The DOI matches its Crossref record.
Clinical Control of Diabetes by the Artificial Pancreas
Abstract
An artificial pancreas capable of maintaining blood sugar homeostasis within the physiological range is described in this paper. The blood sugar is continuously monitored and then interpreted by a minicomputer which in turn controls and implements the delivery of insulin (or glucose). The entire system is automatic and by giving insulin according to a projected blood sugar level the pattern of insulin administration is similar to the biphasic response of the normal pancreas. Five parameters for control can be selected and altered at will so that any level of normoglycemia can be maintained. Hypoglycemia is not encountered, and none of the patients experienced any side effects during or after the trials. The clinical trials involved a two-day study. On the first day the blood sugar profiles were monitored throughout the day. The patients were given their usual doses of subcutaneous insulin and ate measured meals and snacks. On the second day, they received no subcutaneous insulin; insulin was administered intravenously in accordance with the moment-to-moment requirements of the patients who were given meals the same as those of the previous day. Graphs plotted on a common time scale compare the blood sugar patterns on the two successive days and show the significant improvement in blood sugar homeostasis achieved by this artificial pancreas.
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Citations
Cited by
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Wang, J. (2008) · Chemical Reviews · doi:10.1021/cr068123a · Cited by 3,498
Glucose Biosensors: An Overview of Use in Clinical Practice
Yoo, E.-H., & Lee, S.-Y. (2010) · Sensors · doi:10.3390/s100504558 · Cited by 1,137
Continuous glucose monitoring: a review of recent studies demonstrating improved glycemic outcomes
Rodbard, D. (2017) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2017.0035 · Cited by 458
Design and in vitro studies of a needle-type glucose sensor for subcutaneous monitoring
Bindra, D. S., Zhang, Y., Wilson, G. S., Sternberg, R., Thevenot, D. R., Moatti, D., & Reach, G. (1991) · Analytical Chemistry · doi:10.1021/ac00017a008 · Cited by 309
Rizza, R. A., Gerich, J. E., Haymond, M. W., Westland, R. E., Hall, L. D., Clemens, A. H., & Service, F. J. (1980) · New England Journal of Medicine · doi:10.1056/nejm198012043032301 · Cited by 279
The artificial pancreas: current status and future prospects in the management of diabetes
Peyser, T., Dassau, E., Breton, M., & Skyler, J. S. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12431 · Cited by 169
Diurnal Pattern of Insulin Action in Type 1 Diabetes
Hinshaw, L., Dalla Man, C., Nandy, D. K., Saad, A., Bharucha, A. E., Levine, J. A., Rizza, R. A., Basu, R., Carter, R. E., Cobelli, C., et al. (2013) · Diabetes · doi:10.2337/db12-1759 · Cited by 125
A Miniaturized Nafion-Based Glucose Sensor: in vitro and in vivo evaluation in dogs
Moussy, F., Harrison, D. J., & Rajotte, R. V. (1994) · The International Journal of Artificial Organs · doi:10.1177/039139889401700206 · Cited by 67
Hope vs hype: where are we in type 1 diabetes?
Skyler, J. S. (2018) · Diabetologia · doi:10.1007/s00125-017-4530-x · Cited by 51
Nosadini, R., Noy, G. A., Nattrass, M., Alberti, K. G. M. M., Johnston, D. G., Home, P. D., & �rskov, H. (1982) · Diabetologia · doi:10.1007/bf00252845 · Cited by 49
Evolution of Devices in Diabetes Management
Penfornis, A., Personeni, E., & Borot, S. (2011) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2011.0058 · Cited by 49
Glucose Clamp Algorithms and Insulin Time-Action Profiles
Bequette, B. W. (2009) · Journal of Diabetes Science and Technology · doi:10.1177/193229680900300503 · Cited by 43
The metabolic response to glycemic control by the artificial pancreas in diabetic man
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Self-citationRanjan, A., Schmidt, S., Madsbad, S., Holst, J. J., & Nørgaard, K. (2016) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.12627 · Cited by 39
Why control blood glucose levels?
Rossini, A. A. (1976) · Archives of Surgery · doi:10.1001/archsurg.1976.01360210023004 · Cited by 32
Metadata
- Authors
- Albisser, A. M., Leibel, B. S., Ewart, T. G., Davidovac, Z., Botz, C. K., Zingg, W., Schipper, H., & Gander, R.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 1974-05-01
- Volume
- 23
- Issue
- 5
- Pages
- 397-404
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2058391676
- Cited by
- 272
- References
- 0
- FWCI
- 7.84
- Type
- journal article
- Language
- en
- Open access
- closed
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