Adipose Mitochondrial Biogenesis Is Suppressed in db/db and High-Fat Diet–Fed Mice and Improved by Rosiglitazone

Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing

Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482

Obesity is associated with macrophage accumulation in adipose tissue

Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760

A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes

Scherer, P. E., Williams, S. P., Fogliano, M., Baldini, G., & Lodish, H. F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.26746 · Cited by 3,238

Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome

Kadowaki, T. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29126 · Cited by 2,824

Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres

Lin, J., Wu, H., Tarr, P. T., Zhang, C.-Y., Wu, Z., Boss, O., Michael, L. F., Puigserver, P., Isotani, E., Olson, E. N., et al. (2002) · Nature · doi:10.1038/nature00904 · Cited by 2,546

Reactive oxygen species have a causal role in multiple forms of insulin resistance

Houstis, N., Rosen, E. D., & Lander, E. S. (2006) · Nature · doi:10.1038/nature04634 · Cited by 2,525 · cited 1×

Abnormal splicing of the leptin receptor in diabetic mice

Lee, G.-H., Proenca, R., Montez, J. M., Carroll, K. M., Darvishzadeh, J. G., Lee, J. I., & Friedman, J. M. (1996) · Nature · doi:10.1038/379632a0 · Cited by 2,327

Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes

Kelley, D. E., He, J., Menshikova, E. V., & Ritov, V. B. (2002) · Diabetes · doi:10.2337/diabetes.51.10.2944 · Cited by 2,321

Metabolic control through the PGC-1 family of transcription coactivators

Lin, J., Handschin, C., & Spiegelman, B. M. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.004 · Cited by 2,130 · cited 2×

Brown and beige fat: Development, function and therapeutic potential

Harms, M., & Seale, P. (2013) · Nature Medicine · doi:10.1038/nm.3361 · Cited by 2,328

Mitochondrial dysfunction and oxidative stress in metabolic disorders - A step towards mitochondria based therapeutic strategies

Bhatti, J. S., Bhatti, G. K., & Reddy, P. H. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.11.010 · Cited by 1,655

Chronic Peroxisome Proliferator-activated Receptor γ (PPARγ) Activation of Epididymally Derived White Adipocyte Cultures Reveals a Population of Thermogenically Competent, UCP1-containing Adipocytes Molecularly Distinct from Classic Brown Adipocytes

Petrovic, N., Walden, T. B., Shabalina, I. G., Timmons, J. A., Cannon, B., & Nedergaard, J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.053942 · Cited by 1,263

PPARγ agonists Induce a White-to-Brown Fat Conversion through Stabilization of PRDM16 Protein

Ohno, H., Shinoda, K., Spiegelman, B. M., & Kajimura, S. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.019 · Cited by 770

PGC-1 α , Inflammation, and Oxidative Stress: An Integrative View in Metabolism

Rius‐Pérez, S., Torres-Cuevas, I., Millán, I., Ortega, Á., & Pérez, S. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/1452696 · Cited by 671

Transcriptional Control of Mitochondrial Biogenesis and Function

Hock, M. B., & Kralli, A. (2009) · Annual Review of Physiology · doi:10.1146/annurev.physiol.010908.163119 · Cited by 626

The role of mitochondria in the pathogenesis of type 2 diabetes

Patti, M.-E., & Corvera, S. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0027 · Cited by 551

Mitochondrial dysfunction in obesity

de Mello, A. H., Costa, A. B., Engel, J. D. G., & Rezin, G. T. (2018) · Life Sciences · doi:10.1016/j.lfs.2017.11.019 · Cited by 508

Resveratrol induces mitochondrial biogenesis in endothelial cells

Csiszár, A., Labinskyy, N., Pinto, J. T., Ballabh, P., Zhang, H., Losonczy, G., Pearson, K. J., de Cabo, R., Pacher, P., Zhang, C., et al. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00368.2009 · Cited by 459

Mitochondrial dysfunction in type 2 diabetes mellitus: an organ-based analysis

Pinti, M. V., Fink, G. K., Hathaway, Q. A., Durr, A. J., Kunovac, A., & Hollander, J. M. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00314.2018 · Cited by 447

A New Era in Brown Adipose Tissue Biology: Molecular Control of Brown Fat Development and Energy Homeostasis

Kajimura, S., & Saito, M. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021113-170252 · Cited by 439

New insights into PGC ‐1 coactivators: redefining their role in the regulation of mitochondrial function and beyond

Villena, J. A. (2014) · FEBS Journal · doi:10.1111/febs.13175 · Cited by 413

Metabolic adaptation and maladaptation in adipose tissue

Chouchani, E. T., & Kajimura, S. (2019) · Nature Metabolism · doi:10.1038/s42255-018-0021-8 · Cited by 405

Impaired Mitochondrial Biogenesis in Adipose Tissue in Acquired Obesity

Heinonen, S., Buzkova, J., Muniandy, M., Kaksonen, R., Ollikainen, M., Ismail, K., Hakkarainen, A., Lundbom, J., Lundbom, N., Vuolteenaho, K., et al. (2015) · Diabetes · doi:10.2337/db14-1937 · Cited by 362

Contribution of Adipose Tissue Inflammation to the Development of Type 2 Diabetes Mellitus

Burhans, M. S., Hagman, D. K., Kuzma, J. N., Schmidt, K. A., & Kratz, M. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170040 · Cited by 461

Different Adipose Depots: Their Role in the Development of Metabolic Syndrome and Mitochondrial Response to Hypolipidemic Agents

Bjørndal, B., Burri, L., Staalesen, V., Skorve, J., & Berge, R. K. (2011) · Journal of Obesity · doi:10.1155/2011/490650 · Cited by 395

Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases

Lu, Q., Zhu, Y., Deng, C., Liang, Z., Chen, J., Chen, Y., Wang, X., Liu, Y., Tian, Y., & Yang, Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01756-w · Cited by 391

Transcriptional and epigenetic control of brown and beige adipose cell fate and function

Inagaki, T., Sakai, J., & Kajimura, S. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.62 · Cited by 347

Increased Adipose Tissue Oxygen Tension in Obese Compared With Lean Men Is Accompanied by Insulin Resistance, Impaired Adipose Tissue Capillarization, and Inflammation

Goossens, G. H., Bizzarri, A., Venteclef, N., Essers, Y., Cleutjens, J. P., Konings, E., Jocken, J. W. E., Čajlaković, M., Ribitsch, V., Clément, K., et al. (2011) · Circulation · doi:10.1161/circulationaha.111.027813 · Cited by 324

Pharmacological and nutritional agents promoting browning of white adipose tissue

Bonet, M. L., Oliver, P., & Palou, A. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.12.002 · Cited by 286

The Role of Adipose Tissue Mitochondria: Regulation of Mitochondrial Function for the Treatment of Metabolic Diseases

Lee, J. H., Park, A., Oh, K., Lee, S. C., Kim, W. K., & Bae, K. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194924 · Cited by 280

Mitochondrial (Dys)function in Adipocyte (De)differentiation and Systemic Metabolic Alterations

Pauw, A. D., Tejerina, S., Raes, M. J., Keijer, J., & Arnould, T. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.081155 · Cited by 278

Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance

Vernochet, C., Mourier, A., Bezy, O., Macotela, Y., Boucher, J., Rardin, M. J., An, D., Lee, K. Y., Ilkayeva, O. R., Zingaretti, C. M., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.10.016 · Cited by 245

Obesity May Accelerate the Aging Process

Salvestrini, V., Sell, C., & Lorenzini, A. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00266 · Cited by 260

White adipose tissue mitochondrial metabolism in health and in obesity

Heinonen, S., Jokinen, R., Rissanen, A., & Pietiläinen, K. H. (2019) · Obesity Reviews · doi:10.1111/obr.12958 · Cited by 252

Obesity and aging: Molecular mechanisms and therapeutic approaches

Santos, A. L., & Sinha, S. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101268 · Cited by 249

Adipose extracellular matrix remodelling in obesity and insulin resistance

Lin, D., Chun, T., & Kang, L. (2016) · Biochemical Pharmacology · doi:10.1016/j.bcp.2016.05.005 · Cited by 243

PPARγ Agonist Improves Neuronal Insulin Receptor Function in Hippocampus and Brain Mitochondria Function in Rats with Insulin Resistance Induced by Long Term High-Fat Diets

Pipatpiboon, N., Pratchayasakul, W., Chattipakorn, N., & Chattipakorn, S. C. (2012) · Endocrinology · doi:10.1210/en.2011-1502 · Cited by 198

Omega-3 fatty acids and adipose tissue function in obesity and metabolic syndrome

Martínez‐Fernández, L., Laiglesia, L. M., Huerta, A. E., Martínez, J. A., & Moreno-Aliaga, M. J. (2015) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2015.07.003 · Cited by 218

Exercise and adrenaline increase PGC‐1α mRNA expression in rat adipose tissue

Sutherland, L., Bomhof, M. R., Capozzi, L., Basaraba, S. A. U., & Wright, D. C. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2008.165464 · Cited by 204

Mitochondrial Biogenesis as a Pharmacological Target: A New Approach to Acute and Chronic Diseases

Whitaker, R. M., Corum, D. G., Beeson, C., & Schnellmann, R. G. (2015) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010715-103155 · Cited by 202

Uncoupling protein 1 expression and high-fat diets

Fromme, T., & Klingenspor, M. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00411.2010 · Cited by 199

The Impact of Oxidative Stress on Adipose Tissue Energy Balance

Masschelin, P. M., Cox, A. R., Chernis, N., & Hartig, S. M. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2019.01638 · Cited by 207

Pomegranate seed oil, a rich source of punicic acid, prevents diet-induced obesity and insulin resistance in mice

Vroegrijk, I. O. C. M., van Diepen, J. A., van den Berg, S. A. A., Westbroek, I., Keizer, H. G., Gambelli, L., Hontecillas, R., Bassaganya-Riera, J., Zondag, G. C. M., Romijn, J. A., et al. (2011) · Food and Chemical Toxicology · doi:10.1016/j.fct.2011.03.037 · Cited by 177

Mechanisms of human insulin resistance and thiazolidinedione-mediated insulin sensitization

Sears, D. D., Hsiao, G., Hsiao, A., Yu, J., Courtney, C. H., Ofrecio, J. M., Chapman, J., & Subramaniam, S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903032106 · Cited by 177

Exercise Training Induces Mitochondrial Biogenesis and Glucose Uptake in Subcutaneous Adipose Tissue Through eNOS-Dependent Mechanisms

Trevellin, E., Scorzeto, M., Olivieri, M., Granzotto, M., Valerio, A., Tedesco, L., Fabris, R., Serra, R., Quarta, M., Reggiani, C., et al. (2014) · Diabetes · doi:10.2337/db13-1234 · Cited by 181

Metabolic remodeling of white adipose tissue in obesity

Cummins, T. D., Holden, C. R., Sansbury, B. E., Gibb, A., Shah, J., Zafar, N., Tang, Y., Hellmann, J. L., Rai, S. N., Spite, M. R., et al. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00271.2013 · Cited by 176

Role of obesity-associated dysfunctional adipose tissue in cancer: A molecular nutrition approach

Prieto-Hontoria, P. L., Pérez‐Matute, P., Fernández‐Galilea, M., Bustos, M., Martínez, J. A., & Moreno-Aliaga, M. J. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.11.004 · Cited by 167

Isolation and Differentiation of Stromal Vascular Cells to Beige/Brite Cells

Aune, U. L., Ruiz, L., & Kajimura, S. (2013) · Journal of Visualized Experiments · doi:10.3791/50191 · Cited by 168

Overexpression of endothelial nitric oxide synthase prevents diet-induced obesity and regulates adipocyte phenotype

Sansbury, B. E., Cummins, T. D., Tang, Y., Hellmann, J., Holden, C. R., Harbeson, M. A., Chen, Y., Patel, R. P., Spite, M., Bhatnagar, A., et al. (2012) · Circulation Research · doi:10.1161/circresaha.112.266395 · Cited by 156

Insulin Resistance and Mitochondrial Dysfunction

González-Franquesa, A., & Patti, M. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-55330-6_25 · Cited by 160

Adipose Tissue Dysfunction and Impaired Metabolic Health in Human Obesity: A Matter of Oxygen?

Goossens, G. H., & Blaak, E. E. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00055 · Cited by 152

Mitochondrial function/dysfunction in white adipose tissue

Boudina, S., & Graham, T. E. (2014) · Experimental Physiology · doi:10.1113/expphysiol.2014.081414 · Cited by 151

Transcriptional Regulatory Circuits Controlling Brown Fat Development and Activation

Seale, P. (2015) · Diabetes · doi:10.2337/db15-0203 · Cited by 145

Oxygenation of adipose tissue: A human perspective

Lempesis, I. G., van Meijel, R. L. J., Manolopoulos, K. N., & Goossens, G. H. (2019) · Acta Physiologica · doi:10.1111/apha.13298 · Cited by 139

Methionine restriction effects on mitochondrial biogenesis and aerobic capacity in white adipose tissue, liver, and skeletal muscle of F344 rats

Perrone, C. E., Mattocks, D. A. L., Jarvis-Morar, M., Plummer, J. D., & Orentreich, N. (2010) · Metabolism · doi:10.1016/j.metabol.2009.10.023 · Cited by 136

Crosstalk between mitochondrial (dys)function and mitochondrial abundance

Michel, S., Wanet, A., Pauw, A. D., Rommelaere, G., Arnould, T., & Renard, P. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.23021 · Cited by 138

Dietary polyphenols and their roles in fat browning

Silvester, A. J., Aseer, K. R., & Yun, J. W. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.09.028 · Cited by 136

PPARγ stimulation promotes mitochondrial biogenesis and prevents glucose deprivation-induced neuronal cell loss

Miglio, G., Rosa, A. C., Rattazzi, L., Collino, M., Lombardi, G., & Fantozzi, R. (2009) · Neurochemistry International · doi:10.1016/j.neuint.2009.05.001 · Cited by 132

Lipidomics as a Principal Tool for Advancing Biomedical Research

Lam, S. M., & Shui, G. (2013) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2013.06.007 · Cited by 131

Breast milk alkylglycerols sustain beige adipocytes through adipose tissue macrophages

Yu, H., Dilbaz, S., Coßmann, J., Hoang, A. C., Diedrich, V., Herwig, A., Harauma, A., Hoshi, Y., Moriguchi, T., Landgraf, K., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci125646 · Cited by 128

PPARα and Sirt1 Mediate Erythropoietin Action in Increasing Metabolic Activity and Browning of White Adipocytes to Protect Against Obesity and Metabolic Disorders

Wang, L., Teng, R., Di, L., Rogers, H. M., Wu, H., Kopp, J. B., & Noguchi, C. T. (2013) · Diabetes · doi:10.2337/db13-0518 · Cited by 124

The role of mitochondria in the aetiology of insulin resistance and type 2 diabetes

Martin, S. D., & McGee, S. L. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.09.019 · Cited by 117

Cardiotrophin-1 Is a Key Regulator of Glucose and Lipid Metabolism

Moreno-Aliaga, M. J., Pérez-Echarri, N., Marcos‐Gómeź, B., Larequi, E., Gil-Bea, F. J., Viollet, B., Gimenez-Lopez, I., Martínez, J. A., Prìeto, J., & Bustos, M. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.05.013 · Cited by 113

Adipose tissue in health and disease

Harvey, I. C., Boudreau, A., & Stephens, J. M. (2020) · Open Biology · doi:10.1098/rsob.200291 · Cited by 126

Mitochondrial stress: A bridge between mitochondrial dysfunction and metabolic diseases?

Hu, F., & Liu, F. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2011.05.008 · Cited by 119

The Mitochondrial Ca2+ Uptake and the Fine-Tuning of Aerobic Metabolism

Gherardi, G., Monticelli, H., Rizzuto, R., & Mammucari, C. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.554904 · Cited by 109

Adipose tissue NAD+-homeostasis, sirtuins and poly(ADP-ribose) polymerases -important players in mitochondrial metabolism and metabolic health

Jokinen, R., Pirnes-Karhu, S., Pietiläinen, K. H., & Pirinen, E. (2017) · Redox Biology · doi:10.1016/j.redox.2017.02.011 · Cited by 103

Proteome, Phosphoproteome, and Hydroxyproteome of Liver Mitochondria in Diabetic Rats at Early Pathogenic Stages

Deng, W.-J., Nie, S., Dai, J., Wu, J., & Zeng, R. (2009) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m900020-mcp200 · Cited by 101

Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases

Tripathi, M., Yen, P. M., & Singh, B. K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051645 · Cited by 98

Canagliflozin ameliorates obesity by improving mitochondrial function and fatty acid oxidation via PPARα in vivo and in vitro

Wei, D., Liao, L., Wang, H., Zhang, W., Wang, T., & Xu, Z. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117414 · Cited by 96

IL-6 induces lipolysis and mitochondrial dysfunction, but does not affect insulin-mediated glucose transport in 3T3-L1 adipocytes

Ji, C., Chen, X., Gao, C., Jiao, L., Wang, J., Xu, G., Fu, H., Guo, X., & Zhao, Y. (2011) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-011-9361-8 · Cited by 101

From Obesity-Induced Low-Grade Inflammation to Lipotoxicity and Mitochondrial Dysfunction: Altered Multi-Crosstalk between Adipose Tissue and Metabolically Active Organs

Cavaliere, G., Cimmino, F., Trinchese, G., Catapano, A., Petrella, L., D’Angelo, M., Lucchin, L., & Mollica, M. P. (2023) · Antioxidants · doi:10.3390/antiox12061172 · Cited by 104

PPARγ and PPARα synergize to induce robust browning of white fat in vivo

Kroon, T., Harms, M., Maurer, S., Bonnet, L., Alexandersson, I., Lindblom, A., Ahnmark, A., Nilsson, D., Gennemark, P., O’Mahony, G., et al. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.02.007 · Cited by 92

Mitochondrial oxidative injury: a key player in nonalcoholic fatty liver disease

Dornas, W., & Schuppan, D. (2020) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00121.2020 · Cited by 89

SIRT1-PGC1α-NFκB Pathway of Oxidative and Inflammatory Stress during Trypanosoma cruzi Infection: Benefits of SIRT1-Targeted Therapy in Improving Heart Function in Chagas Disease

Wan, X., Wen, J.-J., Koo, S.-J., Liang, L. Y., & Garg, N. J. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005954 · Cited by 87

Autophagy in adipose tissue biology

Zhang, Y., Zeng, X., & Jin, S. V. (2012) · Pharmacological Research · doi:10.1016/j.phrs.2012.09.004 · Cited by 92

MitoNEET-mediated effects on browning of white adipose tissue

Kusminski, C. M., Park, J., & Scherer, P. E. (2014) · Nature Communications · doi:10.1038/ncomms4962 · Cited by 85

Mitochondria and endocrine function of adipose tissue

Medina‐Gómez, G. (2012) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2012.06.002 · Cited by 92

Rosiglitazone-Induced Mitochondrial Biogenesis in White Adipose Tissue Is Independent of Peroxisome Proliferator-Activated Receptor γ Coactivator-1α

Pardo, R., Enguix, N., Lasheras, J., Felíu, J. E., Kralli, A., & Villena, J. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026989 · Cited by 86

Role of Mitochondrial Complex IV in Age-Dependent Obesity

Soro-Arnáiz, I., Li, Q. O. Y., Torres‐Capelli, M., Meléndez‐Rodríguez, F., Veiga, S. R., Veys, K., Sebastián, D., Elorza, A., Tello, D., Hernansanz‐Agustín, P., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.08.041 · Cited by 87

Eicosapentaenoic acid promotes mitochondrial biogenesis and beige-like features in subcutaneous adipocytes from overweight subjects

Laiglesia, L. M., Lorente-Cebrián, S., Prieto-Hontoria, P. L., Fernández-Galilea, M., Ribeiro, S. M. R., Sáinz, N., Martínez, J. A., & Moreno-Aliaga, M. J. (2016) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.07.019 · Cited by 85

Mitochondrial function in vascular endothelial cell in diabetes

Pangare, M., & Makino, A. (2012) · Journal of Smooth Muscle Research · doi:10.1540/jsmr.48.1 · Cited by 87

Podocyte energy metabolism and glomerular diseases

Imasawa, T., & Rossignol, R. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.06.013 · Cited by 84

Adipocyte ALK7 links nutrient overload to catecholamine resistance in obesity

Guo, T., Mármol, P., Moliner, A., Björnholm, M., Zhang, C., Shokat, K. M., & Ibáñez, C. F. (2014) · eLife · doi:10.7554/elife.03245 · Cited by 81

Multi-tissue, selective PPARγ modulation of insulin sensitivity and metabolic pathways in obese rats

Hsiao, G., Chapman, J., Ofrecio, J. M., Wilkes, J. J., Resnik, J. L., Thapar, D., Subramaniam, S., & Sears, D. D. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00219.2010 · Cited by 82

Mitochondrial oxidative stress in obesity: role of the mineralocorticoid receptor

Lefranc, C., Friederich‐Persson, M., Palacios, R., & Cat, A. N. D. (2018) · Journal of Endocrinology · doi:10.1530/joe-18-0163 · Cited by 80

Limited OXPHOS capacity in white adipocytes is a hallmark of obesity in laboratory mice irrespective of the glucose tolerance status

Schöttl, T., Kappler, L., Fromme, T., & Klingenspor, M. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.07.001 · Cited by 77

Fine-tuned iron availability is essential to achieve optimal adipocyte differentiation and mitochondrial biogenesis

Moreno‐Navarrete, J. M., Ortega, F. J., Moreno, M., Ricart, W., & Fernández‐Real, J. M. (2014) · Diabetologia · doi:10.1007/s00125-014-3298-5 · Cited by 78

Melatonin promotes adipogenesis and mitochondrial biogenesis in 3T3‐L1 preadipocytes

Kato, H., Tanaka, G., Masuda, S., Ogasawara, J., Sakurai, T., Kizaki, T., Ohno, H., & Izawa, T. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12259 · Cited by 72

Mitochondria as target of endocrine-disrupting chemicals: implications for type 2 diabetes

Marroquí, L., Tudurí, E., Alonso‐Magdalena, P., Quesada, I., Nadal, Á., & dos Santos, R. S. (2018) · Journal of Endocrinology · doi:10.1530/joe-18-0362 · Cited by 75

Comparative Plasma Lipidome between Human and Cynomolgus Monkey: Are Plasma Polar Lipids Good Biomarkers for Diabetic Monkeys?

Shui, G., Stebbins, J. W., Lam, B. D., Cheong, W. F., Lam, S. M., Gregoire, F. M., Kusonoki, J., & Wenk, M. R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019731 · Cited by 70

Triacylglycerol lipases and metabolic control: implications for health and disease

Watt, M. J., & Spriet, L. L. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00698.2009 · Cited by 66

Mitochondrially-targeted treatment strategies

Bozi, L. H. M., Campos, J. C., Zambelli, V. O., Ferreira, N. D., & Ferreira, J. C. B. (2019) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2019.100836 · Cited by 67

The Potential of the Mediterranean Diet to Improve Mitochondrial Function in Experimental Models of Obesity and Metabolic Syndrome

Khalil, M., Shanmugam, H., Abdallah, H., JohnBritto, J. S., Galerati, I., Gómez‐Ambrosi, J., Frühbeck, G., & Portincasa, P. (2022) · Nutrients · doi:10.3390/nu14153112 · Cited by 70

Maternal malnutrition programs pancreatic islet mitochondrial dysfunction in the adult offspring

Theys, N., Ahn, M., Bouckenooghe, T., Reusens, B., & Remacle, C. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.08.015 · Cited by 68

Mitochondrial bioenergetics is not impaired in nonobese subjects with type 2 diabetes mellitus

Chattopadhyay, M., GuhaThakurta, I., Behera, P., Ranjan, K. R., Khanna, M., Mukhopadhyay, S., & Chakrabarti, S. (2011) · Metabolism · doi:10.1016/j.metabol.2011.04.015 · Cited by 64

A nutritional perspective on UCP1-dependent thermogenesis

Bonet, M. L., Mercader, J., & Palou, A. (2017) · Biochimie · doi:10.1016/j.biochi.2016.12.014 · Cited by 70

Could very low-calorie ketogenic diets turn off low grade inflammation in obesity? Emerging evidence

Barrea, L., Caprio, M., Watanabe, M., Cammarata, G., Feraco, A., Muscogiuri, G., Verde, L., Colao, A., & Savastano, S. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2054935 · Cited by 66

Telmisartan ameliorates insulin sensitivity by activating the AMPK/SIRT1 pathway in skeletal muscle of obese db/db mice

Shiota, A., Shimabukuro, M., Fukuda, D., Soeki, T., Sato, H., Uematsu, E., Hirata, Y., Kurobe, H., Maeda, N., Sakaue, H., et al. (2012) · Cardiovascular Diabetology · doi:10.1186/1475-2840-11-139 · Cited by 65

Influencing Factors of Thermogenic Adipose Tissue Activity

Zhang, G., Sun, Q., & Liu, C. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00029 · Cited by 68

A Combination of Nutriments Improves Mitochondrial Biogenesis and Function in Skeletal Muscle of Type 2 Diabetic Goto–Kakizaki Rats

Shen, W., Hao, J., Tian, C., Ren, J., Yang, L., Li, X., Luo, C., Cotma, C. W., & Liu, J. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002328 · Cited by 63

α-Lipoic acid treatment increases mitochondrial biogenesis and promotes beige adipose features in subcutaneous adipocytes from overweight/obese subjects

Fernández‐Galilea, M., Pérez‐Matute, P., Prieto-Hontoria, P. L., Houssier, M., Burrell, M. A., Langin, D., Martínez, J. A., & Moreno-Aliaga, M. J. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.12.013 · Cited by 62

Prohibitin has an important role in adipocyte differentiation

Ande, S. R., Xu, Z., Gu, Y., & Mishra, S. (2011) · International Journal of Obesity · doi:10.1038/ijo.2011.227 · Cited by 66

Skeletal muscle and beyond: the role of exercise as a mediator of systemic mitochondrial biogenesis

Little, J. P., Safdar, A., Benton, C. R., & Wright, D. C. (2011) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h11-076 · Cited by 62

Adipose tissue oxygen tension

Goossens, G. H., & Blaak, E. E. (2012) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e328358fa87 · Cited by 66

Crif1 Deficiency Reduces Adipose OXPHOS Capacity and Triggers Inflammation and Insulin Resistance in Mice

Ryu, M. J., Kim, S. J., Kim, Y. K., Choi, M. J., Tadi, S., Lee, M. H., Lee, S. E., Chung, H. K., Jung, S. B., Kim, H. J., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003356 · Cited by 65

PPARγ agonists delay age‐associated metabolic disease and extend longevity

Xu, L., Ma, X., Verma, N., Pèrié, L., Pendse, J., Shamloo, S., Josephson, A. M., Wang, D., Qiu, J., Guo, M., et al. (2020) · Aging Cell · doi:10.1111/acel.13267 · Cited by 65

Peroxisome proliferator-activated receptor-γ (PPARγ) agonist is neuroprotective and stimulates PGC-1α expression and CREB phosphorylation in human dopaminergic neurons

Mäkelä, J., Tselykh, T. V., Kukkonen, J. P., Eriksson, O., Korhonen, L., & Lindholm, D. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.11.020 · Cited by 59

Therapeutic Strategies for Mitochondrial Dysfunction and Oxidative Stress in Age-Related Metabolic Disorders

Bhatti, J. S., Kumar, S., Vijayan, M., Bhatti, G. K., & Reddy, P. H. (2017) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2016.12.012 · Cited by 61

doi:10.1155/2011/179454 Research Article Rosiglitazone Induces Mitochondrial Biogenesis in Differentiated

T-l, M. (2016)

Rosiglitazone Induces Mitochondrial Biogenesis in Differentiated Murine 3T3-L1 and C3H/10T1/2 Adipocytes

Rong, J. X., Klein, J.-L. D., Qiu, Y., Xie, M., Johnson, J. H., Waters, K. M., Zhang, V., Kashatus, J. A., Remlinger, K. S., Bing, N., et al. (2011) · PPAR Research · doi:10.1155/2011/179454 · Cited by 43

Rosiglitazone-Induced Mitochondrial Biogenesis in White Adipose Tissue Is Independent of Peroxisome Proliferator-Activated Receptor c Coactivator-1a

Pardo, R., Enguix, N., Lasheras, J., Felíu, J. E., Kralli, A., & Villena, J. A. (2013)

Rosiglitazone-Induced Mitochondrial Biogenesis in White Adipose Tissue Is Independent of Peroxisome Proliferator-Activated Receptor γ Coactivator-1α

Pardo, R., Enguix, N., Lasheras, J., Felíu, J. E., Kralli, A., & Villena, J. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026989 · Cited by 86

Pioglitazone Induces Mitochondrial Biogenesis in Human Subcutaneous Adipose Tissue In Vivo

Bogacka, I., Xie, H., Bray, G. A., & Smith, S. R. (2005) · Diabetes · doi:10.2337/diabetes.54.5.1392 · Cited by 467