Cited by 524Pancreatic and Hepatic Oncology ResearchMetabolism, Diabetes, and CancerPancreatitis Pathology and Treatment

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Diabetes, Pancreatogenic Diabetes, and Pancreatic Cancer

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Andersen, Dana K., Korc, Murray, Petersen, Gloria M., Eibl, Guido, Li, Donghui, Rickels, Michael R., Chari, Suresh T., Abbruzzese, James L.·2017·Diabetes

DOI 10.2337/db16-1477PMC PMC5399609

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Abstract

The relationships between diabetes and pancreatic ductal adenocarcinoma (PDAC) are complex. Longstanding type 2 diabetes (T2DM) is a risk factor for pancreatic cancer, but increasing epidemiological data point to PDAC as also a cause of diabetes due to unknown mechanisms. New-onset diabetes is of particular interest to the oncology community as the differentiation of new-onset diabetes caused by PDAC as distinct from T2DM may allow for earlier diagnosis of PDAC. To address these relationships and raise awareness of the relationships between PDAC and diabetes, a symposium entitled Diabetes, Pancreatogenic Diabetes, and Pancreatic Cancer was held at the American Diabetes Association’s 76th Scientific Sessions in June 2016. This article summarizes the data presented at that symposium, describing the current understanding of the interrelationships between diabetes, diabetes management, and pancreatic cancer, and identifies areas where additional research is needed.

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Authors: Andersen, D. K., Korc, M., Petersen, G. M., Eibl, G., Li, D., Rickels, M. R., Chari, S. T., & Abbruzzese, J. L.
Affiliations: National Institutes of Health (US)
Indiana University Indianapolis (US)
Mayo Clinic (US)
University of California, Los Angeles (US)
The University of Texas MD Anderson Cancer Center (US)
University of Pennsylvania (US)
Duke University (US)
Corresponding author: Abbruzzese, James L.
ORCID: Andersen, Dana K.
Korc, Murray
Petersen, Gloria M.
Eibl, Guido
Li, Donghui
Rickels, Michael R.
Chari, Suresh T.
Abbruzzese, James L.
Venue: Diabetes
Publisher: American Diabetes Association
Published: 2017-04-13
Volume: 66
Issue: 5
Pages: 1103-1110
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/db16-1477
PMC: PMC5399609
OpenAlex: W2615250694
Cited by: 516
References: 50
Citations by year: 2026: 43 · 2025: 55 · 2024: 78 · 2023: 71 · 2022: 79 · 2021: 61 · 2020: 59 · 2019: 40 · 2018: 24 · 2017: 5
FWCI: 15.43
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.diabetesjournals.org/content/license (vor, 7 d)
Locations: Diabetes (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
eScholarship (California Digital Library) (submittedVersion)
IUScholarWorks (Indiana University) (submittedVersion)
Funders: National Institutes of Health
Topics: Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
Keywords: pancreatic ductal adenocarcinoma, type 2 diabetes, pancreatic diabetes, new-onset diabetes, pancreatic cancer risk factors, diabetes management, early cancer detection
MeSH terms: Blood Glucose, Diabetes Mellitus, Diabetes Mellitus, Type 2, Humans, Hypoglycemic Agents, Inflammation, Obesity, Pancreatic Neoplasms, Risk Factors, Causality, Genetic Predisposition to Disease, Carcinoma, Pancreatic Ductal, Pancreatitis, Chronic

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