The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Strength Training Increases Insulin-Mediated Glucose Uptake, GLUT4 Content, and Insulin Signaling in Skeletal Muscle in Patients With Type 2 Diabetes
Open accessAbstract
Strength training represents an alternative to endurance training for patients with type 2 diabetes. Little is known about the effect on insulin action and key proteins in skeletal muscle, and the necessary volume of strength training is unknown. A total of 10 type 2 diabetic subjects and 7 healthy men (control subjects) strength-trained one leg three times per week for 6 weeks while the other leg remained untrained. Each session lasted no more than 30 min. After strength training, muscle biopsies were obtained, and an isoglycemic-hyperinsulinemic clamp combined with arterio-femoral venous catheterization of both legs was carried out. In general, qualitatively similar responses were obtained in both groups. During the clamp, leg blood flow was higher (P < 0.05) in trained versus untrained legs, but despite this, arterio-venous extraction glucose did not decrease in trained legs. Thus, leg glucose clearance was increased in trained legs (P < 0.05) and more than explained by increases in muscle mass. Strength training increased protein content of GLUT4, insulin receptor, protein kinase B-α/β, glycogen synthase (GS), and GS total activity. In conclusion, we found that strength training for 30 min three times per week increases insulin action in skeletal muscle in both groups. The adaptation is attributable to local contraction-mediated mechanisms involving key proteins in the insulin signaling cascade.
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“Training can enhance the responsiveness of skeletal muscles to insulin with increased expression and/or activity of proteins involved in glucose metabolism and insulin signaling ( 39 , 110 , 204 , 270 ).”
From Exercise and Type 2 Diabetes (2010) · cites this paper as [110]
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High-intensity resistance training improves glycemic control in older patients with type 2 diabetes
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Wang, T., Zhang, Y., Zhang, L., Hongjuan, L., Zhao, C., Li, J. N., & Meng, F. (2026) · Maturitas · doi:10.1016/j.maturitas.2026.109054
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“…in glucose metabolism following RE are likely due to a combination of increased skeletal muscle mass [9], upregulated skeletal muscle glucose transporter protein GLUT-4, and increased insulin sensitivity, collectively resulting in improved muscle glycogen storage and glucose utilization [24].”
THE ROLE OF RESISTANCE TRAINING IN MODULATING INSULIN RESISTANCE: A NARRATIVE REVIEW
Deska, G., Wójtowicz, K., Wawrzeczko, A., Jakubiec, M. K., Jankowska, A., Gostół, M., Górska, N., Gąsiorowska, E., & Lewczuk, A. (2026) · International Journal of Innovative Technologies in Social Science · doi:10.31435/ijitss.2(50).2026.5411
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“…that only six weeks of resistance training increased skeletal muscle GLUT4 protein content by approximately 40% in patients with type 2 diabetes, accompanied by increased insulin-stimulated glucose uptake and enhanced insulin signaling, independent of substantial muscle hypertrophy [241].”
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“As an evidence-based cornerstone of diabetes management, progressive resistance training activates glucose transporter type 4 (GLUT4) translocation through insulin-independent pathways during muscle contraction [7].”
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“Mechanistic studies in patients with T2DM have shown that strength training can increase insulin-mediated skeletal muscle glucose uptake, GLUT4 content, and the expression of insulin-signaling proteins (38).”
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Physical activity, exercise and non-alcoholic fatty liver disease
Hallsworth, K. (2012) · OpenGrey (Institut de l'Information Scientifique et Technique)
Metadata
- Authors
- Holten, M. K., Zacho, M., Gaster, M., Juel, C., Wojtaszewski, J. F. P., & Dela, F.
- Affiliations
- University of Copenhagen (DK)
- Rigshospitalet (DK)
- Odense University Hospital (DK)
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2004-02-01
- Volume
- 53
- Issue
- 2
- Pages
- 294-305
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2153401503
- Cited by
- 615
- References
- 48
- Citations by year
- 2026: 36 · 2025: 24 · 2024: 18 · 2023: 20 · 2022: 32 · 2021: 38 · 2020: 30 · 2019: 22 · 2018: 35 · 2017: 29 · 2016: 25 · 2015: 32 · 2014: 25 · 2013: 37 · 2012: 39
- FWCI
- 7.70
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion)
- Funders
- Sundhed og Sygdom, Det Frie Forskningsråd
- University of Cambridge
- National Research Foundation
- Danmarks Grundforskningsfond (504–14)
- Diabetesforeningen
- Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Keywords
- resistance training, type 2 diabetes, insulin action, skeletal muscle, GLUT4, insulin signaling, glycogen synthase, Akt, insulin receptor, glucose uptake, glucose clearance, muscle blood flow, training volume
- MeSH terms
- Biological Transport, Capillaries, Denmark, Diabetes Mellitus, Type 2, Glucose, Glycogen, Humans, Insulin, Leg, Male, Monosaccharide Transport Proteins, Muscle Proteins, Physical Fitness, Reference Values, Tensile Strength, Exercise, Muscle, Skeletal, Muscle Fibers, Skeletal, White People, Glucose Transporter Type 4
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