Anti-inflammatory effects of Rhodiola rosea L.: A review
Open accessAbstract
Rhodiola rosea L., a worldwide botanical adaptogen, has been confirmed to possess protective effects of inflammatory injury for many diseases, including cardiovascular diseases, neurodegenerative diseases, diabetes, sepsis, and cancer. This paper is to review the recent clinical and experimental researches about the anti-inflammatory effects and the related mechanisms of Rhodiola rosea L. extracts, preparations, and the active compounds. From the collected information reviewed, this paper will provide the theoretical basis for its clinical application, and provide the evidences or guidance for future studies and medicinal exploitations of Rhodiola rosea L.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Zingiber officinale, Zingiber officinale + Bixa orellana L., Rhodiola rosea, Cordyceps militaris, and Rhodiola rosea + Cordyceps sinensis have promising effects to improve post-exercise recovery.
“Other herbal and mushroom supplements that have promising effects to improve post-exercise recovery are Zingiber officinale [116], Zingiber officinale + Bixa orellana L. [117], Rhodiola rosea [118], Cordyceps militaris [119], and Rhodiola rosea + Cordyceps sinensis [120].”
From The 4R’s Framework of Nutritional Strategies for Post-Exercise Recovery: A Review with Emphasis on New Generation of Carbohydrates (2020) · cites this paper as [118]
Six groups of compounds predominate in the phytochemical composition of Rhodiola rosea: phenylpropanoids, phenylethanol derivatives, flavonoids, phenolic acids, and mono- and triterpene.
“Six groups of compounds predominate in the phytochemical composition of the plant: phenylpropanoids, phenylethanol derivatives, flavonoids, phenolic acids, and mono- and triterpene [74].”
From Plant Adaptogens—History and Future Perspectives (2021) · cites this paper as [74]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
RETRACTED ARTICLE: Anti-gastric cancer effect of Salidroside through elevating miR-99a expression
Yang, L., Yu, Y., Zhang, Q., et al. (2019) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2019.1652626 · Cited by 19 · see citing works
Self-citationRetractedMantovani, A., Allavena, P., Sica, A., & Balkwill, F. (2008) · Nature · doi:10.1038/nature07205 · Cited by 11,399 · see citing works
The Nuclear Factor NF- B Pathway in InflammationPreprint
Lawrence, T. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001651 · Cited by 4,926 · see citing works
Inflammation in Atherosclerosis
Libby, P. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.179705 · Cited by 3,748 · see citing works
Inflammation in Atherosclerosis
Libby, P., Ridker, P. M., & Hansson, G. K. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.09.009 · Cited by 2,228 · see citing works
Inflammation meets cancer, with NF-κB as the matchmaker
Ben‐Neriah, Y., & Karin, M. (2011) · Nature Immunology · doi:10.1038/ni.2060 · Cited by 1,378 · see citing works
Inflammation in neurodegenerative diseases
Amor, S., Puentes, F., Baker, D., & Van Der Valk, P. (2010) · Immunology · doi:10.1111/j.1365-2567.2009.03225.x · Cited by 1,355 · see citing works
New regulators of NF-κB in inflammation
Ghosh, S., & Hayden, M. S. (2008) · Nature reviews. Immunology · doi:10.1038/nri2423 · Cited by 1,336 · see citing works
Inflammation in CNS neurodegenerative diseases
Stephenson, J., Nutma, E., van der Valk, P., & Amor, S. (2018) · Immunology · doi:10.1111/imm.12922 · Cited by 966 · see citing works
Inflammatory Markers and Risk of Type 2 Diabetes
Wang, X., Bao, W., Liu, J., OuYang, Y.-Y., Wang, D., Rong, S., Xiao, X., Shan, Z.-L., Zhang, Y., Yao, P., et al. (2013) · Diabetes Care · doi:10.2337/dc12-0702 · Cited by 820 · see citing works
Self-citationGuha, M., & Mackman, N. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203298200 · Cited by 799 · see citing works
Inflammation in Atherosclerosis: Transition From Theory to Practice
Libby, P., Okamoto, Y., Rocha, V. Z., & Folco, E. (2010) · Circulation Journal · doi:10.1253/circj.cj-09-0706 · Cited by 799 · see citing works
Lymphoid organ development: from ontogeny to neogenesis
Drayton, D. L., Liao, S., Mounzer, R. H., & Ruddle, N. H. (2006) · Nature Immunology · doi:10.1038/ni1330 · Cited by 777 · see citing works
Hillmer, E. J., Zhang, H., Li, H. S., & Watowich, S. S. (2016) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2016.05.001 · Cited by 740 · see citing works
Targeting inflammation in the treatment of type 2 diabetes: time to start
Donath, M. Y. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4275 · Cited by 690 · see citing works
Inflammation as a Tumor Promoter in Cancer Induction
Philip, M., Rowley, D. A., & Schreiber, H. (2004) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2004.06.006 · Cited by 640 · see citing works
Panossian, A. G., Wikman, G., & Sarris, J. J. (2010) · Phytomedicine · doi:10.1016/j.phymed.2010.02.002 · Cited by 608 · see citing works
GLUTAMATE-INDUCED NEURONAL NECROSIS IN THE INFANT MOUSE HYPOTHALAMUS
Olney, J. W. (1971) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-197101000-00008 · Cited by 416 · see citing works
PI3K-Akt Pathway Suppresses Coagulation and Inflammation in Endotoxemic Mice
Schabbauer, G., Tencati, M., Pedersen, B., Pawliński, R., & Mackman, N. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000143096.15099.ce · Cited by 244 · see citing works
Naturally derived anti-inflammatory compounds from Chinese medicinal plants
Wang, Q., Kuang, H., Su, Y., Sun, Y., Feng, J., Guo, R., & Chan, K. (2012) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2012.12.013 · Cited by 241 · see citing works
Zheng, T., Yang, X., Wu, D., Xing, S., Bian, F., Li, W., Chi, J., Bai, X., Wu, G., Chen, X., et al. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13120 · Cited by 221 · see citing works
Self-citationSTAT3 in the Systemic Inflammation of Cancer Cachexia
Zimmers, T., Fishel, M., & Bonetto, A. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.02.009 · Cited by 216 · see citing works
Zhang, L., Yu, H.-M., Zhao, X., Lin, X.-F., Tan, C., Cao, G.-X., & Wang, Z.-W. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.06.021 · Cited by 215 · see citing works
Self-citationTewari, D., Nabavi, S. F., Nabavi, S. M., Sureda, A., Farooqı, A. A., Atanasov, A. G., Vacca, R. A., Sethi, G., & Bishayee, A. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.09.014 · Cited by 205 · see citing works
Wang, C., Wang, Q., Lou, Y., Xu, J., Feng, Z., Chen, Y., Tang, Q., Zheng, G., Zhang, Z., Wu, Y., et al. (2017) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13368 · Cited by 182 · see citing works
Gao, J. M., He, H., Jiang, W., Chang, X., Zhu, L., Luo, F., Zhou, R., Ma, C., & Yan, T. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.06.045 · Cited by 157 · see citing works
Salidroside provides neuroprotection by modulating microglial polarization after cerebral ischemia
Liu, X., Wen, S., Yan, F., Liu, K., Liu, L., Wang, L., Zhao, S., & Ji, X. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1081-0 · Cited by 157 · see citing works
Chang, X., Luo, F., Jiang, W., et al. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.07.031 · Cited by 139 · see citing works
Zhu, L., Wei, T., Gao, J., et al. (2015) · APOPTOSIS · doi:10.1007/s10495-015-1174-5 · Cited by 127 · see citing works
Gao, J., Zhou, R., You, X., Luo, F., He, H., Chang, X., Zhu, L., Ding, X., & Yan, T. (2016) · Metabolic Brain Disease · doi:10.1007/s11011-016-9813-2 · Cited by 127 · see citing works
Ganzera, M., Akgül, Y., & Khan, I. A. (2001) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.49.465 · Cited by 103 · see citing works
Multiple benefits of targeting inflammation in the treatment of type 2 diabetes
Donath, M. Y. (2016) · Diabetologia · doi:10.1007/s00125-016-3873-z · Cited by 102 · see citing works
Zhu, L., Wei, T., Gao, J., Chang, X., He, H., Miao, M., & Yan, T. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.08.025 · Cited by 100 · see citing works
Protective Role of Salidroside against Aging in A Mouse Model Induced by D-galactose
Mao, G., Deng, H., Yuan, L.-G., Li, D.-D., Li, Y. Y., & Wang, Z. (2010) · Biomedical and Environmental Sciences · doi:10.1016/s0895-3988(10)60047-5 · Cited by 100 · see citing works
Self-citationXing, S.-S., Yang, X.-Y., Zheng, T., Li, W.-J., Wu, D., Chi, J.-Y., Bian, F., Bai, X.-L., Wu, G.-J., Zhang, Y.-Z., et al. (2015) · Vascular Pharmacology · doi:10.1016/j.vph.2015.07.004 · Cited by 99 · see citing works
Self-citationChen, X., Liu, J., Gu, X., & Ding, F. (2008) · Brain Research · doi:10.1016/j.brainres.2008.07.051 · Cited by 93 · see citing works
Activator protein 1 is a key terminal mediator of inflammation‐induced preterm labor in mice
MacIntyre, D. A., Lee, Y. S., Migale, R., et al. (2014) · The FASEB Journal · doi:10.1096/fj.13-247783 · Cited by 92 · see citing works
Rhodiola roseaL. and Alzheimer's Disease: From Farm to Pharmacy
Nabavi, S. F., Braidy, N., Orhan, İ. E., Badiee, A., Daglia, M., & Nabavi, S. M. (2016) · Phytotherapy Research · doi:10.1002/ptr.5569 · Cited by 88 · see citing works
Salidroside inhibits the growth of human breast cancer in vitro and in vivo
Zhao, G., Shi, A., Fan, Z., & Du, Y. (2015) · Oncology Reports · doi:10.3892/or.2015.3857 · Cited by 82 · see citing works
Guan, S., Feng, H., Song, B., Guo, W., Xiong, Y., Huang, G., Zhong, W., Huo, M., Chen, N., Lu, J., et al. (2011) · International Immunopharmacology · doi:10.1016/j.intimp.2011.09.018 · Cited by 80 · see citing works
Ju, L., Wen, X., Wang, C., Wei, Y., Peng, Y., Ding, Y., Feng, L., & Shu, L. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00749 · Cited by 78 · see citing works
Self-citationQi, Z., Qi, S., Ling, L., et al. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.04.004 · Cited by 74 · see citing works
Effects of Salidroside on Myocardial Injury In Vivo In Vitro via Regulation of Nox/NF-κB/AP1 Pathway
Zhu, L., Wei, T., Chang, X., et al. (2015) · Inflammation · doi:10.1007/s10753-015-0134-0 · Cited by 73 · see citing works
The inflammation – cancer connection
Mantovani, A. (2018) · FEBS Journal · doi:10.1111/febs.14395 · Cited by 70 · see citing works
Anti-Inflammatory and Neuroprotective Effects of Constituents Isolated fromRhodiola rosea
Lee, Y., Jung, J., Jang, S., Kim, J., Ali, Z., Khan, I. A., & Oh, S. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/514049 · Cited by 65 · see citing works
Wang, M., Luo, L., Yao, L., Wang, C., Jiang, K., Liu, X., Xu, M., Shen, N., Guo, S., Sun, C., et al. (2016) · Scientific Reports · doi:10.1038/srep25399 · Cited by 60 · see citing works
Rhodiola rosea L.: from golden root to green cell factories
Marchev, A. S., Dinkova‐Kostova, A. T., György, Z., Mirmazloum, I., Aneva, I. Y., & Georgiev, M. I. (2016) · Phytochemistry Reviews · doi:10.1007/s11101-016-9453-5 · Cited by 58 · see citing works
Sun, P., Song, S., Jiang, S., et al. (2016) · Molecules · doi:10.3390/molecules21111490 · Cited by 55 · see citing works
Anticancer effect of salidroside on colon cancer through inhibiting JAK2/STAT3 signaling pathway.
Sun, K., Xia, H., & Rong-long, X. (2015) · Europe PMC (PubMed Central) · Cited by 53 · see citing works
Zheng, H., Qi, S., & Chen, C. (2018) · Molecules · doi:10.3390/molecules23092398 · Cited by 52 · see citing works
Li, L., Sapkota, M., Kim, S.-W., & Soh, Y. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.08.032 · Cited by 51 · see citing works
Zheng, T., Bian, F., Chen, L., Wang, Q., & Jin, S. (2019) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-019-00402-4 · Cited by 47 · see citing works
Antitumor effects of a purified polysaccharide from Rhodiola rosea and its action mechanism
Cai, Z., Li, W., Wang, H., et al. (2012) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2012.05.039 · Cited by 45 · see citing works
Self-citationCao, L., Du, G., & Wang, M. (2006) · Journal of Asian Natural Products Research · doi:10.1080/1028602042000325645 · Cited by 44 · see citing works
Immunity and Inflammation: From Jekyll to Hyde
Xu, W., & Larbi, A. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.11.018 · Cited by 44 · see citing works
Zuo, W., Yan, F., Zhang, B., et al. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.04.001 · Cited by 44 · see citing works
Je, I., Kim, D.-S., Kim, S., Lee, S., Lee, H., Park, E. K., Khang, D., & Kim, S.-H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129829 · Cited by 43 · see citing works
Neurobiology of Brain Disorders
Zigmond, M. J., Coyle, J. T., & Rowland, L. P. (2015) · Elsevier eBooks · doi:10.1016/c2009-0-63918-0 · Cited by 39 · see citing works
Anti-asthma effects of synthetic salidroside through regulation of Th1/Th2 balance
Wang, J., Jin, R.-G., Lu, X. I. A. O., Wang, Q., & Yan, T. (2014) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(14)60078-9 · Cited by 37 · see citing works
Effects of Two Different Rhodiola rosea Extracts on Primary Human Visceral Adipocytes
Pomari, E., Stefanon, B., & Colitti, M. (2015) · Molecules · doi:10.3390/molecules20058409 · Cited by 33 · see citing works
Palumbo, D. R., Occhiuto, F., Spadaro, F., & Circosta, C. (2011) · Phytotherapy Research · doi:10.1002/ptr.3662 · Cited by 33 · see citing works
Osteoprotective effects of salidroside in ovariectomized mice and diabetic mice
Chen, X., Li, X., Yang, M., et al. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.12.025 · Cited by 30 · see citing works
Jacob, R., Nalini, G., & Chidambaranathan, N. (2013) · Annals of Neurosciences · doi:10.5214/ans.0972.7531.200204 · Cited by 24 · see citing works
Yang, D.-W., Kang, O., Lee, Y., Han, S., Lee, S., Cha, S.-W., Seo, Y., Mun, S., Gong, R., Shin, D.-W., et al. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2781 · Cited by 24 · see citing works
MADP, a salidroside analog, protects hippocampal neurons from glutamate induced apoptosis
Xian, H., Zhao, J., Zheng, Y., et al. (2014) · Life Sciences · doi:10.1016/j.lfs.2014.02.040 · Cited by 21 · see citing works
Effect of ethanol extract of Rhodiola rosea on the early nephropathy in type 2 diabetic rats
Wang, Z.-S., Gao, F., & Lu, F. (2013) · Journal of Huazhong University of Science and Technology [Medical Sciences] · doi:10.1007/s11596-013-1127-6 · Cited by 20 · see citing works
Self-citationHypoglycemic and hypolipidaemic activities of polysaccharides from Rhodiola rosea in KKAy mice
Mao, Y. (2017) · Journal of Food Processing and Preservation · doi:10.1111/jfpp.13219 · Cited by 12 · see citing works
Huang, Q., & Hu, X. (2017) · PubMed · Cited by 7 · see citing works
[Salidroside inhibits inflammatory factor release in BV-2 cells through p38 and JNK pathways].
Wang, J., Zhang, Y., & Zhuang, N. (2018) · PubMed · Cited by 6 · see citing works
Self-citationRole of Inflammation in Neurodegenerative Diseases
Appel, S. H., Beers, D. R., & Zhao, W. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-398270-4.00025-2 · Cited by 4 · see citing works
Protection of Salidroside on Primary Astrocytes from Cell Death by Attenuating Oxidative Stress
Zhao, C.-H., Zhu, Z., Wang, Y., et al. (2015) · Chinese Herbal Medicines · doi:10.1016/s1674-6384(15)60056-9 · Cited by 3 · see citing works
Salidroside promotes the expression of GDNF in the MPTP model of Parkinson's disease
张宇红, 陈生弟, 李江林, et al. (2006) · Chin J Neurol · doi:10.3760/j.issn:1006-7876.2006.08.010 · Cited by 2 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- J.W. Gooch, Acute Inflammation, Springer, New York, 2011 872-872.
- C. RE, Clinical Effects of Tibetan Medicine Rhodiola Rosea L. World Latest Medicine Information (Electronic Version), (2019), pp. 198-201 19(31).
Cited by
Sorted by citations
Bai, J., Zhang, Y., Tang, C., Hou, Y., Ai, X., Chen, X., Zhang, Y., Wang, X., & Meng, X. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110985 · Cited by 720 · see citing works
Self-citationPlant Adaptogens—History and Future Perspectives
Todorova, V., Ivanov, K., Delattre, C., Nalbantova, V., Karcheva-Bahchevanska, D., & Ivanova, S. (2021) · Nutrients · doi:10.3390/nu13082861 · Cited by 121 · see citing works
Bonilla, D. A., Pérez-Idárraga, A., Odriozola-Martínez, A., & Kreider, R. B. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18010103 · Cited by 77 · see citing works
- Authors
- Pu, W.-L., Zhang, M.-Y., Bai, R.-Y., Sun, L.-K., Li, W.-H., Yu, Y.-L., Zhang, Y., Song, L., Wang, Z.-X., Peng, Y.-F., Shi, H., Zhou, K., & Li, T.-X.
- Affiliations
- Tianjin University of Traditional Chinese Medicine (CN)
- Corresponding author
- Sun, Li-kang
- Venue
- Biomedicine & Pharmacotherapy
- Publisher
- Elsevier BV
- Published
- 2020-01
- Volume
- 121
- Pages
- 109552
- ISSN
- 0753-3322 (ISSN-L)
- OpenAlex
- W2982855932
- Cited by
- 227
- References
- 72
- Citations by year
- 2026: 30 · 2025: 38 · 2024: 50 · 2023: 41 · 2022: 28 · 2021: 27 · 2020: 13
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Biomedicine & Pharmacotherapy (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Lisa Waller Hayes Foundation
- Chengdu University of Traditional Chinese Medicine
- Natural Science Foundation of Guangxi Zhuang Autonomous Region (XZ2017ZRG-67)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Medicinal Plants and Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ginseng Biological Effects and Applications
- Keywords
- Rhodiola rosea, anti-inflammatory activity, adaptogens, inflammatory injury, cardiovascular disease, neurodegenerative diseases, diabetes mellitus, sepsis, cancer, active compounds, medicinal plants
- MeSH terms
- Animals, Anti-Inflammatory Agents, Humans, Inflammation, Plant Extracts, Rhodiola
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
