Mitochondrial function and diabetes: consequences for skeletal and cardiac muscle metabolism

PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197 · see citing works

How mitochondria produce reactive oxygen species

Murphy, M. P. (2009) · Biochemical Journal · doi:10.1042/bj20081386 · Cited by 8,207 · see citing works

Oxidative stress and diabetic complications

Giacco, F., & Brownlee, M. (2010) · Circulation Research · doi:10.1161/circresaha.110.223545 · Cited by 5,461 · see citing works

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., et al. (2003) · Nature · doi:10.1038/nature01960 · Cited by 3,796 · see citing works

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

Brunet, A., Sweeney, L. B., Sturgill, J. F., Chua, K. F., Greer, P. L., Lin, Y., Tran, H., Ross, S. E., Mostoslavsky, R., Cohen, H. Y., et al. (2004) · Science · doi:10.1126/science.1094637 · Cited by 3,239 · see citing works

Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., & Puigserver, P. (2005) · Nature · doi:10.1038/nature03354 · Cited by 3,160 · see citing works

Reactive oxygen species have a causal role in multiple forms of insulin resistance

Houstis, N., Rosen, E. D., & Lander, E. S. (2006) · Nature · doi:10.1038/nature04634 · Cited by 2,525 · see citing works

AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α

Jäger, S., Handschin, C., St.-Pierre, J., & Spiegelman, B. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705070104 · Cited by 2,491 · see citing works

Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes

Kelley, D. E., He, J., Menshikova, E. V., & Ritov, V. B. (2002) · Diabetes · doi:10.2337/diabetes.51.10.2944 · Cited by 2,321 · see citing works

Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes

Petersen, K. F., Dufour, S., Befroy, D., Garcia, R., & Shulman, G. I. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031314 · Cited by 2,193 · see citing works

Mitochondrial dysfunction and type 2 diabetes

Lowell, B. B., & Shulman, G. I. (2005) · Science · doi:10.1126/science.1104343 · Cited by 2,070 · see citing works

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of <i>PGC1</i> and <i>NRF1</i>

Patti, M. E., Butte, A. J., Crunkhorn, S., Cusi, K., Berria, R., Kashyap, S., Miyazaki, Y., Kohane, I., Costello, M., Saccone, R., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1032913100 · Cited by 1,952 · see citing works

The Effect of Insulin on the Disposal of Intravenous Glucose: Results from Indirect Calorimetry and Hepatic and Femoral Venous Catheterization

DeFronzo, R. A., Jacot, E., Jequier, E., Maeder, E., Wahren, J., & Felber, J. P. (1981) · Diabetes · doi:10.2337/diab.30.12.1000 · Cited by 1,770 · see citing works

Lipid-Induced Insulin Resistance in Human Muscle Is Associated With Changes in Diacylglycerol, Protein Kinase C, and IκB-α

Itani, S. I., Ruderman, N. B., Schmieder, F., & Boden, G. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2005 · Cited by 1,390 · see citing works

Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

Timmers, S., Konings, E., Bilet, L., Houtkooper, R. H., van de Weijer, T., Goossens, G. H., Hoeks, J., van der Krieken, S., Ryu, D., Kersten, S., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.10.002 · Cited by 1,320 · see citing works

Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1 H NMR spectroscopy study

Krssak, M., Falk Petersen, K., Dresner, A., DiPietro, L., Vogel, S. M., Rothman, D. L., Shulman, G. I., & Roden, M. (1999) · Diabetologia · doi:10.1007/s001250051123 · Cited by 1,264 · see citing works

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

Anderson, E. J., Lustig, M. E., Boyle, K. E., Woodlief, T. L., Kane, D. A., Lin, C.-T., Price, J. W., Kang, L., Rabinovitch, P. S., Szeto, H. H., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37048 · Cited by 1,253 · see citing works

Skeletal muscle triglyceride levels are inversely related to insulin action

Pan, D. A., Lillioja, S., Kriketos, A. D., Milner, M. R., Baur, L. A., Bogardus, C., Jenkins, A. B., & Storlien, L. H. (1997) · Diabetes · doi:10.2337/diabetes.46.6.983 · Cited by 1,179 · see citing works

Skeletal Muscle Triglyceride Levels Are Inversely Related to Insulin Action

Pan, D. A., Lillioja, S., Kriketos, A. D., Milner, M. R., Baur, L. A., Bogardus, C., Jenkins, A. B., & Storlien, L. H. (1997) · Diabetes · doi:10.2337/diab.46.6.983 · Cited by 1,179 · see citing works

Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis

He, C., Bassik, M. C., Moresi, V., Sun, K., Wei, Y., Zou, Z., An, Z., Loh, J., Fisher, J., Sun, Q., et al. (2012) · Nature · doi:10.1038/nature10758 · Cited by 1,136 · see citing works

Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS

Nisoli, E., Tonello, C., Cardile, A., Cozzi, V., Bracale, R., Tedesco, L., Falcone, S., Valerio, A., Cantoni, O., Clementi, E., et al. (2005) · Science · doi:10.1126/science.1117728 · Cited by 1,107 · see citing works

Mitochondrial dynamics and mitochondrial quality control

Ni, H.-M., Williams, J. A., & Ding, W.-X. (2015) · Redox Biology · doi:10.1016/j.redox.2014.11.006 · Cited by 931 · see citing works

AMP‐activated protein kinase phosphorylation of endothelial NO synthase

Chen, Z.-P., Mitchelhill, K. I., Michell, B. J., Stapleton, D., Rodríguez‐Crespo, I., Witters, L. A., Power, D. A., de Montellano, P. R. O., & Kemp, B. E. (1999) · FEBS Letters · doi:10.1016/s0014-5793(98)01705-0 · Cited by 835 · see citing works

The Energy Sensor AMP-activated Protein Kinase Directly Regulates the Mammalian FOXO3 Transcription Factor

Greer, E. L., Oskoui, P. R., Banko, M. R., Maniar, J. M., Gygi, M. P., Gygi, S. P., & Brunet, A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705325200 · Cited by 820 · see citing works

Calorie Restriction Increases Muscle Mitochondrial Biogenesis in Healthy Humans

Civitarese, A. E., Carling, S., Heilbronn, L. K., Hulver, M. H., Ukropcova, B., Deutsch, W. A., Smith, S. R., & Ravussin, E. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040076 · Cited by 790 · see citing works

Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3

Brand, M. D., & Esteves, T. C. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.06.002 · Cited by 785 · see citing works

Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency

López-Lluch, G., Hunt, N., Jones, B., Zhu, M., Jamieson, H., Hilmer, S., Cascajo, M. V., Allard, J., Ingram, D. K., Navas, P., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510452103 · Cited by 699 · see citing works

Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects.

Jacob, S., Machann, J., Rett, K., Brechtel, K., Volk, A., Renn, W., Maerker, E., Matthaei, S., Schick, F., Claussen, C. D., et al. (1999) · Diabetes · doi:10.2337/diabetes.48.5.1113 · Cited by 643 · see citing works

Mitochondrial dysfunction and sarcopenia of aging: from signaling pathways to clinical trials

Marzetti, E., Calvani, R., Cesari, M., Buford, T. W., Lorenzi, M., Behnke, B. J., & Leeuwenburgh, C. (2013) · The International Journal of Biochemistry &amp; Cell Biology · doi:10.1016/j.biocel.2013.06.024 · Cited by 627 · see citing works

Cardiac Steatosis in Diabetes Mellitus: A ¹ H-Magnetic Resonance Spectroscopy Study

McGavock, J. M., Lingvay, I., Zib, I., Tillery, T., Salas, N., Unger, R., Levine, B. D., Raskin, P., Victor, R. G., & Szczepaniak, L. S. (2007) · Circulation · doi:10.1161/circulationaha.106.645614 · Cited by 612 · cited 1× · see citing works

Is the Failing Heart Energy Starved?: On Using Chemical Energy to Support Cardiac Function

Ingwall, J. S., & Weiss, R. G. (2004) · Circulation Research · doi:10.1161/01.res.0000137170.41939.d9 · Cited by 604 · see citing works

Mitochondrial Energetics in the Heart in Obesity-Related Diabetes

Boudina, S., Sena, S., Theobald, H., Sheng, X., Wright, J. J., Hu, X. X., Aziz, S., Johnson, J. I., Bugger, H., Zaha, V. G., et al. (2007) · Diabetes · doi:10.2337/db07-0481 · Cited by 586 · see citing works

Mitochondrial respiration is decreased in skeletal muscle of patients with type 2 diabetes

Mogensen, M., Sahlin, K., Fernström, M., Glintborg, D., Vind, B. F., Beck-Nielsen, H., & Højlund, K. (2007) · Diabetes · doi:10.2337/db06-0981 · Cited by 573 · see citing works

Chronic activation of AMP kinase results in NRF-1 activation and mitochondrial biogenesis

Bergeron, R., Ren, J. M., Cadman, K. S., Moore, I. K., Perret, P., Pypaert, M., Young, L. H., Semenkovich, C. F., & Shulman, G. I. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.6.e1340 · Cited by 561 · see citing works

Abnormal Cardiac and Skeletal Muscle Energy Metabolism in Patients With Type 2 Diabetes

Scheuermann-Freestone, M., Madsen, P. L., Manners, D., Blamire, A. M., Buckingham, R. E., Styles, P., Radda, G. K., Neubauer, S., & Clarke, K. (2003) · Circulation · doi:10.1161/01.cir.0000072789.89096.10 · Cited by 525 · see citing works

A critical role for PPARα-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: Modulation by dietary fat content

Finck, B. N., Han, X., Courtois, M., Aimond, F., Nerbonne, J. M., Kovacs, A., Gross, R. W., & Kelly, D. P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0336724100 · Cited by 501 · see citing works

Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes

Chavez, J. A., & Summers, S. A. (2003) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2003.08.020 · Cited by 498 · see citing works

Mitochondrial fission triggered by hyperglycemia is mediated by ROCK1 activation in podocytes and endothelial cells

Wang, W., Wang, Y., Long, J., Wang, J., Haudek, S. B., Overbeek, P., Chang, B. H. J., Schumacker, P. T., & Danesh, F. R. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.009 · Cited by 476 · see citing works

Substrate-specific derangements in mitochondrial metabolism and redox balance in the atrium of the type 2 diabetic human heart

Anderson, E. J., Kypson, A. P., Rodriguez, E., Anderson, C. A., Lehr, E. J., & Neufer, P. D. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.07.031 · Cited by 440 · see citing works

Targeting Sirtuin 1 to Improve Metabolism: All You Need Is NAD+?

Cantó, C., & Auwerx, J. (2012) · Pharmacological Reviews · doi:10.1124/pr.110.003905 · Cited by 433 · see citing works

Oxidative Capacity, Lipotoxicity, and Mitochondrial Damage in Type 2 Diabetes

Schrauwen, P., & Hesselink, M. K. C. (2004) · Diabetes · doi:10.2337/diabetes.53.6.1412 · Cited by 408 · see citing works

Skeletal muscle autophagy and apoptosis during aging: Effects of calorie restriction and life-long exercise

Wohlgemuth, S. E., Seo, A. Y., Marzetti, E., Lees, H. A., & Leeuwenburgh, C. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2009.11.002 · Cited by 397 · see citing works

Resveratrol Supplementation Does Not Improve Metabolic Function in Nonobese Women with Normal Glucose Tolerance

Yoshino, J., Conte, C., Fontana, L., Mittendorfer, B., Imai, S., Schechtman, K. B., Gu, C. C., Kunz, I., Fanelli, F. R., Patterson, B. W., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.09.015 · Cited by 381 · see citing works

Diastolic dysfunction is associatedwith altered myocardial metabolism inasymptomatic normotensive patientswith well-controlled type 2 diabetes mellitus

Diamant, M., Lamb, H. J., Groeneveld, Y., Endert, E. L., Smit, J. W. A., Bax, J. J., Romijn, J. A., de Roos, A., & Radder, J. K. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00625-9 · Cited by 372 · see citing works

Expression of <i>Mfn2</i>, the Charcot-Marie-Tooth Neuropathy Type 2A Gene, in Human Skeletal Muscle

Bach, D., Naon, D., Pich, S., Soriano, F. X., Vega, N., Rieusset, J., Laville, M., Guillet, C., Boirie, Y., Wallberg-Henriksson, H., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.9.2685 · Cited by 369 · see citing works

Lower intrinsic ADP-stimulated mitochondrial respiration underlies in vivo mitochondrial dysfunction in muscle of male type 2 diabetic patients

Phielix, E., Schrauwen-Hinderling, V. B., Mensink, M., Lenaers, E., Meex, R., Hoeks, J., Kooi, M. E., Moonen-Kornips, E., Sels, J.-P., Hesselink, M. K. C., et al. (2008) · Diabetes · doi:10.2337/db08-0391 · Cited by 359 · see citing works

Restoration of Muscle Mitochondrial Function and Metabolic Flexibility in Type 2 Diabetes by Exercise Training Is Paralleled by Increased Myocellular Fat Storage and Improved Insulin Sensitivity

Meex, R. C. R., Schrauwen-Hinderling, V. B., Moonen-Kornips, E., Schaart, G., Mensink, M., Phielix, E., van de Weijer, T., Sels, J.-P., Schrauwen, P., & Hesselink, M. K. C. (2010) · Diabetes · doi:10.2337/db09-1322 · Cited by 355 · see citing works

Protecting the mitochondrial powerhouse

Scheibye‐Knudsen, M., Fang, E. F., Croteau, D. L., Wilson, D. M., & Bohr, V. A. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.11.002 · Cited by 330 · see citing works

Myocardial Contractile Dysfunction Is Associated With Impaired Mitochondrial Function and Dynamics in Type 2 Diabetic but Not in Obese Patients

Montaigne, D., Marechal, X., Coisne, A., Debry, N., Modine, T., Fayad, G., Potelle, C., El Arid, J.-M., Mouton, S., Sebti, Y., et al. (2014) · Circulation · doi:10.1161/circulationaha.113.008476 · Cited by 322 · see citing works

Effects of physical activity and weight loss on skeletal muscle mitochondria and relationship with glucose control in type 2 diabetes.

Toledo, F. G. S., Menshikova, E. V., Ritov, V. B., Azuma, K., Radikova, Z., DeLany, J., & Kelley, D. E. (2007) · Diabetes · doi:10.2337/db07-0141 · Cited by 321 · see citing works

Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control

Noland, R. C., Koves, T. R., Seiler, S. E., Lum, H., Lust, R. M., Ilkayeva, O., Stevens, R. D., Hegardt, F. G., & Muoio, D. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.032888 · Cited by 317 · see citing works

Diacylglycerol Activation of Protein Kinase Cε and Hepatic Insulin Resistance

Jornayvaz, F. R., & Shulman, G. I. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.03.005 · Cited by 315 · see citing works

Impaired in vivo mitochondrial function but similar intramyocellular lipid content in patients with type 2 diabetes mellitus and BMI-matched control subjects

Schrauwen-Hinderling, V. B., Kooi, M. E., Hesselink, M. K. C., Jeneson, J. A. L., Backes, W. H., van Echteld, C. J. A., van Engelshoven, J. M. A., Mensink, M., & Schrauwen, P. (2007) · Diabetologia · doi:10.1007/s00125-006-0475-1 · Cited by 304 · see citing works

Association of telomere length with type 2 diabetes, oxidative stress and UCP2 gene variation

Salpea, K. D., Talmud, P. J., Cooper, J. A., Maubaret, C. G., Stephens, J. W., Abelak, K., & Humphries, S. E. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.09.070 · Cited by 289 · see citing works

Dynamic regulation of PGC‐1α localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response

Anderson, R. M., Barger, J. L., Edwards, M. G., Braun, K. H., O’Connor, C. E., Prolla, T. A., & Weindruch, R. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2007.00357.x · Cited by 283 · see citing works

Effects of weight loss and exercise on insulin resistance, and intramyocellular triacylglycerol, diacylglycerol and ceramide

Dubé, J. J., Amati, F., Toledo, F. G. S., Stefanović-Račić, M., Rossi, A. P., Coen, P. M., & Goodpaster, B. H. (2011) · Diabetologia · doi:10.1007/s00125-011-2065-0 · Cited by 272 · see citing works

Role of calcium and AMP kinase in the regulation of mitochondrial biogenesis and GLUT4 levels in muscle

Ojuka, E. O. (2004) · Proceedings of The Nutrition Society · doi:10.1079/pns2004339 · Cited by 271 · see citing works

Physical training and insulin sensitivity

Koivisto, V. A., Yki‐Järvinen, H., & DeFronzo, R. A. (1986) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610010407 · Cited by 257 · see citing works

DAG accumulation from saturated fatty acids desensitizes insulin stimulation of glucose uptake in muscle cells

Montell, E., Turini, M., Marotta, M., Roberts, M., Noé, V., Ciudad, C. J., Macé, K., & Gómez-Foix, A. M. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.2.e229 · Cited by 245 · see citing works

Acylcarnitines: potential implications for skeletal muscle insulin resistance

Aguer, C., McCoin, C. S., Knotts, T. A., Thrush, A. B., Ono‐Moore, K. D., McPherson, R., Dent, R., Hwang, D. H., Adams, S. H., & Harper, M. (2014) · The FASEB Journal · doi:10.1096/fj.14-255901 · Cited by 243 · see citing works

Mitochondrial cardiomyopathy: pathophysiology, diagnosis, and management.

(2013) · Europe PMC (PubMed Central) · Cited by 209 · see citing works

Mitochondrial Uncoupling: A Key Contributor to Reduced Cardiac Efficiency in Diabetes

Boudina, S., & Abel, E. D. (2006) · Physiology · doi:10.1152/physiol.00008.2006 · Cited by 199 · see citing works

The FoxO transcription factors and metabolic regulation

Nakae, J., Oki, M., & Cao, Y. (2008) · FEBS Letters · doi:10.1016/j.febslet.2007.11.025 · Cited by 176 · see citing works

Obesity Induces Signs of Premature Cardiac Aging in Younger Patients

Niemann, B., Chen, Y., Teschner, M., Li, L., Silber, R., & Rohrbach, S. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.09.040 · Cited by 175 · see citing works

Impact of long-term caloric restriction on cardiac senescence: Caloric restriction ameliorates cardiac diastolic dysfunction associated with aging

Shinmura, K., Tamaki, K., Sano, M., Murata, M., Yamakawa, H., Ishida, H., & Fukuda, K. (2010) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2010.10.018 · Cited by 173 · see citing works

Absence of phosphocreatine resynthesis in human calf muscle during ischaemic recovery

Quistorff, B., Johansen, L., & Sahlin, K. (1993) · Biochemical Journal · doi:10.1042/bj2910681 · Cited by 163 · see citing works

Dysregulation of mitochondrial quality control processes contribute to sarcopenia in a mouse model of premature aging.

Joseph, A.-M., Adhihetty, P. J., Wawrzyniak, N. R., Wohlgemuth, S. E., Picca, A., Kujoth, G. C., Prolla, T. A., & Leeuwenburgh, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069327 · Cited by 161 · see citing works

Hyperpolarized 13C Magnetic Resonance Reveals Early- and Late-Onset Changes to in vivo Pyruvate Metabolism in the Failing Heart

Schroeder, M., Lau, A. Z., Chen, A. P., Gu, Y., Nagendran, J., Barry, J., Hu, X., Dyck, J. R. B., Tyler, D. J., Clarke, K., et al. (2012) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfs192 · Cited by 159 · see citing works

Diabetes and incident heart failure in hypertensive and normotensive participants of the Strong Heart Study

SIMONE, G. D., Devereux, R. B., Chinali, M., Lee, E. T., Galloway, J. M., Barac, A., Panza, J. A., & Howard, B. V. (2010) · Journal of Hypertension · doi:10.1097/hjh.0b013e3283331169 · Cited by 143 · see citing works

Mitochondrial Morphology in Metabolic Diseases

Galloway, C. A., & Yoon, Y. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4779 · Cited by 141 · see citing works

Deleterious action of FA metabolites on ATP synthesis: possible link between lipotoxicity, mitochondrial dysfunction, and insulin resistance

Abdul-Ghani, M. A., Muller, F. L., Liu, Y., Chavez, A. O., Balas, B., Zuo, P., Chang, Z., Tripathy, D., Jani, R., Molina-Carrion, M., et al. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90287.2008 · Cited by 140 · see citing works

The anti-ageing effects of caloric restriction may involve stimulation of macroautophagy and lysosomal degradation, and can be intensified pharmacologically

Bergamini, E., Cavallini, G., Donati, A., & Gori, Z. (2003) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(03)00048-9 · Cited by 134 · see citing works

Re-evaluating lipotoxic triggers in skeletal muscle: Relating intramyocellular lipid metabolism to insulin sensitivity

Bosma, M., Kersten, S., Hesselink, M. K. C., & Schrauwen, P. (2011) · Progress in Lipid Research · doi:10.1016/j.plipres.2011.11.003 · Cited by 134 · see citing works

Mitochondrial Dynamics in Diabetic Cardiomyopathy

Galloway, C. A., & Yoon, Y. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6293 · Cited by 133 · see citing works

Exercise training boosts eNOS-dependent mitochondrial biogenesis in mouse heart: role in adaptation of glucose metabolism

Vettor, R., Valerio, A., Ragni, M., Trevellin, E., Granzotto, M., Olivieri, M., Tedesco, L., Ruocco, C., Fossati, A., Fabris, R., et al. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00617.2013 · Cited by 132 · see citing works

Early or advanced stage type 2 diabetes is not accompanied by in vivo skeletal muscle mitochondrial dysfunction.

De Feyter, H. M., van den Broek, N. M. A., Praet, S. F. E., Nicolay, K., van Loon, L. J. C., & Prompers, J. J. (2008) · European Journal of Endocrinology · doi:10.1530/eje-07-0756 · Cited by 116 · see citing works

Physical activity is the key determinant of skeletal muscle mitochondrial function in type 2 diabetes

van Tienen, F. H. J., Praet, S. F. E., de Feyter, H. M., van den Broek, N. M., Lindsey, P. J., Schoonderwoerd, K. G. C., de Coo, I. F. M., Nicolay, K., Prompers, J. J., Smeets, H. J. M., et al. (2012) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2011-3454 · Cited by 111 · cited 2× · see citing works

Resveratrol enhanced FOXO3 phosphorylation via synergetic activation of SIRT1 and PI3K/Akt signaling to improve the effects of exercise in elderly rat hearts

Lin, C.-H., Lin, C., Ting, W.-J., Pai, P., Kuo, W., Ho, T.-J., Kuo, W.-W., Chang, C.-H., Huang, C., & Lin, W. (2014) · AGE · doi:10.1007/s11357-014-9705-5 · Cited by 101 · see citing works

High Oxidative Capacity Due to Chronic Exercise Training Attenuates Lipid-Induced Insulin Resistance

Phielix, E., Meex, R., Ouwens, D. M., Sparks, L., Hoeks, J., Schaart, G., Moonen-Kornips, E., Hesselink, M. K. C., & Schrauwen, P. (2012) · Diabetes · doi:10.2337/db11-1832 · Cited by 99 · cited 1× · see citing works

Control of the rate of phosphocreatine resynthesis after exercise in trained and untrained human quadriceps muscles

Takahashi, H., Inaki, M., Fujimoto, K., Katsuta, S., Anno, I., N�tsu, M., & Itai, Y. (1995) · European Journal of Applied Physiology · doi:10.1007/bf00635872 · Cited by 97 · see citing works

The role of ampk in controlling metabolism and mitochondrial biogenesis during exercise

Marcinko, K., & Steinberg, G. R. (2014) · Experimental Physiology · doi:10.1113/expphysiol.2014.082255 · Cited by 92 · see citing works

The Mitochondria in Diabetic Heart Failure: From Pathogenesis to Therapeutic Promise

Schilling, J. D. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6294 · Cited by 90 · see citing works

Caloric Restriction Primes Mitochondria for Ischemic Stress by Deacetylating Specific Mitochondrial Proteins of the Electron Transport Chain

Shinmura, K., Tamaki, K., Sano, M., Nakashima-Kamimura, N., Wolf, A. M., Amo, T., Ohta, S., Katsumata, Y., Fukuda, K., Ishiwata, K., et al. (2011) · Circulation Research · doi:10.1161/circresaha.111.243097 · Cited by 88 · see citing works

Cardiolipin as an oxidative target in cardiac mitochondria in the aged rat

Lesnefsky, E. J., & Hoppel, C. L. (2008) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2008.05.444 · Cited by 83 · see citing works

Aerobic Interval Training Attenuates Mitochondrial Dysfunction in Rats Post-Myocardial Infarction: Roles of Mitochondrial Network Dynamics

Jiang, H., Wang, Y., Sun, L., He, X., Zhao, M., Feng, Z., Yu, X., & Zang, W. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15045304 · Cited by 82 · see citing works

GSH or Palmitate Preserves Mitochondrial Energetic/Redox Balance, Preventing Mechanical Dysfunction in Metabolically Challenged Myocytes/Hearts From Type 2 Diabetic Mice

Tocchetti, C. G., Caceres, V., Stanley, B. A., Xie, C., Shi, S., Watson, W. H., O'Rourke, B. P., Spadari-Bratfisch, R. C., Cortassa, S. C., Akar, F. G., et al. (2012) · Diabetes · doi:10.2337/db12-0072 · Cited by 80 · see citing works

Improved Ejection Fraction after Exercise Training in Obesity Is Accompanied by Reduced Cardiac Lipid Content

Schrauwen‐Hinderling, V. B., Hesselink, M. K. C., Meex, R. C. R., van der Made, S. M., Schär, M., Lamb, H. J., Wildberger, J. E., Glatz, J. F. C., Snoep, G., Kooi, M. E., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2076 · Cited by 80 · see citing works

Exercise and physical training: Effects on insulin sensitivity and glucose metabolism

Horton, E. S. (1986) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610020101 · Cited by 79 · see citing works

Alteration of Energy Substrates and ROS Production in Diabetic Cardiomyopathy

Lorenzo, Ó., Ramírez, E., Picatoste, B., Egido, J., & Tuñón, J. (2013) · Mediators of Inflammation · doi:10.1155/2013/461967 · Cited by 70 · see citing works

Long–echo time MR spectroscopy for skeletal muscle acetylcarnitine detection

Lindeboom, L., Nabuurs, C. I. H. C., Joris Hoeks, J., Brouwers, B., Esther Phielix, E., Kooi, M. E., Hesselink, M. K. C., Wildberger, J. E., Stevens, R. D., Koves, T. R., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci74830 · Cited by 68 · see citing works

What Do Magnetic Resonance–Based Measurements of Pi→ATP Flux Tell Us About Skeletal Muscle Metabolism?

Kemp, G. J., & Brindle, K. M. (2012) · Diabetes · doi:10.2337/db11-1725 · Cited by 67 · see citing works

Metabolic Stress and Disorders Related to Alterations in Mitochondrial Fission or Fusion.

Babbar, M., & Sheikh, M. S. (2013) · PubMed · Cited by 66 · see citing works

Unbreak My Heart: Targeting Mitochondrial Autophagy in Diabetic Cardiomyopathy

Kubli, D. A., & Gustafsson, Å. B. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6322 · Cited by 65 · see citing works

How Exercise May Amend Metabolic Disturbances in Diabetic Cardiomyopathy

Hafstad, A. D., Boardman, N., & Aasum, E. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6304 · Cited by 63 · see citing works

Calorie restriction in overweight males ameliorates obesity-related metabolic alterations and cellular adaptations through anti-aging effects, possibly including AMPK and SIRT1 activation

Kitada, M., Kume, S., Takeda-Watanabe, A., Tsuda, S.-I., Kanasaki, K., & Koya, D. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.06.014 · Cited by 60 · see citing works

Protective effect of resveratrol against pressure overload‐induced heart failure

Gupta, P., DiPette, D. J., & Supowit, S. C. (2014) · Food Science & Nutrition · doi:10.1002/fsn3.92 · Cited by 60 · see citing works

Short-term high-intensity interval training improves phosphocreatine recovery kinetics following moderate-intensity exercise in humans

Forbes, S. C., Slade, J. M., & Meyer, R. A. (2008) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h08-099 · Cited by 59 · see citing works

Myocardial Metabolism in Diabetic Cardiomyopathy: Potential Therapeutic Targets

Sung, M. M. Y., Hamza, S. M., & Dyck, J. R. B. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6305 · Cited by 57 · see citing works

Relation between in vivo and in vitro measurements of skeletal muscle oxidative metabolism

Larson‐Meyer, D. E., Newcomer, B. R., Hunter, G. R., Joanisse, D. R., Weinsier, R. L., & Bamman, M. M. (2001) · Muscle & Nerve · doi:10.1002/mus.1202 · Cited by 54 · see citing works

Cardiac lipid content is unresponsive to a physical activity training intervention in type 2 diabetic patients, despite improved ejection fraction

Schrauwen‐Hinderling, V. B., Meex, R. C. R., Hesselink, M. K. C., van de Weijer, T., Leiner, T., Schär, M., Lamb, H. J., Wildberger, J. E., Glatz, J. F. C., Schrauwen, P., et al. (2011) · Cardiovascular Diabetology · doi:10.1186/1475-2840-10-47 · Cited by 50 · see citing works

Exercise training in dilated cardiomyopathy improves rest and stress cardiac function without changes in cardiac high energy phosphate metabolism

Holloway, C. J., Dass, S., Suttie, J. J., Rider, O. J., Cox, P., Cochlin, L. E., Jackson, H., Fast, A. M., Johnson, A. W., Karamitsos, T. D., et al. (2012) · Heart · doi:10.1136/heartjnl-2012-302145 · Cited by 46 · see citing works

Restoring redox balance enhances contractility in heart trabeculae from type 2 diabetic rats exposed to high glucose

Bhatt, N., Aon, M. A., Tocchetti, C. G., Shen, X., Dey, S., Ramirez‐Correa, G. A., O'Rourke, B. P., Gao, W. D., & Cortassa, S. C. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00378.2014 · Cited by 43 · see citing works

Facts and controversies in our understanding of how caloric restriction impacts the mitochondrion

Gouspillou, G., & Hepple, R. T. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.03.004 · Cited by 42 · see citing works

Exercise capacity and quadriceps muscle metabolism following training in subjects with COPD

McKeough, Z. J., Alison, J. A., Bye, P. T. P., Trenell, M. I., Sachinwalla, T., Thompson, C. H., & Kemp, G. J. (2006) · Respiratory Medicine · doi:10.1016/j.rmed.2006.01.017 · Cited by 41 · see citing works

Comparison of measuring energy metabolism by different 31P‐magnetic resonance spectroscopy techniques in resting, ischemic, and exercising muscle

Schmid, A. I., Schrauwen‐Hinderling, V. B., Andreas, M., Wolzt, M., Moser, E., & Roden, M. (2011) · Magnetic Resonance in Medicine · doi:10.1002/mrm.23095 · Cited by 40 · see citing works

Lifestyle changes and lipid metabolism gene expression and protein content in skeletal muscle of subjects with impaired glucose tolerance

Mensink, M., Blaak, E. E., Vidal, H., de Bruin, T. W., Glatz, J. F. C., & Saris, W. H. M. (2003) · Diabetologia · doi:10.1007/s00125-003-1152-2 · Cited by 39 · see citing works

Gene expression profiling of human skeletal muscle in response to stabilized weight loss

Larrouy, D., Barbe, P., Valle, C., Dejean, S., Pelloux, V., Thalamas, C., Bastard, J., Bouil, A. L., Diquet, B., Clément, K., et al. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.1.125 · Cited by 32 · see citing works

Left ventricular function and energy metabolism in middle-aged men undergoing long-lasting sustained aerobic oxidative training

Perseghin, G., COBELLI, F. D., Esposito, A., Belloni, E., Lattuada, G., Canu, T., Invernizzi, P. L., Ragogna, F., Torre, A. L., Scifo, P., et al. (2008) · Heart · doi:10.1136/hrt.2008.154716 · Cited by 25 · see citing works

Can resveratrol help to maintain metabolic health?

Schrauwen, P., & Timmers, S. (2014) · Proceedings of The Nutrition Society · doi:10.1017/s0029665113003856 · Cited by 24 · see citing works

Impact of Exercise Capacity on Myocardial High-Energy Phosphate Metabolism

Klug, G., Zwick, R. H., Frick, M., Wolf, C., Schocke, M. F. H., Conci, E., Jaschke, W. R., Pachinger, O. M., & Metzler, B. (2007) · International Journal of Sports Medicine · doi:10.1055/s-2007-964862 · Cited by 13 · see citing works

Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease

Smith, R. L., Soeters, M. R., Wüst, R. C. I., & Houtkooper, R. H. (2018) · Endocrine Reviews · doi:10.1210/er.2017-00211 · Cited by 787 · see citing works

Pathophysiology and Mechanisms of Nonalcoholic Fatty Liver Disease

Haas, J. T., Francque, S., & Staels, B. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105331 · Cited by 399 · see citing works

Grip Strength as a Marker of Hypertension and Diabetes in Healthy Weight Adults

Mainous, A. G., Tanner, R., Anton, S. D., & Jo, A. (2015) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2015.05.025 · Cited by 161 · see citing works

Effect of exercise on cardiometabolic health of adults with overweight or obesity: Focus on blood pressure, insulin resistance, and intrahepatic fat—A systematic review and meta‐analysis

Battista, F., Ermolao, A., van Baak, M. A., Beaulieu, K., Blundell, J. E., Busetto, L., Carraça, E. V., Encantado, J., Dicker, D., Farpour‐Lambert, N. J., et al. (2021) · Obesity Reviews · doi:10.1111/obr.13269 · Cited by 131 · see citing works

Metabolic Syndrome and Oxidative Stress: A Complex Relationship

Carrier, A. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6929 · Cited by 118 · see citing works

Effects of air pollution on mitochondrial function, mitochondrial DNA methylation, and mitochondrial peptide expression

Breton, C. V., Song, A., Xiao, J., Kim, S., Mehta, H. H., Wan, J., Yen, K., Sioutas, C., Lurmann, F. W., Xue, S., et al. (2019) · Mitochondrion · doi:10.1016/j.mito.2019.04.001 · Cited by 106 · see citing works

Redox implications in adipose tissue (dys)function-A new look at old acquaintances

Jankovic, A., Korac, A., Buzadzic, B., Otasevic, V., Stancic, A., Daiber, A., & Korac, B. (2015) · Redox Biology · doi:10.1016/j.redox.2015.06.018 · Cited by 91 · see citing works

Advanced glycation end products receptor RAGE controls myocardial dysfunction and oxidative stress in high-fat fed mice by sustaining mitochondrial dynamics and autophagy-lysosome pathway

Yu, Y.-C., Wang, L., Delguste, F., Durand, A., Guilbaud, A., Rousselin, C., Schmidt, A. M., Tessier, F. J., Boulanger, É., & Nevière, R. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.08.012 · Cited by 78 · see citing works

Insulin Resistance Is Associated With Reduced Mitochondrial Oxidative Capacity Measured by 31P-Magnetic Resonance Spectroscopy in Participants Without Diabetes From the Baltimore Longitudinal Study of Aging

Fabbri, E., Chia, C. W., Spencer, R. G., Fishbein, K. W., Reiter, D. A., Cameron, D., Zane, A. C., Moore, Z. A., Gonzalez-Freire, M., Zoli, M., et al. (2017) · Diabetes · doi:10.2337/db16-0754 · Cited by 76 · see citing works

Mitochondrial-derived peptides in aging and age-related diseases

Kim, S., Miller, B., Kumagai, H., Silverstein, A. R., Flores, M., & Yen, K. (2020) · GeroScience · doi:10.1007/s11357-020-00262-5 · Cited by 73 · see citing works

The Vicious Cycle of Renal Lipotoxicity and Mitochondrial Dysfunction

Ge, M., Fontanesi, F., Merscher, S., & Fornoni, A. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00732 · Cited by 71 · see citing works

Mitochondrial health, the epigenome and healthspan

Aon, M. A., Cortassa, S., Juhaszova, M., & Sollott, S. J. (2016) · Clinical Science · doi:10.1042/cs20160002 · Cited by 66 · see citing works

Palmitate induces mitochondrial superoxide generation and activates AMPK in podocytes

Lee, E., Choi, J. W., & Lee, H. S. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25867 · Cited by 58 · see citing works

FGF21 ameliorates diabetic cardiomyopathy by activating the AMPK-paraoxonase 1 signaling axis in mice

Wu, F., Wang, B., Zhang, S., Shi, L., Wang, Y., Xiong, R., Pan, X., Gong, F., Li, X., & Lin, Z. (2017) · Clinical Science · doi:10.1042/cs20170271 · Cited by 55 · see citing works

Metabolic and Energy Imbalance in Dysglycemia-Based Chronic Disease

Kalra, S., Unnikrishnan, A., Baruah, M. P., Sahay, R. K., & Bantwal, G. (2021) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s286888 · Cited by 54 · see citing works

O-GlcNAcase deficiency suppresses skeletal myogenesis and insulin sensitivity in mice through the modulation of mitochondrial homeostasis

Wang, X., Feng, Z., Wang, X., Yang, L., Han, S., Cao, K. J., Xu, J., Zhao, L., Zhang, Y., & Liu, J. (2016) · Diabetologia · doi:10.1007/s00125-016-3919-2 · Cited by 51 · see citing works

Oxidative phosphorylation and mitochondrial function differ between human prostate tissue and cultured cells

Schöpf, B., Schäfer, G., Weber, A., Talasz, H., Eder, I. E., Klocker, H., & Gnaiger, E. (2016) · FEBS Journal · doi:10.1111/febs.13733 · Cited by 50 · see citing works

Natural activators of adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK) and their pharmacological activities

Vazirian, M., Nabavi, S. M., Jafari, S., & Manayi, A. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.09.079 · Cited by 46 · see citing works

Prevalence of Diabetes and Its Determinants in the Young Adults Indian Population-Call for Yoga Intervention

Nagarathna, R., Bali, P., Anand, A., Srivastava, V., Patil, S. S., Sharma, G., Manasa, K., Pannu, V. S., Singh, A., & Nagendra, H. R. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.507064 · Cited by 51 · see citing works

GlyNAC (Glycine and N-Acetylcysteine) Supplementation Improves Impaired Mitochondrial Fuel Oxidation and Lowers Insulin Resistance in Patients with Type 2 Diabetes: Results of a Pilot Study

Sekhar, R. V. (2022) · Antioxidants · doi:10.3390/antiox11010154 · Cited by 44 · see citing works

Exercise Training Reduces Intrathoracic Fat Regardless of Defective Glucose Tolerance

Honkala, S. M., Motiani, K. K., Eskelinen, J., Savolainen, A., Saunavaara, V., Virtanen, K. A., Löyttyniemi, E., Kapanen, J., Knuuti, J. M., Kalliokoski, K. K., et al. (2017) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001232 · Cited by 35 · see citing works

Impaired mitochondrial energy supply coupled to increased H2O2 emission under energy/redox stress leads to myocardial dysfunction during Type I diabetes

Tocchetti, C. G., Stanley, B. A., Sivakumaran, V., Bedja, D., O'Rourke, B. P., Paolocci, N., Cortassa, S. C., & Aon, M. A. (2015) · Clinical Science · doi:10.1042/cs20150204 · Cited by 34 · see citing works

Mitochondrial health is enhanced in rats with higher vs. lower intrinsic exercise capacity and extended lifespan

Aon, M. A., Cortassa, S. C., Juhaszova, M., González-Reyes, J. A., Calvo‐Rubio, M., Villalba, J. M., Lachance, A. D., Ziman, B. D., Mitchell, S. J., Murt, K. N., et al. (2021) · npj Aging and Mechanisms of Disease · doi:10.1038/s41514-020-00054-3 · Cited by 23 · see citing works

Unchanged mitochondrial phenotype, but accumulation of lipids in the myometrium in obese pregnant women

Gam, C. M. B. F., Larsen, L. H., Mortensen, O. H., Engelbrechtsen, L., Poulsen, S. S., Qvortrup, K., Mathiesen, E. R., Damm, P., & Quistorff, B. (2017) · The Journal of Physiology · doi:10.1113/jp274838 · Cited by 23 · see citing works

Control of Adipose Cell Browning and Its Therapeutic Potential

Lizcano, F., & Arroyave, F. (2020) · Metabolites · doi:10.3390/metabo10110471 · Cited by 23 · see citing works

Kidney and lipids: novel potential therapeutic targets for dyslipidemia in kidney disease?

Zuzda, K., Grycuk, W., Małyszko, J. S., & Małyszko, J. (2022) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2022.2161887 · Cited by 15 · see citing works

Diabetes Increases the Vulnerability of the Cardiac Mitochondrial Network to Criticality

Vetter, L., Cortassa, S. C., O'Rourke, B. P., Armoundas, A. A., Bedja, D., Jende, J. M. E., Bendszus, M., Paolocci, N., Sollott, S. J., Aon, M. A., et al. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00175 · Cited by 14 · see citing works

Association between diesel exhaust exposure and mitochondrial DNA methylation

Seow, W. J., Hu, W., Dai, Y., Vermeulen, R. C. H., Byun, H., Wong, J. Y. Y., Bassig, B. A., Blechter, B., Duan, H., Niu, Y., et al. (2022) · Carcinogenesis · doi:10.1093/carcin/bgac077 · Cited by 11 · see citing works

lncRNA UCA1 inhibits mitochondrial dysfunction of skeletal muscle in type 2 diabetes mellitus by sequestering miR-143-3p to release FGF21

Huang, S., Wu, K., Li, B., & Liu, Y. (2023) · Cell and Tissue Research · doi:10.1007/s00441-022-03733-7 · Cited by 11 · see citing works

Citrate Synthase Insufficiency Leads to Specific Metabolic Adaptations in the Heart and Skeletal Muscles Upon Low-Carbohydrate Diet Feeding in Mice

Sumi, K., Hatanaka, Y., Takahashi, R., Wada, N. A., Ono, C., Sakamoto, Y. S., Sone, H., & Iida, K. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.925908 · Cited by 10 · see citing works

The Levels of Polycyclic Aromatic Hydrocarbons and Their Derivatives in Plasma and Their Effect on Mitochondrial DNA Methylation in the Oilfield Workers

Jia, Y., Li, W., Li, Y., Zhao, L., Li, C., Wang, L., Fang, J., Song, S., Ji, Y., Fang, T., et al. (2023) · Toxics · doi:10.3390/toxics11050466 · Cited by 9 · see citing works

Empowering mitochondrial metabolism: Exploring L-lactate supplementation as a promising therapeutic approach for metabolic syndrome

Cai, M., Li, S., Cai, K., Du, X., Han, J., & Hu, J. (2024) · Metabolism · doi:10.1016/j.metabol.2024.155787 · Cited by 11 · see citing works

Unlocking metabolic flexibility in heart failure with preserved ejection fraction: Bridging fundamental mechanisms to clinical innovation

Xia, J., Nong, Y., Teng, J., Mohammed, S. A., Liu, J., Pang, Y., Costantino, S., Ruschitzka, F. T., Hamdani, N., Abdellatif, M., et al. (2025) · iScience · doi:10.1016/j.isci.2025.113471 · Cited by 11 · see citing works

Molecular basis of arrhythmic substrate in ageing murine peroxisome proliferator-activated receptor γ co-activator deficient hearts modelling mitochondrial dysfunction

Edling, C. E., Fazmin, I. T., Saadeh, K., Chadda, K. R., Ahmad, S., Valli, H., Huang, C. L.-H., & Jeevaratnam, K. (2019) · Bioscience Reports · doi:10.1042/bsr20190403 · Cited by 9 · see citing works

The continuum of disrupted metabolic tempo, mitochondrial substrate congestion, and metabolic gridlock toward the development of non-communicable diseases

Tippairote, T., Bjørklund, G., & Yaovapak, A. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1907299 · Cited by 8 · see citing works

Molecular basis of ventricular arrhythmogenicity in a Pgc-1α deficient murine model

Saadeh, K., Chadda, K. R., Ahmad, S., Valli, H., Nanthakumar, N., Fazmin, I. T., Edling, C. E., Huang, C. L.-H., & Jeevaratnam, K. (2021) · Molecular Genetics and Metabolism Reports · doi:10.1016/j.ymgmr.2021.100753 · Cited by 7 · see citing works

Kcnma1 is involved in mitochondrial homeostasis in diabetes‐related skeletal muscle atrophy

Gao, S., Liu, Y., Wen, R., Huang, X., Li, P., Yang, Y., Yang, N., & Zhang, T. (2023) · The FASEB Journal · doi:10.1096/fj.202201397rr · Cited by 6 · see citing works

Grape polyphenols and exercise training have distinct molecular effects on cardiac hypertrophy in a model of obese insulin-resistant rats

Lambert, K., Demion, M., Lagacé, J., Hokayem, M., Dass, M., Virsolvy, A., Jover, B. F., Bourret, A., & Bisbal, C. (2020) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2020.108522 · Cited by 4 · see citing works

Evaluating the correlation of the impairment between skeletal muscle and heart using MRI in a spontaneous type 2 diabetes mellitus rhesus monkey model

Chen, Y., Zeng, W., Chen, W., Zhang, Y., Zhu, T., Sun, J., Liang, Z., Wang, L., Yang, Z., Wu, B., et al. (2020) · Acta Diabetologica · doi:10.1007/s00592-019-01460-0 · Cited by 4 · see citing works

METTL16-m6A-PGC-1α axis contributes to exercise-induced mitochondrial adaptations in skeletal muscle of high-fat diet-fed insulin-resistant mice

Chen, C., Jiang, C. H., Xiang, Q., Hu, Y., Wu, H., Huang, C., Zhou, H., Xu, Y., Hou, M., Liu, W., et al. (2026) · BMC Biology · doi:10.1186/s12915-026-02519-5 · Cited by 3 · see citing works

Imaging in Precision Medicine for Diabetes

Zaharia, O., Schrauwen‐Hinderling, V. B., & Roden, M. (2022) · Springer eBooks · doi:10.1007/978-3-030-98927-9_4 · Cited by 1 · see citing works

Aerobic Training Modulates the Expression of Components of the mPTP Through the Reduction of Oxidative Stress in the Soleus Muscle of Streptozotocin-Induced Diabetic Rats

Sánchez‐Briones, L. A., Sánchez‐Duarte, S., Marquez-Gamiño, S., Vera‐Delgado, K. S., Vera-Delgado, M. G., Montoya-Pérez, R. D. C., Caudillo‐Cisneros, C., & Sánchez‐Duarte, E. (2026) · Diabetology · doi:10.3390/diabetology7010018 · Cited by 1 · see citing works

Rutin improves diabetes-induced muscle atrophy in mice.

Xianchu, L., & Ming, L. (2023) · Pakistan Journal of Pharmaceutical Sciences · doi:10.36721/pjps.2023.36.1.reg.217-221.1 · Cited by 1 · see citing works

İnsülin 100 Yıllık Mucize Hormon

Cerit, E. T., Barlas, T., Atalar, K., Bahçelioğlu, M., Kaplanoğlu, G. T., Seymen, C. M., Erdem, H. B., Ergün, M. A., Demir, Ö., Gülbahar, Ö., et al. (2022) · Akademisyen Kitabevi eBooks · doi:10.37609/akya.871

COMPARAÇÃO DAS EXPRESSÕES DA FORÇA DE PREENSÃO MANUAL COM OS COMPONENTES DA SÍNDROME METABÓLICA EM ADULTOS

Júnior, J. J. A. D. S., Amaral, T. L. M., Monteiro, G. T. R., Amaral, C. D. A., de Vasconcellos, M. T. L., & Reverter-Masia, J. (2025) · Revista Contemporânea · doi:10.56083/rcv5n10-097

Impact de la stéatohépatite non alcoolique sur le remodelage myocardique et sur les complications cardiovasculaires

Decoin, R. (2023) · doi:10.70675/86ee210fz0966z4d73zaab2z3d0fa1adefed

Molecular Mechanisms of Obesity-Associated Oxidative Stress and Therapeutic Strategies

Wang, R., Luo, Y., Liu, L., Zhang, J., Li, R., & Zhang, N. (2026) · Antioxidants · doi:10.3390/antiox15091193

Type 2 diabetes, mitochondrial biology and the heart

Sack, M. N. (2009) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2009.02.001 · Cited by 53 · see citing works

Altered mitochondrial metabolism in the insulin‐resistant heart

Makrecka‐Kuka, M., Liepinsh, E., Murray, A. J., Lemieux, H., Dambrova, M., Tepp, K., Puurand, M., Käämbre, T., Han, W. H., de Goede, P., et al. (2019) · Acta Physiologica · doi:10.1111/apha.13430 · Cited by 93 · see citing works

The role of mitochondria in insulin resistance and type 2 diabetes mellitus

Szendroedi, J., Phielix, E., & Roden, M. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.138 · Cited by 600 · see citing works

Muscle mitochondria and insulin resistance: a human perspective

Hoeks, J., & Schrauwen, P. (2012) · Trends in Endocrinology &amp; Metabolism · doi:10.1016/j.tem.2012.05.007 · Cited by 94 · see citing works

Targeting Mitochondria in Diabetes

Jakovljevic, N. K., Pavlović, K., Jotić, A., Lalic, K. S., Stoiljkovic, M. M., Lukić, L., Milicic, T. J., Macesic, M. V., Gajović, J. S., & Lalic, N. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126642 · Cited by 90 · see citing works