]Dumont Y Jacques D Bouchard P Quirion R Species differences in the expression and distribution of the neuropeptide Y Y1, Y2, Y4, and Y5 receptors in rodents, guinea pig, and primates brains J Comp Neurol 1998 12 21 402 3 372 384 9853905
[90]Gehlert DR Schober DA Gackenheimer SL Beavers L Gadski R Lundell I 125I]Leu31, Pro34-PYY is a high affinity radioligand for rat PP1/Y4 and Y1 receptors: evidence for heterogeneity in pancreatic polypeptide receptors Peptides 1997 18 3 397 401 9145427

Sorted by citations

Cognitive impairment by antibiotic-induced gut dysbiosis: analysis of gut microbiota-brain communication
Fröhlich, E. E., Farzi, A., Mayerhofer, R., Reichmann, F., Jačan, A., Wagner, B., Zinser, E., Bordag, N., Magnes, C., Fröhlich, E., et al. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.02.020 · Cited by 720 · see citing works
Self-citation
Anxiety, depression, and the microbiome: A role for gut peptides
Lach, G., Schellekens, H., Dinan, T. G., & Cryan, J. F. (2018) · Neurotherapeutics · doi:10.1007/s13311-017-0585-0 · Cited by 573 · see citing works
Detecting Activated Cell Populations Using Single-Cell RNA-Seq
Wu, Y. E., Pan, L., Zuo, Y., Li, X., & Hong, W. (2017) · Neuron · doi:10.1016/j.neuron.2017.09.026 · Cited by 438 · see citing works
Psychedelics and Neuroplasticity: A Systematic Review Unraveling the Biological Underpinnings of Psychedelics.
de Vos, C. M. H., Mason, N. L., & Kuypers, K. P. C. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.724606 · Cited by 269 · see citing works
Novel pharmacological targets in drug development for the treatment of anxiety and anxiety-related disorders
Sartori, S. B., & Singewald, N. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.107402 · Cited by 236 · see citing works
Early life stress alters transcriptomic patterning across reward circuitry in male and female mice
Peña, C. J., Smith, M., Ramakrishnan, A., Cates, H. M., Bagot, R. C., Kronman, H. G., Patel, B., Chang, A. B., Purushothaman, I., Dudley, J., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13085-6 · Cited by 219 · see citing works
The Role of the Microbiome-Brain-Gut Axis in the Pathogenesis of Depressive Disorder
Młynarska, E., Gadzinowska, J., Tokarek, J., Forycka, J., Szuman, A., Franczyk, B., & Rysz, J. (2022) · Nutrients · doi:10.3390/nu14091921 · Cited by 109 · see citing works
Visceral Inflammation and Immune Activation Stress the Brain
Holzer, P., Farzi, A., Hassan, A. M., Zenz, G., Jačan, A., & Reichmann, F. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01613 · Cited by 84 · see citing works
Self-citation
A randomized dose-ranging study of neuropeptide Y in patients with posttraumatic stress disorder
Sayed, S., Van Dam, N. T., Horn, S. R., Kautz, M. M., Parides, M., Costi, S., Collins, K. A., Iacoviello, B., Iosifescu, D. V., Mathé, A. A., et al. (2018) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyx109 · Cited by 79 · see citing works
NPY-Y1 receptor signaling controls spatial learning and perineuronal net expression
Bertocchi, I., Mele, P., Ferrero, G., Oberto, A., Carulli, D., & Eva, C. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108425 · Cited by 26 · see citing works
Hypothalamic stress systems in mood disorders
(2021) · Handbook of Clinical Neurology · doi:10.1016/b978-0-12-819973-2.00003-4 · Cited by 15 · see citing works
Genome to Phenome: A Systems Biology Approach to PTSD Using an Animal Model
Chakraborty, N., Meyerhoff, J., Jett, M., & Hammamieh, R. (2017) · Methods in Molecular Biology · doi:10.1007/978-1-4939-6952-4_6 · Cited by 14 · see citing works
Genetic variations in genes of the stress response pathway are associated with prolonged abstinence from heroin
Levran, O., Peles, E., Randesi, M., Correa da Rosa, J., Shen, P.-H., Rotrosen, J., Adelson, M., & Kreek, M. J. (2018) · Pharmacogenomics · doi:10.2217/pgs-2017-0179 · Cited by 13 · see citing works

Pharmacological modulation of anxiety-related behaviors in the murine Suok test
Kalueff, A. V., Keisala, T., Minasyan, A., & Tuohimaa, P. (2007) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2007.05.002 · Cited by 11 · see citing works
Use of the elevated plus-maze test with opaque or transparent walls in the detection of mouse strain differences and the anxiolytic effects of diazepam
Hagenbuch, N., Feldon, J., & Yee, B. K. (2005) · Behavioural Pharmacology · doi:10.1097/01.fbp.0000189811.77049.3e · Cited by 52 · see citing works
Marble burying as a test of the delayed anxiogenic effects of acute immobilisation stress in mice
Kedia, S., & Chattarji, S. (2014) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2014.06.012 · Cited by 101 · see citing works
Anxiogenic and anxiolytic effects on escape-related behaviours in the unstable elevated plus maze: concomitant effects on locomotor activity
King, S. M., Green, S., & Vale, A. (1999) · BIROn (Birkbeck, University of London) · Cited by 1 · see citing works
Anxiolytic and anxiogenic drugs: Changes in behaviour and endocrine responses
File, S. E., Johnston, A. L., & Baldwin, H. A. (1988) · Stress Medicine · doi:10.1002/smi.2460040407 · Cited by 49 · see citing works

Authors: Reichmann, F., & Holzer, P.
Affiliations: Medical University of Graz (AT)
Corresponding author: Reichmann, Florian
ORCID: Reichmann, Florian
Holzer, Peter
Venue: Neuropeptides
Publisher: Elsevier BV
Published: 2016-02
Volume: 55
Pages: 99-109
ISSN: 0143-4179 (ISSN-L)
DOI: 10.1016/j.npep.2015.09.008
PMC: PMC4830398
OpenAlex: W1891173294
Cited by: 490
References: 184
Citations by year: 2026: 43 · 2025: 47 · 2024: 57 · 2023: 44 · 2022: 55 · 2021: 62 · 2020: 53 · 2019: 39 · 2018: 34 · 2017: 37 · 2016: 16 · 2015: 2 · 2014: 1
FWCI: 3.53
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuropeptides (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Austrian Science Fund (P23097-B18, P25912-B23, W1241-B18)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords: neuropeptide Y, stress, stress resilience, anxiolytic effects, neuroprotection, NPY receptors, Y1 receptor, Y2 receptor, hypothalamus, brainstem, limbic system, post-traumatic stress disorder, neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, Huntington's disease, stress coping, feeding behaviour
MeSH terms: Animals, Homeostasis, Humans, Hypothalamus, Neurons, Neuropeptide Y, Stress, Physiological, Receptors, Neuropeptide Y

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Neuropeptide Y: a stressful review

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks