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Diabetes, Pancreatogenic Diabetes, and Pancreatic Cancer
Open accessAbstract
The relationships between diabetes and pancreatic ductal adenocarcinoma (PDAC) are complex. Longstanding type 2 diabetes (T2DM) is a risk factor for pancreatic cancer, but increasing epidemiological data point to PDAC as also a cause of diabetes due to unknown mechanisms. New-onset diabetes is of particular interest to the oncology community as the differentiation of new-onset diabetes caused by PDAC as distinct from T2DM may allow for earlier diagnosis of PDAC. To address these relationships and raise awareness of the relationships between PDAC and diabetes, a symposium entitled Diabetes, Pancreatogenic Diabetes, and Pancreatic Cancer was held at the American Diabetes Association’s 76th Scientific Sessions in June 2016. This article summarizes the data presented at that symposium, describing the current understanding of the interrelationships between diabetes, diabetes management, and pancreatic cancer, and identifies areas where additional research is needed.
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“A distinguishing feature is concurrent pancreatic exocrine insuf fi ciency (consider screening individuals with acute and chronic pancreatitis for exocrine pancreatic insuf fi ciency by measuring fecal elastase), pathological pancreatic imaging (endoscopic ultrasound, MRI, and computed tomography), and absence of type 1 diabetes -associated autoimmunity (116 -120).”
From 2. Diagnosis and Classification of Diabetes: Standards of Care in Diabetes—2024 (2024) · cites this paper as [119]
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“Thus, new-onset diabetes can be considered an early warning sign of pancreatic ductal adenocarcinoma,22”
From Early detection of pancreatic cancer (2020) · cites this paper as [22]
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Metadata
- Authors
- Andersen, D. K., Korc, M., Petersen, G. M., Eibl, G., Li, D., Rickels, M. R., Chari, S. T., & Abbruzzese, J. L.
- Affiliations
- National Institutes of Health (US)
- Indiana University Indianapolis (US)
- Mayo Clinic (US)
- University of California, Los Angeles (US)
- The University of Texas MD Anderson Cancer Center (US)
- University of Pennsylvania (US)
- Duke University (US)
- Corresponding author
- Abbruzzese, James L.
- ORCID
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2017-04-13
- Volume
- 66
- Issue
- 5
- Pages
- 1103-1110
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- PMC
- PMC5399609
- OpenAlex
- W2615250694
- Cited by
- 516
- References
- 50
- Citations by year
- 2026: 43 · 2025: 55 · 2024: 78 · 2023: 71 · 2022: 79 · 2021: 61 · 2020: 59 · 2019: 40 · 2018: 24 · 2017: 5
- FWCI
- 15.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- IUScholarWorks (Indiana University) (submittedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Keywords
- pancreatic ductal adenocarcinoma, type 2 diabetes, pancreatic diabetes, new-onset diabetes, pancreatic cancer risk factors, diabetes management, early cancer detection
- MeSH terms
- Blood Glucose, Diabetes Mellitus, Diabetes Mellitus, Type 2, Humans, Hypoglycemic Agents, Inflammation, Obesity, Pancreatic Neoplasms, Risk Factors, Causality, Genetic Predisposition to Disease, Carcinoma, Pancreatic Ductal, Pancreatitis, Chronic
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