Can Diabetes Be Surgically Cured? Long-Term Metabolic Effects of Bariatric Surgery in Obese Patients with Type 2 Diabetes Mellitus
Open accessAbstract
OBJECTIVE: Evaluate the long-term effects of bariatric surgery on type 2 diabetes (T2DM) remission and metabolic risk factors. BACKGROUND: Although the impressive antidiabetic effects of bariatric surgery have been shown in short- and medium-term studies, the durability of these effects is uncertain. Specifically, long-term remission rates following bariatric surgery are largely unknown. METHODS: Clinical outcomes of 217 patients with T2DM who underwent bariatric surgery between 2004 and 2007 and had at least 5-year follow-up were assessed. Complete remission was defined as glycated hemoglobin (A1C) less than 6% and fasting blood glucose (FBG) less than 100 mg/dL off diabetic medications. Changes in other metabolic comorbidities, including hypertension, dyslipidemia, and diabetic nephropathy, were assessed. RESULTS: At a median follow-up of 6 years (range: 5-9) after surgery (Roux-en-Y gastric bypass, n = 162; gastric banding, n = 32; sleeve gastrectomy, n = 23), a mean excess weight loss (EWL) of 55% was associated with mean reductions in A1C from 7.5% ± 1.5% to 6.5% ± 1.2% (P < 0.001) and FBG from 155.9 ± 59.5 mg/dL to 114.8 ± 40.2 mg/dL (P < 0.001). Long-term complete and partial remission rates were 24% and 26%, respectively, whereas 34% improved (>1% decrease in A1C without remission) from baseline and 16% remained unchanged. Shorter duration of T2DM (P < 0.001) and higher long-term EWL (P = 0.006) predicted long-term remission. Recurrence of T2DM after initial remission occurred in 19% and was associated with longer duration of T2DM (P = 0.03), less EWL (P = 0.02), and weight regain (P = 0.015). Long-term control rates of low high-density lipoprotein, high low-density lipoprotein, high triglyceridemia, and hypertension were 73%, 72%, 80%, and 62%, respectively. Diabetic nephropathy regressed (53%) or stabilized (47%). CONCLUSIONS: Bariatric surgery can induce a significant and sustainable remission and improvement of T2DM and other metabolic risk factors in severely obese patients. Surgical intervention within 5 years of diagnosis is associated with a high rate of long-term remission.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Complete remission rates decrease with time; one study found 43% complete remission after 2 years post-surgery, dropping to 24% after 5 years.
“The consensus in the literature is that complete remission rates decrease with time, as demonstrated in one study where 43% of patients had complete remission after 2 years post-surgery, which dropped to 24% after 5 years.294,295”
From A review of current trends with type 2 diabetes epidemiology, aetiology, pathogenesis, treatments and future perspectives (2021) · cites this paper as [295]
Recent findings suggest that a persistent impairment in insulin secretion is a crucial factor in failure to sustain T2D remission after bariatric surgery.
“Recent findings suggest that a persistent impairment in insulin secretion is a crucial factor in failure to sustain T2D remission after bariatric surgery.295–297”
From A review of current trends with type 2 diabetes epidemiology, aetiology, pathogenesis, treatments and future perspectives (2021) · cites this paper as [295]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
10-year follow-up of intensive glucose control in type 2 diabetes
Holman, R. R., Paul, S. K., Bethel, M. A., Matthews, D. R., & Neil, H. A. W. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0806470 · Cited by 7,751 · see citing works
General Cardiovascular Risk Profile for Use in Primary Care: The Framingham Heart Study
D’Agostino, R. B., Vasan, R. S., Pencina, M. J., Wolf, P. A., Cobain, M., Massaro, J. M., & Kannel, W. B. (2008) · Circulation · doi:10.1161/circulationaha.107.699579 · Cited by 7,491 · see citing works
Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001
Mokdad, A. H., Ford, E. S., Bowman, B. A., Dietz, W. H., Vinicor, F., Bales, V. S., & Marks, J. S. (2003) · JAMA · doi:10.1001/jama.289.1.76 · Cited by 5,866 · see citing works
Effects of Bariatric Surgery on Mortality in Swedish Obese Subjects
Sjöström, L., Narbro, K., Sjöström, C. D., Karason, K., Larsson, B., Wedel, H., Lystig, T., Sullivan, M., Bouchard, C., Carlsson, B., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa066254 · Cited by 4,668 · see citing works
Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery
Sjöström, L., Lindroos, A.-K., Peltonen, M., Torgerson, J., Bouchard, C., Carlsson, B., Dahlgren, S., Larsson, B., Narbro, K., Sjöström, C. D., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa035622 · Cited by 4,457 · see citing works
Standards of medical care in diabetes—2013
American Diabetes Association (2013) · Diabetes Care · doi:10.2337/dc13-s011 · Cited by 4,369 · see citing works
Finucane, M. M., Stevens, G. A., Cowan, M. J., Danaei, G., Lin, J. K., Paciorek, C. J., Singh, G. M., Gutierrez, H. R., Lu, Y., Bahalim, A. N., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(10)62037-5 · Cited by 4,050 · see citing works
Weight and Type 2 Diabetes after Bariatric Surgery: Systematic Review and Meta-analysis
Buchwald, H., Estok, R., Fahrbach, K., Banel, D., Jensen, M. D., Pories, W. J., Bantle, J. P., & Sledge, I. (2009) · The American Journal of Medicine · doi:10.1016/j.amjmed.2008.09.041 · Cited by 2,551 · see citing works
Pories, W. J., Swanson, M. S., MacDonald, K. G., Long, S. B., Morris, P. G., Brown, B. M., Barakat, H. A., deRamon, R. A., Israel, G., Dolezal, J. M., et al. (1995) · Annals of Surgery · doi:10.1097/00000658-199509000-00011 · Cited by 2,293 · see citing works
Obesity and Diabetes in the Developing World — A Growing Challenge
Hossain, P., Kawar, B., & El Nahas, M. (2007) · New England Journal of Medicine · doi:10.1056/nejmp068177 · Cited by 2,200 · see citing works
Bariatric Surgery versus Intensive Medical Therapy in Obese Patients with Diabetes
Schauer, P. R., Kashyap, S. R., Wolski, K., Brethauer, S. A., Kirwan, J. P., Pothier, C. E., Thomas, S., Abood, B., Nissen, S. E., & Bhatt, D. L. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1200225 · Cited by 2,164 · see citing works
Self-citationMicroalbuminuria Predicts Clinical Proteinuria and Early Mortality in Maturity-Onset Diabetes
Mogensen, C. E. (1984) · New England Journal of Medicine · doi:10.1056/nejm198402093100605 · Cited by 1,918 · see citing works
Bariatric Surgery versus Intensive Medical Therapy for Diabetes — 3-Year Outcomes
Schauer, P. R., Bhatt, D. L., Kirwan, J. P., Wolski, K., Brethauer, S. A., Navaneethan, S. D., Aminian, A., Pothier, C. E., Kim, E. S. H., Nissen, S. E., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1401329 · Cited by 1,901 · see citing works
Self-citationSjöström, L. (2013) · Journal of Internal Medicine · doi:10.1111/joim.12012 · Cited by 1,835 · see citing works
Bariatric Surgery versus Conventional Medical Therapy for Type 2 Diabetes
Mingrone, G., Panunzi, S., De Gaetano, A., Guidone, C., Iaconelli, A., Leccesi, L., Nanni, G., Pomp, A., Castagneto, M., Ghirlanda, G., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1200111 · Cited by 1,791 · see citing works
Bariatric Surgery and Long-term Cardiovascular Events
Sjöström, L., Peltonen, M., Jacobson, P., Sjöström, C. D., Karason, K., Wedel, H., Ahlin, S., Anveden, Å., Bengtsson, C., Bergmark, G., et al. (2012) · JAMA · doi:10.1001/jama.2011.1914 · Cited by 1,656 · see citing works
Dixon, J. B., O’Brien, P. E., Playfair, J., Chapman, L., Schachter, L. M., Skinner, S., Proietto, J., Bailey, M., & Anderson, M. (2008) · JAMA · doi:10.1001/jama.299.3.316 · Cited by 1,434 · see citing works
Effect of laparoscopic Roux-en Y gastric bypass on type 2 diabetes mellitus
Schauer, P. R., Burguera, B., Ikramuddin, S., Cottam, D., Gourash, W., Hamad, G., Eid, G. M., Mattar, S., Ramanathan, R., Barinas-Mitchel, E., et al. (2003) · Annals of Surgery · doi:10.1097/01.sla.0000089851.41115.1b · Cited by 1,183 · see citing works
Self-citationHow do we define cure of diabetes?
Buse, J. B., Caprio, S., Cefalu, W. T., Ceriello, A., Del Prato, S., Inzucchi, S. E., McLaughlin, S., Phillips, G. L., Robertson, R. P., Rubino, F., et al. (2009) · Diabetes Care · doi:10.2337/dc09-9036 · Cited by 1,003 · see citing works
Secular Trends in Cardiovascular Disease Risk Factors According to Body Mass Index in US Adults
Gregg, E. W. (2005) · JAMA · doi:10.1001/jama.293.15.1868 · Cited by 959 · see citing works
Risk Factors for Renal Dysfunction in Type 2 Diabetes
Retnakaran, R., Cull, C. A., Thorne, K. I., Adler, A. I., Holman, R. R., & for the UKPDS Study Group (2006) · Diabetes · doi:10.2337/db05-1620 · Cited by 927 · see citing works
Bariatric surgery and prevention of type 2 diabetes in Swedish obese subjects
Carlsson, L. M. S., Peltonen, M., Ahlin, S., Anveden, Å., Bouchard, C., Carlsson, B., Jacobson, P., Lönroth, H., Maglio, C., Näslund, I., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1112082 · Cited by 794 · see citing works
Sjöström, L., Gummesson, A., Sjöström, C. D., Narbro, K., Peltonen, M., Wedel, H., Bengtsson, C., Bouchard, C., Carlsson, B., Dahlgren, S., et al. (2009) · The Lancet Oncology · doi:10.1016/s1470-2045(09)70159-7 · Cited by 770 · see citing works
The Prevalence of Meeting A1C, Blood Pressure, and LDL Goals Among People With Diabetes, 1988–2010
Stark Casagrande, S., Fradkin, J. E., Saydah, S. H., Rust, K. F., & Cowie, C. C. (2013) · Diabetes Care · doi:10.2337/dc12-2258 · Cited by 719 · see citing works
Health benefits of gastric bypass surgery after 6 years
Adams, T. D., Davidson, L. E., Litwin, S. E., Kolotkin, R. L., LaMonte, M. J., Pendleton, R. C., Strong, M. B., Vinik, R., Wanner, N. A., Hopkins, P. N., et al. (2012) · JAMA · doi:10.1001/2012.jama.11164 · Cited by 674 · see citing works
Peterli, R., Wölnerhanssen, B. K., Peters, T. T. A., Devaux, N., Kern, B. E., Christoffel-Courtin, C., Drewe, J., von Flüe, M., & Beglinger, C. (2009) · Annals of Surgery · doi:10.1097/sla.0b013e3181ae32e3 · Cited by 565 · see citing works
Results of 281 Consecutive Total Laparoscopic Roux-en-Y Gastric Bypasses to Treat Morbid Obesity
DeMaria, E. J., Sugerman, H. J., Kellum, J. M., Meador, J. G., & Wolfe, L. G. (2002) · Annals of Surgery · doi:10.1097/00000658-200205000-00005 · Cited by 561 · see citing works
Gall, M.-A., Hougaard, P., Borch‐Johnsen, K., & Parving, H. (1997) · BMJ · doi:10.1136/bmj.314.7083.783 · Cited by 439 · see citing works
Arterburn, D. E., Bogart, A., Sherwood, N. E., Sidney, S., Coleman, K. J., Haneuse, S., O’Connor, P. J., Theis, M. K., Campos, G. M., McCulloch, D., et al. (2013) · Obesity Surgery · doi:10.1007/s11695-012-0802-1 · Cited by 426 · see citing works
Bariatric Surgery Versus Intensive Medical Therapy in Obese Patients With Diabetes
Schauer, P. R., Kashyap, S. R., Wolski, K., Brethauer, S. A., Kirwan, J. P., Pothier, C. E., Thomas, S., Abood, B., Nissen, S. E., & Bhatt, D. L. (2013) · Survey of Anesthesiology · doi:10.1097/sa.0b013e31827f316e · Cited by 410 · see citing works
Self-citationInterdisciplinary European Guidelines on Metabolic and Bariatric Surgery
Fried, M., Yumuk, V., Oppert, J., Scopinaro, N., Torres, A. J., Weiner, R. A., Yashkov, Y. I., & Frühbeck, G. (2013) · Obesity Facts · doi:10.1159/000355480 · Cited by 320 · see citing works
Metabolic Effects of Bariatric Surgery in Patients With Moderate Obesity and Type 2 Diabetes
Kashyap, S. R., Bhatt, D. L., Wolski, K., Watanabe, R. M., Abdul‐Ghani, M. A., Abood, B., Pothier, C. E., Brethauer, S. A., Nissen, S. E., Gupta, M. K., et al. (2013) · Diabetes Care · doi:10.2337/dc12-1596 · Cited by 286 · see citing works
Self-citationEffects of gastric bypass surgery in patients with type 2 diabetes and only mild obesity
Cohen, R. V., Pinheiro, J. C., Schiavon, C. A., Salles, J. E., Wajchenberg, B. L., & Cummings, D. E. (2012) · Diabetes Care · doi:10.2337/dc11-2289 · Cited by 282 · see citing works
Cleary, P. A., Orchard, T. J., GENUTH, S. M., Wong, N. D., Detrano, R., Backlund, J. C., Zinman, B., Jacobson, A. M., Sun, W., Lachin, J. M., et al. (2006) · Diabetes · doi:10.2337/db06-0653 · Cited by 263 · see citing works
Sleeve gastrectomy and type 2 diabetes mellitus: a systematic review
Gill, R. S., Birch, D. W., Shi, X., Sharma, A. M., & Karmali, S. (2010) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2010.07.011 · Cited by 256 · see citing works
Jiménez, A., Casamitjana, R., Flores, L., Viaplana, J., Corcelles, R., Lacy, A. M., & Vidal, J. (2012) · Annals of Surgery · doi:10.1097/sla.0b013e318262ee6b · Cited by 237 · see citing works
Analysis of factors associated with durable remission of diabetes after Roux-en-Y gastric bypass
Chikunguwo, S. M., Wolfe, L. G., Dodson, P. W., Meador, J. G., Baugh, N., Clore, J. N., Kellum, J. M., & Maher, J. W. (2009) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2009.11.003 · Cited by 227 · see citing works
Laparoscopic Sleeve Gastrectomy for Super Obese Patients
Eid, G. M., Brethauer, S. A., Mattar, S. G., Titchner, R. L., GOURASH, W. F., & Schauer, P. R. (2012) · Annals of Surgery · doi:10.1097/sla.0b013e31825fe905 · Cited by 174 · see citing works
Self-citationCardiovascular events after bariatric surgery in obese subjects with type 2 diabetes
Romeo, S., Maglio, C., Burza, M. A., Pirazzi, C., Sjöholm, K., Jacobson, P., Svensson, P.-A., Peltonen, M., Sjöström, L., & Carlsson, L. M. S. (2012) · Diabetes Care · doi:10.2337/dc12-0193 · Cited by 172 · see citing works
Effects of Bilio-Pancreatic Diversion on Diabetic Complications
Iaconelli, A., Panunzi, S., Gaetano, A. D., Manco, M., Guidone, C., Leccesi, L., Gniuli, D., Nanni, G., Castagneto, M., Ghirlanda, G., et al. (2011) · Diabetes Care · doi:10.2337/dc10-1761 · Cited by 141 · see citing works
Johnson, B. L., Blackhurst, D. W., Latham, B. B., Cull, D. L., Bour, E. S., Oliver, T. L., Williams, B. R., Taylor, S. M., & Scott, J. D. (2013) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2012.12.019 · Cited by 132 · see citing works
Progression to Overt Nephropathy in Type 2 Diabetes
Bruno, G., Merletti, F., Biggeri, A., Bargero, G., Ferrero, S., Pagano, G., & Perin, P. C. (2003) · Diabetes Care · doi:10.2337/diacare.26.7.2150 · Cited by 118 · see citing works
Effects of bariatric surgery on diabetic nephropathy after 5 years of follow-up
Heneghan, H., Cetin, D. C., Navaneethan, S. D., Orzech, N., Brethauer, S. A., & Schauer, P. R. (2012) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2012.08.016 · Cited by 98 · see citing works
Self-citationNavaneethan, S. D., Kelly, K. R., Sabbagh, F. H. E., Schauer, P. R., Kirwan, J. P., & Kashyap, S. R. (2009) · Obesity Surgery · doi:10.1007/s11695-009-0026-1 · Cited by 82 · see citing works
Self-citationLegacy Effects from DCCT and UKPDS: What They Mean and Implications for Future Diabetes Trials
Murray, P. T., Chune, G., & Raghavan, V. A. (2010) · Current Atherosclerosis Reports · doi:10.1007/s11883-010-0128-1 · Cited by 78 · see citing works
Billing, P. S., Crouthamel, M. R., Oling, S., & Landerholm, R. W. (2013) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2013.07.005 · Cited by 76 · see citing works
Research Fundamentals: Follow-up of Subjects in Clinical Trials: Addressing Subject Attrition
Woolard, R. H., Carty, K., Wirtz, P. W., Longabaugh, R., Nirenberg, T. D., Minugh, P. A., Becker, B. M., & Clifford, P. R. (2004) · Academic Emergency Medicine · doi:10.1197/j.aem.2003.09.021 · Cited by 70 · see citing works
Is Ambulatory Laparoscopic Roux-En-Y Gastric Bypass Associated With Higher Adverse Events?
Morton, J. M., Winegar, D. A., Blackstone, R. P., & Wolfe, B. M. (2013) · Annals of Surgery · doi:10.1097/sla.0000000000000227 · Cited by 67 · see citing works
Caiazzo, R. J., Arnalsteen, L., Pigeyre, M., Dezfoulian, G., Verkindt, H., Kirkby‐Bott, J., Mathurin, P., Fontaine, P., Romon, M., & Pattou, F. N. (2010) · British journal of surgery · doi:10.1002/bjs.6993 · Cited by 54 · see citing works
Lakdawala, M. A., Shaikh, S. S., Bandukwala, S., Remedios, C., Shah, M. A., & Bhasker, A. G. (2012) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2012.07.017 · Cited by 54 · see citing works
Bariatric surgery for diabetes: The International Diabetes Federation takes a position
Dixon, J. B., Zimmet, P., Alberti, K. G. M. M., Mbanya, J. C., Rubino, F., & on behalf of the INTERNATIONAL DIABETES FEDERATION TASKFORCE on EPIDEMIOLOGY and PREVENTION (2011) · Journal of Diabetes · doi:10.1111/j.1753-0407.2011.00144.x · Cited by 47 · see citing works
Laparoscopic Gastric Banding Is Safe in Outpatient Surgical Centers
Cobourn, C. S., Mumford, D., Chapman, M. A., & Wells, L. (2010) · Obesity Surgery · doi:10.1007/s11695-009-0065-7 · Cited by 44 · see citing works
Sultan, S. T., Gupta, D., Parikh, M., Youn, H. A., Kurian, M. S., Fielding, G., & Ren‐Fielding, C. J. (2010) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2010.02.043 · Cited by 36 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Bariatric Surgery versus Intensive Medical Therapy for Diabetes — 5-Year Outcomes
Schauer, P. R., Bhatt, D. L., Kirwan, J. P., Wolski, K., Aminian, A., Brethauer, S. A., Navaneethan, S. D., Singh, R. P., Pothier, C. E., Nissen, S. E., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1600869 · Cited by 2,934 · see citing works
Self-citationBariatric Surgery versus Intensive Medical Therapy for Diabetes — 3-Year Outcomes
Schauer, P. R., Bhatt, D. L., Kirwan, J. P., Wolski, K., Brethauer, S. A., Navaneethan, S. D., Aminian, A., Pothier, C. E., Kim, E. S. H., Nissen, S. E., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1401329 · Cited by 1,901 · see citing works
Self-citationSjöström, L., Peltonen, M., Jacobson, P., Ahlin, S., Andersson-Assarsson, J., Anveden, Å., Bouchard, C., Carlsson, B., Karason, K., Lönroth, H., et al. (2014) · JAMA · doi:10.1001/jama.2014.5988 · Cited by 1,054 · see citing works
Why does obesity cause diabetes?
Klein, S., Gastaldelli, A., Yki-Järvinen, H., & Scherer, P. E. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2021.12.012 · Cited by 939 · see citing works
Salminen, P., Helmiö, M., Ovaska, J., Juuti, A., Leivonen, M., Peromaa-Haavisto, P., Hurme, S., Soinio, M., Nuutila, P., & Victorzon, M. (2018) · JAMA · doi:10.1001/jama.2017.20313 · Cited by 946 · see citing works
Bariatric Surgery Reduces Features of Nonalcoholic Steatohepatitis in Morbidly Obese Patients
Lassailly, G., Caiazzo, R., Buob, D., Pigeyre, M., Verkindt, H., Labreuche, J., Raverdy, V., Leteurtre, E., Dharancy, S., Louvet, A., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.04.014 · Cited by 762 · see citing works
El Ansari, W., & Elhag, W. (2021) · Obesity Surgery · doi:10.1007/s11695-020-05160-5 · Cited by 482 · see citing works
Reed, J., Bain, S., & Kanamarlapudi, V. (2021) · Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy · doi:10.2147/dmso.s319895 · Cited by 441 · see citing works
Weight Regain Following Sleeve Gastrectomy—a Systematic Review
Lauti, M., Kularatna, M., Hill, A. G., & MacCormick, A. D. (2016) · Obesity Surgery · doi:10.1007/s11695-016-2152-x · Cited by 412 · see citing works
Courcoulas, A. P., Belle, S. H., Neiberg, R. H., Pierson, S. K., Eagleton, J. K., Kalarchian, M. A., DeLany, J. P., Lang, W., & Jakicic, J. M. (2015) · JAMA Surgery · doi:10.1001/jamasurg.2015.1534 · Cited by 376 · see citing works
ElSayed, N. A., Aleppo, G., Aroda, V. R., Bannuru, R. R., Brown, F. M., Bruemmer, D., Collins, B. S., Hilliard, M. E., Isaacs, D., Johnson, E. L., et al. (2023) · Diabetes Care · doi:10.2337/dc23-s008 · Cited by 244 · see citing works
Effects of diet versus gastric bypass on metabolic function in diabetes
Yoshino, M., Kayser, B. D., Yoshino, J., Stein, R. I., Reeds, D., Eagon, J. C., Eckhouse, S. R., Watrous, J. D., Jain, M., Knight, R., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2003697 · Cited by 246 · see citing works
American Diabetes Association Professional Practice Committee, ElSayed, N. A., McCoy, R. G., Aleppo, G., Balapattabi, K., Beverly, E. A., Briggs Early, K., Bruemmer, D., Echouffo-Tcheugui, J. B., Ekhlaspour, L., et al. (2025) · Diabetes Care · doi:10.2337/dc25-s008 · Cited by 236 · see citing works
American Diabetes Association Professional Practice Committee (2022) · Diabetes Care · doi:10.2337/dc22-s008 · Cited by 244 · see citing works
Schauer, P. R., Mingrone, G., Ikramuddin, S., & Wolfe, B. (2016) · Diabetes Care · doi:10.2337/dc16-0382 · Cited by 215 · see citing works
Self-citationAmerican Diabetes Association Professional Practice Committee, ElSayed, N. A., Aleppo, G., Bannuru, R. R., Bruemmer, D., Collins, B. S., Ekhlaspour, L., Hilliard, M. E., Johnson, E. L., Khunti, K., et al. (2024) · Diabetes Care · doi:10.2337/dc24-s008 · Cited by 213 · see citing works
Determinants of diabetes remission and glycemic control after bariatric surgery
Panunzi, S., Carlsson, L., De Gaetano, A., Peltonen, M., Rice, T., Sjöström, L., Mingrone, G., & Dixon, J. B. (2016) · Diabetes Care · doi:10.2337/dc15-0575 · Cited by 198 · see citing works
The role of bariatric surgery to treat diabetes: current challenges and perspectives
Koliaki, C., Liatis, S., le Roux, C. W., & Kokkinos, A. (2017) · BMC Endocrine Disorders · doi:10.1186/s12902-017-0202-6 · Cited by 167 · see citing works
American Diabetes Association (2021) · Diabetes Care · doi:10.2337/dc21-s008 · Cited by 158 · see citing works
Rubino, F., Nathan, D. M., Eckel, R. H., Schauer, P. R., Alberti, K. G. M. M., Zimmet, P. Z., Del Prato, S., Ji, L., Sadikot, S. M., Herman, W. H., et al. (2016) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2016.05.018 · Cited by 157 · see citing works
Self-citationfor the Indian Bariatric Surgery Outcome Reporting (IBSOR) Group, Baig, S. J., Priya, P., Mahawar, K. K., & Shah, S. (2019) · Obesity Surgery · doi:10.1007/s11695-019-03734-6 · Cited by 127 · see citing works
Saad, F., Yassin, A., Doros, G., & Haider, A. (2016) · International Journal of Obesity · doi:10.1038/ijo.2015.139 · Cited by 131 · see citing works
Non-pharmacological Treatment Options in the Management of Diabetes Mellitus
Raveendran, A. V. (2018) · European Endocrinology · doi:10.17925/ee.2018.14.2.31 · Cited by 122 · see citing works
Weight regain after bariatric surgery—how should it be defined?
Nedelcu, M., Khwaja, H. A., & Rogula, T. G. (2016) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2016.04.028 · Cited by 121 · see citing works
Self-citationLate Relapse of Diabetes After Bariatric Surgery: Not Rare, but Not a Failure
Aminian, A., Vidal, J., Salminen, P., Still, C. D., Nor Hanipah, Z., Sharma, G., Tu, C., Wood, G. C., Ibarzabal, A., Jimenez, A., et al. (2020) · Diabetes Care · doi:10.2337/dc19-1057 · Cited by 122 · see citing works
Self-citationInsulin-associated weight gain in obese type 2 diabetes mellitus patients: What can be done?
Brown, A., Guess, N., Dornhorst, A., Taheri, S., & Frost, G. (2017) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.13009 · Cited by 113 · see citing works
Khorgami, Z., Shoar, S., Saber, A. A., Howard, C. A., Danaei, G., & Sclabas, G. M. (2019) · Obesity Surgery · doi:10.1007/s11695-018-3552-x · Cited by 100 · see citing works
Quan, Y., Huang, A., Ye, M., Xu, M., Zhuang, B., Zhang, P., Yu, B., & Min, Z. (2015) · Gastroenterology Research and Practice · doi:10.1155/2015/152852 · Cited by 93 · see citing works
Bariatric surgery in obese patients with type 1 diabetes
Kirwan, J. P., Aminian, A., Kashyap, S. R., Burguera, B., Brethauer, S. A., & Schauer, P. R. (2016) · Diabetes Care · doi:10.2337/dc15-2732 · Cited by 80 · see citing works
Self-citationExercise and bariatric surgery: an effective therapeutic strategy
Coen, P. M., Carnero, E. A., & Goodpaster, B. H. (2018) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000168 · Cited by 71 · see citing works
Dicker, D., Yahalom, R., Comaneshter, D. S., & Vinker, S. (2016) · Obesity Surgery · doi:10.1007/s11695-015-2025-8 · Cited by 70 · see citing works
Bariatric surgery and diabetes remission: Who would have thought it?
Singh, A., Singh, R., & Kota, S. (2015) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/2230-8210.163113 · Cited by 48 · see citing works
Lifestyle Management for Enhancing Outcomes after Bariatric Surgery
Kalarchian, M., Turk, M., Elliott, J., & Gourash, W. (2014) · Current Diabetes Reports · doi:10.1007/s11892-014-0540-y · Cited by 36 · see citing works
Wilson, E. R., Kyle, T. K., Nadglowski, J. F., & Stanford, F. C. (2017) · Obesity · doi:10.1002/oby.21746 · Cited by 29 · see citing works
Diabetes remission and relapse after bariatric surgery: a nationwide population-based study
Conte, C., Lapeyre-Mestre, M., Hanaire, H., & Ritz, P. (2020) · Obesity Surgery · doi:10.1007/s11695-020-04924-3 · Cited by 29 · see citing works
Morissette, A., & Mulvihill, E. E. (2024) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.3389/jpps.2024.13065 · Cited by 8 · see citing works
- Authors
- Brethauer, S. A., Aminian, A., Romero-Talamás, H., Batayyah, E., Mackey, J., Kennedy, L., Kashyap, S. R., Kirwan, J. P., Rogula, T., Kroh, M., Chand, B., & Schauer, P. R.
- Affiliations
- Cleveland Clinic (US)
- Loyola University Chicago (US)
- Corresponding author
- Brethauer, Stacy A.
- Aminian, Ali
- Batayyah, Esam
- Mackey, Jennifer
- Rogula, Tomasz
- Kroh, Matthew
- Schauer, Philip R.
- ORCID
- Venue
- Annals of Surgery
- Published
- 2013-10
- Volume
- 258
- Issue
- 4
- Pages
- 628-637
- ISSN
- 0003-4932 (ISSN-L)
- PMC
- PMC4110959
- OpenAlex
- W2094282883
- Cited by
- 552
- References
- 53
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 19 · 2023: 31 · 2022: 29 · 2021: 35 · 2020: 36 · 2019: 34 · 2018: 51 · 2017: 66 · 2016: 66 · 2015: 97 · 2014: 63 · 2013: 7 · 2012: 1
- FWCI
- 76.54
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annals of Surgery (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (KL2TR000440)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK089547)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Surgery › Minimally Invasive Surgical Techniques
- Keywords
- type 2 diabetes, bariatric surgery, diabetes remission, obesity, Roux-en-Y gastric bypass, gastric banding, sleeve gastrectomy, excess weight loss, HbA1c, fasting blood glucose, weight regain, metabolic comorbidities, hypertension, dyslipidemia, diabetic nephropathy, long-term outcomes, predictors of remission
- MeSH terms
- Adult, Aged, Diabetes Mellitus, Type 2, Female, Follow-Up Studies, Humans, Male, Middle Aged, Obesity, Recurrence, Retrospective Studies, Risk Factors, ROC Curve, Biomarkers, Multivariate Analysis, Logistic Models, Treatment Outcome, Bariatric Surgery
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
