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Cited by 331

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Insulin Regulation of Lipolysis in Nondiabetic and IDDM Subjects

Jensen, Michael D, Caruso, Michela, Heiling, Valarie, Miles, John M·1989·Diabetes
DOI 10.2337/diab.38.12.1595
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Abstract

To determine whether insulin regulation of lipolysis is abnormal in subjects with poorly controlled insulin-dependent diabetes mellitus (IDDM), free-fatty acid flux ([1-14C]palmitate) was measured under conditions ranging from complete insulin withdrawal to hyperinsulinemia. Seven nondiabetic and seven IDDM subjects were studied with the pancreatic clamp technique to control plasma insulin, growth hormone, and glucagon concentrations at the desired levels. Preliminary studies were performed to validate the experimental design. The palmitate flux response to insulin withdrawal (2.5 ± 0.2 vs. 2.5 ± 0.2 μmol · kg−1 · min−1) and maximally antilipolytic insulin concentrations (0.17 ± 0.02 vs. 0.23 ± 0.03 μmol · kg−1 · min−1) were not different in nondiabetic and IDDM subjects, respectively. In contrast, IDDM subjects required significantly greater plasma free-insulin concentrations to result in equivalent suppression of palmitate flux compared with nondiabetic subjects. Lipolysis was found to be very sensitive to insulin in nondiabetic humans, with half-maximal suppression occurring at plasma free-insulin concentrations of ∼12 pM (< 2 μU/ml). We conclude that adipose tissue lipolysis is normally exquisitely sensitive to insulin and that sensitivity, but not responsiveness to insulin, is impaired in poorly controlled IDDM.

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Metadata

Authors
Jensen, M. D., Caruso, M., Heiling, V., & Miles, J. M.
Venue
Diabetes
Publisher
American Diabetes Association
Published
1989-12-01
Volume
38
Issue
12
Pages
1595-1601
ISSN
  • 0012-1797 (ISSN-L)
  • 1939-327X
DOI
10.2337/diab.38.12.1595
OpenAlex
W2003950656
Cited by
331
References
0
FWCI
4.16
Type
journal article
Language
en
Open access
closed

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