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Skeletal Muscle Triglyceride Levels Are Inversely Related to Insulin Action
Abstract
In animal studies, increased amounts of triglyceride associated with skeletal muscle (mTG) correlate with reduced skeletal muscle and whole body insulin action. The aim of this study was to test this relationship in humans. Subjects were 38 nondiabetic male Pima Indians (mean age 28 ± 1 years). Insulin sensitivity at physiological (M) and supraphysiological (MZ) insulin levels was assessed by the euglycemic clamp. Lipid and carbohydrate oxidation were determined by indirect calorimetry before and during insulin administration. mTG was determined in vastus lateralis muscles obtained by percutaneous biopsy. Percentage of body fat (mean 29 ± 1%, range 14–44%) was measured by underwater weighing. In simple regressions, negative relationships were found between mTG (mean 5.4 ± 0.3 μmol/g, range 1.3–1.9 μmol/g) and log10M (r = −0.53, P ≤ 0.001), MZ (r = −0.44, P = 0.006), and nonoxidative glucose disposal (r = −0.48 and −0.47 at physiological and supraphysiological insulin levels, respectively, both P = 0.005) but not glucose or lipid oxidation. mTG was not related to any measure of adiposity. In multiple regressions, measures of insulin resistance (log10M, MZ, log10[fasting insulin]) were significantly related to mTG independent of all measures of obesity (percentage of body fat, BMI, waist-to-thigh ratio). In turn, all measures of obesity were related to the insulin resistance measures independent of mTG. The obesity measures and mTG accounted for similar proportions of the variance in insulin resistance in these relationships. The results suggest that in this human population, as in animal models, skeletal muscle insulin sensitivity is strongly influenced by local supplies of triglycerides, as well as by remote depots and circulating lipids. The mechanism(s) underlying the relationship between mTG and insulin action on skeletal muscle glycogen synthesis may be central to an understanding of insulin resistance.
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“Muscle biopsy studies [53, 54] have demonstrated increased triglyceride content in skeletal muscle of obese NGT subjects compared to lean individuals and an inverse relationship between muscle insulin sensitivity and the intramuscular triglyceride content.”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [53]
In the citing paper
“The mechanism via which obesity causes insulin resistance in skeletal muscle is related to the accumulation of fat in the myocytes.”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [53]
In the citing paper
“These lipids interfere with insulin signaling and represent one of the key aspects that could contribute to insulin resistance in situations of high-fat feeding or lipid infusion (Pan et al, 1997; Krssak et al, 1999; Goodpaster et al, 2000).”
From Mitochondrial response to nutrient availability and its role in metabolic disease (2014) · cites this paper as Pan et al, 1997
In the citing paper
“For instance, IMCL levels were increased in first-level relatives of T2DM patients and associated with impaired insulin-stimulated glucose uptake in muscle (Pan et al, 1997).”
From Mitochondrial response to nutrient availability and its role in metabolic disease (2014) · cites this paper as Pan et al, 1997
Citations
Cites
Randle, P. J., Garland, P. B., Hales, C. N., & Newsholme, E. A. (1963) · The Lancet · doi:10.1016/s0140-6736(63)91500-9 · Cited by 5,093
Mechanisms of fatty acid-induced inhibition of glucose uptake.
Boden, G., Chen, X., Ruiz, J., White, J. V., & Rossetti, L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117252 · Cited by 3,720
DeFronzo, R. A., Jacot, E., Jequier, E., Maeder, E., Wahren, J., & Felber, J. P. (1981) · Diabetes · doi:10.2337/diab.30.12.1000 · Cited by 1,770
Shulman, G. I., Rothman, D. L., Jue, T., Stein, P., DeFronzo, R. A., & Shulman, R. G. (1990) · New England Journal of Medicine · doi:10.1056/nejm199001253220403 · Cited by 1,248
Storlien, L. H., Jenkins, A. B., Chisholm, D. J., Pascoe, W. S., Khouri, S., & Kraegen, E. W. (1991) · Diabetes · doi:10.2337/diab.40.2.280 · Cited by 967
Self-citationRole of Insulin Resistance in Human Disease (Syndrome X): An Expanded Definition
Reaven, G. M. (1993) · Annual Review of Medicine · doi:10.1146/annurev.me.44.020193.001005 · Cited by 908
Keys, A. B., & Brožek, J. (1953) · Physiological Reviews · doi:10.1152/physrev.1953.33.3.245 · Cited by 855
What if Minkowski Had Been Ageusic? An Alternative Angle on Diabetes
McGarry, J. D. (1992) · Science · doi:10.1126/science.1439783 · Cited by 657
Fish Oil Prevents Insulin Resistance Induced by High-Fat Feeding in Rats
Storlien, L. H., Kraegen, E. W., Chisholm, D. J., Ford, G. L., Bruce, D. G., & Pascoe, W. S. (1987) · Science · doi:10.1126/science.3303333 · Cited by 648
Self-citationMuscle triglyceride utilization during exercise: effect of training
Hurley, B. F., Nemeth, P. M., Martin, W. H., Hagberg, J. M., Dalsky, G. P., & Holloszy, J. O. (1986) · Journal of Applied Physiology · doi:10.1152/jappl.1986.60.2.562 · Cited by 522
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Koo, Y. D., Choi, J. W., Kim, M., Chae, S., Ahn, B. Y., Kim, M., Oh, B., Hwang, D., Seol, J. H., Kim, Y., et al. (2015) · Diabetes · doi:10.2337/db15-0115 · Cited by 65
Diet, obesity and diabetes: a current update
Walker, C. G., Zariwala, M. G., Holness, M. J., & Sugden, M. C. (2006) · Clinical Science · doi:10.1042/cs20060150 · Cited by 62
Predictors of weight loss and reversal of comorbidities in malabsorptive bariatric surgery
Mora, M. E. V., Simeoni, B., Gagliardi, L., Scarfone, A., Nanni, G., Castagneto, M., Manco, M., Mingrone, G., & Ferrannini, E. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.6.1292 · Cited by 65
Intramuscular Lipid Metabolism in the Insulin Resistance of Smoking
Bergman, B. C., Perreault, L., Hunerdosse, D. M., Koehler, M. C., Samek, A. M., & Eckel, R. H. (2009) · Diabetes · doi:10.2337/db09-0481 · Cited by 66
PPARs and the orchestration of metabolic fuel selection
Sugden, M. C., Zariwala, M. G., & Holness, M. J. (2009) · Pharmacological Research · doi:10.1016/j.phrs.2009.03.014 · Cited by 64
Role of fat metabolism in burn trauma-induced skeletal muscle insulin resistance
Cree‐Green, M., Aarsland, A. A., Herndon, D. N., & Wolfe, R. R. (2007) · Critical Care Medicine · doi:10.1097/01.ccm.0000278066.05354.53 · Cited by 63
Yang, E. J., Lim, S. K., Lim, J., Kim, K. W., Jang, H. C., & Paik, N. (2011) · Metabolism · doi:10.1016/j.metabol.2011.07.005 · Cited by 64
Peripheral Effect of α-Melanocyte-stimulating Hormone on Fatty Acid Oxidation in Skeletal Muscle
An, J. J., Rhee, Y., Kim, S. H., Kim, D. M., Han, D., Hwang, J. H., Jin, Y.-J., Soo, B., Baik, J., Lee, W. T., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603454200 · Cited by 66
Lane, R. H., Kelley, D. E., Ritov, V. H., Tsirka, A. E., & Gruetzmacher, E. M. (2001) · Pediatric Research · doi:10.1203/00006450-200107000-00016 · Cited by 64
Bonen, A., Benton, C. R., Campbell, S. E., Chabowski, A., Clarke, D. C., Han, X. ‐., Glatz, J. F. C., & Luiken, J. J. F. P. (2003) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2003.01157.x · Cited by 65
Mitochondrial dynamics in skeletal muscle insulin resistance and type 2 diabetes
Fealy, C. E., Mulya, A., Axelrod, C. L., & Kirwan, J. P. (2018) · Translational Research · doi:10.1016/j.trsl.2018.07.011 · Cited by 63
Perilipin 2 and lipid droplets provide reciprocal stabilization
Xu, S., Zou, F., Diao, Z., Zhang, S., Deng, Y., Zhu, X., Cui, L., Yu, J., Zhang, Z., Bamigbade, A. T., et al. (2019) · Biophysics Reports · doi:10.1007/s41048-019-0091-5 · Cited by 63
Kaibori, M., Ishizaki, M., Iida, H., Matsui, K., Sakaguchi, T., Inoue, K., Mizuta, T., Ide, Y., Iwasaka, J., Kimura, Y., et al. (2015) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-015-2838-8 · Cited by 64
Intramuscular fatty acid metabolism evaluated with stable isotopic tracers
Guo, Z., & Jensen, M. D. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.84.5.1674 · Cited by 63
Decreased visceral adiposity accounts for leptin effect on hepatic but not peripheral insulin action
Barzilai, N., She, L., Liu, L., Wang, J., Hu, M., Vuguin, P. M., & Rossetti, L. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.2.e291 · Cited by 63
Intramyocellular lipid droplets and insulin sensitivity, the human perspective
Gemmink, A., Goodpaster, B. H., Schrauwen, P., & Hesselink, M. K. C. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2017.07.010 · Cited by 62
Muscle strength is a marker of insulin resistance in patients with type 2 diabetes: a pilot study
NOMURA, T., IKEDA, Y., NAKAO, S., ITO, K., ISHIDA, K., SUEHIRO, T., & HASHIMOTO, K. (2007) · Endocrine Journal · doi:10.1507/endocrj.k07-055 · Cited by 61
Akahori, T., Sho, M., Kinoshita, S., Nagai, M., Nishiwada, S., Tanaka, T., Tamamoto, T., Ohbayashi, C., Hasegawa, M., Kichikawa, K., et al. (2015) · World Journal of Surgery · doi:10.1007/s00268-015-3205-3 · Cited by 63
Perilipin 4 in human skeletal muscle: localization and effect of physical activity
Pourteymour, S., Lee-Ødegård, S., Langleite, T. M., Eckardt, K., Hjorth, M., Bindesbøll, C., Dalen, K. T., Birkeland, K. I., Drevon, C. A., Holen, T., et al. (2015) · Physiological Reports · doi:10.14814/phy2.12481 · Cited by 62
Muscle-Specific Overexpression of CD36 Reverses the Insulin Resistance and Diabetes of MKR Mice
Héron‐Milhavet, L., Haluzı́k, M., Yakar, S., Gavrilova, O., Pack, S., Jou, W., Ibrahimi, A., Kim, H., Hunt, D. G., Yau, D., et al. (2004) · Endocrinology · doi:10.1210/en.2003-1543 · Cited by 61
Reduced PDK4 Expression Associates with Increased Insulin Sensitivity in Postobese Patients
Rosa, G., Rocco, P. D., Manco, M., Greco, A. V., Castagneto, M., Vidal, H., & Mingrone, G. (2003) · Obesity Research · doi:10.1038/oby.2003.28 · Cited by 62
Subcutaneous adipose tissue accumulation protects systemic glucose tolerance and muscle metabolism
Booth, A. D., Magnuson, A. M., Fouts, J. K., Wei, Y., Wang, D., Pagliassotti, M. J., & Foster, M. T. (2018) · Adipocyte · doi:10.1080/21623945.2018.1525252 · Cited by 61
Hu, J., Cai, X., Li, N., Zhu, Q., Wen, W., Hong, J., Zhang, D., Yao, X., Luo, Q., & Sun, L. (2022) · Nature and Science of Sleep · doi:10.2147/nss.s362101 · Cited by 61
Ecophysiology of Omega Fatty Acids: A Lid for Every Jar
Arnold, W., Giroud, S., Valencak, T. G., & Ruf, T. (2015) · Physiology · doi:10.1152/physiol.00047.2014 · Cited by 68
Driscoll, S. D., Meininger, G. E., Ljungquist, K. L., Hadigan, C. M., Torriani, M., Klibanski, A., Frontera, W. R., & Grinspoon, S. K. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031858 · Cited by 61
Holst, D. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(03)00179-4 · Cited by 60
Costford, S. R., Chaudhry, S. N., Salkhordeh, M., & Harper, M. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00401.2005 · Cited by 60
Ruan, H., & Pownall, H. J. (2001) · Diabetes · doi:10.2337/diabetes.50.2.233 · Cited by 60
Lessard, S. J., Giudice, S. L. L., Lau, W. A. K., Reid, J. J., Turner, N. A., Febbraio, M. A., Hawley, J. A., & Watt, M. J. (2004) · Endocrinology · doi:10.1210/en.2004-0659 · Cited by 61
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Amati, F. (2012) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.01036.x · Cited by 59
Lipid induced overexpression of NF-κB in skeletal muscle cells is linked to insulin resistance
Barma, P., Bhattacharya, S., Bhattacharya, A., Kundu, R., Dasgupta, S., Biswas, A., Bhattacharya, S., Roy, S. S., & Bhattacharya, S. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.11.014 · Cited by 59
Muscle Triglyceride and Glycogen in Endurance Exercise: Implications for Performance
Johnson, N. A., Stannard, S. R., & Thompson, M. W. (2004) · Sports Medicine · doi:10.2165/00007256-200434030-00002 · Cited by 59
Cruz, E. M. S., Valentim, J. M. B. D. M., da Rosa, C. V. D., Simões, M., Comar, J. F., Chuffa, L. G. D. A., & Seiva, F. R. F. (2020) · Biology Open · doi:10.1242/bio.047282 · Cited by 61
Huang, Y., Gao, S., Chen, J., Albrecht, E., Zhao, R., & Yang, X. (2016) · Oncotarget · doi:10.18632/oncotarget.14375 · Cited by 59
Todd, M. K., Watt, M. J., Le, J., Hevener, A. L., & Turcotte, L. P. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00080.2006 · Cited by 58
Stettler, R., Ith, M., Acheson, K. J., Décombaz, J., Boesch, C., Tappy, L., & Binnert, C. (2005) · Diabetes Care · doi:10.2337/diacare.28.6.1404 · Cited by 62
Sampling the intramyocellular triglycerides from skeletal muscle
Guo, Z., Mishra, P. K., & Macura, S. I. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31592-3 · Cited by 58
Nadeau, K. J., Ehlers, L. B., Aguirre, L. E., Moore, R. L., Jew, K. N., Ortmeyer, H. K., Hansen, B. C., Reusch, J. E. B., & Draznin, B. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00543.2005 · Cited by 57
The impact of bed rest on human skeletal muscle metabolism
Eggelbusch, M., Charlton, B. T., Bosutti, A., Ganse, B., Giakoumaki, I., Grootemaat, A. E., Hendrickse, P. W., Jaspers, Y. R. J., Kemp, S., Kerkhoff, T. J., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.101372 · Cited by 61
Inhibition of adipose tissue lipolysis increases intramuscular lipid use in type 2 diabetic patients
van Loon, L. J. C., MANDERS, R. J. F., Koopman, R., Kaastra, B., Stegen, J. H. C. H., Gijsen, A. P., Saris, W. H. M., & KEIZER, H. A. (2005) · Diabetologia · doi:10.1007/s00125-005-1889-x · Cited by 57
Mango modulates body fat and plasma glucose and lipids in mice fed a high-fat diet
Lucas, E. A., Li, W., Peterson, S., Brown, A., Kuvibidila, S. R., Perkins-Veazie, P. M., Clarke, S. L., & Smith, B. J. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511002066 · Cited by 57
Early responses of insulin signaling to high-carbohydrate and high-fat overfeeding
Adochio, R., Leitner, J. W., Gray, K., Draznin, B., & Cornier, M. (2009) · Nutrition & Metabolism · doi:10.1186/1743-7075-6-37 · Cited by 58
Turner, N. A., & Robker, R. L. (2014) · Molecular Human Reproduction · doi:10.1093/molehr/gau042 · Cited by 56
Glatz, J. F. C., Bonen, A., & Luiken, J. J. F. P. (2002) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200207000-00003 · Cited by 58
Bhullar, A. S., Anoveros‐Barrera, A., Dunichand‐Hoedl, A. R., Martins, K. J. B., Bigam, D. L., Khadaroo, R. G., McMullen, T. P. W., Bathe, O. F., Putman, C. T., Clandinin, M. T., et al. (2020) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12533 · Cited by 57
Rico‐Sanz, J., Moosavi, M., Thomas, E. L., McCarthy, J. P., Coutts, G. A., Saeed, N., & Bell, J. D. (2000) · Lipids · doi:10.1007/s11745-000-0647-2 · Cited by 55
Insulin resistance of muscle glucose transport in male and female rats fed a high-sucrose diet
Kim, J., Nolte, L. A., Hansen, P. A., Han, D., Kawanaka, K., & Holloszy, J. O. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.276.3.r665 · Cited by 55
Aerobic Exercise Is Necessary to Improve Glucose Utilization with Moderate Weight Loss in Women
Ryan, A. S., Nicklas, B. J., & Berman, D. M. (2006) · Obesity · doi:10.1038/oby.2006.122 · Cited by 56
Fatty acid binding protein 4 in human skeletal muscle
Fischer, H., Gustafsson, T. P., Sundberg, C. J., Norrbom, J., Ekman, M., Johansson, O., & Jansson, E. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.05.083 · Cited by 54
Progress with thiazolidinediones in the management of type 2 diabetes mellitus
Meriden, T. (2004) · Clinical Therapeutics · doi:10.1016/s0149-2918(04)90017-3 · Cited by 54
Dunford, E. C., & Riddell, M. C. (2016) · Metabolites · doi:10.3390/metabo6040044 · Cited by 55
Perreault, L., Bergman, B. C., Hunerdosse, D. M., & Eckel, R. H. (2010) · Obesity · doi:10.1038/oby.2010.76 · Cited by 53
Timmers, S., den Bosch, J. D. V., Hesselink, M. K. C., van Beurden, D., Schaart, G., Ferraz, M. J., Losen, M. H., Martínez‐Martínez, P., Baets, M. H. D., Aerts, J. M. F. G., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0014503 · Cited by 53
Subsarcolemmal lipid droplet responses to a combined endurance and strength exercise intervention
Li, Y.-C., Lee, S., Langleite, T., Norheim, F., Pourteymour, S., Jensen, J., Stadheim, H. K., Storås, T., Davanger, S., Gulseth, H., et al. (2014) · Physiological Reports · doi:10.14814/phy2.12187 · Cited by 51
Blood Glucose Regulation during Prolonged, Submaximal, Continuous Exercise: A Guide for Clinicians
Goodwin, M. L. (2010) · Journal of Diabetes Science and Technology · doi:10.1177/193229681000400325 · Cited by 53
Gemmink, A., Bosma, M., Kuijpers, H., Hoeks, J., Schaart, G., van Zandvoort, M., Schrauwen, P., & Hesselink, M. (2016) · Diabetologia · doi:10.1007/s00125-016-3865-z · Cited by 54
Bell-Anderson, K. S., Schmitz‐Peiffer, C., Lim-Fraser, M., Biden, T. J., Cooney, G. J., & Kraegen, E. W. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.5.e1196 · Cited by 53
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Furler, S. M., Poynten, A. M., Kriketos, A. D., Lowy, A. J., Ellis, B. A., Maclean, E., Courtenay, B. G., Kraegen, E. W., Campbell, L. V., & Chisholm, D. J. (2001) · Obesity Research · doi:10.1038/oby.2001.70 · Cited by 53
Self-citationRegulation of skeletal muscle lipolysis and oxidative metabolism by the co-lipase CGI-58
Badin, P.-M., Loubière, C., Coonen, M. L. J., Louche, K., Tavernier, G., Bourlier, V., Mairal, A., Rustan, A. C., Smith, S. R., Langin, D., et al. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m019182 · Cited by 52
Chow, L. S., From, A. H. L., & Seaquist, E. R. (2009) · Metabolism · doi:10.1016/j.metabol.2009.07.009 · Cited by 54
Ingram, K. H., Lara‐Castro, C., Gower, B. A., Makowsky, R., Allison, D. B., Newcomer, B. R., Muñoz, A. J., Beasley, T. M., Lawrence, J. C., Lopez‐Ben, R., et al. (2011) · Obesity · doi:10.1038/oby.2011.45 · Cited by 53
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Paseban, M., Butler, A. E., & Sahebkar, A. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28123 · Cited by 54
Thyfault, J. P. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00924.2007 · Cited by 53
Kuk, J. L., Kilpatrick, K., Davidson, L. E., HUDSON, R. W., & Ross, R. L. (2008) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h08-060 · Cited by 51
Bruce, C. R., Risis, S., Babb, J. R., Yang, C., Lee, R. S., Henstridge, D. C., & Febbraio, M. A. (2012) · Endocrinology · doi:10.1210/en.2012-1847 · Cited by 55
Kobayashi, A., Kaido, T., Hamaguchi, Y., Okumura, S., Taura, K., Hatano, E., Okajima, H., & Üemoto, S. (2015) · Journal of Hepato-Biliary-Pancreatic Sciences · doi:10.1002/jhbp.302 · Cited by 51
Maltais, A., Alméras, N., Lemieux, I., Tremblay, A., Bergeron, J., Poirier, P., & Després, J. (2018) · Metabolism · doi:10.1016/j.metabol.2018.04.003 · Cited by 51
Færch, K., Lau, C. J., Tetens, I., Pedersen, O. B., Jørgensen, T., Borch‐Johnsen, K., & Glümer, C. (2005) · Journal of Nutrition · doi:10.1093/jn/135.5.1177 · Cited by 51
Muurling, M., Mensink, R. P., Pijl, H., Romijn, J. A., Havekes, L. M., & Voshol, P. J. (2003) · Metabolism · doi:10.1016/s0026-0495(03)00109-4 · Cited by 51
Intramuscular triglyceride content is increased in IDDM
Ebeling, P. R., Essén-Gustavsson, B., Tuominen, J. A., & Koivisto, V. A. (1998) · Diabetologia · doi:10.1007/s001250050875 · Cited by 51
Effects of troglitazone on substrate storage and utilization in insulin-resistant rats
Sreenan, S., Keck, S., Fuller, T., Cockburn, B. N., & Burant, C. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.6.e1119 · Cited by 51
Fat in Liver/Muscle Correlates More Strongly With Insulin Sensitivity in Rats Than Abdominal Fat
Lim, S. K., Son, K. R., Song, I. C., Park, H. S., Jin, C. J., Jang, H. C., Park, K. S., Kim, Y., & Lee, H. K. (2008) · Obesity · doi:10.1038/oby.2008.486 · Cited by 53
TOF‐SIMS Analysis of Lipid Accumulation in the Skeletal Muscle of ob/ob Mice
Magnusson, Y. K., Friberg, P., Sjövall, P., Malm, J., & Chen, Y. (2008) · Obesity · doi:10.1038/oby.2008.424 · Cited by 51
Wang, Z. Q., Yu, Y., Zhang, X. H., Floyd, Z. E., & Cefalu, W. T. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.77 · Cited by 50
Marked Heterogeneity of Human Skeletal Muscle Lipolysis at Rest
Toft, E., Qvisth, V., Nennesmo, I., Rydén, M., Bolinder, H., Enoksson, S., Bolinder, J., & Arner, P. (2002) · Diabetes · doi:10.2337/diabetes.51.12.3376 · Cited by 50
Feng, Y., Lund, J., Li, Y., Knabenes, I. K., Bakke, S. S., Kase, E. T., Lee, Y. K., Kimmel, A. R., Thoresen, G. H., Rustan, A. C., et al. (2017) · Journal of Lipid Research · doi:10.1194/jlr.m079764 · Cited by 51
Watt, M. J. (2008) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2008.05075.x · Cited by 50
Muscle lipid metabolism in the metabolic syndrome
Perseghin, G. (2005) · Current Opinion in Lipidology · doi:10.1097/01.mol.0000174401.07056.56 · Cited by 50
Han, D.-H., Nolte, L. A., Ju, J.-S., Coleman, T., Holloszy, J. O., & Semenkovich, C. F. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00434.2003 · Cited by 49
Rieusset, J., Chauvin, M., Durand, A., Bravard, A., Laugerette, F., Michalski, M., & Vidal, H. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.11.135 · Cited by 54
Samjoo, I. A., Safdar, A., Hamadeh, M. J., Glover, A. W., Mocellin, N. J., Santana, J. O., Little, J. P., Steinberg, G. R., Raha, S., & Tarnopolsky, M. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066322 · Cited by 56
Kim, J. W., Park, S. H., Kim, Y., Im, M., & Han, H. (2016) · Annals of Pediatric Endocrinology & Metabolism · doi:10.6065/apem.2016.21.3.143 · Cited by 49
Kriketos, A. D., Furler, S. M., Gan, S. K., Poynten, A. M., Chisholm, D. J., & Campbell, L. V. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020848 · Cited by 48
Self-citationRedman, L. M., Elkind-Hirsch, K., & Ravussin, E. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.01.137 · Cited by 44
Whytock, K. L., & Goodpaster, B. H. (2025) · Circulation Research · doi:10.1161/circresaha.125.325532 · Cited by 57
Taheripak, G., Bakhtiyari, S., Rajabibazl, M., Pasalar, P., & Meshkani, R. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.09.019 · Cited by 48
Laurens, C., Louche, K., Sengenès, C., Coué, M., Langin, D., Moro, C., & Bourlier, V. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.193 · Cited by 48
Mogensen, M., Vind, B. F., Højlund, K., Beck‐Nielsen, H., & Sahlin, K. (2009) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2009.01063.x · Cited by 47
Mitochondrial function and diabetes: consequences for skeletal and cardiac muscle metabolism
Schrauwen-Hinderling, V. B., Kooi, M. E., & Schrauwen, P. (2016) · Antioxidants & Redox Signaling · doi:10.1089/ars.2015.6291 · Cited by 47
Liu, P. J., Lou, H. P., & Zhu, Y. N. (2020) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s259770 · Cited by 47
Intracellular to Interorgan Mitochondrial Communication in Striated Muscle in Health and Disease
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Thrush, A. B., Brindley, D. N., Chabowski, A., Heigenhauser, G. J. F., & Dyck, D. J. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2565 · Cited by 48
Douglass, J. D., Malik, N., Chon, S., Wells, K., Zhou, Y. X., Choi, A. S., Joseph, L. B., & Storch, J. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00025 · Cited by 47
Baloğlu, F. K., Garip, Ş., Heise, S., Brockmann, G. A., & Severcan, F. (2015) · The Analyst · doi:10.1039/c4an02008a · Cited by 47
IRS posttranslational modifications in regulating insulin signaling
Peng, J., & He, L. (2017) · Journal of Molecular Endocrinology · doi:10.1530/jme-17-0151 · Cited by 49
Polonsky, K. S., & Burant, C. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-29738-7.00031-9 · Cited by 53
Exercise effects on muscle quality in older adults: a systematic review and meta-analysis
Radaelli, R., Taaffe, D. R., Newton, R. U., Galvao, D. A., & López, P. (2021) · Scientific Reports · doi:10.1038/s41598-021-00600-3 · Cited by 51
Lane, R. H., MacLennan, N. K., Daood, M. J., Hsu, J. L., Janke, S. M., Pham, T. D., Puri, A. R., & Watchko, J. F. (2003) · Pediatric Research · doi:10.1203/01.pdr.0000064583.40495.51 · Cited by 46
Singh, M. K., Krisan, A. D., Crain, A., Collins, D. E., & Yaspelkis, B. B. (2003) · Metabolism · doi:10.1016/s0026-0495(03)00158-6 · Cited by 47
Leptin, skeletal muscle lipids, and lipid-induced insulin resistance
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Metadata
- Authors
- Pan, D. A., Lillioja, S., Kriketos, A. D., Milner, M. R., Baur, L. A., Bogardus, C., Jenkins, A. B., & Storlien, L. H.
- Affiliations
- University of Wollongong (AU)
- National Institute of Diabetes and Digestive and Kidney Diseases (US)
- Royal Prince Alfred Hospital (AU)
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 1997-06-01
- Volume
- 46
- Issue
- 6
- Pages
- 983-988
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2134604231
- Cited by
- 1,179
- References
- 37
- Citations by year
- 2026: 2 · 2025: 17 · 2024: 14 · 2023: 26 · 2022: 23 · 2021: 28 · 2020: 25 · 2019: 32 · 2018: 31 · 2017: 42 · 2016: 36 · 2015: 47 · 2014: 44 · 2013: 28 · 2012: 56
- FWCI
- 18.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Research Online (University of Wollongong) (submittedVersion)
- Figshare (submittedVersion)
- Funders
- Diabetes Australia Research Trust
- Diabetes Australia
- Grains Research and Development Corporation
- Juvenile Diabetes Research Foundation Australia
- National Institutes of Health
- Medical Research Council
- National Health and Medical Research Council
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- insulin resistance, skeletal muscle insulin sensitivity, nonoxidative glucose disposal, lipid oxidation, glucose oxidation, obesity, adiposity, Pima Indians, vastus lateralis, euglycemic clamp
- MeSH terms
- Adult, Arizona, Biopsy, Body Composition, Body Constitution, Humans, Indians, North American, Insulin, Male, Obesity, Regression Analysis, Triglycerides, Glucose Clamp Technique, Muscle, Skeletal
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