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Cited by 264

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

The Effect of Intensive Glycemic Treatment on Coronary Artery Calcification in Type 1 Diabetic Participants of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study

Open access
Cleary, Patricia A., Orchard, Trevor J., Genuth, Saul, Wong, Nathan D., Detrano, Robert, Backlund, Jye-Yu C., Zinman, Bernard, Jacobson, Alan, Sun, Wanjie, Lachin, John M., Nathan, David M., for the DCCT/EDIC Research Group·2006·Diabetes
DOI 10.2337/db06-0653
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Abstract

The Epidemiology of Diabetes Interventions and Complications (EDIC) study, an observational follow-up of the Diabetes Control and Complications Trial (DCCT) type 1 diabetes cohort, measured coronary artery calcification (CAC), an index of atherosclerosis, with computed tomography (CT) in 1,205 EDIC patients at ∼7–9 years after the end of the DCCT. We examined the influence of the 6.5 years of prior conventional versus intensive diabetes treatment during the DCCT, as well as the effects of cardiovascular disease risk factors, on CAC. The prevalences of CAC >0 and >200 Agatston units were 31.0 and 8.5%, respectively. Compared with the conventional treatment group, the intensive group had significantly lower geometric mean CAC scores and a lower prevalence of CAC >0 in the primary retinopathy prevention cohort, but not in the secondary intervention cohort, and a lower prevalence of CAC >200 in the combined cohorts. Waist-to-hip ratio, smoking, hypertension, and hypercholesterolemia, before or at the time of CT, were significantly associated with CAC in univariate and multivariate analyses. CAC was associated with mean HbA1c (A1C) levels before enrollment, during the DCCT, and during the EDIC study. Prior intensive diabetes treatment during the DCCT was associated with less atherosclerosis, largely because of reduced levels of A1C during the DCCT.

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Metadata

Authors
Cleary, P. A., Orchard, T. J., Genuth, S., Wong, N. D., Detrano, R., Backlund, J.-Y. C., Zinman, B., Jacobson, A., Sun, W., Lachin, J. M., Nathan, D. M., & for the DCCT/EDIC Research Group
Venue
Diabetes
Publisher
American Diabetes Association
Published
2006-12-01
Volume
55
Issue
12
Pages
3556-3565
ISSN
  • 0012-1797 (ISSN-L)
  • 1939-327X
DOI
10.2337/db06-0653
OpenAlex
W2102643074
Cited by
264
References
48
FWCI
9.48
Type
journal article
Language
en
Open access
bronze

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