The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.
Contributions of β-Cell Dysfunction and Insulin Resistance to the Pathogenesis of Impaired Glucose Tolerance and Impaired Fasting Glucose
Open accessAbstract
Impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) are intermediate states in glucose metabolism that exist between normal glucose tolerance and overt diabetes. Epidemiological studies demonstrate that the two categories describe distinct populations with only partial overlap, suggesting that different metabolic abnormalities characterize IGT and IFG. Insulin resistance and impaired β-cell function, the primary defects observed in type 2 diabetes, both can be detected in subjects with IGT and IFG. However, clinical studies suggest that the site of insulin resistance varies between the two disorders. While subjects with IGT have marked muscle insulin resistance with only mild hepatic insulin resistance, subjects with IFG have severe hepatic insulin resistance with normal or near-normal muscle insulin sensitivity. Both IFG and IGT are characterized by a reduction in early-phase insulin secretion, while subjects with IGT also have impaired late-phase insulin secretion. The distinct metabolic features present in subjects with IFG and IGT may require different therapeutic interventions to prevent their progression to type 2 diabetes.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“However, progressive β-cell failure is required and ultimately responsible for type 2 diabetes to become fully manifest ( 1 , 34 , 35 , 37 , 38 ).”
From Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes (2009) · cites this paper as [37]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Because the great majority of glucose disposal after intravenous glucose administration occurs in muscle, these results provide strong evidence that insulin resistance in muscle is the earliest demonstrable defect in the natural history of type 2 diabetes, but that the development of overt type 2 diabetes occurs only in those individuals whose β-cells are unable to compensate for the defect in”
From Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes (2009) · cites this paper as [37]
Experimental — accuracy not yet measuredIn the citing paper
“Fasting glucose is maintained between 3.9 and 5.6 mmol/L37 and the post-meal increases rarely exceed 3 mmol/L.38”
From Prediabetes: a high-risk state for diabetes development (2012) · cites this paper as [37]
In the citing paper
“This is in line with the notion that insulin resistance starts years before diabetes development and that decreased beta-cell function is already present in the prediabetic stage.37,42”
From Prediabetes: a high-risk state for diabetes development (2012) · cites this paper as [37]
In the citing paper
“Studies using different measures of β-cell function have reported severely abnormal (up to 80% decreased) insulin secretion in prediabetic people.37,42,48”
From Prediabetes: a high-risk state for diabetes development (2012) · cites this paper as [37]
In the citing paper
“Both IFG and IGT subjects present with insulin resistance, however the site of insulin resistance is different: High hepatic insulin resistance is a typical finding in IFG with almost normal values in skeletal muscle.38,39,45 In IGT, the main site of insulin resistance is the muscle with only modest changes in liver insulin sensitivity.37,38”
From Prediabetes: a high-risk state for diabetes development (2012) · cites this paper as [37]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011
Glucose clamp technique: a method for quantifying insulin secretion and resistance.
DeFronzo, R. A., Tobin, J. D., & Andres, R. (1979) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1979.237.3.e214 · Cited by 7,425
Self-citationReport of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (1997) · Diabetes Care · doi:10.2337/diacare.20.7.1183 · Cited by 6,220
Matsuda, M., & DeFronzo, R. A. (1999) · Diabetes Care · doi:10.2337/diacare.22.9.1462 · Cited by 5,621
Self-citationClassification and diagnosis of diabetes mellitus and other categories of glucose intolerance.
National Diabetes Data Group (1979) · Diabetes · doi:10.2337/diab.28.12.1039 · Cited by 4,909
Katz, A., Nambi, S. S., Mather, K., Baron, A. D., Follmann, D. A., Sullivan, G., & Quon, M. J. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.7.6661 · Cited by 3,931
Follow-up report on the diagnosis of diabetes mellitus
The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus* (2003) · Diabetes Care · doi:10.2337/diacare.26.11.3160 · Cited by 3,784
The Triumvirate: β-Cell, Muscle, Liver: A Collusion Responsible for NIDDM
DeFronzo, R. A. (1988) · Diabetes · doi:10.2337/diab.37.6.667 · Cited by 2,456
Bonora, E., Targher, G., Alberiche, M., Bonadonna, R. C., Saggiani, F., Zenere, M. B., Monauni, T., & Muggeo, M. (2000) · Diabetes Care · doi:10.2337/diacare.23.1.57 · Cited by 2,456
Flagged first, then by citations
Research works printed but not linked: 1
- Qiau Q, Hu G, Tuomilehto J, Balkau B, Bord-Johnsen K, for the DECODE Study Group: Age and sex specific prevalence of diabetes and impaired glucose regulation in 13 European cohorts. In Proceedings of the 37th Annual Meeting of the European Diabetes Epidemiology Group, 2002. Oxford, U.K., European Diabetes Epidemiology Group, 2002, p. A37
Cited by
Sorted by citations
DeFronzo, R. A. (2009) · Diabetes · doi:10.2337/db09-9028 · Cited by 3,016
Self-citationPrediabetes: a high-risk state for diabetes development
Tabák, A. G., Herder, C., Rathmann, W., Brunner, E. J., & Kivimäki, M. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60283-9 · Cited by 2,958
DeFronzo, R. A., Ferrannini, E., Groop, L., Henry, R. R., Herman, W. H., Holst, J. J., Hu, F. B., Kahn, C. R., Raz, I., Shulman, G. I., et al. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.19 · Cited by 2,611
Self-citationSkeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes
DeFronzo, R. A., & Tripathy, D. (2009) · Diabetes Care · doi:10.2337/dc09-s302 · Cited by 2,102
Self-citationImpaired Fasting Glucose and Impaired Glucose Tolerance
Nathan, D. M., Davidson, M. B., DeFronzo, R. A., Heine, R. J., Henry, R. R., Pratley, R., & Zinman, B. (2007) · Diabetes Care · doi:10.2337/dc07-9920 · Cited by 1,396
Self-citationFull accounting of diabetes and pre-diabetes in the U.S. population in 1988–1994 and 2005–2006
Cowie, C. C., Rust, K. F., Ford, E. S., Eberhardt, M. S., Byrd-Holt, D. D., Li, C., Williams, D. E., Gregg, E. W., Bainbridge, K. E., Saydah, S. H., et al. (2009) · Diabetes Care · doi:10.2337/dc08-1296 · Cited by 1,154
Tabák, A. G., Jokela, M., Akbaraly, T. N., Brunner, E. J., Kivimäki, M., & Witte, D. R. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60619-x · Cited by 898
DeFronzo, R. A. (2010) · Diabetologia · doi:10.1007/s00125-010-1684-1 · Cited by 908
Self-citationRonald, C. W., & Chan, J. C. N. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12098 · Cited by 841
Prevalence of Diabetes by Race and Ethnicity in the United States, 2011-2016
Cheng, Y. J., Kanaya, A. M., Araneta, M. R. G., Saydah, S. H., Kahn, H. S., Gregg, E. W., Fujimoto, W. Y., & Imperatore, G. (2019) · JAMA · doi:10.1001/jama.2019.19365 · Cited by 713
Insulin Resistance and Atherosclerosis: Implications for Insulin-Sensitizing Agents
Di Pino, A., & DeFronzo, R. A. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00141 · Cited by 535
Self-citationThe Gut Microbiota in Prediabetes and Diabetes: A Population-Based Cross-Sectional Study
Wu, H., Tremaroli, V., Schmidt, C., Lundqvist, A., Olsson, L. M., Kramer, M. M., Gummesson, A., Perkins, R., Bergström, G. M. L., & Bäckhed, F. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.06.011 · Cited by 545
Global Prevalence of Prediabetes
Rooney, M. R., Fang, M., Ogurtsova, K., Özkan, B., Echouffo-Tcheugui, J. B., Boyko, E. J., Magliano, D. J., & Selvin, E. (2023) · Diabetes Care · doi:10.2337/dc22-2376 · Cited by 576
Health benefits of resveratrol: Evidence from clinical studies
Singh, A. P., Singh, R., Verma, S. S., Rai, V., Kaschula, C. H., Maiti, P., & Gupta, S. C. (2019) · Medicinal Research Reviews · doi:10.1002/med.21565 · Cited by 523
The role of the kidneys in glucose homeostasis: a new path towards normalizing glycaemia
DeFronzo, R. A., Davidson, J. A., & Prato, S. D. (2011) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2011.01511.x · Cited by 497
Self-citationPrevalence of prediabetes among adolescents and young adults in the United States, 2005-2016
Andes, L. J., Cheng, Y. J., Rolka, D. B., Gregg, E. W., & Imperatore, G. (2020) · JAMA Pediatrics · doi:10.1001/jamapediatrics.2019.4498 · Cited by 380
Targeting hepatic glucose metabolism in the treatment of type 2 diabetes
Rines, A. K., Sharabi, K., Tavares, C. D. J., & Puigserver, P. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.151 · Cited by 390
DeFronzo, R. A., & Abdul‐Ghani, M. A. (2011) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2011.03.013 · Cited by 324
Self-citationPathophysiologic Approach to Therapy in Patients With Newly Diagnosed Type 2 Diabetes
DeFronzo, R. A., Eldor, R., & Abdul‐Ghani, M. A. (2013) · Diabetes Care · doi:10.2337/dcs13-2011 · Cited by 323
Self-citationAbdul-Ghani, M. A., Abdul‐Ghani, T., Ali, N., & DeFronzo, R. A. (2008) · Diabetes Care · doi:10.2337/dc08-0225 · Cited by 309
Self-citationDunstan, D. W., Salmon, J., Healy, G. N., Shaw, J. E., Jolley, D., Zimmet, P., & Owen, N. G. (2007) · Diabetes Care · doi:10.2337/dc06-1996 · Cited by 260
Preservation of β-Cell Function: The Key to Diabetes Prevention
DeFronzo, R. A., & Abdul-Ghani, M. A. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0246 · Cited by 247
Self-citationType 2 diabetes: A 21st century epidemic
Jaacks, L. M., Siegel, K. R., Gujral, U. P., & Narayan, K. M. V. (2016) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2016.05.003 · Cited by 264
Fasting Versus Postload Plasma Glucose Concentration and the Risk for Future Type 2 Diabetes
Abdul‐Ghani, M. A., Lyssenko, V., Tuomilehto, J., DeFronzo, R. A., & Groop, L. (2008) · Diabetes Care · doi:10.2337/dc08-1264 · Cited by 253
Self-citationKe, C., Narayan, K. M. V., Chan, J. C. N., Jha, P., & Shah, B. R. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00669-4 · Cited by 263
Garber, A. J., Handelsman, Y., EINHORN, D. F., Bergman, D. A., Bloomgarden, Z. T., Fonseca, V. A., Garvey, W. T., Gavin, J. R., Grunberger, G., Horton, E. S., et al. (2008) · Endocrine Practice · doi:10.4158/ep.14.7.933 · Cited by 239
The role of hepatic fat accumulation in pathogenesis of non-alcoholic fatty liver disease (NAFLD)
Liu, Q., Bengmark, S., & Qu, S. (2010) · Lipids in Health and Disease · doi:10.1186/1476-511x-9-42 · Cited by 233
de Pablos‐Velasco, P., Parhofer, K. G., Bradley, C., Eschwège, E., Gönder-Frederick, L., Maheux, P., Wood, I., & Simon, D. (2014) · Clinical Endocrinology · doi:10.1111/cen.12119 · Cited by 218
Hughson, R. L., Robertson, A. D., Arbeille, P., Shoemaker, J. K., Rush, J. W. E., Fraser, K. S., & Greaves, D. K. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00802.2015 · Cited by 219
Prato, S. D. (2009) · Diabetic Medicine · doi:10.1111/j.1464-5491.2009.02847.x · Cited by 207
Review of methods for detecting glycemic disorders
Bergman, M., Abdul‐Ghani, M. A., DeFronzo, R. A., Manco, M., Sesti, G., Fiorentino, T. V., Ceriello, A., Rhee, M. K., Phillips, L. S., Chung, S. T., et al. (2020) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2020.108233 · Cited by 210
Self-citationŠestan, M., Marinović, S., Kavazović, I., Cekinović, Đ., Wueest, S., Turk Wensveen, T., Brizić, I., Jonjić, S., Konrad, D., Wensveen, F. M., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.05.005 · Cited by 189
Muscle and adipose tissue insulin resistance: malady without mechanism?
Fazakerley, D. J., Krycer, J. R., Kearney, A. L., HOCKING, S. L., & James, D. E. (2018) · Journal of Lipid Research · doi:10.1194/jlr.r087510 · Cited by 188
Yip, W., Sequeira, I., Plank, L., & Poppitt, S. (2017) · Nutrients · doi:10.3390/nu9111273 · Cited by 177
Pathophysiology of prediabetes
Ferrannini, E., Gastaldelli, A., & Iozzo, P. (2011) · Medical Clinics of North America · doi:10.1016/j.mcna.2010.11.005 · Cited by 177
Periodontitis and implant complications in diabetes
Nibali, L., Gkranias, N., Mainas, G., & Pino, A. D. (2022) · Periodontology 2000 · doi:10.1111/prd.12451 · Cited by 187
Insulin Resistance and Mitochondrial Dysfunction
González-Franquesa, A., & Patti, M. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-55330-6_25 · Cited by 160
Dysfunction of Persisting β Cells Is a Key Feature of Early Type 2 Diabetes Pathogenesis
Cohrs, C. M., Panzer, J. K., Drotar, D. M., Enos, S. J., Kipke, N., Chen, C., Bozsak, R., Schöniger, E., Ehehalt, F., Distler, M., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.03.033 · Cited by 159
Cohort profile: the German Diabetes Study (GDS)
The GDS Group, Szendroedi, J., Saxena, A., Weber, K. S., Straßburger, K., Herder, C., Burkart, V., Nowotny, B., Icks, A., Kuß, O., et al. (2016) · Cardiovascular Diabetology · doi:10.1186/s12933-016-0374-9 · Cited by 157
López, S., Bermúdez, B., Pacheco, Y. M., Villar, J. R., Abia, R., & Muriana, F. J. G. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.3.638 · Cited by 150
Pathophysiology of prediabetes
Abdul-Ghani, M. A., & DeFronzo, R. A. (2009) · Current Diabetes Reports · doi:10.1007/s11892-009-0032-7 · Cited by 149
Self-citationType 2 Diabetes Can Be Prevented With Early Pharmacological Intervention
DeFronzo, R. A., & Abdul‐Ghani, M. A. (2011) · Diabetes Care · doi:10.2337/dc11-s221 · Cited by 150
Self-citationThe impact of liver fat vs visceral fat in determining categories of prediabetes
Kantartzis, K., Machann, J., Schick, F., Fritsche, A., Häring, H., & Stefan, N. (2010) · Diabetologia · doi:10.1007/s00125-010-1663-6 · Cited by 146
Færch, K., Vaag, A. A., Holst, J. J., Glümer, C., Pedersen, O. B., & Borch‐Johnsen, K. (2008) · Diabetologia · doi:10.1007/s00125-008-0951-x · Cited by 144
Cefalu, W. T., Buse, J. B., Tuomilehto, J. O., Fleming, G. A., Ferrannini, E., Gerstein, H. C., Bennett, P. H., Ramachandran, A., Raz, I., Rosenstock, J., et al. (2016) · Diabetes Care · doi:10.2337/dc16-0873 · Cited by 148
Haak, T., Meinicke, T. W., Jones, R., Weber, S., von Eynatten, M., & Woerle, H. J. (2012) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2012.01590.x · Cited by 139
Ma, M., Liu, H., Yu, J., He, S., Li, P., Ma, C., Zhang, H., Xu, L., Ping, F., Li, W., et al. (2020) · Lipids in Health and Disease · doi:10.1186/s12944-020-01303-w · Cited by 140
The shape of plasma glucose concentration curve during OGTT predicts future risk of type 2 diabetes
Abdul‐Ghani, M. A., Lyssenko, V., Tuomi, T., DeFronzo, R. A., & Groop, L. (2010) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.1084 · Cited by 139
Self-citationFiorentino, T. V., Marini, M. A., Andreozzi, F., Arturi, F., Succurro, E., Perticone, M., Sciacqua, A., Hribal, M. L., Perticone, F., & Sesti, G. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-2573 · Cited by 138
Twigg, S. M., Kamp, M. C., Davis, T. M. E., Neylon, E. K., & Flack, J. R. (2007) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2007.tb00998.x · Cited by 133
Postprandial hyperglycemia on vascular endothelial function: mechanisms and consequences
Mah, E., & Bruno, R. S. (2012) · Nutrition Research · doi:10.1016/j.nutres.2012.08.002 · Cited by 139
Bergman, M. (2012) · Endocrine · doi:10.1007/s12020-012-9830-9 · Cited by 142
Plasma Glucose Concentration and Prediction of Future Risk of Type 2 Diabetes
Abdul‐Ghani, M. A., & DeFronzo, R. A. (2009) · Diabetes Care · doi:10.2337/dc09-s309 · Cited by 131
Self-citationAfsaneh, E., Sharifdini, A., Ghazzaghi, H., & Ghobadi, M. Z. (2022) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-022-00969-9 · Cited by 150
Metabolic Abnormalities Underlying the Different Prediabetic Phenotypes in Obese Adolescents
Cali, A. M. G., Bonadonna, R. C., Trombetta, M., Weiss, R., & Caprio, S. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1722 · Cited by 124
Distinct β-Cell Defects in Impaired Fasting Glucose and Impaired Glucose Tolerance
Kanat, M., Mari, A., Norton, L., Winnier, D., DeFronzo, R. A., Jenkinson, C., & Abdul-Ghani, M. A. (2012) · Diabetes · doi:10.2337/db11-0995 · Cited by 122
Self-citationFu, Q.-Y., Li, Q., Lin, X.-M., Qiao, R.-Y., Yang, R., Li, X.-M., Dong, Z.-B., Xiang, L., Zheng, X., Lu, J., et al. (2017) · Molecules · doi:10.3390/molecules22050849 · Cited by 124
Novel views on new-onset diabetes after transplantation: development, prevention and treatment
Hecking, M., Werzowa, J., Haidinger, M., Horl, W. H., Pascual, J., Budde, K., Luan, F. L., Ojo, A., de Vries, A. P. J., Porrini, E., et al. (2013) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfs583 · Cited by 120
Adiponectin: A Promising Target for the Treatment of Diabetes and Its Complications
Begum, M., Choubey, M., Tirumalasetty, M. B., Arbee, S., Mohib, M. M., Wahiduzzaman, M., Mamun, M. A., Uddin, M. B., & Mohiuddin, M. S. (2023) · Life · doi:10.3390/life13112213 · Cited by 138
Type 2 diabetes mellitus: epidemiology, pathophysiology, unmet needs and therapeutical perspectives
Virally, M., Blickle, J., Girard, J. R., Halimi, S., Simon, D., & Guillausseau, P.-J. (2007) · Diabetes & Metabolism · doi:10.1016/j.diabet.2007.07.001 · Cited by 122
Hayashi, T., Boyko, E. J., Satō, K., McNeely, M. J., Leonetti, D. L., Kahn, S. E., & Fujimoto, W. Y. (2012) · Diabetes Care · doi:10.2337/dc12-0246 · Cited by 122
Resistin’s, obesity and insulin resistance: the continuing disconnect between rodents and humans
Huang, X., & Yang, Z. (2015) · Journal of Endocrinological Investigation · doi:10.1007/s40618-015-0408-2 · Cited by 113
Nguyen, Q. M., Srinivasan, S. R., Xu, J.-H., Chen, W., & Berenson, G. S. (2008) · Diabetes Care · doi:10.2337/dc08-0898 · Cited by 109
Prevention of Diabetes With Pioglitazone in ACT NOW
DeFronzo, R. A., Tripathy, D., Schwenke, D. C., Banerji, M., Bray, G. A., Buchanan, T. A., Clement, S. C., Gastaldelli, A., Henry, R. R., Kitabchi, A. E., et al. (2013) · Diabetes · doi:10.2337/db13-0265 · Cited by 109
Self-citationDash, S., Sano, H., Rochford, J. J., Semple, R. K., Yeo, G. S. H., Hyden, C. S. S., Soos, M. A., Clark, J., Rodin, A., Langenberg, C., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900909106 · Cited by 106
Manco, M., Panunzi, S., Macfarlane, D. P., Golay, A., Melander, O., Konrad, T., Petrie, J. R., & Mingrone, G. (2010) · Diabetes Care · doi:10.2337/dc09-2261 · Cited by 107
Empagliflozin Treatment Is Associated With Improved β-Cell Function in Type 2 Diabetes Mellitus
Jobori, H. A., Daniele, G., Adams, J. M., Cersósimo, E., Solis‐Herrera, C., Triplitt, C. L., DeFronzo, R. A., & Abdul-Ghani, M. A. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-01838 · Cited by 103
Self-citationZúñiga, L. Y., la Mora, M. C. A.-D. A.-D., González-Ortı́z, M., Ramos-Nuñez, J. L., & Martínez‐Abundis, E. (2017) · Journal of Medicinal Food · doi:10.1089/jmf.2017.0110 · Cited by 102
Polycystic ovary syndrome and type 2 diabetes mellitus: A state-of-the-art review
Livadas, S., Anagnostis, P. G., Bosdou, J. Κ., Bantouna, D., & Paparodis, R. D. (2022) · World Journal of Diabetes · doi:10.4239/wjd.v13.i1.5 · Cited by 111
Kirkham, S., Akilen, R., Sharma, S., & Tsiami, A. A. (2009) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2009.01094.x · Cited by 102
Nguyen, Q. M., Srinivasan, S. R., Xu, J.-H., Chen, W., Kieltyka, L., & Berenson, G. S. (2009) · Diabetes Care · doi:10.2337/dc09-1635 · Cited by 102
Asghari, G., Farhadnejad, H., Teymoori, F., Mirmiran, P., Tohidi, M., & Azizi, F. (2017) · Journal of Diabetes · doi:10.1111/1753-0407.12639 · Cited by 102
Wang, Q., Jokelainen, J. J., AUVINEN, J. P., Puukka, K. S., Keinanen-Kiukaanniemi, S. M., Järvelin, M., Kettunen, J., Mäkinen, V., & Ala‐Korpela, M. (2019) · BMC Medicine · doi:10.1186/s12916-019-1440-4 · Cited by 102
Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c
NCD Risk Factor Collaboration (NCD-RisC), Zhou, B., Sheffer, K. E., Bennett, J. E., Gregg, E. W., Danaei, G., Singleton, R. K., Shaw, J. E., Mishra, A., Lhoste, V. P. F., et al. (2023) · Nature Medicine · doi:10.1038/s41591-023-02610-2 · Cited by 94
Metabolic and behavioural effects of sucrose and fructose/glucose drinks in the rat
Sheludiakova, A., Rooney, K. B., & Boakes, R. A. (2011) · European Journal of Nutrition · doi:10.1007/s00394-011-0228-x · Cited by 97
Abdul-Ghani, M. A., Matsuda, M., Jani, R., Jenkinson, C. P., Coletta, D. K., Kaku, K., & DeFronzo, R. A. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00674.2007 · Cited by 91
Self-citationHsueh, W., McLellan, K., Wyne, K., & Villagomez, E. (2014) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s39564 · Cited by 91
The pathogenetic role of β-cell mitochondria in type 2 diabetes
Fex, M., Nicholas, L. M., Vishnu, N., Medina, A., Sharoyko, V. V., Nicholls, D. G., Spégel, P., & Mulder, H. (2018) · Journal of Endocrinology · doi:10.1530/joe-17-0367 · Cited by 93
Prediabetes and type 2 diabetes in youth: an emerging epidemic disease?
Cali, A. M. G., & Caprio, S. (2008) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e3282f57251 · Cited by 88
Actos Now for the prevention of diabetes (ACT NOW) study
DeFronzo, R. A., Banerji, M., Bray, G. A., Buchanan, T. A., Clement, S., Henry, R. R., Kitabchi, A. E., Mudaliar, S., Musi, N., Ratner, R., et al. (2009) · BMC Endocrine Disorders · doi:10.1186/1472-6823-9-17 · Cited by 89
Self-citationTriglyceride glucose-body mass index in identifying high-risk groups of pre-diabetes
Jiang, C., Yang, R., Kuang, M., Meng, Y., Zhong, M., & Zou, Y. (2021) · Lipids in Health and Disease · doi:10.1186/s12944-021-01594-7 · Cited by 91
Association Between Diabetes and Hippocampal Atrophy in Elderly Japanese: The Hisayama Study
Hirabayashi, N., Hata, J., Ohara, T., Mukai, N., Nagata, M., Shibata, M., Gotoh, S., Furuta, Y., Yamashita, F., Yoshihara, K., et al. (2016) · Diabetes Care · doi:10.2337/dc15-2800 · Cited by 89
Curcumin and insulin resistance—Molecular targets and clinical evidences
Jiménez‐Osorio, A. S., Monroy, A., & Alavez, S. (2016) · BioFactors · doi:10.1002/biof.1302 · Cited by 86
Romeo, S., Vidal‐Puig, A., Husain, M., Ahima, R. S., Arca, M., Bhatt, D. L., Diehl, A. M., Fontana, L., Foo, R., Frühbeck, G., et al. (2025) · European Heart Journal · doi:10.1093/eurheartj/ehaf314 · Cited by 93
Clinical Proof-of-Concept Study With MSDC-0160, a Prototype mTOT-Modulating Insulin Sensitizer
Colca, J. R., VanderLugt, J. T., Adams, W. J., Shashlo, A., McDonald, W. G., Liang, J., Zhou, R., & Orloff, D. G. (2013) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2013.10 · Cited by 85
Serum Fetuin-A Associates with Type 2 Diabetes and Insulin Resistance in Chinese Adults
Song, A., Xu, M., Bi, Y., Xu, Y., Huang, Y., Li, M., Wang, T., Wu, Y., Liu, Y., Li, X., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019228 · Cited by 83
Type 2 Diabetes: Why We Are Winning the Battle but Losing the War? 2015 Kelly West Award Lecture
Narayan, K. M. V. (2016) · Diabetes Care · doi:10.2337/dc16-0205 · Cited by 88
Relationship between urinary bisphenol A levels and prediabetes among subjects free of diabetes
Sabanayagam, C., Teppala, S., & Shankar, A. (2013) · Acta Diabetologica · doi:10.1007/s00592-013-0472-z · Cited by 85
Armenise, C., Lefebvre, G., Carayol, J., Bonnel, S., Bolton, J. L., Cara, A. D., Gheldof, N., Descombes, P., Langin, D., Saris, W. H. M., et al. (2017) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.117.156216 · Cited by 82
Novel agents for the treatment of type 2 diabetes
DeFronzo, R. A., Triplitt, C. L., Abdul-Ghani, M., & Cersosimo, E. (2014) · Diabetes Spectrum · doi:10.2337/diaspect.27.2.100 · Cited by 83
Self-citationYates, T. E., Henson, J. J., Edwardson, C. L., Dunstan, D. W., Bodicoat, D. H., Khunti, K., & Davies, M. J. (2015) · Preventive Medicine · doi:10.1016/j.ypmed.2015.04.005 · Cited by 82
Barnes, R. A., Wong, T., Ross, G. P., Griffiths, M. M., Smart, C. E., Collins, C. E., MacDonald-Wicks, L., & Flack, J. R. (2020) · Diabetes Care · doi:10.2337/dc19-0800 · Cited by 80
Silva, N., Atlantis, E. E., & Ismail, K. (2011) · Current Psychiatry Reports · doi:10.1007/s11920-011-0245-8 · Cited by 82
Resistant Starch Bagels Reduce Fasting and Postprandial Insulin in Adults at Risk of Type 2 Diabetes
Dainty, S. A., Klingel, S. L., Pilkey, S. E., McDonald, E., McKeown, B., Emes, M. J., & Duncan, A. M. (2016) · Journal of Nutrition · doi:10.3945/jn.116.239418 · Cited by 80
Treviño, S., Waalkes, M. P., Hernández, J. A. F., León‐Chávez, B. A., Aguilar‐Alonso, P., & Brambila, E. (2015) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2015.07.010 · Cited by 82
Barregård, L., Bergström, G. M. L., & Fagerberg, B. (2012) · Environmental Research · doi:10.1016/j.envres.2012.11.005 · Cited by 80
Feng, Y., Zhang, Z., & Dong, Z.-Z. (2015) · npj Primary Care Respiratory Medicine · doi:10.1038/npjpcrm.2015.5 · Cited by 79
Lorenzo, C., Hartnett, S. D., Hanley, A. J., Rewers, M., Wagenknecht, L. E., Karter, A. J., & Haffner, S. M. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-3185 · Cited by 82
van Ommen, B., Wopereis, S., van Empelen, P., van Keulen, H. M., Otten, W., Kasteleyn, M. J., Molema, J. J. W., de Hoogh, I. M., Chavannes, N. H., Numans, M. E., et al. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00381 · Cited by 78
Medina-Larqué, A. S., Rodríguez-Daza, M.-C., Alezandro, M. R., Dudonné, S., Pilon, G., Levy, E. H., Marette, A., Roy, D., Jacques, H., & Desjardins, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.871080 · Cited by 82
Metadata
- Authors
- Abdul-Ghani, M. A., Tripathy, D., & DeFronzo, R. A.
- Affiliations
- The University of Texas at San Antonio Health Science Center (US)
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2006-05-01
- Volume
- 29
- Issue
- 5
- Pages
- 1130-1139
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W4241031718
- Cited by
- 744
- References
- 93
- Citations by year
- 2026: 30 · 2025: 30 · 2024: 61 · 2023: 54 · 2022: 45 · 2021: 33 · 2020: 39 · 2019: 37 · 2018: 32 · 2017: 44 · 2016: 45 · 2015: 37 · 2014: 35 · 2013: 38 · 2012: 29
- FWCI
- 29.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes Care (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- impaired glucose tolerance, impaired fasting glucose, beta-cell dysfunction, insulin resistance, type 2 diabetes, hepatic insulin resistance, skeletal muscle insulin sensitivity, first-phase insulin secretion, prediabetes, diabetes prevention
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
