The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Strength Training Increases Insulin-Mediated Glucose Uptake, GLUT4 Content, and Insulin Signaling in Skeletal Muscle in Patients With Type 2 Diabetes
Open accessAbstract
Strength training represents an alternative to endurance training for patients with type 2 diabetes. Little is known about the effect on insulin action and key proteins in skeletal muscle, and the necessary volume of strength training is unknown. A total of 10 type 2 diabetic subjects and 7 healthy men (control subjects) strength-trained one leg three times per week for 6 weeks while the other leg remained untrained. Each session lasted no more than 30 min. After strength training, muscle biopsies were obtained, and an isoglycemic-hyperinsulinemic clamp combined with arterio-femoral venous catheterization of both legs was carried out. In general, qualitatively similar responses were obtained in both groups. During the clamp, leg blood flow was higher (P < 0.05) in trained versus untrained legs, but despite this, arterio-venous extraction glucose did not decrease in trained legs. Thus, leg glucose clearance was increased in trained legs (P < 0.05) and more than explained by increases in muscle mass. Strength training increased protein content of GLUT4, insulin receptor, protein kinase B-α/β, glycogen synthase (GS), and GS total activity. In conclusion, we found that strength training for 30 min three times per week increases insulin action in skeletal muscle in both groups. The adaptation is attributable to local contraction-mediated mechanisms involving key proteins in the insulin signaling cascade.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Training can enhance the responsiveness of skeletal muscles to insulin with increased expression and/or activity of proteins involved in glucose metabolism and insulin signaling ( 39 , 110 , 204 , 270 ).”
From Exercise and Type 2 Diabetes (2010) · cites this paper as [110]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Boulé, N. G., Haddad, E., Kenny, G. P., Wells, G. A., & Sigal, R. J. (2001) · JAMA · doi:10.1001/jama.286.10.1218 · Cited by 1,889
Thomas, J. A., Schlender, K. K., & Larner, J. (1968) · Analytical Biochemistry · doi:10.1016/0003-2697(68)90127-9 · Cited by 1,198
Castaneda, C., Layne, J. E., Munoz-Orians, L., Gordon, P. L., Walsmith, J., Foldvari, M., Roubenoff, R., Tucker, K. L., & Nelson, M. E. (2002) · Diabetes Care · doi:10.2337/diacare.25.12.2335 · Cited by 844
High-intensity resistance training improves glycemic control in older patients with type 2 diabetes
Dunstan, D. W., Daly, R. M., Owen, N., Jolley, D., de Courten, M., Shaw, J., & Zimmet, P. (2002) · Diabetes Care · doi:10.2337/diacare.25.10.1729 · Cited by 771
Kim, Y.-B., Nikoulina, S. E., Ciaraldi, T. P., Henry, R. R., & Kahn, B. B. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6928 · Cited by 487
Krook, A., Björnholm, M., Galuska, D., Jiang, X. J., Fahlman, R., Myers, M. G., Wallberg-Henriksson, H., & Zierath, J. R. (2000) · Diabetes · doi:10.2337/diabetes.49.2.284 · Cited by 375
Mourier, A., Gautier, J.-F., Kerviler, E. D., Bigard, A. X., Villette, J.-M., Garnier, J.-P., Duvallet, A., Guezennec, C. Y., & Cathelineau, G. (1997) · Diabetes Care · doi:10.2337/diacare.20.3.385 · Cited by 361
Blood flow and muscle metabolism: a focus on insulin action
Clark, M. G., Wallis, M. G., Barrett, E. J., Keske, M. A., Richards, S. M., Clerk, L. H., & Rattigan, S. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00408.2002 · Cited by 359
Combined aerobic and resistance exercise improves glycemic control and fitness in type 2 diabetes
Maiorana, A., O’Driscoll, G., Goodman, C., Taylor, R. R., & GREEN, D. J. (2002) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(01)00368-0 · Cited by 353
Dela, F., Larsen, J. J., Mikines, K. J., Ploug, T., Petersen, L. N., & Galbo, H. (1995) · Diabetes · doi:10.2337/diab.44.9.1010 · Cited by 286
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–200 of 612
Celis-Morales, C. A., Lyall, D. M., Steell, L., Gray, S. R., Iliodromiti, S., Anderson, J. J., Mackay, D., Welsh, P. I., Yates, T. E., Pell, J. P., et al. (2018) · BMC Medicine · doi:10.1186/s12916-018-1063-1 · Cited by 103
“There are also data from randomised trials of resistance training—which improves strength—that such interventions improve glucose regulation, lipid profile, adiposity and type 2 diabetes risk [32, 33].”
BackgroundResistance exercise: good for more than just Grandma and Grandpa's muscles.
Phillips, S. M. (2007) · Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · doi:10.1139/h07-129 · Cited by 95
“2006), and glucoregulatory proteins such as GLUT4 and glycogen synthase (Holten et al. 2004), as well as hexokinase (Tang et al.”
BackgroundÁlvarez, C., Ramírez‐Campillo, R., Ramírez‐Vélez, R., & Izquierdo, M. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01037.2016 · Cited by 103
Efficiency of vibration exercise for glycemic control in type 2 diabetes patients
Baum, K., Votteler, T., & Schiab, J. (2007) · International Journal of Medical Sciences · doi:10.7150/ijms.4.159 · Cited by 96
Modification of Insulin Sensitivity and Glycemic Control by Activity and Exercise
ROBERTS, C. K., LITTLE, J. P., & THYFAULT, J. P. (2013) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318295cdbb · Cited by 95
“Using the OGTT method, RT also improves insulin action in subjects with impaired glucose tolerance or T2D (35,62).”
BackgroundMethodTrain like an athlete: applying exercise interventions to manage type 2 diabetes
Savikj, M., & Zierath, J. R. (2020) · Diabetologia · doi:10.1007/s00125-020-05166-9 · Cited by 105
Wang, Y., Simar, D., & Singh, M. A. F. (2009) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.928 · Cited by 94
Conceição, M. S., Bonganha, V., VECHIN, F. C., Berton, R. P. D. B., Lixandrão, M. E., Damas, F., Souza, Chacon‐Mikahil, M. P. T., & Libardi, C. A. (2013) · Clinical Interventions in Aging · doi:10.2147/cia.s44245 · Cited by 97
Fraser, B. J., Schmidt, M. D., Huynh, Q. L., Dwyer, T., Venn, A., & Magnussen, C. G. (2017) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2017.03.021 · Cited by 92
Bailey, D. P., Boddy, L. M., Savory, L. A., Denton, S. J., & Kerr, C. J. (2012) · European Journal of Pediatrics · doi:10.1007/s00431-012-1719-3 · Cited by 91
“It is known that physical exercise results in skeletal muscle cell adaptations in adults [25] and some of these adaptations, such as increased capillary density and limb blood flow [26], increased mitochondrial electron transport chain enzyme activity [25] and increased mitochondrial volume and density [25], may be me…”
BackgroundThe Subacute Effects of Exercise: Concept, Characteristics, and Clinical Implications
da Nóbrega, A. C. L. (2005) · Exercise and Sport Sciences Reviews · doi:10.1097/00003677-200504000-00005 · Cited by 87
Hansen, J. S., Zhao, X., Irmler, M., Liu, X., Hoene, M., Scheler, M., Li, Y., Beckers, J., de Angelis, M. H., Häring, H., et al. (2015) · Diabetologia · doi:10.1007/s00125-015-3584-x · Cited by 93
“It has been reported that the increase in GLUT4 protein is more pronounced in diabetic individuals compared with healthy controls after 6 weeks of exercise training, while the levels were similar at baseline [24].”
ResultChildhood Muscular Fitness Phenotypes and Adult Metabolic Syndrome
Fraser, B. J., Huynh, Q. L., Schmidt, M. D., Dwyer, T., Venn, A., & Magnussen, C. G. (2016) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000955 · Cited by 91
Malin, S. K., Nightingale, J., Choi, S., Chipkin, S. R., & Braun, B. (2013) · Obesity · doi:10.1002/oby.20235 · Cited by 88
Aging, Resistance Training, and Diabetes Prevention
Flack, K. D., Davy, K. P., Hulver, M. W., Winett, R. A., Frisard, M. I., & Davy, B. M. (2010) · Journal of Aging Research · doi:10.4061/2011/127315 · Cited by 101
Westcott, W. L., Winett, R. A., Annesi, J. J., Wojcik, J. R., Anderson, E. S., & Madden, P. J. (2009) · The Physician and Sportsmedicine · doi:10.3810/psm.2009.06.1709 · Cited by 92
Leisure-Time Physical Activity and the Metabolic Syndrome in the Finnish Diabetes Prevention Study
Ilanne‐Parikka, P., Laaksonen, D. E., Eriksson, J. G., Lakka, T. A., Lindstr, J., Peltonen, M., Aunola, S., Keinanen-Kiukaanniemi, S. M., Uusitupa, M. I. J., & Tuomilehto, J. O. (2010) · Diabetes Care · doi:10.2337/dc09-2155 · Cited by 87
Influence of acute exercise on hyperglycemia in insulin-treated type 2 diabetes
PRAET, S. F., MANDERS, R. J., LIEVERSE, A. G., KUIPERS, H., STEHOUWER, C. D., KEIZER, H. A., & VAN LOON, L. J. (2006) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000235352.09061.1d · Cited by 85
Yi, D., Khang, A. R., Lee, H. W., Son, S. M., & Kang, Y. H. (2018) · Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy · doi:10.2147/dmso.s166875 · Cited by 86
“Muscle biopsy in the strength training group revealed increased protein content of glucose transporter 4, insulin receptor, protein kinase B, and glycogen synthase, as well as increased total activity of glycogen synthase.(44) Further controlled experimental studies are required to clarify the mechanism underlying the…”
Wojtaszewski, J. F. P., & Richter, E. A. (2006) · Essays in Biochemistry · doi:10.1042/bse0420031 · Cited by 109
Self-citationOrlando, G., Balducci, S., Bazzucchi, I., Pugliese, G., & Sacchetti, M. (2015) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2658 · Cited by 88
Praet, S. F. E., Jonkers, R. A. M., Schep, G., Stehouwer, C. D. A., Kuipers, H., Keizer, H. A., & van Loon, L. J. (2008) · European Journal of Endocrinology · doi:10.1530/eje-07-0169 · Cited by 80
Exercise Interventions and Peripheral Arterial Function: Implications for Cardio-Metabolic Disease
Phillips, S. A., Mahmoud, A. M., Brown, M. D., & Haus, J. M. (2015) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2014.12.005 · Cited by 78
Resistance Training and Older Adults with Type 2 Diabetes Mellitus: Strength of the Evidence
Hovanec, N., Sawant, A., Overend, T. J., Petrella, R. J., & Vandervoort, A. A. (2012) · Journal of Aging Research · doi:10.1155/2012/284635 · Cited by 79
Resistance Training Is an Effective Tool against Metabolic and Frailty Syndromes
Sundell, J. (2010) · Advances in Preventive Medicine · doi:10.4061/2011/984683 · Cited by 94
Burr, J. F., Rowan, C. P., Jamnik, V., & Riddell, M. C. (2010) · The Physician and Sportsmedicine · doi:10.3810/psm.2010.04.1764 · Cited by 78
Zanuso, S., Sacchetti, M., Sundberg, C. J., Orlando, G., Benvenuti, P., & Balducci, S. (2017) · British Journal of Sports Medicine · doi:10.1136/bjsports-2016-096724 · Cited by 78
Tan, S., Li, W., & Wang, J. (2012) · Europe PMC (PubMed Central) · Cited by 76
Exercise in Aging: Its Important Role in Mortality, Obesity and Insulin Resistance
Ryan, A. S. (2010) · Aging Health · doi:10.2217/ahe.10.46 · Cited by 78
Andersen, T. R., Schmidt, J. F., Thomassen, M., Hornstrup, T., Frandsen, U., Randers, M. B., Hansen, P. R., Krustrup, P., & Bangsbo, J. (2014) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.12259 · Cited by 79
Muscle-Strengthening Activity and Its Association With Insulin Sensitivity
Cheng, Y. J., Gregg, E. W., de Rekeneire, N., Williams, D. E., Imperatore, G., Caspersen, C. J., & Kahn, H. S. (2007) · Diabetes Care · doi:10.2337/dc07-0372 · Cited by 71
Codella, R., Ialacqua, M., Terruzzi, I., & Luzi, L. (2018) · Endocrine · doi:10.1007/s12020-018-1603-7 · Cited by 72
A coding and non-coding transcriptomic perspective on the genomics of human metabolic disease
Timmons, J. A., Atherton, P. J., Larsson, O. S., Sood, S., Blokhin, I. O., Brogan, R. J., Volmar, C., Josse, A. R., Slentz, C. A., Wahlestedt, C., et al. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky570 · Cited by 70
Mejora de la forma física como terapia antienvejecimiento
Garzón, M. J. C., Ortega, F. B., & Ruiz, J. R. (2005) · Medicina Clínica · doi:10.1157/13071011 · Cited by 69
Mensberg, P., Nyby, S., Jørgensen, P. G., Storgaard, H., Jensen, M. T., Sivertsen, J., Holst, J. J., Kiens, B., Richter, E. A., Knop, F. K., et al. (2016) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12797 · Cited by 73
Bernardo, B. L., Wachtmann, T. S., Cosgrove, P. G., Kühn, M., Opsahl, A., Judkins, K. M., Freeman, T. B., Hadcock, J. R., & LeBrasseur, N. K. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011307 · Cited by 68
Ahmadizad, S., Ghorbani, S., Ghasemikaram, M., & Bahmanzadeh, M. (2014) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2013.12.019 · Cited by 75
Inflammation, hepatic enzymes and resistance training in individuals with metabolic risk factors
Levinger, I., Goodman, C. A., Peake, J. M., GARNHAM, A. P., Hare, D. L., Jerums, G., & Selig, S. E. (2009) · Diabetic Medicine · doi:10.1111/j.1464-5491.2009.02679.x · Cited by 68
Rabøl, R., Larsen, S., Højberg, P. V., Almdal, T., Boushel, R., Haugaard, S. B., Andersen, J. L., Madsbad, S., & Dela, F. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1844 · Cited by 68
Self-citationOlver, T. D., & Laughlin, M. H. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00440.2015 · Cited by 67
Kenny, H. C., Rudwill, F., Breen, L., Salanova, M., Blottner, D., Heise, T., Heer, M., Blanc, S., & O’Gorman, D. J. (2017) · Diabetologia · doi:10.1007/s00125-017-4298-z · Cited by 64
Martínez‐Vizcaíno, V., Sánchez‐López, M., Notario‐Pacheco, B., Salcedo‐Aguilar, F., Solera-Martínez, M., Morales, P. F., López-Martínez, S., García-Prieto, J. C., Arias-Palencia, N. M., Torrijos-Niño, C., et al. (2014) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/s12966-014-0154-4 · Cited by 70
Iglay, H. B., Thyfault, J. P., Apolzan, J. W., & Campbell, W. W. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.4.1005 · Cited by 63
Russell, R., Hu, D., Greenaway, T. M., Blackwood, S. J., Dwyer, R. M., Sharman, J. E., Jones, G., Squibb, K. A., Brown, A. A., Otáhal, P., et al. (2017) · Diabetes Care · doi:10.2337/dc16-2750 · Cited by 64
Seyedizadeh, S. H., Cheragh-Birjandi, S., & Nia, M. R. H. (2020) · Journal of Diabetes Research · doi:10.1155/2020/6978128 · Cited by 64
Improvement of obesity-linked skeletal muscle insulin resistance by strength and endurance training
Meo, S. D., Iossa, S., & Venditti, P. (2017) · Journal of Endocrinology · doi:10.1530/joe-17-0186 · Cited by 69
“Another important adaptation responsible for the insulin-sensitizing effect of the training independent of an increase in muscle mass might be the enhanced insulin receptor protein expression (Holten et al. 2004).”
BackgroundLi, S., Zhang, R., Pan, G., Zheng, L., & Li, C. (2017) · Pediatric Diabetes · doi:10.1111/pedi.12596 · Cited by 61
Nutrition and Physical Activity in Nonalcoholic Fatty Liver Disease
de Oliveira, C. P. M. S., Sanches, P. D. L., de Abreu-Silva, E. O., & Marcadenti, A. (2015) · Journal of Diabetes Research · doi:10.1155/2016/4597246 · Cited by 64
Leitlinie körperliche Aktivität zur Sekundärprävention und Therapie kardiovaskulärer Erkrankungen
Bjarnason‐Wehrens, B., Schulz, O., Gielen, S., Halle, M., Dürsch, M., Hambrecht, R., Lowis, H., Kindermann, W., Schulze, R., & Rauch, B. (2009) · Clinical Research in Cardiology Supplements · doi:10.1007/s11789-009-0078-8 · Cited by 58
Shiotsu, Y., Watanabe, Y., Tujii, S., & Yanagita, M. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.06.020 · Cited by 61
Muscular strength and markers of insulin resistance in European adolescents: the HELENA Study
Jiménez‐Pavón, D., Ortega, F. B., Valtueña, J., Castro‐Piñero, J., Gómez‐Martínez, S., Zaccaria, M., Gottrand, F., Molnár, D., Sjöstróm, M., González‐Gross, M., et al. (2011) · European Journal of Applied Physiology · doi:10.1007/s00421-011-2216-5 · Cited by 59
“In adults, it has been suggested that higher muscular strength and muscle mass might be relevant factors against insulin resistance (Holten et al. 2004; Koopman et al. 2006; Rattarasarn et al. 2010), while in adolescents, the concrete mechanisms are not yet established.”
BackgroundLew, K. S., Pearson, J. T., Schwenke, D. O., & Katare, R. (2017) · Cardiovascular Diabetology · doi:10.1186/s12933-016-0484-4 · Cited by 57
Stuart, C. A., Howell, M. E. A., BAKER, J. D., Dykes, R., Duffourc, M. M., Ramsey, M. W., & Stone, M. H. (2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181ad7f36 · Cited by 54
Exercise in the Treatment and Prevention of Diabetes
Colberg, S. R., & Grieco, C. R. (2009) · Current Sports Medicine Reports · doi:10.1249/jsr.0b013e3181ae0654 · Cited by 55
Croymans, D. M., Paparisto, E., Lee, M. M., Brandt, N., Le, B. K., Lohan, D. G., Lee, C. C., & Roberts, C. K. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00485.2013 · Cited by 56
Beneficial Effects of Exercise on Muscle Mitochondrial Function in Diabetes Mellitus
Lumini‐Oliveira, J., Magalhães, J., Oliveira, P. J., & Ascensão, A. A. M. R. (2008) · Sports Medicine · doi:10.2165/00007256-200838090-00003 · Cited by 55
Atashak, S., Peeri, M., Azarbayjani, M. A., Stannard, S. R., & Haghighi, M. M. (2011) · Europe PMC (PubMed Central) · Cited by 54
Childhood cardiorespiratory fitness, muscular fitness and adult measures of glucose homeostasis
Fraser, B. J., Blizzard, L., Schmidt, M. D., Juonala, M., Dwyer, T., Venn, A., & Magnussen, C. G. (2018) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2018.02.002 · Cited by 56
Lower muscle strength gains in older men with type 2 diabetes after resistance training
Ibáñez, J., Gorostiaga, E. M., Alonso, A. M., Forga, L., Argüelles, I., Larrión, J. L., & Izquierdo, M. (2008) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2007.06.008 · Cited by 55
Chien, Y.-H., Tsai, C.-J., Wang, D., Chuang, P.-H., & Lin, H. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph192215009 · Cited by 68
Hussain, M., Hameed, U. A., Manzar, M. D., Raza, S., & Shareef, M. Y. (2012) · North American Journal of Medical Sciences · doi:10.4103/1947-2714.99507 · Cited by 55
“Previous research has found that strength training for 30 minutes three times per week increases insulin action in skeletal muscle by the said mechanisms.[21] Upper body and lower body muscular strength gains in the PRT group may have led to increased insulin action in skeletal muscle, an effect that may be attributed…”
Insulin resistance and mitochondrial function in skeletal muscle
Dela, F., & Helge, J. W. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.09.019 · Cited by 57
Self-citationDunford, E. C., & Riddell, M. C. (2016) · Metabolites · doi:10.3390/metabo6040044 · Cited by 55
Physical Exercise Prescription in Metabolic Chronic Disease
Stefani, L., & Galanti, G. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-5717-5_6 · Cited by 57
Steenberg, D. E., Jørgensen, N. B., Birk, J. B., Sjøberg, K. A., Kiens, B., Richter, E. A., & Wojtaszewski, J. F. P. (2018) · The Journal of Physiology · doi:10.1113/jp276735 · Cited by 53
“Muscle insulin sensitivity increases as an adaptive response to chronic exercise training (Dela et al. 1992; Holten et al. 2004; Frøsig et al. 2007a) involving changes in muscle size, morphology, capillarization and protein composition.”
BackgroundSelf-citationFraser, B. J., Blizzard, L., Buscot, M., Schmidt, M. D., Dwyer, T., Venn, A., & Magnussen, C. G. (2020) · Sports Medicine · doi:10.1007/s40279-020-01328-2 · Cited by 52
Liang, Z., Zhang, M., Wang, C., Hao, F., Yu, Y., Tian, S., & Yuan, Y. (2024) · Sports Medicine · doi:10.1007/s40279-024-02057-6 · Cited by 56
“However, combining the two exercise modalities may yield better benefits owing to their different physiological effects on large and individual muscle groups [48–50].”
Dela, F., Ingersen, A., Andersen, N. B., Nielsen, M. B., Petersen, H. H. H., HANSEN, C. N., Larsen, S., Wojtaszewski, J. F. P., & Helge, J. W. (2018) · Acta Physiologica · doi:10.1111/apha.13245 · Cited by 54
“A two‐step, isoglycaemic, hyperinsulinaemic clamp with insulin infusion at 80 and 400 mU/min/ m(2) was performed as previously described.(3) Plasma glucose was maintained at isoglycaemia by arterial blood analyses (ABL 700, Radiometer, Bronshoj, Denmark) every 5 minutes and subsequent adjustment of glucose infusion ra…”
MethodResultInfluentialSelf-citationEnhancement of anaerobic glycolysis – a role of PGC-1α4 in resistance exercise
Koh, J., Pataky, M. W., Dasari, S., Klaus, K. A., Vučković, I., Ruegsegger, G. N., Kumar, A. P., Robinson, M. M., & Nair, K. S. (2022) · Nature Communications · doi:10.1038/s41467-022-30056-6 · Cited by 54
Effects of Whole Body Vibration Plus Diet on Insulin-Resistance in Middle-Aged Obese Subjects
Bellia, A., Sallì, M., Lombardo, M., D’Adamo, M., Guglielmi, V., Tirabasso, C., Giordani, L., Federici, M., Lauro, D., Foti, C., et al. (2013) · International Journal of Sports Medicine · doi:10.1055/s-0033-1354358 · Cited by 51
Ramírez‐Vélez, R., Carrillo, H. A., Correa‐Bautista, J. E., Schmidt‐RioValle, J., González‐Jiménez, E., Correa‐Rodríguez, M., González‐Ruíz, K., & García‐Hermoso, A. (2018) · Nutrients · doi:10.3390/nu10081027 · Cited by 51
Efficacy of Dietary and Supplementation Interventions for Individuals with Type 2 Diabetes
Lewgood, J., Oliveira, B., Korzepa, M., Forbes, S. C., Little, J. P., Breen, L., Bailie, R., & Candow, D. G. (2021) · Nutrients · doi:10.3390/nu13072378 · Cited by 52
Sigal, R. J., Kenny, G. P., Boulé, N. G., Wells, G. A., Prud'homme, D., Fortier, M., Reid, R. D., Tulloch, H., Coyle, D., Phillips, P., et al. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-147-6-200709180-00005 · Cited by 48
Li, J., Cheng, W., & Ma, H. (2022) · Journal of Diabetes Research · doi:10.1155/2022/9273830 · Cited by 53
Shepherd, S. O., Cocks, M. S., Tipton, K. D., Witard, O. C., Ranasinghe, A. M., Barker, T. A., Wagenmakers, A. J. M., & Shaw, C. S. (2014) · Experimental Physiology · doi:10.1113/expphysiol.2014.078014 · Cited by 52
Muscular strengthening activity patterns and metabolic health risk among US adults*
Churilla, J. R., Magyari, P. M., Ford, E. S., Fitzhugh, E. C., & Johnson, T. M. (2011) · Journal of Diabetes · doi:10.1111/j.1753-0407.2011.00172.x · Cited by 47
Pilates Method Training: Functional and Blood Glucose Responses of Older Women With Type 2 Diabetes
Melo, K. C. B., Araújo, F. D. S., Júnior, C. C. M. C., de Andrade, K. T. P., & Moreira, S. R. (2018) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000002704 · Cited by 47
A Review of Exercise as Medicine in Cardiovascular Disease: Pathology and Mechanism
Gronek, P., Wieliński, D., Cygański, P., Rynkiewicz, A., Zając, A., Maszczyk, A., Gronek, J., Podstawski, R., Czarny, W., Balkó, Š., et al. (2020) · Aging and Disease · doi:10.14336/ad.2019.0516 · Cited by 53
“The main mechanisms include insulin-mediated glucose uptake [95, 96], post-receptor insulin signalling [97], increased transport of glucose to the muscles due to enlarged muscle capillary network and up-regulation of glucose transporter (GLUT4) [98, 99].”
BackgroundTraining-induced changes in membrane transport proteins of human skeletal muscle
Juel, C. (2006) · European Journal of Applied Physiology · doi:10.1007/s00421-006-0140-x · Cited by 46
“Functional tests demonstrate that leg glucose clearance increases with strength training in one study (Holten et al. 2004), whereas a decreased glucose clearance has been found in another study (Friedlander et al. 1997).”
BackgroundSelf-citationRoles of physical exercise-induced MiR-126 in cardiovascular health of type 2 diabetes
Ma, Y., Liu, H., Wang, Y., Xuan, J., Gao, X. H., Ding, H., Ma, C., Chen, Y., & Yang, Y. (2022) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-022-00942-6 · Cited by 48
Monleón, D., Garcia-Valles, R., Morales, J. M., Brioche, T., González, G. O., López-Grueso, R., Gómez‐Cabrera, M. C., & Viña, J. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00585.2014 · Cited by 45
He, N., & Ye, H. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-1792-1_17 · Cited by 51
Does a Hypertrophying Muscle Fibre Reprogramme its Metabolism Similar to a Cancer Cell?
Wackerhage, H., Vechetti, I. J., Baumert, P., Gehlert, S., Becker, L., Jaspers, R. T., & de Angelis, M. H. (2022) · Sports Medicine · doi:10.1007/s40279-022-01676-1 · Cited by 46
van Buuren, F., Horstkotte, D., Mellwig, K. P., Fründ, A., Vlachojannis, M., Bogunovic, N., Dimitriadis, Z., Vortherms, J., Humphrey, R. H., & Niebauer, J. (2015) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2014.0315 · Cited by 45
Kim, J.-S., Lee, Y., Kim, J.-C., Ko, Y.-H. K., Yoon, C. S., & Yi, H. (2014) · Biology of Sport · doi:10.5604/20831862.1093775 · Cited by 45
McMillin, S. L., Schmidt, D. L., Kahn, B. B., & Witczak, C. A. (2017) · Diabetes · doi:10.2337/db16-1075 · Cited by 45
Sellami, M., Bragazzi, N. L., Slimani, M., Hayes, L. D., Jabbour, G., Giorgio, A. D., & Dugué, B. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16101709 · Cited by 50
“Other studies examined the effect of resistance training in insulin sensitivity in elderly subjects and reported that strength training induced improvement in insulin-stimulated glucose uptake promoted by glucose transporter type 4 (GLUT-4) in elderly [41].”
BackgroundQadir, R., Sculthorpe, N. F., Todd, T., & Brown, E. C. (2021) · Sports Medicine - Open · doi:10.1186/s40798-021-00321-x · Cited by 54
The Physiological Role of Irisin in the Regulation of Muscle Glucose Homeostasis
Yano, N., Zhao, Y., & Zhao, T. C. (2021) · Endocrines · doi:10.3390/endocrines2030025 · Cited by 46
Physical activity: the forgotten tool for type 2 diabetes management
Colberg, S. R. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00070 · Cited by 47
“, 2003), regular resistance work improves overall glycemic control and insulin sensitivity by increasing levels of muscle GLUT4, insulin receptors, protein kinase B, glycogen synthase, and glycogen synthase total activity following acute training (Holten et al., 2004).”
Savoia, A., Landi, S., Vannini, F., & Baldi, A. (2013) · Dermatology and Therapy · doi:10.1007/s13555-013-0026-x · Cited by 43
Resistance Training Improves Insulin Signaling and Action in Skeletal Muscle
Yaspelkis, B. B. (2006) · Exercise and Sport Sciences Reviews · doi:10.1097/00003677-200601000-00009 · Cited by 42
Nutritional Strategies to Combat Type 2 Diabetes in Aging Adults: The Importance of Protein
Beaudry, K. M., & Devries, M. C. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00138 · Cited by 41
Paquin, J., Lagacé, J., Brochu, M., & Dionne, I. J. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.656909 · Cited by 49
Gurudut, P., & Rajan, A. P. (2017) · Journal of Exercise Rehabilitation · doi:10.12965/jer.1735032.516 · Cited by 46
“This further leads to the regulation of GLUT-4 activity, increasing its translocation at the cellular level (Cheng and Kujala, 2012; Holten et al., 2004).”
BackgroundLi, J., Li, J., & Lu, Y. (2021) · Journal of Exercise Science & Fitness · doi:10.1016/j.jesf.2021.08.002 · Cited by 54
Impaired overload-induced hypertrophy in obese Zucker rat slow-twitch skeletal muscle
Paturi, S., Gutta, A. K., Kakarla, S. K., Katta, A., Arnold, E. C., Wu, M., Rice, K. M., & Blough, E. R. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00330.2009 · Cited by 42
mTOR function in skeletal muscle: a focal point for overnutrition and exercise
Rivas, D. A., Lessard, S. J., & Coffey, V. G. (2009) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h09-073 · Cited by 39
“Endurance-type and resistance-type exercise has been shown to enhance insulin sensitivity and training-specific adaptation in skeletal muscle (Coffey and Hawley 2007; Hawley and Lessard 2008; Wojtaszewski and Richter 2006; Holten et al. 2004; Ishii et al. 1998; Yaspelkis 2006; Houmard et al. 2004).”
BackgroundImpact of exercise intensity and duration on insulin sensitivity in women with T2D
Segerström, Å. B., Glans, F., Eriksson, K., Holmbäck, A. M., Groop, L., Thorsson, O., & Wollmer, P. (2010) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2010.05.003 · Cited by 42
“The studies on resistance and combined exercise show consistently an increase in insulin sensitivity [5,7,8,46,47].”
BackgroundFluorescent protein-based detection of unconjugated bilirubin in newborn serum
Iwatani, S., Nakamura, H., Kurokawa, D., Yamana, K., Nishida, K., Fukushima, S., Koda, T., Nishimura, N., Nishio, H., Iijima, K., et al. (2016) · Scientific Reports · doi:10.1038/srep28489 · Cited by 40
Metadata
- Authors
- Holten, M. K., Zacho, M., Gaster, M., Juel, C., Wojtaszewski, J. F. P., & Dela, F.
- Affiliations
- University of Copenhagen (DK)
- Rigshospitalet (DK)
- Odense University Hospital (DK)
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2004-02-01
- Volume
- 53
- Issue
- 2
- Pages
- 294-305
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2153401503
- Cited by
- 615
- References
- 48
- Citations by year
- 2026: 36 · 2025: 24 · 2024: 18 · 2023: 20 · 2022: 32 · 2021: 38 · 2020: 30 · 2019: 22 · 2018: 35 · 2017: 29 · 2016: 25 · 2015: 32 · 2014: 25 · 2013: 37 · 2012: 39
- FWCI
- 7.70
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion)
- Funders
- Sundhed og Sygdom, Det Frie Forskningsråd
- University of Cambridge
- National Research Foundation
- Danmarks Grundforskningsfond (504–14)
- Diabetesforeningen
- Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Keywords
- resistance training, type 2 diabetes, insulin action, skeletal muscle, GLUT4, insulin signaling, glycogen synthase, Akt, insulin receptor, glucose uptake, glucose clearance, muscle blood flow, training volume
- MeSH terms
- Biological Transport, Capillaries, Denmark, Diabetes Mellitus, Type 2, Glucose, Glycogen, Humans, Insulin, Leg, Male, Monosaccharide Transport Proteins, Muscle Proteins, Physical Fitness, Reference Values, Tensile Strength, Exercise, Muscle, Skeletal, Muscle Fibers, Skeletal, White People, Glucose Transporter Type 4
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
